Published in J Am Chem Soc on July 01, 2009
Bacterial cell-wall recycling. Ann N Y Acad Sci (2012) 1.60
Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane. FASEB J (2011) 1.25
Messenger functions of the bacterial cell wall-derived muropeptides. Biochemistry (2012) 1.17
The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa. Bioorg Chem (2014) 1.08
Reactions of the three AmpD enzymes of Pseudomonas aeruginosa. J Am Chem Soc (2013) 1.06
Crystal structures of bacterial peptidoglycan amidase AmpD and an unprecedented activation mechanism. J Biol Chem (2011) 1.00
Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa. J Am Chem Soc (2013) 0.97
Studying a cell division amidase using defined peptidoglycan substrates. J Am Chem Soc (2009) 0.91
Cell-wall remodeling by the zinc-protease AmpDh3 from Pseudomonas aeruginosa. J Am Chem Soc (2013) 0.91
AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains. Antimicrob Agents Chemother (2011) 0.90
Environment sensing and response mediated by ABC transporters. BMC Genomics (2011) 0.89
Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. Angew Chem Int Ed Engl (2016) 0.87
Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase. J Biol Chem (2011) 0.86
Catalytic spectrum of the penicillin-binding protein 4 of Pseudomonas aeruginosa, a nexus for the induction of β-lactam antibiotic resistance. J Am Chem Soc (2014) 0.86
Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a D,L-carboxypeptidase controlling the helical cell shape. Acta Crystallogr D Biol Crystallogr (2014) 0.85
Involvement of mutation in ampD I, mrcA, and at least one additional gene in β-lactamase hyperproduction in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2013) 0.83
Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli. ACS Chem Biol (2014) 0.83
Inhibitors for Bacterial Cell-Wall Recycling. ACS Med Chem Lett (2012) 0.82
Purification, crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltF from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.82
Host-guest chemistry of the peptidoglycan. J Med Chem (2010) 0.82
The putative hydrolase YycJ (WalJ) affects the coordination of cell division with DNA replication in Bacillus subtilis and may play a conserved role in cell wall metabolism. J Bacteriol (2010) 0.81
Three Yersinia enterocolitica AmpD Homologs Participate in the Multi-Step Regulation of Chromosomal Cephalosporinase, AmpC. Front Microbiol (2016) 0.77
The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of l,d-Carboxypeptidase. J Biol Chem (2015) 0.77
Muropeptide Binding and the X-Ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa. J Am Chem Soc (2017) 0.76
Conformational itinerary of Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle. J Biol Chem (2013) 0.76
Impact of AmpC Derepression on Fitness and Virulence: the Mechanism or the Pathway? MBio (2016) 0.75
Separation and quantification of muropeptides with high-performance liquid chromatography. Anal Biochem (1988) 4.65
Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria. Cell (1997) 3.48
How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan). Microbiol Mol Biol Rev (2008) 3.12
AmpD, essential for both beta-lactamase regulation and cell wall recycling, is a novel cytosolic N-acetylmuramyl-L-alanine amidase. Mol Microbiol (1995) 2.90
Three-dimensional structure of the bacterial cell wall peptidoglycan. Proc Natl Acad Sci U S A (2006) 2.81
Constitutive septal murein synthesis in Escherichia coli with impaired activity of the morphogenetic proteins RodA and penicillin-binding protein 2. J Bacteriol (2001) 2.00
Growth of Escherichia coli: significance of peptidoglycan degradation during elongation and septation. J Bacteriol (2008) 1.65
Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria. J Org Chem (2004) 1.33
Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. J Am Chem Soc (2008) 1.21
Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. J Am Chem Soc (2009) 1.19
Mutational analysis of the catalytic centre of the Citrobacter freundii AmpD N-acetylmuramyl-L-alanine amidase. Biochem J (2004) 1.17
N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism. Cell Mol Life Sci (2008) 1.04
Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functions. Chemistry (2008) 0.97
beta-Lactamase induction and cell wall recycling in gram-negative bacteria. Drug Resist Updat (1998) 0.91
Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity. Chem Rev (2005) 4.48
Tackling antibiotic resistance. Nat Rev Microbiol (2011) 3.95
Versatility of aminoglycosides and prospects for their future. Clin Microbiol Rev (2003) 3.72
Three-dimensional structure of the bacterial cell wall peptidoglycan. Proc Natl Acad Sci U S A (2006) 2.81
A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci (2005) 2.54
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res (2008) 1.88
Potent mechanism-based inhibitors for matrix metalloproteinases. J Biol Chem (2005) 1.83
Dichlorobis(1-ethylimidazole)zinc(II). Acta Crystallogr Sect E Struct Rep Online (2007) 1.79
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function. Proc Natl Acad Sci U S A (2013) 1.75
The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. J Biol Chem (2004) 1.74
Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70. J Am Chem Soc (2005) 1.67
Recent advances in MMP inhibitor design. Cancer Metastasis Rev (2006) 1.66
2-(Thio-phen-2-yl)-1-(thio-phen-2-ylmeth-yl)-1H-benzimidazole. Acta Crystallogr Sect E Struct Rep Online (2012) 1.64
Bacterial cell-wall recycling. Ann N Y Acad Sci (2012) 1.60
Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. Antimicrob Agents Chemother (2009) 1.51
Cyanide: a strong-field ligand for ferrohemes and hemoproteins? Angew Chem Int Ed Engl (2008) 1.50
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples. Chem Biol (2006) 1.50
Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. J Am Chem Soc (2008) 1.50
Cell surface association of matrix metalloproteinase-9 (gelatinase B). Cancer Metastasis Rev (2003) 1.45
Squaraine-derived rotaxanes: sterically protected fluorescent near-IR dyes. J Am Chem Soc (2005) 1.44
Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. Chem Biol (2002) 1.42
Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus. J Biol Chem (2003) 1.38
The future of the β-lactams. Curr Opin Microbiol (2010) 1.36
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. Cancer Res (2005) 1.36
High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase. J Am Chem Soc (2002) 1.36
Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria. J Org Chem (2004) 1.33
Self-assembly of fluorescent inclusion complexes in competitive media including the interior of living cells. J Am Chem Soc (2007) 1.33
{Bis[2-(diphenyl-phosphino)eth-yl]phenyl-phosphine-κP,P',P''}chloridoplatinium(II) hexa-fluoridophosphate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.32
Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase. Biochemistry (2005) 1.32
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor. Int J Cancer (2006) 1.32
Activation of BlaR1 protein of methicillin-resistant Staphylococcus aureus, its proteolytic processing, and recovery from induction of resistance. J Biol Chem (2011) 1.30
Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa. Biochemistry (2007) 1.28
Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases. J Biol Chem (2009) 1.28
Iminonitroso Diels-Alder reactions for efficient derivatization and functionalization of complex diene-containing natural products. Org Lett (2007) 1.28
Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. J Biol Chem (2013) 1.27
Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. Proc Natl Acad Sci U S A (2007) 1.27
Extracellular proteases as targets for treatment of cancer metastases. Chem Soc Rev (2004) 1.26
Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens. Biochemistry (2006) 1.25
Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane. FASEB J (2011) 1.25
Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime. Antimicrob Agents Chemother (2002) 1.23
Design of novel antibiotics that bind to the ribosomal acyltransfer site. J Am Chem Soc (2002) 1.23
Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall. J Am Chem Soc (2005) 1.22
The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins. J Biol Chem (2004) 1.22
Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. J Am Chem Soc (2008) 1.21
Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases. J Biol Chem (2009) 1.21
Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. J Am Chem Soc (2013) 1.21
Synthesis of a fragment of bacterial cell wall. J Org Chem (2004) 1.20
Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. J Am Chem Soc (2009) 1.19
Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma. J Am Chem Soc (2007) 1.19
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography. J Am Chem Soc (2003) 1.18
Messenger functions of the bacterial cell wall-derived muropeptides. Biochemistry (2012) 1.17
Three decades of the class A beta-lactamase acyl-enzyme. Curr Protein Pept Sci (2009) 1.17
Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium. Proc Natl Acad Sci U S A (2006) 1.17
Proton-mediated electron configuration change in high-spin iron(II) porphyrinates. J Am Chem Soc (2005) 1.17
X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction. J Am Chem Soc (2004) 1.15
Evolution of natural product scaffolds by acyl- and arylnitroso hetero-diels-alder reactions: new chemistry on piperine. J Org Chem (2008) 1.14
Singlet oxygen generation using iodinated squaraine and squaraine-rotaxane dyes. New J Chem (2007) 1.14
Heme carbonyls: environmental effects on nu(C-O) and Fe-C/C-O bond length correlations. J Am Chem Soc (2005) 1.13
Synthetic peptidoglycan motifs for germination of bacterial spores. Chembiochem (2010) 1.12
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme. J Biol Chem (2002) 1.12
Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics. J Am Chem Soc (2014) 1.11
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases. Chem Biol Drug Des (2009) 1.11
Metabolism of a highly selective gelatinase inhibitor generates active metabolite. Chem Biol Drug Des (2007) 1.10
Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab (2009) 1.10
Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity. J Am Chem Soc (2014) 1.10
Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study. Stroke (2012) 1.10
Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia. Mol Neurodegener (2012) 1.10
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth. Am J Pathol (2007) 1.09
Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. J Biol Chem (2010) 1.09
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors. Org Lett (2005) 1.08
Short alkylated peptoid mimics of antimicrobial lipopeptides. Antimicrob Agents Chemother (2010) 1.08
Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli. J Am Chem Soc (2002) 1.08
Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii. Chem Biol (2013) 1.08
Electronic configuration of high-spin imidazole-ligated iron(II) octaethylporphyrinates. Inorg Chem (2006) 1.07
Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity. J Biol Chem (2004) 1.07
A practical synthesis of nitrocefin. J Org Chem (2005) 1.07
Reactions of the three AmpD enzymes of Pseudomonas aeruginosa. J Am Chem Soc (2013) 1.06
Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1. J Biol Chem (2007) 1.06