Published in Somatic Cell Genet on July 01, 1975
3' deletions cause aniridia by preventing PAX6 gene expression. Proc Natl Acad Sci U S A (2000) 1.78
Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet (2000) 1.51
Detection of deletion mutations in pSV2gpt-transformed cells. Mol Cell Biol (1984) 1.42
Evidence for reactive oxygen species inducing mutations in mammalian cells. Proc Natl Acad Sci U S A (1986) 1.15
Isolation and characterization of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-resistant mutants of the Chinese hamster ovary cell line. Mol Cell Biol (1982) 0.78
Quantitative and molecular analyses of genetic risk: a study with ionizing radiation. Environ Health Perspect (1993) 0.78
A mutagen-testing assay based on heterogeneity in diameter and integrated optical density of mammalian cell colonies. Proc Natl Acad Sci U S A (1984) 0.77
Energy-related pollutants in the environment: use of short-term tests for mutagenicity in the isolation and identification of biohazards. Environ Health Perspect (1978) 0.76
Molecular markers of ionizing radiation-induced gene mutations in mammalian cells. Environ Health Perspect (1996) 0.75
Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone. Proc Natl Acad Sci U S A (1971) 6.12
Further changes in differentiation state accompanying the conversion of Chinese hamster cells of fibroblastic form by dibutyryl adenosine cyclic 3':5'-monophosphate and hormones. Proc Natl Acad Sci U S A (1971) 3.23
Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins. Annu Rev Microbiol (1993) 3.09
Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infect Immun (1994) 3.01
Membrane dynamics in the action of dibutyryl adenosine 3':5'-cyclic monophosphate and testosterone on mammalian cells. Proc Natl Acad Sci U S A (1972) 2.86
An electron microscopy study of the effects on dibutyryl cyclic AMP on Chinese hamster ovary cells. Cell (1974) 2.85
Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide. J Bacteriol (2000) 2.85
Host cellular immune response to pneumococcal lung infection in mice. Infect Immun (2000) 2.74
Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes. Infect Immun (1994) 2.49
The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus. J Infect Dis (1995) 2.47
Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. Infect Immun (1991) 2.32
Morphologic differentiation of mouse neuroblastoma cells induced in vitro by dibutyryl adenosine 3':5'-cyclic monophosphate. Nat New Biol (1971) 2.17
Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae. Mol Microbiol (1991) 2.11
A neuraminidase from Streptococcus pneumoniae has the features of a surface protein. Infect Immun (1994) 2.04
Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon. Gut (1986) 1.93
Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity. Infect Immun (1989) 1.91
Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains. Infect Immun (2001) 1.86
Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. J Clin Invest (1995) 1.77
Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infect Immun (1995) 1.72
Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae. Infect Immun (2000) 1.69
Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivo. Am J Respir Cell Mol Biol (1991) 1.64
Proinflammatory interactions of pneumolysin with human neutrophils. J Infect Dis (2001) 1.62
Growth of Clostridium difficile and production of toxins A and B in complex and defined media. J Med Microbiol (1986) 1.62
Streptococcus pneumoniae: virulence factors and variation. Clin Microbiol Infect (2010) 1.55
Catabolite repression in Escherichia coli: the role of glucose 6-phosphate. Biochem Biophys Res Commun (1967) 1.43
A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae. Mol Microbiol (2004) 1.42
Detection of deletion mutations in pSV2gpt-transformed cells. Mol Cell Biol (1984) 1.42
Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa. Infect Immun (1995) 1.41
Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency. Infect Immun (2000) 1.40
Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. Am J Respir Crit Care Med (1996) 1.38
The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro. Microb Pathog (1990) 1.37
A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs. Infect Immun (1997) 1.36
Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microb Pathog (1998) 1.35
Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae. Infect Immun (2001) 1.35
A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers. Biochem J (1998) 1.30
The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses. Infect Immun (2000) 1.28
The immune response to and expression of cross-reactive retroviral gag sequences in autoimmune disease. Br J Rheumatol (1992) 1.27
A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): development and definition of the system. Mutat Res (1977) 1.25
Association between chloroform levels in finished drinking water supplies and various site-specific cancer mortality rates. J Environ Pathol Toxicol (1979) 1.23
The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. J Mol Biol (1998) 1.20
The CR mutation and catabolite repression in Escherichia coli. Biochem Biophys Res Commun (1968) 1.18
The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease. Infect Immun (2004) 1.17
Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae. J Mol Biol (1998) 1.16
Evidence for reactive oxygen species inducing mutations in mammalian cells. Proc Natl Acad Sci U S A (1986) 1.15
Pneumolysin activates phospholipase A in pulmonary artery endothelial cells. Infect Immun (1994) 1.13
Extrapolation of the relative risk of radiogenic neoplasms across mouse strains and to man. Radiat Res (1988) 1.13
Clostridium difficile--a spectrum of virulence and analysis of putative virulence determinants in the hamster model of antibiotic-associated colitis. J Med Microbiol (1987) 1.13
The hemagglutination-inhibition assay for erythropoietin. Its specificity, reproducibility and sensitivity. Isr J Med Sci (1971) 1.13
Delta 32 deletion of CCR5 gene and association with asthma or atopy. Lancet (2000) 1.12
Role of two-component systems in the virulence of Streptococcus pneumoniae. J Med Microbiol (2006) 1.12
ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract. Infect Immun (2003) 1.12
Chemical mutagenesis of mammalian cells can be quantified. Nature (1977) 1.11
Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide--pneumolysoid conjugate. Vaccine (1994) 1.10
Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils. Infect Immun (2001) 1.09
Hemopoietic chimerism in imported and laboratory-bred marmosets. Transplantation (1969) 1.08
A program of statistical designs for optimizing specific transfer ribonucleic acid assay conditions. Anal Chem (1971) 1.08
Nonparametric estimation of the distribution of time to onset for specific diseases in survival/sacrifice experiments. Biometrics (1984) 1.07
Effect of pneumolysin on rat brain ciliary function: comparison of brain slices with cultured ependymal cells. Pediatr Res (2000) 1.06
Streptococcus pneumoniae produces at least two distinct enzymes with neuraminidase activity: cloning and expression of a second neuraminidase gene in Escherichia coli. Infect Immun (1991) 1.05
Effects of dose on the induction of dominant-lethal mutations and heritable translocations with ethyl methanesulfonate in male mice. Genetics (1974) 1.05
Dynamics of pneumococcal colonization in healthy Dutch children. Microbiology (2006) 1.05
Patterns of cell proliferation during recovery from oxygen injury. Species differences. Am Rev Respir Dis (1986) 1.05
A role in cell-binding for the C-terminus of pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae. FEMS Microbiol Lett (1994) 1.05
The effect of the pneumococcal toxin, pneumolysin on brain ependymal cilia. Microb Pathog (1999) 1.04
The interaction of Streptococcus pneumoniae with intact human respiratory mucosa in vitro. Eur Respir J (1992) 1.03
Functional analysis of pneumolysin by use of monoclonal antibodies. Infect Immun (1996) 1.02
Analyses of mutation in pSV2gpt-transformed CHO cells. Mutat Res (1986) 1.01
Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro. J Antimicrob Chemother (2007) 1.01
Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form. J Biol Chem (1994) 1.00
Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis. Cell Death Dis (2012) 1.00
Clostridium difficile enterotoxin (toxin A): new results. Biochem Soc Trans (1984) 0.99
Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol activated toxin of Streptococcus pneumoniae. Acta Otolaryngol (1993) 0.99
Quantitative and molecular analyses of ethyl methanesulfonate- and ICR 191-induced mutation in AS52 cells. Mutat Res (1986) 0.99
Chloride persistence in a deiced access road drainage system. J Environ Qual (2001) 0.99
Production and release of toxins A and B by Clostridium difficile. J Med Microbiol (1984) 0.98
Breast cancer patients' clinical outcome measures are associated with Src kinase family member expression. Br J Cancer (2010) 0.98
Biological mode of action of Clostridium difficile toxin A: a novel enterotoxin. J Med Microbiol (1987) 0.98
Subunit organisation and symmetry of pore-forming, oligomeric pneumolysin. FEBS Lett (1995) 0.98
Development of a multiplexed bead-based immunoassay for the simultaneous detection of antibodies to 17 pneumococcal proteins. Eur J Clin Microbiol Infect Dis (2010) 0.98
Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin. Microb Pathog (1997) 0.96
1.2 Angstroms crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold. FEBS Lett (2005) 0.96
Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine. J Clin Microbiol (2009) 0.96
Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo. FEMS Microbiol Lett (2001) 0.95
The spatial distribution of dividing and DNA-synthesizing cells in mouse epithelium. J Cell Physiol (1965) 0.95
Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective. Mutat Res (1989) 0.94
The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program. Mutat Res (1981) 0.94
Quantitative and molecular analyses of radiation-induced mutation in AS52 cells. Radiat Res (1986) 0.93
Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea. Curr Eye Res (1995) 0.93
Maturation of rat megakaryocytes studied by microspectrophotometric measurement of DNA. Proc Soc Exp Biol Med (1965) 0.93
The effects of Clostridium difficile crude toxins and toxin A on ileal and colonic loops in immune and non-immune rabbits. J Med Microbiol (1987) 0.92
Selective growth of some rodent epithelial cells in a medium containing citrulline. Proc Natl Acad Sci U S A (1979) 0.92
Prostatocutaneous urinary fistula to the thigh after retropubic prostatectomy in a patient with polycythaemia rubra vera. Br J Urol (1986) 0.91
Quantitative analyses of radiation- and chemical-induced lethality and mutagenesis in Chinese hamster ovary cells. Radiat Res (1978) 0.91
The dose-response relationship for ultraviolet-light-induced mutations at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster ovary cells. Somatic Cell Genet (1975) 0.90