Published in Arch Toxicol on May 16, 2009
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. J Biol Chem (2011) 2.25
Lifestyle factors and reproductive health: taking control of your fertility. Reprod Biol Endocrinol (2013) 1.93
Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress. Hepatology (2010) 1.91
Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology (2013) 1.73
Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. J Cell Biol (2011) 1.72
Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism. PLoS One (2014) 1.57
Inflammation in alcoholic liver disease. Annu Rev Nutr (2012) 1.49
Gut-liver axis in alcoholic liver disease. Gastroenterology (2014) 1.42
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. J Exp Med (2012) 1.30
Oxidative damage to RNA: mechanisms, consequences, and diseases. Cell Mol Life Sci (2010) 1.29
Cellular and mitochondrial effects of alcohol consumption. Int J Environ Res Public Health (2010) 1.22
Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complement Altern Med (2013) 1.18
Acetaldehyde adducts in alcoholic liver disease. Oxid Med Cell Longev (2010) 1.18
Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence. J Dig Dis (2012) 1.14
Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries. Biochem Res Int (2011) 1.14
CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. Biochem Biophys Res Commun (2010) 1.12
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. PPAR Res (2010) 1.11
ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications. Pharmacol Ther (2011) 1.09
Alcohol and acetaldehyde in public health: from marvel to menace. Int J Environ Res Public Health (2010) 1.06
Oxidative stress as a crucial factor in liver diseases. World J Gastroenterol (2014) 1.04
Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues. J Histochem Cytochem (2010) 1.01
Thiamin uptake by pancreatic acinar cells: effect of chronic alcohol feeding/exposure. Am J Physiol Gastrointest Liver Physiol (2011) 1.01
Protein carbonylation in a murine model for early alcoholic liver disease. Chem Res Toxicol (2012) 1.00
Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicol Sci (2012) 1.00
Investigating the pathobiology of alcoholic pancreatitis. Alcohol Clin Exp Res (2011) 0.99
The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2. PLoS One (2013) 0.99
Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug Metab Dispos (2010) 0.98
Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease. J Toxicol (2012) 0.97
Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice. Antioxid Redox Signal (2011) 0.97
Estrogen-related receptor γ controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. Gut (2012) 0.96
Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. Redox Biol (2013) 0.94
Review of natural products with hepatoprotective effects. World J Gastroenterol (2014) 0.94
Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury. Hepatology (2013) 0.94
Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats. World J Gastroenterol (2010) 0.94
Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology (2012) 0.93
Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.92
Current concepts on the role of nitric oxide in portal hypertension. World J Gastroenterol (2013) 0.92
Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. Zebrafish (2013) 0.91
Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor. Br J Pharmacol (2011) 0.91
Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes. Expert Opin Drug Metab Toxicol (2012) 0.91
Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. Lipids Health Dis (2011) 0.90
Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice. Cell Mol Immunol (2014) 0.90
Serum metabolomic profiling in acute alcoholic hepatitis identifies multiple dysregulated pathways. PLoS One (2014) 0.89
Chronic-alcohol-abuse-induced oxidative stress in the development of acute respiratory distress syndrome. ScientificWorldJournal (2012) 0.88
Effect of Korean red ginseng extract on liver damage induced by short-term and long-term ethanol treatment in rats. J Ginseng Res (2013) 0.88
Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity. Expert Opin Drug Metab Toxicol (2010) 0.87
Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis. Biochim Biophys Acta (2012) 0.86
Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment. Toxicology (2010) 0.86
Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult. Dig Dis Sci (2013) 0.86
Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice. Lipids Health Dis (2013) 0.86
Should autism be considered a canary bird telling that Homo sapiens may be on its way to extinction? Microb Ecol Health Dis (2012) 0.86
Advances and New Concepts in Alcohol-Induced Organelle Stress, Unfolded Protein Responses and Organ Damage. Biomolecules (2015) 0.86
Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion. J Proteome Res (2011) 0.85
Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Am J Physiol Gastrointest Liver Physiol (2013) 0.83
A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease. Biomolecules (2015) 0.83
Dietary supplementation of blueberry juice enhances hepatic expression of metallothionein and attenuates liver fibrosis in rats. PLoS One (2013) 0.83
Chronic liver inflammation: clinical implications beyond alcoholic liver disease. World J Gastroenterol (2014) 0.83
Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications. Redox Biol (2014) 0.82
Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models. J Biol Chem (2013) 0.82
Chronic alcohol consumption potentiates the development of diabetes through pancreatic β-cell dysfunction. World J Biol Chem (2015) 0.81
Role of MGST1 in reactive intermediate-induced injury. World J Gastroenterol (2011) 0.81
Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity. Biomolecules (2015) 0.81
Aging and alcohol interact to alter hepatic DNA hydroxymethylation. Alcohol Clin Exp Res (2014) 0.81
Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico. World J Gastroenterol (2015) 0.80
Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1. Toxicol Lett (2011) 0.80
Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis. World J Gastroenterol (2012) 0.80
Alcohol and the Intestine. Biomolecules (2015) 0.80
Effects of xenobiotics on total antioxidant capacity. Interdiscip Toxicol (2012) 0.80
GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose. Eur J Nutr (2014) 0.80
Hepatoprotective Effect of Fermented Soybean (Nutrient Enriched Soybean Tempeh) against Alcohol-Induced Liver Damage in Mice. Evid Based Complement Alternat Med (2013) 0.79
Peroxisome proliferator-activated receptor α, a potential therapeutic target for alcoholic liver disease. World J Gastroenterol (2014) 0.79
Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage. Cytotechnology (2013) 0.79
Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice. Dig Liver Dis (2015) 0.79
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury. Oxid Med Cell Longev (2016) 0.78
Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein. J Biomed Sci (2011) 0.78
Determining antioxidant activities of lactobacilli cell-free supernatants by cellular antioxidant assay: a comparison with traditional methods. PLoS One (2015) 0.78
Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen. PLoS One (2011) 0.78
Alcohol drinking and mammary cancer: Pathogenesis and potential dietary preventive alternatives. World J Clin Oncol (2014) 0.78
Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction in alveolar type 2 cells. Am J Physiol Lung Cell Mol Physiol (2014) 0.78
Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat. Am J Pathol (2014) 0.78
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling. Redox Biol (2014) 0.78
Moderate (2%, v/v) Ethanol Feeding Alters Hepatic Wound Healing after Acute Carbon Tetrachloride Exposure in Mice. Biomolecules (2016) 0.78
Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats. BMC Complement Altern Med (2015) 0.77
Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease. PLoS One (2013) 0.77
Integrated expression profiles of mRNA and microRNA in the liver of Fructus Meliae Toosendan water extract injured mice. Front Pharmacol (2015) 0.77
Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury. Biochem Biophys Res Commun (2015) 0.77
Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases. Curr Mol Pharmacol (2015) 0.77
Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway. PLoS One (2014) 0.77
Tissue-specific upregulation of HSP72 in mice following short-term administration of alcohol. Cell Stress Chaperones (2012) 0.77
HIV-1, HCV and alcohol in the CNS: potential interactions and effects on neuroinflammation. Curr HIV Res (2014) 0.76
Antioxidant and Hepatoprotective Effects of Procyanidins from Wild Grape (Vitis amurensis) Seeds in Ethanol-Induced Cells and Rats. Int J Mol Sci (2016) 0.76
Autophagy in the liver: cell's cannibalism and beyond. Arch Pharm Res (2016) 0.76
Comparative anti-inflammatory and hepatoprotective activities of Astragalus gummifer Labill herb and roots in rats. Afr J Tradit Complement Altern Med (2014) 0.76
Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model. World J Gastroenterol (2014) 0.76
Chronic ingestion of alcohol modulates expression of ubiquitin editing enzyme A20 in lung macrophages. Multidiscip Respir Med (2011) 0.76
The right choice of antihypertensives protects primary human hepatocytes from ethanol- and recombinant human TGF-β1-induced cellular damage. Hepat Med (2013) 0.76
In Vitro Antioxidant Activities of Enzymatic Hydrolysate from Schizochytrium sp. and Its Hepatoprotective Effects on Acute Alcohol-Induced Liver Injury In Vivo. Mar Drugs (2017) 0.76
Some in vitro/in vivo chemically-induced experimental models of liver oxidative stress in rats. Biomed Res Int (2014) 0.75
Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates. Epigenetics (2015) 0.75
Micronuclei in bone marrow and liver in relation to hepatic metabolism and antioxidant response due to coexposure to chloroform, dichloromethane, and toluene in the rat model. Biomed Res Int (2014) 0.75
Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice. Hepatology (2014) 1.62
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic Biol Med (2010) 1.47
Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling. Hepatology (2012) 1.40
Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice. Hepatology (2005) 0.98
Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug Metab Dispos (2010) 0.98
Milk osteopontin, a nutritional approach to prevent alcohol-induced liver injury. Am J Physiol Gastrointest Liver Physiol (2013) 0.96
CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases. Int J Hepatol (2011) 0.95
Role of Itk signalling in the interaction between influenza A virus and T-cells. J Gen Virol (2012) 0.95
Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver. Free Radic Biol Med (2012) 0.94
Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis. Breast Cancer Res (2012) 0.91
Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis. Biochim Biophys Acta (2013) 0.91
An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis. Phytomedicine (2013) 0.86
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free Radic Biol Med (2013) 0.84
Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells. Free Radic Biol Med (2011) 0.83
Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice. Gastroenterology (2011) 0.82
Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free Radic Biol Med (2009) 0.82
Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice. Hepatology (2011) 0.82
Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells. Toxicol In Vitro (2007) 0.80
Synergistic toxic interactions between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury. Adv Exp Med Biol (2015) 0.78
N-(2-Hy-droxy-eth-yl)-5-(4-meth-oxy-phen-yl)-4H-pyrazole-3-carboxamide. Acta Crystallogr Sect E Struct Rep Online (2012) 0.75