PubRank

Roel A Ophoff

Author PubWeight™ 187.71‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Large recurrent microdeletions associated with schizophrenia. Nature 2008 20.25
2 Common variants conferring risk of schizophrenia. Nature 2009 10.37
3 Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013 8.02
4 Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011 7.98
5 Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet 2013 7.44
6 Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 2010 6.90
7 Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet 2008 4.78
8 Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet 2009 4.38
9 Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet 2012 3.73
10 Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet 2011 3.65
11 Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet 2010 3.55
12 The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One 2009 3.41
13 Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol 2012 3.05
14 ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. Lancet Neurol 2007 2.80
15 Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nat Genet 2007 2.63
16 Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet 2010 2.61
17 Recurrent CNVs disrupt three candidate genes in schizophrenia patients. Am J Hum Genet 2008 2.61
18 A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Nat Genet 2010 2.56
19 Copy-number variation in sporadic amyotrophic lateral sclerosis: a genome-wide screen. Lancet Neurol 2008 2.54
20 Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet 2012 2.29
21 Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Hum Mol Genet 2011 2.21
22 Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biol Psychiatry 2010 2.07
23 Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2009 2.03
24 Wnt signaling and Dupuytren's disease. N Engl J Med 2011 2.02
25 Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness. Am J Psychiatry 2011 1.94
26 The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav 2014 1.90
27 Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat Genet 2011 1.88
28 Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genet 2011 1.80
29 Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients. BMC Genomics 2009 1.72
30 Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects. BMC Genomics 2012 1.70
31 Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet 2013 1.68
32 European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene. Hum Mol Genet 2011 1.58
33 Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet 2008 1.46
34 A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes. PLoS One 2012 1.45
35 Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. Ann Neurol 2011 1.45
36 Migraine: a complex genetic disorder. Lancet Neurol 2007 1.39
37 Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Syst Biol 2011 1.30
38 At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. Biol Psychiatry 2011 1.26
39 Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder. Schizophr Res 2012 1.24
40 Gene-network analysis identifies susceptibility genes related to glycobiology in autism. PLoS One 2009 1.23
41 A genome-wide survey of segmental duplications that mediate common human genetic variation of chromosomal architecture. Hum Genomics 2004 1.22
42 Is human blood a good surrogate for brain tissue in transcriptional studies? BMC Genomics 2010 1.22
43 Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain. Arch Gen Psychiatry 2012 1.20
44 Genetic contributions to social impulsivity and aggressiveness in vervet monkeys. Biol Psychiatry 2004 1.19
45 Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients. Biol Psychiatry 2011 1.18
46 Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes. Eur J Hum Genet 2012 1.14
47 Analysis of genome-wide copy number variation in Irish and Dutch ALS populations. Hum Mol Genet 2008 1.12
48 Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9. Hepatology 2011 1.09
49 A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Hum Mol Genet 2010 1.08
50 FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands. Arch Neurol 2010 1.08
51 A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related species. Proc Natl Acad Sci U S A 2007 1.04
52 A genetic linkage map of the vervet monkey (Chlorocebus aethiops sabaeus). Mamm Genome 2007 1.04
53 Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome. Am J Med Genet B Neuropsychiatr Genet 2009 1.02
54 Paternal age and psychiatric disorders: findings from a Dutch population registry. Schizophr Res 2011 1.01
55 Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations. Psychiatr Genet 2004 1.01
56 Finding suitable phenotypes for genetic studies of schizophrenia: heritability and segregation analysis. Biol Psychiatry 2008 1.01
57 The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior. Psychiatr Genet 2012 0.99
58 A common variant in DRD3 receptor is associated with autism spectrum disorder. Biol Psychiatry 2008 0.98
59 Current status and future prospects for epigenetic psychopharmacology. Epigenetics 2012 0.96
60 Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biol Psychiatry 2012 0.96
61 Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis. PLoS One 2012 0.95
62 Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS. PLoS One 2012 0.95
63 Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls. Schizophr Bull 2010 0.94
64 Genetic overlap among intelligence and other candidate endophenotypes for schizophrenia. Biol Psychiatry 2008 0.94
65 New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. Int J Epidemiol 2015 0.93
66 Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. Diabetes 2007 0.92
67 A large genome scan for rare CNVs in amyotrophic lateral sclerosis. Hum Mol Genet 2010 0.92
68 TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. Am J Med Genet B Neuropsychiatr Genet 2012 0.91
69 Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner. BMC Genomics 2012 0.91
70 Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry 2014 0.90
71 Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder. Biol Psychiatry 2012 0.89
72 No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. Am J Med Genet B Neuropsychiatr Genet 2011 0.89
73 Prediction of serotonin transporter promoter polymorphism genotypes from single nucleotide polymorphism arrays using machine learning methods. Psychiatr Genet 2012 0.89
74 Increased paternal age and the influence on burden of genomic copy number variation in the general population. Hum Genet 2013 0.88
75 Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid. PLoS One 2012 0.87
76 A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation. Biol Psychiatry 2013 0.87
77 Genetic causes of developmental disorders. Curr Opin Neurol 2013 0.86
78 WNT2 locus is involved in genetic susceptibility of Peyronie's disease. J Sex Med 2012 0.86
79 Chromosome 19p13 loci in Finnish migraine with aura families. Am J Med Genet B Neuropsychiatr Genet 2005 0.86
80 Seasonal changes in gene expression represent cell-type composition in whole blood. Hum Mol Genet 2014 0.86
81 Systematic genotype-phenotype analysis of autism susceptibility loci implicates additional symptoms to co-occur with autism. Eur J Hum Genet 2009 0.84
82 Analysis of segmental duplications reveals a distinct pattern of continuation-of-synteny between human and mouse genomes. Hum Genet 2006 0.84
83 Sex-dependent novelty response in neurexin-1α mutant mice. PLoS One 2012 0.84
84 Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup. Am J Med Genet B Neuropsychiatr Genet 2008 0.84
85 The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism. Schizophr Res 2013 0.83
86 Accommodating chromosome inversions in linkage analysis. Am J Hum Genet 2006 0.83
87 Markov Models for inferring copy number variations from genotype data on Illumina platforms. Hum Hered 2009 0.83
88 A common variant in ERBB4 regulates GABA concentrations in human cerebrospinal fluid. Neuropsychopharmacology 2012 0.82
89 No evidence that common genetic risk variation is shared between schizophrenia and autism. Am J Med Genet B Neuropsychiatr Genet 2012 0.81
90 Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2009 0.81
91 D-amino acid aberrations in cerebrospinal fluid and plasma of smokers. Neuropsychopharmacology 2013 0.81
92 Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background. BMC Genomics 2010 0.80
93 No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Hum Mol Genet 2013 0.80
94 Effects of season of birth and a common MTHFR gene variant on the risk of schizophrenia. Eur Neuropsychopharmacol 2010 0.79
95 Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples. PLoS One 2012 0.77
96 Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice. PLoS One 2011 0.77
97 Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder. Genet Med 2012 0.76
98 Genetic variation and the risk of haloperidol-related parkinsonism in elderly patients: a candidate gene approach. J Clin Psychopharmacol 2013 0.76
99 BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects. Prog Neuropsychopharmacol Biol Psychiatry 2012 0.76
100 Replication and refinement of the role of rs548181 in schizophrenia: results from a family based study. Am J Med Genet B Neuropsychiatr Genet 2012 0.75
101 [Genetic variation with increased risk of schizophrenia]. Ned Tijdschr Geneeskd 2010 0.75