Published in Cancer on August 01, 2009
Epigenetics and cardiovascular disease. Nat Rev Cardiol (2010) 1.68
Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. Hum Genet (2013) 1.43
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res (2009) 1.32
Cellular signaling and biological functions of R-spondins. Cell Signal (2011) 1.25
MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index. Carcinogenesis (2010) 1.24
Genome-wide association study of antibody response to smallpox vaccine. Vaccine (2012) 1.23
The R-spondin family of proteins: emerging regulators of WNT signaling. Int J Biochem Cell Biol (2012) 1.09
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer. PLoS One (2012) 1.06
SILAC-based quantitative proteomic approach to identify potential biomarkers from the esophageal squamous cell carcinoma secretome. Cancer Biol Ther (2010) 1.00
Hypermethylation of multiple tumor-related genes associated with DNMT3b up-regulation served as a biomarker for early diagnosis of esophageal squamous cell carcinoma. Epigenetics (2011) 0.96
Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma. Int J Cancer (2011) 0.93
Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis (2013) 0.92
Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer. J Exp Clin Cancer Res (2010) 0.92
Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance. Int J Clin Exp Pathol (2012) 0.90
Low risk of second primary malignancies among never smokers with human papillomavirus-associated index oropharyngeal cancers. Head Neck (2012) 0.87
Comprehensive genomic characterization of cutaneous malignant melanoma cell lines derived from metastatic lesions by whole-exome sequencing and SNP array profiling. PLoS One (2013) 0.85
Aberrant methylation of the 3q25 tumor suppressor gene PTX3 in human esophageal squamous cell carcinoma. World J Gastroenterol (2011) 0.85
Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells. Biol Reprod (2012) 0.84
Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation. Epigenetics (2013) 0.84
Hypermethylation of a cluster of Krüppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma. Am J Pathol (2011) 0.84
Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A. Mol Cancer (2010) 0.83
Innovative rapid gene methylation analysis of surgical margin tissues in head and neck cancer. Ann Surg Oncol (2014) 0.83
Towards a molecular systems model of coronary artery disease. Curr Cardiol Rep (2014) 0.82
Neurofilament Heavy polypeptide CpG island methylation associates with prognosis of renal cell carcinoma and prediction of antivascular endothelial growth factor therapy response. Cancer Med (2014) 0.81
Causes and Consequences of Age-Related Changes in DNA Methylation: A Role for ROS? Biology (Basel) (2014) 0.81
Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influenced by various stimuli experienced in daily life. Hypertens Res (2015) 0.79
A novel autoantibody test for the detection of pre-neoplastic lung lesions. Mol Cancer (2014) 0.78
Identification of a DNA methylation marker that detects the presence of lymph node metastases of gastric cancers. Oncol Lett (2012) 0.77
Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance. Dig Dis Sci (2015) 0.76
Aberrant DNA hypermethylation reduces the expression of the desmosome-related molecule periplakin in esophageal squamous cell carcinoma. Cancer Med (2015) 0.76
ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy. J Cancer Res Clin Oncol (2014) 0.76
Cigarette Smoking and the Risk of Adult Myeloid Disease: A Meta-Analysis. PLoS One (2015) 0.75
High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes. BMC Cancer (2016) 0.75
The degree of methylation burden is determined by the exposure period to carcinogenic factors. Cancer Sci (2016) 0.75
Culture-induced recurrent epigenetic aberrations in human pluripotent stem cells. PLoS Genet (2017) 0.75
Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer (2000) 8.85
Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell (2002) 5.69
Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol (2009) 5.56
A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol (2011) 4.22
Gastric cancer treated in 1991 in Japan: data analysis of nationwide registry. Gastric Cancer (2006) 3.06
MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev (2010) 2.70
High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res (2006) 2.69
Endoscopic mucosal resection. Gastrointest Endosc (2003) 2.64
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc Natl Acad Sci U S A (2007) 2.30
Gastric cancer treatment in Japan: 2008 annual report of the JGCA nationwide registry. Gastric Cancer (2011) 2.18
Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer (2006) 2.11
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci U S A (2006) 2.10
Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry. Gastric Cancer (2012) 2.09
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci (2006) 2.00
Forty-three cases of obturator hernia. Am J Surg (2004) 1.98
Gait disturbance due to foot drop is refractory to treatment in nonsystemic vasculitic neuropathy. Eur Neurol (2014) 1.97
Changing trends in the proportion of adenocarcinoma of the esophagogastric junction in a large tertiary referral center in Japan. J Gastroenterol Hepatol (2008) 1.93
Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology (2012) 1.91
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis (2002) 1.81
Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res (2010) 1.80
A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. EMBO J (2006) 1.71
Histopathological criteria for additional treatment after endoscopic mucosal resection for esophageal cancer: analysis of 464 surgically resected cases. Mod Pathol (2006) 1.68
DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer (2009) 1.66
Prognostic significance of CXCL12 expression in patients with colorectal carcinoma. Am J Clin Pathol (2009) 1.66
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Mol Cell Biol (2005) 1.64
Endoscopic submucosal dissection for residual/locally recurrent lesions after endoscopic therapy for colorectal tumors. J Gastroenterol Hepatol (2010) 1.64
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol (2004) 1.63
Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology (2006) 1.60
CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res (2005) 1.57
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res (2006) 1.55
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell (2009) 1.53
Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. Int J Cancer (2012) 1.53
CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma. Am J Pathol (2008) 1.52
Two distinct pathways of tumorigenesis of adenocarcinomas of the esophagogastric junction, related or unrelated to intestinal metaplasia. Pathol Int (2007) 1.50
Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab (2011) 1.49
Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: analysis of results in 140 surgically resected patients. Gastric Cancer (2003) 1.48
Salvage esophagectomy after high-dose chemoradiotherapy for esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg (2009) 1.48
Inflammatory fibroid polyps of the stomach and Helicobacter pylori. J Gastroenterol Hepatol (2004) 1.40
Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. Oncogene (2003) 1.38
Identification of silencing of nine genes in human gastric cancers. Cancer Res (2002) 1.37
Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer Epidemiol Biomarkers Prev (2003) 1.36
Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. Am J Pathol (2002) 1.36
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res (2004) 1.35
Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro. PLoS One (2013) 1.34
Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori. Lab Invest (2007) 1.32
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res (2009) 1.32
Current state of gastric stump carcinoma in Japan: based on the results of a nationwide survey. World J Surg (2010) 1.32
Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clin Cancer Res (2005) 1.31
Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev (2006) 1.28
Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. Oncogene (2004) 1.27
Identification of 20 genes aberrantly methylated in human breast cancers. Int J Cancer (2005) 1.27
Catalytic mechanism of type 2 isopentenyl diphosphate:dimethylallyl diphosphate isomerase: verification of a redox role of the flavin cofactor in a reaction with no net redox change. Biochem Biophys Res Commun (2004) 1.26
Predictive histopathologic factors for lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma. Dis Colon Rectum (2005) 1.26
Mdx respiratory impairment following fibrosis of the diaphragm. Neuromuscul Disord (2008) 1.25
Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer. Surgery (2006) 1.25
Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers. Cancer Sci (2004) 1.23
Gastric cancer with metastasis to the gingiva. J Gastroenterol Hepatol (2004) 1.23
Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis. Cancer Res (2007) 1.21
Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas. Int J Cancer (2007) 1.21
Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus (2011) 1.20
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology (2003) 1.20
New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase. J Biol Chem (2009) 1.19
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development (2013) 1.19
Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma. Oncology (2009) 1.19
Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma. Carcinogenesis (2006) 1.19
Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. Oncology (2008) 1.19
Diagnostic and therapeutic applications of epigenetics. Jpn J Clin Oncol (2005) 1.17
Less aggressive features of colorectal cancer with liver metastases showing macroscopic intrabiliary extension. Pathol Int (2002) 1.16
Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia. J Cancer Res Clin Oncol (2003) 1.16
The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. Int J Cancer (2009) 1.16
Silencing of the UCHL1 gene in human colorectal and ovarian cancers. Int J Cancer (2006) 1.15
Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci (2004) 1.14
Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma. Hum Pathol (2006) 1.14
Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci (2004) 1.13
Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma. Int J Oncol (2009) 1.13
Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females. Alcohol Clin Exp Res (2006) 1.12
Protein clusters associated with carcinogenesis, histological differentiation and nodal metastasis in esophageal cancer. Proteomics (2006) 1.11
Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein. J Leukoc Biol (2004) 1.11
Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial. Gastrointest Endosc (2003) 1.11
Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer. Int J Cancer (2013) 1.11
Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma. Mod Pathol (2010) 1.11
Production of Sry knockout mouse using TALEN via oocyte injection. Sci Rep (2013) 1.11
Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice. Cancer Res (2005) 1.10
Beta-catenin mutations in sporadic fundic gland polyps. Virchows Arch (2001) 1.09
Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils. Cancer Sci (2003) 1.09
Second primary carcinoma in the gastric tube constructed as an esophageal substitute after esophagectomy. J Am Coll Surg (2002) 1.08
Surgical treatment of early gastric cancer. Dig Surg (2007) 1.08