Published in EMBO J on February 23, 2006
DNA methylation: roles in mammalian development. Nat Rev Genet (2013) 6.65
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res (2009) 3.81
DNA hypomethylation in cancer cells. Epigenomics (2009) 3.71
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76
A subset of methylated CpG sites differentiate psoriatic from normal skin. J Invest Dermatol (2011) 1.73
DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle (2009) 1.64
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA. Proc Natl Acad Sci U S A (2006) 1.43
Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons. Proc Natl Acad Sci U S A (2007) 1.40
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. EMBO J (2007) 1.34
A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev (2009) 1.33
Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun Rev (2008) 1.31
Small interfering RNA directed reversal of urokinase plasminogen activator demethylation inhibits prostate tumor growth and metastasis. Cancer Res (2007) 1.29
MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J Biol Chem (2011) 1.23
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J Biol Chem (2013) 1.22
Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren's syndrome. Arthritis Rheumatol (2014) 1.20
Specific targeting of cytosine methylation to DNA sequences in vivo. Nucleic Acids Res (2006) 1.12
Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection. PLoS Pathog (2013) 1.10
The pharmacology of second-generation chimeric antigen receptors. Nat Rev Drug Discov (2015) 1.09
Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure. J Immunol (2008) 1.07
Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies. Mol Cell Biol (2010) 1.07
Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. J Biol Chem (2010) 1.06
Memories of lost enhancers. Genes Dev (2010) 1.05
Influence of photoperiod on hormones, behavior, and immune function. Front Neuroendocrinol (2010) 1.04
IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). PLoS One (2009) 1.04
The effect of preconception paternal alcohol exposure on epigenetic remodeling of the h19 and rasgrf1 imprinting control regions in mouse offspring. Front Genet (2012) 1.03
The epigenetic landscape of mammary gland development and functional differentiation. J Mammary Gland Biol Neoplasia (2010) 1.02
Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells. PLoS One (2012) 1.01
Interindividual variability and co-regulation of DNA methylation differ among blood cell populations. Epigenetics (2012) 1.00
Epigenetics of human T cells during the G0-->G1 transition. Genome Res (2009) 0.99
Conserved intergenic elements and DNA methylation cooperate to regulate transcription at the il17 locus. J Biol Chem (2012) 0.93
Recent thymic emigrants and mature naive T cells exhibit differential DNA methylation at key cytokine loci. J Immunol (2013) 0.92
Mechanisms behind functional avidity maturation in T cells. Clin Dev Immunol (2012) 0.90
DNA methylation: a marker for carcinogen exposure and cancer risk. Environ Health Prev Med (2007) 0.89
Epigenetic regulation of TNFA expression in periodontal disease. J Periodontol (2013) 0.87
Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation. J Immunol (2015) 0.87
Plasticity of DNA methylation in mouse T cell activation and differentiation. BMC Mol Biol (2012) 0.86
TET proteins and 5-methylcytosine oxidation in the immune system. Cold Spring Harb Symp Quant Biol (2014) 0.84
The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression. Curr Top Microbiol Immunol (2012) 0.84
Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance. Semin Immunol (2007) 0.83
Epigenetic up-regulation of leukemia inhibitory factor (LIF) gene during the progression to breast cancer. Mol Cells (2010) 0.83
T-cell identity and epigenetic memory. Curr Top Microbiol Immunol (2012) 0.82
Transcriptional gene silencing in humans. Nucleic Acids Res (2016) 0.82
Radiation-induced hypomethylation triggers urokinase plasminogen activator transcription in meningioma cells. Neoplasia (2013) 0.80
A permissive chromatin structure is adopted prior to site-specific DNA demethylation of developmentally expressed genes involved in macronuclear differentiation. Epigenetics Chromatin (2013) 0.78
Oct1 and OCA-B are selectively required for CD4 memory T cell function. J Exp Med (2015) 0.78
Hypomethylation of Interleukin-6 Promoter is Associated with the Risk of Coronary Heart Disease. Arq Bras Cardiol (2016) 0.78
Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylation. Peptides (2012) 0.77
Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis. Osteoarthritis Cartilage (2015) 0.77
Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease. J Hematol Oncol (2016) 0.77
Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs. Eur J Immunol (2016) 0.75
Twist1/Dnmt3a and miR186 establish a regulatory circuit that controls inflammation-associated prostate cancer progression. Oncogenesis (2017) 0.75
Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation. J Cell Sci (2016) 0.75
Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects. Oncoimmunology (2017) 0.75
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell (1993) 11.95
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science (2003) 8.81
Small interfering RNA-induced transcriptional gene silencing in human cells. Science (2004) 7.29
T cell memory. Annu Rev Immunol (1998) 5.20
Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat Immunol (2003) 4.83
Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem (1994) 4.00
Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes. Cell (1986) 3.88
Immune responses in interleukin-2-deficient mice. Science (1993) 3.29
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science (1993) 3.24
Transcriptional regulation of the IL-2 gene. Curr Opin Immunol (1995) 3.14
IL-2, regulatory T cells, and tolerance. J Immunol (2004) 3.13
Severe combined immunodeficiency due to a specific defect in the production of interleukin-2. N Engl J Med (1990) 2.84
Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J (2000) 2.14
The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol (2003) 1.93
Demethylase activity is directed by histone acetylation. J Biol Chem (2001) 1.91
Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Mol Cell Biol (1995) 1.89
Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest (2004) 1.87
CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J Exp Med (2003) 1.82
The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim Biophys Acta (1995) 1.67
Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. Genes Dev (1993) 1.64
Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP. J Biol Chem (2003) 1.56
Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. EMBO J (2004) 1.52
Signals from CD28 induce stable epigenetic modification of the IL-2 promoter. J Immunol (2005) 1.52
The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2. Mol Cell Biol (1990) 1.49
Relationships between chromatin organization and DNA methylation in determining gene expression. Semin Cancer Biol (1999) 1.47
Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors. Mol Cell Biol (1994) 1.46
A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1. J Biol Chem (1995) 1.39
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol Cell Biol (2004) 1.30
Nuclear transcription factors that bind to elements of the IL-2 promoter. Induction requirements in primary human T cells. J Immunol (1991) 1.23
Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells. Convergence of costimulatory signals and differences from transformed T cells. J Biol Chem (1996) 1.15
Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci (2004) 1.14
Chromatin remodeling of the interleukin-2 gene: distinct alterations in the proximal versus distal enhancer regions. Nucleic Acids Res (1998) 1.12
Transcriptional regulation of 15-lipoxygenase expression by promoter methylation. Exp Cell Res (2004) 1.05
B cell development and immunoglobulin transcription in Oct-1-deficient mice. Proc Natl Acad Sci U S A (2004) 1.03
Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. J Biol Chem (2004) 0.99
Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription. EMBO J (1997) 0.98
In vivo footprinting of the human IL-2 gene reveals a nuclear factor bound to the transcription start site in T cells. Nucleic Acids Res (1993) 0.92
Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter. J Biol Chem (2004) 0.91
Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell (2005) 5.74
Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell (2002) 5.69
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol (2007) 4.12
Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Genes Dev (2009) 3.62
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (2003) 3.49
Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. J Bacteriol (2005) 3.28
Epigenetic control of rDNA loci in response to intracellular energy status. Cell (2008) 3.22
High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res (2006) 2.69
Prophages of Staphylococcus aureus Newman and their contribution to virulence. Mol Microbiol (2006) 2.20
Dissemination of methicillin-resistant staphylococci among healthy Japanese children. J Clin Microbiol (2005) 2.13
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. J Clin Invest (2009) 2.08
Retracted Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol (2003) 2.08
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci (2006) 2.00
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell (2008) 1.94
Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Int Immunol (2004) 1.92
Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology (2012) 1.91
Retracted The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Cell (2003) 1.88
Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal (2011) 1.88
Frontiers, opportunities, and challenges in biochemical and chemical catalysis of CO2 fixation. Chem Rev (2013) 1.86
CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J Exp Med (2003) 1.82
Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res (2010) 1.80
Zic3 is required for maintenance of pluripotency in embryonic stem cells. Mol Biol Cell (2007) 1.77
DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer (2009) 1.66
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Mol Cell Biol (2005) 1.64
Accelerated tumor growth in mice deficient in DNAM-1 receptor. J Exp Med (2008) 1.63
CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res (2005) 1.57
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res (2006) 1.55
Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg. J Biol Chem (2002) 1.53
Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. Int J Cancer (2012) 1.53
Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. EMBO J (2004) 1.52
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways. Nat Cell Biol (2009) 1.51
Ubc9 is essential for viability of higher eukaryotic cells. Exp Cell Res (2002) 1.49
Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse. Biol Reprod (2013) 1.49
Molecular approaches to the photocatalytic reduction of carbon dioxide for solar fuels. Acc Chem Res (2009) 1.49
Phenol-soluble modulin alpha 3 enhances the human neutrophil lysis mediated by Panton-Valentine leukocidin. J Infect Dis (2009) 1.47
Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation. Mol Cell Biol (2003) 1.43
Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor. Blood (2005) 1.39
Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. Oncogene (2003) 1.38
Identification of silencing of nine genes in human gastric cancers. Cancer Res (2002) 1.37
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res (2004) 1.35
Retracted Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. EMBO J (2004) 1.35
Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence. PLoS Pathog (2011) 1.34
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res (2009) 1.32
Possible role of mouse poly(A) polymerase mGLD-2 during oocyte maturation. Dev Biol (2005) 1.30
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells. Proc Natl Acad Sci U S A (2006) 1.30
Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface. J Biol Chem (2004) 1.29
Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus. Antimicrob Agents Chemother (2010) 1.29
Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev (2006) 1.28
Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. Oncogene (2004) 1.27
Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP. Science (2002) 1.27
Identification of 20 genes aberrantly methylated in human breast cancers. Int J Cancer (2005) 1.27
Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers. Cancer Sci (2004) 1.23
Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs. Dev Cell (2012) 1.23
Suppression of eosinophilic airway inflammation by treatment with alpha-galactosylceramide. Eur J Immunol (2005) 1.22
Reversible hydrogen storage using CO2 and a proton-switchable iridium catalyst in aqueous media under mild temperatures and pressures. Nat Chem (2012) 1.22
Thermodynamics and kinetics of CO2, CO, and H+ binding to the metal centre of CO2 reduction catalysts. Chem Soc Rev (2011) 1.22
Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med (2003) 1.21
Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas. Int J Cancer (2007) 1.21
Extreme genetic diversity of methicillin-resistant Staphylococcus epidermidis strains disseminated among healthy Japanese children. J Clin Microbiol (2008) 1.21
Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus (2011) 1.20
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology (2003) 1.20
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development (2013) 1.19
Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. Oncology (2008) 1.19
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J (2004) 1.18
CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. J Biol Chem (2003) 1.18
Diagnostic and therapeutic applications of epigenetics. Jpn J Clin Oncol (2005) 1.17
Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia. J Cancer Res Clin Oncol (2003) 1.16
Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass. Proc Natl Acad Sci U S A (2005) 1.16
A nonclassical vitamin D receptor pathway suppresses renal fibrosis. J Clin Invest (2013) 1.16
The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. Int J Cancer (2009) 1.16
Silencing of the UCHL1 gene in human colorectal and ovarian cancers. Int J Cancer (2006) 1.15
Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. J Biol Chem (2003) 1.14
Analysis of the role of Aurora B on the chromosomal targeting of condensin I. Nucleic Acids Res (2007) 1.14
Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci (2004) 1.14
Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci (2004) 1.13
Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma. Int J Oncol (2009) 1.13
Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep (2013) 1.12
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Nat Struct Mol Biol (2009) 1.12
Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development. Mol Cell Biol (2002) 1.11
RNA content in the nucleolus alters p53 acetylation via MYBBP1A. EMBO J (2011) 1.11
Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer. Int J Cancer (2013) 1.11
Recent developments in transition metal carbides and nitrides as hydrogen evolution electrocatalysts. Chem Commun (Camb) (2013) 1.09
Estrogen inhibits transforming growth factor beta signaling by promoting Smad2/3 degradation. J Biol Chem (2010) 1.09
Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment. J Exp Med (2002) 1.08