Published in Mol Syst Biol on November 03, 2009
Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models. Mol Syst Biol (2010) 2.41
Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature (2011) 1.82
Microbial laboratory evolution in the era of genome-scale science. Mol Syst Biol (2011) 1.78
Glycolytic strategy as a tradeoff between energy yield and protein cost. Proc Natl Acad Sci U S A (2013) 1.75
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Comput Biol (2011) 1.66
Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction. Mol Syst Biol (2013) 1.58
Bacterial growth laws and their applications. Curr Opin Biotechnol (2011) 1.52
The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci (2016) 1.36
Emergence of robust growth laws from optimal regulation of ribosome synthesis. Mol Syst Biol (2014) 1.34
Promoters maintain their relative activity levels under different growth conditions. Mol Syst Biol (2013) 1.26
Economics of membrane occupancy and respiro-fermentation. Mol Syst Biol (2011) 1.23
Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria. Mol Syst Biol (2015) 1.21
Rethinking glycolysis: on the biochemical logic of metabolic pathways. Nat Chem Biol (2012) 1.17
Mechanistic links between cellular trade-offs, gene expression, and growth. Proc Natl Acad Sci U S A (2015) 1.17
Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood (2012) 1.13
Pathway thermodynamics highlights kinetic obstacles in central metabolism. PLoS Comput Biol (2014) 1.11
Transcriptional regulation is insufficient to explain substrate-induced flux changes in Bacillus subtilis. Mol Syst Biol (2013) 1.11
Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness. Mol Biol Cell (2011) 1.11
Prediction of microbial growth rate versus biomass yield by a metabolic network with kinetic parameters. PLoS Comput Biol (2012) 1.07
Redox balance is key to explaining full vs. partial switching to low-yield metabolism. BMC Syst Biol (2012) 1.04
Overflow metabolism in Escherichia coli results from efficient proteome allocation. Nature (2015) 1.03
Synechocystis: Not Just a Plug-Bug for CO2, but a Green E. coli. Front Bioeng Biotechnol (2014) 1.01
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife (2014) 0.99
Division of labour and the evolution of multicellularity. Proc Biol Sci (2011) 0.99
Availability of public goods shapes the evolution of competing metabolic strategies. Proc Natl Acad Sci U S A (2013) 0.99
Is cancer a metabolic disease? Am J Pathol (2013) 0.99
Global abundance of microbial rhodopsins. ISME J (2012) 0.98
Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell Rep (2014) 0.98
Bacterial growth laws reflect the evolutionary importance of energy efficiency. Proc Natl Acad Sci U S A (2014) 0.98
Multi-omics approach to study the growth efficiency and amino acid metabolism in Lactococcus lactis at various specific growth rates. Microb Cell Fact (2011) 0.97
How fast-growing bacteria robustly tune their ribosome concentration to approximate growth-rate maximization. FEBS J (2015) 0.96
Computing the functional proteome: recent progress and future prospects for genome-scale models. Curr Opin Biotechnol (2015) 0.94
Yeast and cancer cells - common principles in lipid metabolism. Biochim Biophys Acta (2012) 0.92
A Resource Allocation Trade-Off between Virulence and Proliferation Drives Metabolic Versatility in the Plant Pathogen Ralstonia solanacearum. PLoS Pathog (2016) 0.91
Systems biology of lactic acid bacteria: a critical review. Microb Cell Fact (2011) 0.91
Transcriptional regulation of main metabolic pathways of cyoA, cydB, fnr, and fur gene knockout Escherichia coli in C-limited and N-limited aerobic continuous cultures. Microb Cell Fact (2011) 0.90
Intracellular metabolite levels shape sulfur isotope fractionation during microbial sulfate respiration. Proc Natl Acad Sci U S A (2014) 0.90
Carbon catabolite repression correlates with the maintenance of near invariant molecular crowding in proliferating E. coli cells. BMC Syst Biol (2013) 0.87
A basic set of homeostatic controller motifs. Biophys J (2012) 0.86
Minimization of extracellular space as a driving force in prokaryote association and the origin of eukaryotes. Biol Direct (2014) 0.85
Synthetic approaches to understanding biological constraints. Curr Opin Chem Biol (2012) 0.85
Microbial resource utilization traits and trade-offs: implications for community structure, functioning, and biogeochemical impacts at present and in the future. Front Microbiol (2015) 0.84
Metabolic shift of Escherichia coli under salt stress in the presence of glycine betaine. Appl Environ Microbiol (2014) 0.83
An evolutionary perspective on the Crabtree effect. Front Mol Biosci (2014) 0.83
Metabolic shifts: a fitness perspective for microbial cell factories. Biotechnol Lett (2012) 0.83
PrfA regulation offsets the cost of Listeria virulence outside the host. Environ Microbiol (2015) 0.82
Systems and photosystems: cellular limits of autotrophic productivity in cyanobacteria. Front Bioeng Biotechnol (2015) 0.82
Can metabolic plasticity be a cause for cancer? Warburg-Waddington legacy revisited. Clin Epigenetics (2011) 0.82
Molecular-level tradeoffs and metabolic adaptation to simultaneous stressors. Curr Opin Biotechnol (2010) 0.82
How biochemical constraints of cellular growth shape evolutionary adaptations in metabolism. Genetics (2013) 0.82
Functional and regulatory profiling of energy metabolism in fission yeast. Genome Biol (2016) 0.81
Analysis of fluorescent reporters indicates heterogeneity in glucose uptake and utilization in clonal bacterial populations. BMC Microbiol (2013) 0.80
Metabolic Trade-offs in Yeast are Caused by F1F0-ATP synthase. Sci Rep (2016) 0.80
Growth rate-dependent control in Enterococcus faecalis: effects on the transcriptome and proteome, and strong regulation of lactate dehydrogenase. Appl Environ Microbiol (2011) 0.80
Physiological and proteomic analysis of Escherichia coli iron-limited chemostat growth. J Bacteriol (2014) 0.79
A synthetic growth switch based on controlled expression of RNA polymerase. Mol Syst Biol (2015) 0.79
In silico evolution of diauxic growth. BMC Evol Biol (2015) 0.79
Unlocking the Constraints of Cyanobacterial Productivity: Acclimations Enabling Ultrafast Growth. MBio (2016) 0.79
Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question. Stud Hist Philos Biol Biomed Sci (2016) 0.79
Predicting internal cell fluxes at sub-optimal growth. BMC Syst Biol (2015) 0.79
Cellular Growth Arrest and Persistence from Enzyme Saturation. PLoS Comput Biol (2016) 0.78
Constrained Allocation Flux Balance Analysis. PLoS Comput Biol (2016) 0.78
The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons. Nucleic Acids Res (2015) 0.78
Optimality principles in the regulation of metabolic networks. Metabolites (2012) 0.77
Metabolic modelling in a dynamic evolutionary framework predicts adaptive diversification of bacteria in a long-term evolution experiment. BMC Evol Biol (2016) 0.77
Epistasis for growth rate and total metabolic flux in yeast. PLoS One (2012) 0.77
Cellular trade-offs and optimal resource allocation during cyanobacterial diurnal growth. Proc Natl Acad Sci U S A (2017) 0.77
Understanding regulation of metabolism through feasibility analysis. PLoS One (2012) 0.76
Optimal programs of pathway control: dissecting the influence of pathway topology and feedback inhibition on pathway regulation. BMC Bioinformatics (2015) 0.76
Revisiting the thermodynamic theory of optimal ATP stoichiometries by analysis of various ATP-producing metabolic pathways. J Mol Evol (2010) 0.76
A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression with Growth Rate. PLoS One (2016) 0.76
Understanding Dupuytren's Disease Using Systems Biology: A Move Away from Reductionism. Front Physiol (2012) 0.76
Dynamical Allocation of Cellular Resources as an Optimal Control Problem: Novel Insights into Microbial Growth Strategies. PLoS Comput Biol (2016) 0.76
Computational strategies for a system-level understanding of metabolism. Metabolites (2014) 0.76
Perception and regulatory principles of microbial growth control. PLoS One (2015) 0.76
Deciphering the Principles of Bacterial Nitrogen Dietary Preferences: a Strategy for Nutrient Containment. MBio (2016) 0.76
Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1. Toxicol Appl Pharmacol (2014) 0.76
Constraint-based stoichiometric modelling from single organisms to microbial communities. J R Soc Interface (2016) 0.75
Mutational robustness of morphological traits in the ciliate Tetrahymena thermophila. J Eukaryot Microbiol (2014) 0.75
Analytic derivation of bacterial growth laws from a simple model of intracellular chemical dynamics. Theory Biosci (2016) 0.75
The complex relationship between microbial growth rate and yield and its implications for ecosystem processes. Front Microbiol (2015) 0.75
Mapping high-growth phenotypes in the flux space of microbial metabolism. J R Soc Interface (2015) 0.75
Modeling the Overproduction of Ribosomes when Antibacterial Drugs Act on Cells. Biophys J (2016) 0.75
Metabolism at evolutionary optimal States. Metabolites (2015) 0.75
Modeling central metabolism and energy biosynthesis across microbial life. BMC Genomics (2016) 0.75
The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization. PLoS Comput Biol (2016) 0.75
Bud-Localization of CLB2 mRNA Can Constitute a Growth Rate Dependent Daughter Sizer. PLoS Comput Biol (2015) 0.75
Adaptation to different types of stress converge on mitochondrial metabolism. Mol Biol Cell (2016) 0.75
Metabolic evolution and the self-organization of ecosystems. Proc Natl Acad Sci U S A (2017) 0.75
Making life difficult for Clostridium difficile: augmenting the pathogen's metabolic model with transcriptomic and codon usage data for better therapeutic target characterization. BMC Syst Biol (2017) 0.75
Food environments select microorganisms based on selfish energetic behavior. Front Microbiol (2013) 0.75
Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle. Sci Rep (2015) 0.75
Evolutionary pressures on microbial metabolic strategies in the chemostat. Sci Rep (2016) 0.75
Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker? Med Sci Monit (2015) 0.75
Physiological, biomass elemental composition and proteomic analyses of Escherichia coli ammonium-limited chemostat growth, and comparison with iron- and glucose-limited chemostat growth. Microbiology (2015) 0.75
Toward Multiscale Models of Cyanobacterial Growth: A Modular Approach. Front Bioeng Biotechnol (2016) 0.75
Enzymatic Strategies and Carbon Use Efficiency of a Litter-Decomposing Fungus Grown on Maize Leaves, Stems, and Roots. Front Microbiol (2016) 0.75
Transition of an Anaerobic Escherichia coli Culture to Aerobiosis: Balancing mRNA and Protein Levels in a Demand-Directed Dynamic Flux Balance Analysis. PLoS One (2016) 0.75
Necessary and sufficient conditions for protocell growth. J Math Biol (2016) 0.75
Taking chances and making mistakes: non-genetic phenotypic heterogeneity and its consequences for surviving in dynamic environments. J R Soc Interface (2017) 0.75
Exploring the metabolic and genetic control of gene expression on a genomic scale. Science (1997) 60.15
On the origin of cancer cells. Science (1956) 49.55
Dependency on medium and temperature of cell size and chemical composition during balanced grown of Salmonella typhimurium. J Gen Microbiol (1958) 18.23
Cancer cell metabolism: Warburg and beyond. Cell (2008) 11.80
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell (2006) 9.80
Genome-scale models of microbial cells: evaluating the consequences of constraints. Nat Rev Microbiol (2004) 9.61
In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol (2001) 8.88
Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations. Proc Natl Acad Sci U S A (1994) 8.16
Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature (2002) 7.38
Does the ribosome translate cancer? Nat Rev Cancer (2003) 6.89
Patterns of protein synthesis in E. coli: a catalog of the amount of 140 individual proteins at different growth rates. Cell (1978) 6.70
Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. Appl Environ Microbiol (1994) 6.26
Cooperation and competition in the evolution of ATP-producing pathways. Science (2001) 6.04
Optimality and evolutionary tuning of the expression level of a protein. Nature (2005) 5.94
Advances in flux balance analysis. Curr Opin Biotechnol (2003) 5.50
Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division. Exp Cell Res (1977) 4.31
Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast. Mol Biol Cell (2007) 4.27
Self-sustained replication of an RNA enzyme. Science (2009) 3.80
Change from homo- to heterolactic fermentation by Streptococcus lactis resulting from glucose limitation in anaerobic chemostat cultures. J Bacteriol (1979) 3.50
Evolution of Escherichia coli during growth in a constant environment. Genetics (1987) 3.44
Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network. Proc Natl Acad Sci U S A (2003) 3.15
Metabolic flux responses to pyruvate kinase knockout in Escherichia coli. J Bacteriol (2002) 3.06
Regulation of ribosome production in Escherichia coli: synthesis and stability of ribosomal RNA and of ribosomal protein messenger RNA at different growth rates. J Mol Biol (1977) 2.98
Aerobic glycolysis during lymphocyte proliferation. Nature (1976) 2.94
Multiple duplications of yeast hexose transport genes in response to selection in a glucose-limited environment. Mol Biol Evol (1998) 2.90
Control of key metabolic intersections in Bacillus subtilis. Nat Rev Microbiol (2007) 2.81
Resource competition and social conflict in experimental populations of yeast. Nature (2006) 2.44
Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae. Genome Biol (2006) 2.43
Intracellular crowding defines the mode and sequence of substrate uptake by Escherichia coli and constrains its metabolic activity. Proc Natl Acad Sci U S A (2007) 2.42
How did Saccharomyces evolve to become a good brewer? Trends Genet (2006) 2.29
Costs of accuracy determined by a maximal growth rate constraint. Q Rev Biophys (1984) 2.28
Analysis of growth of Lactobacillus plantarum WCFS1 on a complex medium using a genome-scale metabolic model. J Biol Chem (2006) 2.17
Modeling Lactococcus lactis using a genome-scale flux model. BMC Microbiol (2005) 2.14
Glycolysis, glutaminolysis and cell proliferation. Cell Biol Int Rep (1982) 2.03
The regulation of carbohydrate metabolism in Klebsiella aerogenes NCTC 418 organisms, growing in chemostat culture. Arch Microbiol (1975) 2.01
Selection of laboratory wild-type phenotype from natural isolates of Escherichia coli in chemostats. Mol Biol Evol (1992) 1.96
Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 1.89
Is maximization of molar yield in metabolic networks favoured by evolution? J Theor Biol (2007) 1.88
Overflow metabolism in Escherichia coli during steady-state growth: transcriptional regulation and effect of the redox ratio. Appl Environ Microbiol (2006) 1.77
Effect of specific growth rate on fermentative capacity of baker's yeast. Appl Environ Microbiol (1998) 1.75
Impact of the solvent capacity constraint on E. coli metabolism. BMC Syst Biol (2008) 1.61
The role of energy-spilling reactions in the growth of Klebsiella aerogenes NCTC 418 in aerobic chemostat culture. Arch Microbiol (1976) 1.54
Evolution of cross-feeding in microbial populations. Am Nat (2004) 1.46
Bacterial growth: constant obsession with dN/dt. J Bacteriol (1999) 1.46
Game-theoretical approaches to studying the evolution of biochemical systems. Trends Biochem Sci (2005) 1.36
Kinetics of growth and sugar consumption in yeasts. Antonie Van Leeuwenhoek (1993) 1.34
Limiting factors in Escherichia coli fed-batch production of recombinant proteins. Biotechnol Bioeng (2003) 1.31
A systems biology approach to study glucose repression in the yeast Saccharomyces cerevisiae. Biotechnol Bioeng (2007) 1.23
Physiological properties of Saccharomyces cerevisiae from which hexokinase II has been deleted. Appl Environ Microbiol (2001) 1.12
Why can't a cell grow infinitely fast? Can J Microbiol (1988) 1.09
Constraints on microbial metabolism drive evolutionary diversification in homogeneous environments. J Evol Biol (2007) 1.09
Bioenergetic consequences of microbial adaptation to low-nutrient environments. J Biotechnol (1997) 1.03
Experimental rejection of a nonadaptive explanation for increased cell size in Escherichia coli. J Bacteriol (1996) 1.02
In vivo kinetics of primary metabolism in Saccharomyces cerevisiae studied through prolonged chemostat cultivation. Metab Eng (2005) 0.93
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest (2008) 7.05
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest (2007) 3.28
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J Clin Invest (2007) 2.80
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med (2005) 2.44
Reconstructing the metabolic network of a bacterium from its genome. Trends Microbiol (2005) 2.03
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood (2006) 1.98
Accelerating the reconstruction of genome-scale metabolic networks. BMC Bioinformatics (2006) 1.97
Lost in transition: start-up of glycolysis yields subpopulations of nongrowing cells. Science (2014) 1.96
Integrating genome assemblies with MAIA. Bioinformatics (2010) 1.70
A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry (2008) 1.66
De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology. Microb Cell Fact (2012) 1.62
Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression. J Immunol (2005) 1.61
CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res (2003) 1.54
Correlation between sequence conservation and the genomic context after gene duplication. Nucleic Acids Res (2005) 1.54
Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology (2003) 1.47
Co-regulation of metabolic genes is better explained by flux coupling than by network distance. PLoS Comput Biol (2008) 1.46
Distinct monocyte gene-expression profiles in autoimmune diabetes. Diabetes (2008) 1.25
Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features. PLoS One (2011) 1.25
Effective treatment of psoriasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Th17 pathways. J Invest Dermatol (2011) 1.24
Exploring genetic variation in the tomato (Solanum section Lycopersicon) clade by whole-genome sequencing. Plant J (2014) 1.22
Genome data mining of lactic acid bacteria: the impact of bioinformatics. Curr Opin Biotechnol (2004) 1.19
Gene therapy: is IL2RG oncogenic in T-cell development? Nature (2006) 1.18
Thioredoxin reductase is a key factor in the oxidative stress response of Lactobacillus plantarum WCFS1. Microb Cell Fact (2007) 1.17
Gross deletions involving IGHM, BTK, or Artemis: a model for genomic lesions mediated by transposable elements. Am J Hum Genet (2008) 1.12
Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice. Diabetes (2005) 1.11
Genome-scale model of Streptococcus thermophilus LMG18311 for metabolic comparison of lactic acid bacteria. Appl Environ Microbiol (2009) 1.10
Community flux balance analysis for microbial consortia at balanced growth. PLoS One (2013) 1.08
Intestinal lipid absorption is not affected in CD36 deficient mice. Mol Cell Biochem (2002) 1.07
FAME, the Flux Analysis and Modeling Environment. BMC Syst Biol (2012) 1.04
Predicting metabolic fluxes using gene expression differences as constraints. IEEE/ACM Trans Comput Biol Bioinform (2010) 1.03
The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis. J Lipid Res (2004) 1.03
Topology of molecular interaction networks. BMC Syst Biol (2013) 1.03
GRASS: a generic algorithm for scaffolding next-generation sequencing assemblies. Bioinformatics (2012) 1.00
Availability of public goods shapes the evolution of competing metabolic strategies. Proc Natl Acad Sci U S A (2013) 0.99
De novo detection of copy number variation by co-assembly. Bioinformatics (2012) 0.99
GATA3 expression is decreased in psoriasis and during epidermal regeneration; induction by narrow-band UVB and IL-4. PLoS One (2011) 0.98
A critical view of metabolic network adaptations. HFSP J (2008) 0.98
Bioinformatics and systems biology: bridging the gap between heterogeneous student backgrounds. Brief Bioinform (2013) 0.96
Standardized assay medium to measure Lactococcus lactis enzyme activities while mimicking intracellular conditions. Appl Environ Microbiol (2011) 0.95
The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice. J Hepatol (2004) 0.94
Role of phosphate in the central metabolism of two lactic acid bacteria--a comparative systems biology approach. FEBS J (2012) 0.93
Understanding the physiology of Lactobacillus plantarum at zero growth. Mol Syst Biol (2010) 0.93
Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2013) 0.93
Effect of amino acid availability on vitamin B12 production in Lactobacillus reuteri. Appl Environ Microbiol (2009) 0.92
Laboratory evolution of new lactate transporter genes in a jen1Δ mutant of Saccharomyces cerevisiae and their identification as ADY2 alleles by whole-genome resequencing and transcriptome analysis. FEMS Yeast Res (2012) 0.91
A data integration and visualization resource for the metabolic network of Synechocystis sp. PCC 6803. Plant Physiol (2014) 0.89
The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies. BMC Bioinformatics (2006) 0.89
Exploring variation-aware contig graphs for (comparative) metagenomics using MaryGold. Bioinformatics (2013) 0.88
The diversity of protein turnover and abundance under nitrogen-limited steady-state conditions in Saccharomyces cerevisiae. Mol Biosyst (2011) 0.88
Metabolic pathway alignment between species using a comprehensive and flexible similarity measure. BMC Syst Biol (2008) 0.87
A specific mutation in the promoter region of the silent cel cluster accounts for the appearance of lactose-utilizing Lactococcus lactis MG1363. Appl Environ Microbiol (2012) 0.87
Functional identification in Lactobacillus reuteri of a PocR-like transcription factor regulating glycerol utilization and vitamin B12 synthesis. Microb Cell Fact (2011) 0.86
Functional ingredient production: application of global metabolic models. Curr Opin Biotechnol (2005) 0.86
A practical guide to genome-scale metabolic models and their analysis. Methods Enzymol (2011) 0.86
Introgression browser: high-throughput whole-genome SNP visualization. Plant J (2015) 0.86
Towards metagenome-scale models for industrial applications--the case of Lactic Acid Bacteria. Curr Opin Biotechnol (2012) 0.85
MetDFBA: incorporating time-resolved metabolomics measurements into dynamic flux balance analysis. Mol Biosyst (2014) 0.84
IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells. Blood (2011) 0.83
Metabolic states with maximal specific rate carry flux through an elementary flux mode. FEBS J (2014) 0.83
Metabolic shifts: a fitness perspective for microbial cell factories. Biotechnol Lett (2012) 0.83
Response of apolipoprotein E*3-Leiden transgenic mice to dietary fatty acids: combining liver proteomics with physiological data. FASEB J (2005) 0.82
How biochemical constraints of cellular growth shape evolutionary adaptations in metabolism. Genetics (2013) 0.82
Multi-tasking of biosynthetic and energetic functions of glycolysis explained by supply and demand logic. Bioessays (2014) 0.82
Beyond genomic variation--comparison and functional annotation of three Brassica rapa genomes: a turnip, a rapid cycling and a Chinese cabbage. BMC Genomics (2014) 0.81
Acute inhibition of hepatic beta-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity. J Lipid Res (2005) 0.80
Basic concepts and principles of stoichiometric modeling of metabolic networks. Biotechnol J (2013) 0.80
Systems biology from micro-organisms to human metabolic diseases: the role of detailed kinetic models. Biochem Soc Trans (2010) 0.80
Making the difference: integrating structural variation detection tools. Brief Bioinform (2014) 0.80
Exploring sequence characteristics related to high-level production of secreted proteins in Aspergillus niger. PLoS One (2012) 0.80
Gene network requirements for regulation of metabolic gene expression to a desired state. Sci Rep (2013) 0.79
Lactic Acid Bacteria: embarking on 30 more years of research. Microb Cell Fact (2014) 0.76
Understanding regulation of metabolism through feasibility analysis. PLoS One (2012) 0.76
Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain. J Lipid Res (2002) 0.75
SPiCE: a web-based tool for sequence-based protein classification and exploration. BMC Bioinformatics (2014) 0.75
DNA microarray studies of hematopoietic subpopulations. Methods Mol Biol (2009) 0.75
Evolutionary optimization of kernel weights improves protein complex comembership prediction. IEEE/ACM Trans Comput Biol Bioinform (2009) 0.75
Exploiting next-generation sequencing to solve the haplotyping puzzle in polyploids: a simulation study. Brief Bioinform (2017) 0.75
Single-molecule protein sequencing through fingerprinting: computational assessment. Phys Biol (2015) 0.75
Inferring differences in the distribution of reaction rates across conditions. Mol Biosyst (2012) 0.75