| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates.
|
Nat Med
|
2006
|
2.83
|
|
2
|
Concern
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.
|
J Clin Invest
|
2012
|
2.23
|
|
3
|
Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs.
|
Anesthesiology
|
2014
|
2.06
|
|
4
|
Prolonged survival of porcine hepatocytes in cynomolgus monkeys.
|
Gastroenterology
|
2006
|
2.04
|
|
5
|
Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion.
|
J Diabetes Complications
|
2009
|
1.26
|
|
6
|
HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma.
|
Clin Chem
|
2007
|
1.22
|
|
7
|
Biochemical mechanisms of cyclosporine neurotoxicity.
|
Mol Interv
|
2004
|
1.19
|
|
8
|
Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
|
Transplantation
|
2005
|
1.10
|
|
9
|
Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.
|
Cancer Res
|
2009
|
1.09
|
|
10
|
Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS.
|
Anal Biochem
|
2007
|
1.09
|
|
11
|
Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells.
|
Br J Pharmacol
|
2009
|
1.04
|
|
12
|
Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury.
|
JPEN J Parenter Enteral Nutr
|
2003
|
1.01
|
|
13
|
Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells.
|
Pharm Res
|
2002
|
1.00
|
|
14
|
Effects of lovastatin on breast cancer cells: a proteo-metabonomic study.
|
Breast Cancer Res
|
2010
|
1.00
|
|
15
|
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
|
J Pharmacol Exp Ther
|
2003
|
0.99
|
|
16
|
Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy.
|
Cardiovasc Res
|
2012
|
0.99
|
|
17
|
Cyclosporine induces endothelial cell release of complement-activating microparticles.
|
J Am Soc Nephrol
|
2013
|
0.99
|
|
18
|
Pharmacokinetics of mycophenolate mofetil and sirolimus in children.
|
Ther Drug Monit
|
2008
|
0.98
|
|
19
|
Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects.
|
Drug Metab Pharmacokinet
|
2003
|
0.97
|
|
20
|
Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness.
|
J Appl Physiol (1985)
|
2005
|
0.95
|
|
21
|
Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation.
|
Nephron Exp Nephrol
|
2009
|
0.94
|
|
22
|
A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.
|
Anal Bioanal Chem
|
2011
|
0.92
|
|
23
|
Polymer-free biolimus a9-coated stent demonstrates more sustained intimal inhibition, improved healing, and reduced inflammation compared with a polymer-coated sirolimus-eluting cypher stent in a porcine model.
|
Circ Cardiovasc Interv
|
2010
|
0.91
|
|
24
|
Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared.
|
Rapid Commun Mass Spectrom
|
2011
|
0.90
|
|
25
|
Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes.
|
Mol Cancer Ther
|
2011
|
0.90
|
|
26
|
Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function.
|
Chem Res Toxicol
|
2009
|
0.90
|
|
27
|
Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study.
|
J Proteome Res
|
2010
|
0.90
|
|
28
|
Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension.
|
Proteomics
|
2007
|
0.89
|
|
29
|
Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability.
|
Twin Res Hum Genet
|
2010
|
0.89
|
|
30
|
Development and validation of a high-throughput assay for quantification of the proliferation inhibitor ABT-578 using LC/LC-MS/MS in blood and tissue samples.
|
Ther Drug Monit
|
2005
|
0.89
|
|
31
|
Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin.
|
Am J Physiol Lung Cell Mol Physiol
|
2007
|
0.88
|
|
32
|
Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter.
|
EuroIntervention
|
2013
|
0.88
|
|
33
|
Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism.
|
Chem Res Toxicol
|
2010
|
0.87
|
|
34
|
Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.
|
J Pharmacol Exp Ther
|
2002
|
0.87
|
|
35
|
Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats.
|
Anesth Analg
|
2009
|
0.87
|
|
36
|
Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2006
|
0.87
|
|
37
|
Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation.
|
Ther Drug Monit
|
2016
|
0.86
|
|
38
|
Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.
|
J Mass Spectrom
|
2007
|
0.86
|
|
39
|
Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT.
|
Transpl Int
|
2004
|
0.85
|
|
40
|
Proteomics and metabolomics in renal transplantation-quo vadis?
|
Transpl Int
|
2012
|
0.85
|
|
41
|
Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.
|
Ther Drug Monit
|
2004
|
0.85
|
|
42
|
Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2009
|
0.85
|
|
43
|
The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts.
|
Xenotransplantation
|
2005
|
0.84
|
|
44
|
Transplantation: toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides.
|
Curr Opin Investig Drugs
|
2003
|
0.84
|
|
45
|
The pharmacokinetics of Biolimus A9 after elution from the Nobori stent in patients with coronary artery disease: the NOBORI PK study.
|
Catheter Cardiovasc Interv
|
2008
|
0.84
|
|
46
|
Identification and characterization of a bacterial cytochrome P450 for the metabolism of diclofenac.
|
Appl Microbiol Biotechnol
|
2009
|
0.83
|
|
47
|
Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m.
|
Free Radic Biol Med
|
2009
|
0.83
|
|
48
|
Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study.
|
Int J Cancer
|
2011
|
0.83
|
|
49
|
Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.
|
J Cereb Blood Flow Metab
|
2002
|
0.82
|
|
50
|
Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury.
|
PLoS One
|
2012
|
0.82
|
|
51
|
Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose.
|
Br J Clin Pharmacol
|
2010
|
0.82
|
|
52
|
Cyclosporine can increase isoflurane MAC.
|
Anesth Analg
|
2002
|
0.82
|
|
53
|
CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy.
|
J Am Soc Nephrol
|
2013
|
0.82
|
|
54
|
Pharmacokinetics of enteric-coated mycophenolate sodium in stable liver transplant recipients.
|
Clin Transplant
|
2007
|
0.82
|
|
55
|
Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages.
|
J Control Release
|
2005
|
0.82
|
|
56
|
A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity.
|
Nephron Physiol
|
2008
|
0.82
|
|
57
|
Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease.
|
BMC Nephrol
|
2013
|
0.81
|
|
58
|
Sirolimus (rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts.
|
Circulation
|
2003
|
0.81
|
|
59
|
Urinary catalytic iron in patients with type 2 diabetes without microalbuminuria--a substudy of the ACCORD Trial.
|
Clin Chem
|
2010
|
0.81
|
|
60
|
Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism.
|
Xenobiotica
|
2013
|
0.81
|
|
61
|
Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients.
|
Clin Pharmacokinet
|
2013
|
0.81
|
|
62
|
A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors.
|
Pediatr Blood Cancer
|
2012
|
0.81
|
|
63
|
An automated, highly sensitive LC-MS/MS assay for the quantification of the opiate antagonist naltrexone and its major metabolite 6beta-naltrexol in dog and human plasma.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2008
|
0.81
|
|
64
|
Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat.
|
PLoS One
|
2012
|
0.81
|
|
65
|
Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood.
|
Ther Drug Monit
|
2005
|
0.81
|
|
66
|
Liquid chromatography and mass spectrometry in food allergen detection.
|
J Food Prot
|
2011
|
0.81
|
|
67
|
Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin.
|
J Clin Pharmacol
|
2011
|
0.81
|
|
68
|
A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children.
|
J Sep Sci
|
2011
|
0.81
|
|
69
|
Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2013
|
0.80
|
|
70
|
Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients.
|
Biopharm Drug Dispos
|
2013
|
0.80
|
|
71
|
Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma.
|
Clin Chim Acta
|
2013
|
0.80
|
|
72
|
Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture.
|
Biomed Chromatogr
|
2009
|
0.80
|
|
73
|
Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101.
|
Drug Metab Dispos
|
2008
|
0.79
|
|
74
|
Characterization of potential allergens in fenugreek (Trigonella foenum-graecum) using patient sera and MS-based proteomic analysis.
|
J Proteomics
|
2010
|
0.79
|
|
75
|
Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice.
|
Brain Res
|
2010
|
0.79
|
|
76
|
Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure.
|
Am J Transplant
|
2005
|
0.79
|
|
77
|
Everolimus and sirolimus in transplantation-related but different.
|
Expert Opin Drug Saf
|
2015
|
0.79
|
|
78
|
Cyclosporine toxicity in immunosuppressed streptozotocin-diabetic nonhuman primates.
|
Toxicology
|
2005
|
0.79
|
|
79
|
Identification of everolimus metabolite patterns in trough blood samples of kidney transplant patients.
|
Ther Drug Monit
|
2007
|
0.79
|
|
80
|
Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.
|
J Pharm Biomed Anal
|
2013
|
0.79
|
|
81
|
Crossreactivity of isolated everolimus metabolites with the Innofluor Certican immunoassay for therapeutic drug monitoring of everolimus.
|
Ther Drug Monit
|
2007
|
0.78
|
|
82
|
Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns.
|
J Mass Spectrom
|
2011
|
0.78
|
|
83
|
Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats.
|
Inflammation
|
2013
|
0.78
|
|
84
|
Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.
|
Neurotoxicology
|
2010
|
0.78
|
|
85
|
Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation.
|
Eur Surg Res
|
2006
|
0.78
|
|
86
|
Pharmacokinetics of pyridostigmine in a child with postural tachycardia syndrome.
|
Pediatrics
|
2006
|
0.77
|
|
87
|
Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.
|
Ther Drug Monit
|
2015
|
0.77
|
|
88
|
Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months.
|
Anesth Analg
|
2011
|
0.77
|
|
89
|
Characterization of sirolimus metabolites in pediatric solid organ transplant recipients.
|
Pediatr Transplant
|
2008
|
0.76
|
|
90
|
Neurobehavioural activation during peripheral immunosuppression.
|
Int J Neuropsychopharmacol
|
2012
|
0.76
|
|
91
|
Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects.
|
Anal Bioanal Chem
|
2014
|
0.76
|
|
92
|
A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2011
|
0.76
|
|
93
|
MF101: a multi-component botanical selective estrogen receptor beta modulator for the treatment of menopausal vasomotor symptoms.
|
Expert Opin Investig Drugs
|
2012
|
0.76
|
|
94
|
Unexpectedly high exposure to enteric-coated mycophenolate sodium upon once-daily dosing.
|
Pediatr Nephrol
|
2006
|
0.75
|
|
95
|
Risk of impaired coagulation in warfarin patients ascending to altitude (>2400 m).
|
High Alt Med Biol
|
2006
|
0.75
|
|
96
|
Genetic and structure-function studies of missense mutations in human endothelial lipase.
|
PLoS One
|
2013
|
0.75
|
|
97
|
Long-term cross-validation of everolimus therapeutic drug monitoring assays: the Zortracker study.
|
Ther Drug Monit
|
2015
|
0.75
|
|
98
|
Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee.
|
Ther Drug Monit
|
2016
|
0.75
|
|
99
|
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.
|
J Clin Invest
|
2017
|
0.75
|
|
100
|
Analytical Aspects of the Implementation of Biomarkers in Clinical Transplantation.
|
Ther Drug Monit
|
2016
|
0.75
|
|
101
|
Roger Jelliffe MD, FCP, FAAPS Obituary.
|
Ther Drug Monit
|
2020
|
0.75
|
|
102
|
Randomized, double-blind, placebo-controlled, single intravenous dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of the novel coronary smooth muscle cell proliferation inhibitor Biolimus A9 in healthy individuals.
|
J Clin Pharmacol
|
2010
|
0.75
|
|
103
|
A High-throughput HPLC-MS/MS Assay for the Detection, Quantification, and Simultaneous Structural Confirmation of 136 Drugs and Metabolites in Human Urine.
|
Ther Drug Monit
|
2017
|
0.75
|
|
104
|
Cyclosporin twice or three times daily dosing in pediatric transplant patients - it is not the same!
|
Pediatr Transplant
|
2006
|
0.75
|
|
105
|
An Atmospheric Pressure Ionization MS/MS Assay using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine.
|
Ther Drug Monit
|
2017
|
0.75
|