Cellular adaptation to hypoxia and p53 transcription regulation.

PubWeight™: 0.81‹?›

🔗 View Article (PMC 2676422)

Published in J Zhejiang Univ Sci B on May 01, 2009

Authors

Yang Zhao1, Xue-qun Chen, Ji-zeng Du

Author Affiliations

1: Lab of Neurobiology and Physiology, Department of Physiology, School of Medicine, Zhejiang University, Hangzhou 310058, China.

Articles cited by this

Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26

Regulation of p53 stability by Mdm2. Nature (1997) 18.20

T antigen is bound to a host protein in SV40-transformed cells. Nature (1979) 17.78

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science (1994) 13.51

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53

Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52

DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J (1999) 4.68

Regulation of p53 downstream genes. Semin Cancer Biol (1998) 4.22

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell (2005) 4.16

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science (1995) 3.74

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev (1999) 3.41

Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc Natl Acad Sci U S A (1994) 3.36

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat Genet (1998) 3.01

Refined solution structure of the oligomerization domain of the tumour suppressor p53. Nat Struct Biol (1995) 2.75

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis. Mol Cell Biol (1990) 2.73

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev (1993) 2.53

Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci U S A (1996) 2.30

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol (2001) 2.19

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell (1995) 2.06

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature (1998) 1.68

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity. Proc Natl Acad Sci U S A (2003) 1.63

An inherited mutation outside the highly conserved DNA-binding domain of the p53 tumor suppressor protein in children and adults with sporadic adrenocortical tumors. J Clin Endocrinol Metab (2001) 1.42

Oxygen-dependent gene expression in fishes. Am J Physiol Regul Integr Comp Physiol (2005) 1.41

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc Natl Acad Sci U S A (2004) 1.41

Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol (2006) 1.37

Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome. Oncogene (1998) 1.31

A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network. Cancer Res (2005) 1.26

Production of human RAP30 and RAP74 in bacterial cells. Protein Expr Purif (1993) 1.21

Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution. J Biol Chem (2001) 1.20

Binding of natively unfolded HIF-1alpha ODD domain to p53. Mol Cell (2005) 1.18

Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A (2002) 1.18

HIF-1alpha and p53: the ODD couple? Trends Biochem Sci (2005) 1.12

p53-induced apoptosis as a safeguard against cancer. Biochem Biophys Res Commun (1999) 1.03

Mdm2 and HIF-1alpha interaction in tumor cells during hypoxia. J Cell Physiol (2005) 0.99

Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblastoma cell line. Biochem Biophys Res Commun (2007) 0.93

p53--a key player in tumoral and evolutionary adaptation: a lesson from the Israeli blind subterranean mole rat. Cell Cycle (2005) 0.93

Mechanism of functional inactivation of a Li-Fraumeni syndrome p53 that has a mutation outside of the DNA-binding domain. Cancer Res (2001) 0.93