Published in J Biol Chem on February 26, 2003
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol (2004) 2.74
Hypoxia-responsive transcription factors. Pflugers Arch (2005) 2.64
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol (2003) 1.83
p53 regulation of metabolic pathways. Cold Spring Harb Perspect Biol (2009) 1.79
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proc Natl Acad Sci U S A (2009) 1.71
Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J (2005) 1.67
Reciprocal influence of the p53 and the hypoxic pathways. Cell Death Dis (2011) 1.60
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. J Clin Invest (2009) 1.50
Retracted Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells. PLoS One (2013) 1.40
Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! Ann Rheum Dis (2005) 1.35
Metabolic stress in autophagy and cell death pathways. Cold Spring Harb Perspect Biol (2012) 1.30
Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system. Mol Biol Cell (2004) 1.27
PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene (2008) 1.26
DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. Mol Cell Biol (2004) 1.22
Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol (2004) 1.22
p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1). Biochem J (2004) 1.19
p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway. Cell Death Differ (2013) 1.17
Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1 alpha. J Biol Chem (2008) 1.08
p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO J (2011) 1.07
Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells. J Exp Clin Cancer Res (2012) 1.05
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. Am J Physiol Cell Physiol (2010) 1.04
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation. Neoplasia (2010) 1.03
Targeted genes and interacting proteins of hypoxia inducible factor-1. Int J Biochem Mol Biol (2012) 1.02
p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. J Clin Endocrinol Metab (2005) 1.01
Pharmacologic activation of p53 by small-molecule MDM2 antagonists. Curr Pharm Des (2011) 0.99
Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies. J Toxicol (2011) 0.99
Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis. EMBO Rep (2007) 0.99
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease. Nitric Oxide (2011) 0.99
Improved diabetic wound healing through topical silencing of p53 is associated with augmented vasculogenic mediators. Wound Repair Regen (2010) 0.98
Iron deprivation in cancer--potential therapeutic implications. Nutrients (2013) 0.98
Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation. Exp Mol Med (2008) 0.96
Inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cells. PLoS One (2012) 0.94
Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction. Am J Physiol Lung Cell Mol Physiol (2011) 0.92
Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells. Tissue Eng Part A (2014) 0.92
MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner. J Biol Chem (2014) 0.92
Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line. Antioxid Redox Signal (2008) 0.91
p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. Toxicol Appl Pharmacol (2013) 0.89
Hypoxia and senescence: the impact of oxygenation on tumor suppression. Mol Cancer Res (2011) 0.89
Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α. Cell Death Dis (2013) 0.89
Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells. BMC Cardiovasc Disord (2008) 0.87
Hypoxia, stem cells and bone tumor. Cancer Lett (2011) 0.86
Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology? Free Radic Biol Med (2012) 0.86
Effects of HIF-1alpha on human gastric cancer cell apoptosis at different CO(2) pressures. Clin Exp Med (2008) 0.81
Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis. J Funct Foods (2015) 0.81
Cellular adaptation to hypoxia and p53 transcription regulation. J Zhejiang Univ Sci B (2009) 0.81
Tight control of hypoxia-inducible factor-α transient dynamics is essential for cell survival in hypoxia. J Biol Chem (2014) 0.81
Modeling the interplay between the HIF-1 and p53 pathways in hypoxia. Sci Rep (2015) 0.79
Therapeutic considerations for Mdm2: not just a one trick pony. Expert Opin Drug Discov (2008) 0.79
The effect of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) on cell viability under hypoxia. Mol Vis (2013) 0.79
HIF-1α and HIF-2α: siblings in promoting angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation. PLoS One (2014) 0.79
Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. Am J Physiol Endocrinol Metab (2013) 0.78
LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep (2015) 0.78
Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes. PLoS One (2015) 0.78
PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. J Neurooncol (2013) 0.78
Computational analysis of signaling patterns in single cells. Semin Cell Dev Biol (2014) 0.78
RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis. Oncotarget (2016) 0.77
A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity. PLoS One (2015) 0.75
Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors. Sci Rep (2017) 0.75
Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model. PLoS Comput Biol (2017) 0.75
BPA-toxicity via superoxide anion overload and a deficit in β-catenin signaling in human bone mesenchymal stem cells. Environ Toxicol (2016) 0.75
The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease. Oxid Med Cell Longev (2015) 0.75
Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis. Hepatoma Res (2016) 0.75
Modes of p53 regulation. Cell (2009) 9.31
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60
Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06
Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06
Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00
Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem (2005) 1.77
SnapShot: p53 posttranslational modifications. Cell (2008) 1.75
Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71
Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70
Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70
Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67
The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis. Hypertens Res (2011) 1.51
p53 regulation by ubiquitin. FEBS Lett (2011) 1.51
Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50
p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50
SIRT1 and p53, effect on cancer, senescence and beyond. Biochim Biophys Acta (2010) 1.46
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev (2006) 1.44
Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Arch Surg (2009) 1.42
SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell (2010) 1.41
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36
ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol (2007) 1.35
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Dynamics in the p53-Mdm2 ubiquitination pathway. Cell Cycle (2004) 1.33
Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther (2009) 1.29
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26
Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23
MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21
Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Biochem Biophys Res Commun (2004) 1.18
Mechanism of fast peptide recognition by SH3 domains. Angew Chem Int Ed Engl (2008) 1.17
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17
Artificial polyploidy improves bacterial single cell genome recovery. PLoS One (2012) 1.10
Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins. J Biol Chem (2005) 1.09
Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol (2010) 1.08
Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol (2007) 1.08
RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma pigmentosum group A (XPA). J Biol Chem (2008) 1.06
Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. PLoS One (2010) 1.06
New insights into p53 activation. Cell Res (2010) 1.06
Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma eriocheiris infection using a deep sequencing approach. Fish Shellfish Immunol (2011) 1.06
Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04
Draft Genome Sequence of Methylomicrobium buryatense Strain 5G, a Haloalkaline-Tolerant Methanotrophic Bacterium. Genome Announc (2013) 1.04
Potential roles of N-glycosylation in cell adhesion. Glycoconj J (2012) 1.04
[Epidemiological survey of mental illnesses in the people aged 15 and older in Zhejiang Province, China]. Zhonghua Yu Fang Yi Xue Za Zhi (2005) 1.04
Handheld recirculation system and customized media for microfluidic cell culture. Lab Chip (2005) 1.03
Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Mol Biol Cell (2008) 1.03
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol (2009) 1.03
Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines. J Biol Chem (2012) 1.03
Monoubiquitination: the signal for p53 nuclear export? Cell Cycle (2004) 1.02
SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02
SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01