Published in J Biol Chem on April 21, 2003
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Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol (2010) 2.46
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Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure. Cardiovasc Res (2010) 1.73
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest (2004) 1.58
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest (2007) 1.53
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Free and bound intracellular calmodulin measurements in cardiac myocytes. Cell Calcium (2006) 1.21
Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione. Biochemistry (2008) 1.17
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction. Biochem Biophys Res Commun (2010) 1.16
Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms. J Am Heart Assoc (2014) 1.16
Mechanism of calmodulin inhibition of cardiac sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor). Biophys J (2004) 1.10
The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol (2010) 1.09
Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. J Biol Chem (2008) 1.06
X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i. J Mol Cell Cardiol (2012) 1.03
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel. Biophys J (2011) 1.00
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Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res (2013) 0.98
Calmodulin-binding locations on the skeletal and cardiac ryanodine receptors. J Biol Chem (2012) 0.95
S100A1: Structure, Function, and Therapeutic Potential. Curr Chem Biol (2009) 0.95
Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor. J Physiol (2013) 0.93
X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch. Cardiovasc Res (2013) 0.91
Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol (2016) 0.90
S100A1 and calmodulin regulation of ryanodine receptor in striated muscle. Cell Calcium (2011) 0.89
Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity. J Mol Cell Cardiol (2015) 0.88
Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts. Cardiovasc Res (2012) 0.85
Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling. J Biol Chem (2010) 0.85
Role of the Met3534-Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide. Biophys J (2005) 0.85
In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Circ Res (2012) 0.84
Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation. Biochemistry (2014) 0.82
Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676. Br J Pharmacol (2005) 0.81
Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1. Am J Physiol Heart Circ Physiol (2013) 0.81
Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release. J Biol Chem (2015) 0.80
Aberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyte. Biochem J (2011) 0.80
Calcium handling proteins: structure, function, and modulation by exercise. Heart Fail Rev (2014) 0.79
Two potential calmodulin-binding sequences in the ryanodine receptor contribute to a mobile, intra-subunit calmodulin-binding domain. J Cell Sci (2013) 0.79
Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors. Br J Pharmacol (2009) 0.79
Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)-Organized Dyads. Circulation (2016) 0.78
Identification of ATP-binding regions in the RyR1 Ca²⁺ release channel. PLoS One (2012) 0.78
Calcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1). Biophys Chem (2014) 0.77
Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy? Diabetes Metab Syndr Obes (2012) 0.76
Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin. Biophys J (2016) 0.75
IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor. JAKSTAT (2016) 0.75
The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+-binding but not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor. J Biol Chem (2016) 0.75
Calcium Signaling and Cardiac Arrhythmias. Circ Res (2017) 0.75
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks. Biophys J (2002) 1.80
Ca(2+) sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle. Proc Natl Acad Sci U S A (2007) 1.67
Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants. J Biol Chem (2003) 1.58
(De)constructing the ryanodine receptor: modeling ion permeation and selectivity of the calcium release channel. J Phys Chem B (2005) 1.57
Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1. Am J Physiol Cell Physiol (2011) 1.55
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest (2007) 1.53
Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. Proc Natl Acad Sci U S A (2003) 1.44
p21-activated kinase 1 predicts recurrence and survival in patients with non-metastatic clear cell renal cell carcinoma. Int J Urol (2015) 1.40
The evolution of Helicobacter pylori antibiotics resistance over 10 years in Beijing, China. Helicobacter (2010) 1.26
Two rings of negative charges in the cytosolic vestibule of type-1 ryanodine receptor modulate ion fluxes. Biophys J (2005) 1.23
Probing the role of negatively charged amino acid residues in ion permeation of skeletal muscle ryanodine receptor. Biophys J (2005) 1.20
Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes. J Biol Chem (2006) 1.20
Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel. J Biol Chem (2002) 1.19
Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4. Proc Natl Acad Sci U S A (2011) 1.19
Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione. Biochemistry (2008) 1.17
Characterization of recessive RYR1 mutations in core myopathies. Hum Mol Genet (2006) 1.12
Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol Cell Biol (2008) 1.12
Mechanism of calmodulin inhibition of cardiac sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor). Biophys J (2004) 1.10
Regulation of ion channel structure and function by reactive oxygen-nitrogen species. Am J Physiol Lung Cell Mol Physiol (2003) 1.10
Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. Cell Calcium (2008) 1.08
Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum. J Gen Physiol (2010) 1.08
Structural determinants of skeletal muscle ryanodine receptor gating. J Biol Chem (2013) 1.03
A role for the RNA-binding protein MOS2 in microRNA maturation in Arabidopsis. Cell Res (2013) 1.02
High Jagged1 expression predicts poor outcome in clear cell renal cell carcinoma. Jpn J Clin Oncol (2010) 1.02
Single channel properties of heterotetrameric mutant RyR1 ion channels linked to core myopathies. J Biol Chem (2008) 1.01
Diketopyridylryanodine has three concentration-dependent effects on the cardiac calcium-release channel/ryanodine receptor. J Biol Chem (2003) 0.99
Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. J Biol Chem (2005) 0.99
Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res (2013) 0.98
Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3β/Snail signaling in renal cell carcinoma. Cancer Sci (2013) 0.96
Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel. Biochemistry (2005) 0.96
Location of ryanodine and dihydropyridine receptors in frog myocardium. Biophys J (2003) 0.96
Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene. Neuromuscul Disord (2010) 0.95
Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma. PLoS One (2013) 0.95
A structural model of the pore-forming region of the skeletal muscle ryanodine receptor (RyR1). PLoS Comput Biol (2009) 0.94
Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor. J Physiol (2013) 0.93
Different regions in skeletal and cardiac muscle ryanodine receptors are involved in transducing the functional effects of calmodulin. J Biol Chem (2004) 0.93
Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing Snail protein. Cancer Sci (2012) 0.92
Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes. J Gen Physiol (2002) 0.92
Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia. J Physiol (2013) 0.91
Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells. Cancer Sci (2013) 0.90
Excitation-contraction coupling in airway smooth muscle. J Biol Chem (2006) 0.90
Occurrence of atypical Ca2+ transients in triadin-binding deficient-RYR1 mutants. Biochem Biophys Res Commun (2006) 0.90
Sorafenib suppresses growth and survival of hepatoma cells by accelerating degradation of enhancer of zeste homolog 2. Cancer Sci (2013) 0.88
Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. Am J Physiol Heart Circ Physiol (2011) 0.88
Two central core disease (CCD) deletions in the C-terminal region of RYR1 alter muscle excitation-contraction (EC) coupling by distinct mechanisms. Hum Mutat (2007) 0.87
Silencing genes of sarcoplasmic reticulum proteins clarifies their roles in excitation-contraction coupling. J Physiol (2009) 0.86
Low Expression of Mucin-4 Predicts Poor Prognosis in Patients With Clear-Cell Renal Cell Carcinoma. Medicine (Baltimore) (2016) 0.85
Clinical and functional effects of a deletion in a COOH-terminal lumenal loop of the skeletal muscle ryanodine receptor. Hum Mol Genet (2003) 0.84
Tumor miR-125b predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection. Cancer Sci (2014) 0.83
Effects of quercetin on single Ca(2+) release channel behavior of skeletal muscle. Biophys J (2002) 0.83
Does Ca2+/calmodulin-dependent protein kinase deltac activate or inhibit the cardiac ryanodine receptor ion channel? Circ Res (2007) 0.82
Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1. Am J Physiol Heart Circ Physiol (2013) 0.81
A recessive ryanodine receptor 1 mutation in a CCD patient increases channel activity. Cell Calcium (2008) 0.81
Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels. Proteins (2009) 0.81
Mass spectrometric analysis and mutagenesis predict involvement of multiple cysteines in redox regulation of the skeletal muscle ryanodine receptor ion channel complex. Res Rep Biol (2011) 0.81
Analysis of energy utilization and body composition in kidney, bladder, and adrenal cancer patients. Urol Oncol (2010) 0.80
Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. PLoS One (2013) 0.80
PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban. J Clin Invest (2015) 0.79
Aldolase potentiates DIDS activation of the ryanodine receptor in rabbit skeletal sarcoplasmic reticulum. Biochem J (2006) 0.79
ST6Gal-I predicts postoperative clinical outcome for patients with localized clear-cell renal cell carcinoma. Asian Pac J Cancer Prev (2014) 0.79
Singular diffraction-free surface plasmon beams generated by overlapping phase-shifted sources. Opt Lett (2013) 0.79
Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma. Medicine (Baltimore) (2015) 0.79
Prognostic significance of p21-activated kinase 6 expression in patients with clear cell renal cell carcinoma. Ann Surg Oncol (2014) 0.79
Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma. Tumour Biol (2015) 0.79
Continuous modulations of femtosecond laser-induced periodic surface structures and scanned line-widths on silicon by polarization changes. Opt Express (2013) 0.78
One-pot synthesis of benzamide over a robust tandem catalyst based on center radially fibrous silica encapsulated TS-1. Chem Commun (Camb) (2013) 0.78