Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.

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Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurol (2010) 4.19

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurol (2010) 3.61

State of play in amyotrophic lateral sclerosis genetics. Nat Neurosci (2013) 3.54

Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med (2013) 2.89

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat Rev Neurol (2011) 2.73

Clinical genetics of amyotrophic lateral sclerosis: what do we really know? Nat Rev Neurol (2011) 2.55

Controversies and priorities in amyotrophic lateral sclerosis. Lancet Neurol (2013) 2.52

Genetics of motor neuron disorders: new insights into pathogenic mechanisms. Nat Rev Genet (2009) 2.31

ENDEAVOUR update: a web resource for gene prioritization in multiple species. Nucleic Acids Res (2008) 2.31

Genome-wide analysis of the heritability of amyotrophic lateral sclerosis. JAMA Neurol (2014) 2.22

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2009) 2.03

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep (2014) 1.93

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet (2009) 1.93

Molecular genetics of migraine. Hum Genet (2009) 1.91

Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients. BMC Genomics (2009) 1.72

A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology (2009) 1.67

SMN1 gene duplications are associated with sporadic ALS. Neurology (2012) 1.62

Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. Nat Genet (2013) 1.57

Follow-up association study of linkage regions reveals multiple candidate genes for carotid plaque in Dominicans. Atherosclerosis (2012) 1.47

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet (2008) 1.46

DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein. Front Mol Neurosci (2008) 1.31

DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. Neuron (2011) 1.30

Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. Am J Hum Genet (2008) 1.27

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis. Ann Neurol (2011) 1.21

The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci. PLoS One (2009) 1.19

Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials. Aging Dis (2013) 1.18

Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology. PLoS One (2012) 1.13

Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway. PLoS One (2008) 1.13

The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels. J Neurosci (2009) 1.03

A common haplotype within the PON1 promoter region is associated with sporadic ALS. Amyotroph Lateral Scler (2008) 1.02

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. Neurobiol Aging (2012) 1.02

Genome-wide association studies in neurological disorders. Lancet Neurol (2008) 1.01

Screening for replication of genome-wide SNP associations in sporadic ALS. Eur J Hum Genet (2008) 1.01

Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis. Cell Mol Life Sci (2013) 1.00

A high-density genome-wide association screen of sporadic ALS in US veterans. PLoS One (2012) 1.00

Genetic determinants of phenotypic diversity in humans. Genome Biol (2008) 1.00

The landscape of human genes involved in the immune response to parasitic worms. BMC Evol Biol (2010) 0.99

A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis. Hum Mol Genet (2013) 0.98

Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits. Biochemistry (2009) 0.97

Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations. Eur J Hum Genet (2009) 0.96

Clinical neurogenetics: amyotrophic lateral sclerosis. Neurol Clin (2013) 0.96

Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS. PLoS One (2012) 0.95

Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization. J Biol Chem (2012) 0.94

Familial risks for amyotrophic lateral sclerosis and autoimmune diseases. Neurogenetics (2008) 0.94

Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway. BMC Med Genomics (2011) 0.93

Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells. J Neurosci (2010) 0.89

Targeting angiogenin in therapy of amyotropic lateral sclerosis. Expert Opin Ther Targets (2008) 0.89

Increased paternal age and the influence on burden of genomic copy number variation in the general population. Hum Genet (2013) 0.88

Joint analysis of tightly linked SNPs in screening step of genome-wide association studies leads to increased power. Eur J Hum Genet (2009) 0.88

A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism. Channels (Austin) (2009) 0.88

Neuronal voltage-gated K+ (Kv) channels function in macromolecular complexes. Neurosci Lett (2010) 0.86

Genomic medicine and neurological disease. Hum Genet (2011) 0.85

Modulatory mechanisms and multiple functions of somatodendritic A-type K (+) channel auxiliary subunits. Front Cell Neurosci (2014) 0.84

Next-generation sequencing in understanding complex neurological disease. Expert Rev Neurother (2013) 0.84

Markov Models for inferring copy number variations from genotype data on Illumina platforms. Hum Hered (2009) 0.83

A new TASK for Dipeptidyl Peptidase-like Protein 6. PLoS One (2013) 0.81

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem (2013) 0.81

Genome-wide association studies in neurology. Ann Transl Med (2014) 0.80

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Hum Mol Genet (2013) 0.80

Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells. PLoS One (2012) 0.80

Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis. BMC Med Genet (2009) 0.80

Toward precision medicine in amyotrophic lateral sclerosis. Ann Transl Med (2016) 0.79

Use of biomarkers in ALS drug development and clinical trials. Brain Res (2014) 0.79

Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels. Sci Rep (2015) 0.78

DPP6 domains responsible for its localization and function. J Biol Chem (2014) 0.77

Current and future directions in genomics of amyotrophic lateral sclerosis. Phys Med Rehabil Clin N Am (2008) 0.77

Familial Amyotrophic Lateral Sclerosis. Neurol Clin (2015) 0.77

Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis. Neurobiol Aging (2010) 0.76

Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis. Neurobiol Dis (2015) 0.76

Genome-wide association studies in amyotrophic lateral sclerosis. Eur J Hum Genet (2008) 0.75

Single-nucleotide Polymorphism rs2275294 in ZNF512B is not Associated with Susceptibility to Amyotrophic Lateral Sclerosis in a Large Chinese Cohort. Chin Med J (Engl) (2015) 0.75

Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population. Clin Ophthalmol (2009) 0.75

Copy number variations play important roles in heredity of common diseases: a novel method to calculate heritability of a polymorphism. Sci Rep (2015) 0.75

Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complex. J Biol Chem (2015) 0.75

Screening for novel hexanucleotide repeat expansions at ALS- and FTD-associated loci. Neurol Genet (2016) 0.75

Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. PLoS One (2015) 0.75

The Analysis of Two BDNF Polymorphisms G196A/C270T in Chinese Sporadic Amyotrophic Lateral Sclerosis. Front Aging Neurosci (2017) 0.75

Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron (2011) 18.73

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet (2009) 14.86

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65

Genotype, haplotype and copy-number variation in worldwide human populations. Nature (2008) 12.40

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Common variants conferring risk of schizophrenia. Nature (2009) 10.37

Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature (2006) 9.31

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet (2007) 8.50

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98

Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron (2010) 7.87

Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66

Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet (2008) 7.63

Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44

novoSNP, a novel computational tool for sequence variation discovery. Genome Res (2005) 7.42

Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (2013) 6.34

Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med (2005) 6.33

Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes. Am J Hum Genet (2006) 6.10

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52

Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3. Brain (2006) 5.36

Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med (2009) 5.27

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol (2012) 5.18

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet (2008) 5.05

A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study. Lancet Neurol (2011) 5.01

Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet (2009) 4.79

Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet (2008) 4.78

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71

Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46

Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet (2012) 4.41

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38

Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. JAMA (2006) 4.26

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet (2003) 4.19

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurol (2010) 4.19

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature (2013) 4.03

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93

Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol (2007) 3.93

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis. Nat Genet (2006) 3.88

Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet (2011) 3.68

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet (2011) 3.65

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurol (2010) 3.61