|
1
|
Cellular and molecular pathobiology of pulmonary arterial hypertension.
|
J Am Coll Cardiol
|
2004
|
5.79
|
|
2
|
Inflammation, growth factors, and pulmonary vascular remodeling.
|
J Am Coll Cardiol
|
2009
|
3.75
|
|
3
|
Cellular and molecular basis of pulmonary arterial hypertension.
|
J Am Coll Cardiol
|
2009
|
3.69
|
|
4
|
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage.
|
Am J Pathol
|
2006
|
2.70
|
|
5
|
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
Circulation
|
2012
|
2.54
|
|
6
|
Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension.
|
Am J Physiol Lung Cell Mol Physiol
|
2007
|
2.46
|
|
7
|
Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis.
|
Circ Res
|
2002
|
2.22
|
|
8
|
Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.
|
Am J Physiol Lung Cell Mol Physiol
|
2006
|
1.93
|
|
9
|
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall.
|
Am J Physiol Lung Cell Mol Physiol
|
2009
|
1.81
|
|
10
|
MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts.
|
Circ Res
|
2013
|
1.80
|
|
11
|
Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia.
|
Cardiovasc Res
|
2008
|
1.72
|
|
12
|
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
|
Proc Natl Acad Sci U S A
|
2012
|
1.70
|
|
13
|
Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells.
|
Am J Physiol Lung Cell Mol Physiol
|
2003
|
1.68
|
|
14
|
Distensibility of the normal human lung circulation during exercise.
|
Am J Physiol Lung Cell Mol Physiol
|
2005
|
1.62
|
|
15
|
Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development.
|
Circ Res
|
2006
|
1.54
|
|
16
|
Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves.
|
Am J Physiol Heart Circ Physiol
|
2008
|
1.54
|
|
17
|
Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries.
|
Neurology
|
2012
|
1.52
|
|
18
|
Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling.
|
Am J Physiol Lung Cell Mol Physiol
|
2008
|
1.48
|
|
19
|
Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal?
|
Circ Res
|
2005
|
1.48
|
|
20
|
Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension.
|
J Immunol
|
2011
|
1.39
|
|
21
|
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.
|
Circ Res
|
2012
|
1.37
|
|
22
|
Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor.
|
J Biol Chem
|
2002
|
1.35
|
|
23
|
Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts.
|
Am J Physiol Cell Physiol
|
2003
|
1.34
|
|
24
|
Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment.
|
Am J Physiol Lung Cell Mol Physiol
|
2009
|
1.32
|
|
25
|
Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society.
|
Circulation
|
2015
|
1.30
|
|
26
|
High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells.
|
Ann Biomed Eng
|
2009
|
1.26
|
|
27
|
Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation.
|
J Appl Physiol (1985)
|
2004
|
1.17
|
|
28
|
Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1.
|
Am J Pathol
|
2006
|
1.16
|
|
29
|
Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
|
PLoS One
|
2011
|
1.09
|
|
30
|
The renin-angiotensin system in pulmonary hypertension.
|
Am J Respir Crit Care Med
|
2013
|
1.08
|
|
31
|
Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling.
|
Am J Respir Cell Mol Biol
|
2010
|
1.05
|
|
32
|
In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation.
|
J Appl Physiol (1985)
|
2010
|
1.04
|
|
33
|
Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts.
|
J Appl Physiol (1985)
|
2004
|
1.04
|
|
34
|
Physiologic and molecular consequences of endothelial Bmpr2 mutation.
|
Respir Res
|
2011
|
1.03
|
|
35
|
Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.
|
Circulation
|
2004
|
1.02
|
|
36
|
Impact of residual stretch and remodeling on collagen engagement in healthy and pulmonary hypertensive calf pulmonary arteries at physiological pressures.
|
Ann Biomed Eng
|
2012
|
1.02
|
|
37
|
Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells.
|
Angiogenesis
|
2007
|
1.01
|
|
38
|
High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile protein expression.
|
Am J Physiol Lung Cell Mol Physiol
|
2012
|
1.00
|
|
39
|
Progenitor cells in pulmonary vascular remodeling.
|
Pulm Circ
|
2011
|
0.96
|
|
40
|
Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase.
|
Biochem Biophys Res Commun
|
2003
|
0.96
|
|
41
|
Lung vascular cell heterogeneity: endothelium, smooth muscle, and fibroblasts.
|
Proc Am Thorac Soc
|
2008
|
0.96
|
|
42
|
Clinical trials in neonates and children: Report of the pulmonary hypertension academic research consortium pediatric advisory committee.
|
Pulm Circ
|
2013
|
0.94
|
|
43
|
Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling.
|
Adv Exp Med Biol
|
2007
|
0.94
|
|
44
|
A microstructurally driven model for pulmonary artery tissue.
|
J Biomech Eng
|
2011
|
0.93
|
|
45
|
Linked opening angle and histological and mechanical aspects of the proximal pulmonary arteries of healthy and pulmonary hypertensive rats and calves.
|
Am J Physiol Heart Circ Physiol
|
2011
|
0.93
|
|
46
|
Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities.
|
Am J Physiol Lung Cell Mol Physiol
|
2003
|
0.92
|
|
47
|
P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.
|
Am J Physiol Cell Physiol
|
2010
|
0.92
|
|
48
|
Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase.
|
Am J Respir Cell Mol Biol
|
2003
|
0.92
|
|
49
|
Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors.
|
J Vasc Res
|
2009
|
0.92
|
|
50
|
Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling.
|
Cardiovasc Res
|
2012
|
0.91
|
|
51
|
Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways.
|
J Biol Chem
|
2004
|
0.91
|
|
52
|
Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia.
|
Am J Physiol Lung Cell Mol Physiol
|
2005
|
0.90
|
|
53
|
PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells.
|
Am J Physiol Lung Cell Mol Physiol
|
2009
|
0.90
|
|
54
|
Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension.
|
Pulm Circ
|
2013
|
0.90
|
|
55
|
MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension.
|
Am J Physiol Heart Circ Physiol
|
2012
|
0.88
|
|
56
|
Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling.
|
Mol Biol Cell
|
2003
|
0.88
|
|
57
|
High Pulsatility Flow Induces Acute Endothelial Inflammation through Overpolarizing Cells to Activate NF-κB.
|
Cardiovasc Eng Technol
|
2013
|
0.88
|
|
58
|
Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling.
|
PLoS One
|
2013
|
0.87
|
|
59
|
Mechanics and Function of the Pulmonary Vasculature: Implications for Pulmonary Vascular Disease and Right Ventricular Function.
|
Compr Physiol
|
2012
|
0.87
|
|
60
|
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
|
Am J Physiol Lung Cell Mol Physiol
|
2012
|
0.86
|
|
61
|
Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression.
|
Mol Biol Cell
|
2006
|
0.86
|
|
62
|
Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension.
|
Am J Physiol Heart Circ Physiol
|
2011
|
0.86
|
|
63
|
Bronchus-associated lymphoid tissue in pulmonary hypertension produces pathologic autoantibodies.
|
Am J Respir Crit Care Med
|
2013
|
0.86
|
|
64
|
Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
|
Circulation
|
2014
|
0.84
|
|
65
|
Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner.
|
J Immunol
|
2009
|
0.84
|
|
66
|
Hypertension, nitrate-nitrite, and xanthine oxidoreductase catalyzed nitric oxide generation: pros and cons.
|
Hypertension
|
2013
|
0.84
|
|
67
|
Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling.
|
Chest
|
2005
|
0.83
|
|
68
|
Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury.
|
Am J Respir Cell Mol Biol
|
2012
|
0.83
|
|
69
|
Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension.
|
Am J Physiol Lung Cell Mol Physiol
|
2012
|
0.83
|
|
70
|
Activation of the unfolded protein response is associated with pulmonary hypertension.
|
Pulm Circ
|
2012
|
0.82
|
|
71
|
Hypoxia reversibly inhibits epithelial sodium transport but does not inhibit lung ENaC or Na-K-ATPase expression.
|
Am J Physiol Lung Cell Mol Physiol
|
2002
|
0.82
|
|
72
|
Complementary effects of extracellular nucleotides and platelet-derived extracts on angiogenesis of vasa vasorum endothelial cells in vitro and subcutaneous Matrigel plugs in vivo.
|
Vasc Cell
|
2011
|
0.81
|
|
73
|
Angiogenic therapy for bronchopulmonary dysplasia: rationale and promise.
|
Circulation
|
2005
|
0.81
|
|
74
|
Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia.
|
J Pediatr Surg
|
2005
|
0.81
|
|
75
|
Plasma proteomics of differential outcome to long-term therapy in children with idiopathic pulmonary arterial hypertension.
|
Proteomics Clin Appl
|
2012
|
0.81
|
|
76
|
Yin and Yang of an endothelial cell: from normal to the extreme in growth, secretion, and transdifferentiation capabilities.
|
Paediatr Respir Rev
|
2004
|
0.81
|
|
77
|
Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration.
|
Free Radic Biol Med
|
2010
|
0.80
|
|
78
|
Cell-based therapies in pulmonary hypertension: who, what, and when?
|
Am J Physiol Lung Cell Mol Physiol
|
2011
|
0.78
|
|
79
|
Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis.
|
Pediatr Infect Dis J
|
2004
|
0.78
|
|
80
|
Validation of a pressure diameter method for determining modulus and strain of collagen engagement for long branches of bovine pulmonary arteries.
|
J Biomech Eng
|
2012
|
0.78
|
|
81
|
High proliferative potential endothelial colony-forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization.
|
Am J Physiol Lung Cell Mol Physiol
|
2014
|
0.77
|
|
82
|
Hypoxia-induced alterations in protein kinase C zeta signaling result in augmented fibroblast proliferation.
|
Chest
|
2005
|
0.77
|
|
83
|
Mechanics and function of the pulmonary vasculature: implications for pulmonary vascular disease and right ventricular function.
|
Compr Physiol
|
2012
|
0.77
|
|
84
|
Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling.
|
Chest
|
2005
|
0.77
|
|
85
|
Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension.
|
Anesth Analg
|
2016
|
0.75
|
|
86
|
Constitutive Modeling of Anisotropic Finite-Deformation Hyperelastic Behaviors of Soft Materials Reinforced by Tortuous Fibers.
|
Int J Struct Changes Sol
|
2010
|
0.75
|
|
87
|
Response to letter regarding article, “histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid”.
|
Circulation
|
2013
|
0.75
|
|
88
|
Correction: Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation.
|
PLoS One
|
2017
|
0.75
|
|
89
|
Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro.
|
J Mater Chem B Mater Biol Med
|
2020
|
0.75
|
|
90
|
[Relevant issues in the pathology and pathobiology of pulmonary hypertension].
|
Turk Kardiyol Dern Ars
|
2014
|
0.75
|
|
91
|
Mechanics and mechanisms of pulmonary hypertension: An introduction to the 55(th) annual Thomas L. Petty Aspen Lung Conference.
|
Pulm Circ
|
2013
|
0.75
|