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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Shifts in growth strategies reflect tradeoffs in cellular economics. Mol Syst Biol 2009 2.26
2 Reconstructing the metabolic network of a bacterium from its genome. Trends Microbiol 2005 2.03
3 Accelerating the reconstruction of genome-scale metabolic networks. BMC Bioinformatics 2006 1.97
4 Lost in transition: start-up of glycolysis yields subpopulations of nongrowing cells. Science 2014 1.96
5 CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res 2003 1.54
6 Correlation between sequence conservation and the genomic context after gene duplication. Nucleic Acids Res 2005 1.54
7 Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 2003 1.47
8 Co-regulation of metabolic genes is better explained by flux coupling than by network distance. PLoS Comput Biol 2008 1.46
9 Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features. PLoS One 2011 1.25
10 Genome data mining of lactic acid bacteria: the impact of bioinformatics. Curr Opin Biotechnol 2004 1.19
11 Thioredoxin reductase is a key factor in the oxidative stress response of Lactobacillus plantarum WCFS1. Microb Cell Fact 2007 1.17
12 Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice. Diabetes 2005 1.11
13 Genome-scale model of Streptococcus thermophilus LMG18311 for metabolic comparison of lactic acid bacteria. Appl Environ Microbiol 2009 1.10
14 Community flux balance analysis for microbial consortia at balanced growth. PLoS One 2013 1.08
15 Intestinal lipid absorption is not affected in CD36 deficient mice. Mol Cell Biochem 2002 1.07
16 FAME, the Flux Analysis and Modeling Environment. BMC Syst Biol 2012 1.04
17 Predicting metabolic fluxes using gene expression differences as constraints. IEEE/ACM Trans Comput Biol Bioinform 2010 1.03
18 The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis. J Lipid Res 2004 1.03
19 Availability of public goods shapes the evolution of competing metabolic strategies. Proc Natl Acad Sci U S A 2013 0.99
20 A critical view of metabolic network adaptations. HFSP J 2008 0.98
21 Bioinformatics and systems biology: bridging the gap between heterogeneous student backgrounds. Brief Bioinform 2013 0.96
22 Standardized assay medium to measure Lactococcus lactis enzyme activities while mimicking intracellular conditions. Appl Environ Microbiol 2011 0.95
23 The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice. J Hepatol 2004 0.94
24 Role of phosphate in the central metabolism of two lactic acid bacteria--a comparative systems biology approach. FEBS J 2012 0.93
25 Understanding the physiology of Lactobacillus plantarum at zero growth. Mol Syst Biol 2010 0.93
26 Effect of amino acid availability on vitamin B12 production in Lactobacillus reuteri. Appl Environ Microbiol 2009 0.92
27 A data integration and visualization resource for the metabolic network of Synechocystis sp. PCC 6803. Plant Physiol 2014 0.89
28 A specific mutation in the promoter region of the silent cel cluster accounts for the appearance of lactose-utilizing Lactococcus lactis MG1363. Appl Environ Microbiol 2012 0.87
29 Functional identification in Lactobacillus reuteri of a PocR-like transcription factor regulating glycerol utilization and vitamin B12 synthesis. Microb Cell Fact 2011 0.86
30 Functional ingredient production: application of global metabolic models. Curr Opin Biotechnol 2005 0.86
31 A practical guide to genome-scale metabolic models and their analysis. Methods Enzymol 2011 0.86
32 Towards metagenome-scale models for industrial applications--the case of Lactic Acid Bacteria. Curr Opin Biotechnol 2012 0.85
33 MetDFBA: incorporating time-resolved metabolomics measurements into dynamic flux balance analysis. Mol Biosyst 2014 0.84
34 Metabolic shifts: a fitness perspective for microbial cell factories. Biotechnol Lett 2012 0.83
35 Metabolic states with maximal specific rate carry flux through an elementary flux mode. FEBS J 2014 0.83
36 How biochemical constraints of cellular growth shape evolutionary adaptations in metabolism. Genetics 2013 0.82
37 Response of apolipoprotein E*3-Leiden transgenic mice to dietary fatty acids: combining liver proteomics with physiological data. FASEB J 2005 0.82
38 Multi-tasking of biosynthetic and energetic functions of glycolysis explained by supply and demand logic. Bioessays 2014 0.82
39 Basic concepts and principles of stoichiometric modeling of metabolic networks. Biotechnol J 2013 0.80
40 Systems biology from micro-organisms to human metabolic diseases: the role of detailed kinetic models. Biochem Soc Trans 2010 0.80
41 Acute inhibition of hepatic beta-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity. J Lipid Res 2005 0.80
42 Gene network requirements for regulation of metabolic gene expression to a desired state. Sci Rep 2013 0.79
43 Understanding regulation of metabolism through feasibility analysis. PLoS One 2012 0.76
44 Lactic Acid Bacteria: embarking on 30 more years of research. Microb Cell Fact 2014 0.76
45 Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain. J Lipid Res 2002 0.75
46 Inferring differences in the distribution of reaction rates across conditions. Mol Biosyst 2012 0.75