Published in J Biol Chem on December 20, 2013
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr (2005) 61.38
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr (2004) 31.52
Likelihood-enhanced fast translation functions. Acta Crystallogr D Biol Crystallogr (2005) 29.38
Integration, scaling, space-group assignment and post-refinement. Acta Crystallogr D Biol Crystallogr (2010) 23.35
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr D Biol Crystallogr (2006) 14.21
Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. Biophys J (1999) 13.18
Growth of the stress-bearing and shape-maintaining murein sacculus of Escherichia coli. Microbiol Mol Biol Rev (1998) 8.34
Peptidoglycan structure and architecture. FEMS Microbiol Rev (2008) 6.69
From the regulation of peptidoglycan synthesis to bacterial growth and morphology. Nat Rev Microbiol (2011) 4.98
Recycling of murein by Escherichia coli. J Bacteriol (1985) 3.27
How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan). Microbiol Mol Biol Rev (2008) 3.12
Improvements in the analysis of domain motions in proteins from conformational change: DynDom version 1.50. J Mol Graph Model (2002) 2.59
The sugar kinase/heat shock protein 70/actin superfamily: implications of conserved structure for mechanism. Annu Rev Biophys Biomol Struct (1996) 1.97
Relationship between growth rate and ATP concentration in Escherichia coli: a bioassay for available cellular ATP. J Biol Chem (2003) 1.63
Structural dynamics of yeast hexokinase during catalysis. Philos Trans R Soc Lond B Biol Sci (1981) 1.43
Evolution and regulatory role of the hexokinases. Biochim Biophys Acta (1998) 1.43
Changes in the proton potential and the cellular energetics of Escherichia coli during growth by aerobic and anaerobic respiration or by fermentation. Eur J Biochem (1998) 1.42
The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action. J Biol Chem (2000) 1.34
Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate. J Bacteriol (2005) 1.32
Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. J Am Chem Soc (2009) 1.31
Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii. J Biol Chem (2007) 1.27
Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation. J Mol Biol (2006) 1.09
Structures of enterococcal glycerol kinase in the absence and presence of glycerol: correlation of conformation to substrate binding and a mechanism of activation by phosphorylation. Biochemistry (2004) 1.05
Structure and reaction mechanism of L-rhamnulose kinase from Escherichia coli. J Mol Biol (2006) 0.98
Nano-structure of the laminin γ-1 short arm reveals an extended and curved multidomain assembly. Matrix Biol (2010) 0.93
Recognition of viral RNA stem-loops by the tandem double-stranded RNA binding domains of PKR. RNA (2013) 0.87
Research applications of the Cambridge Structural Database (CSD). Chem Soc Rev (2004) 0.87
Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase. J Biol Chem (2011) 0.86
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol (2008) 3.46
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors. J Biol Chem (2005) 2.22
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc Natl Acad Sci U S A (2009) 2.12
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol (2012) 1.89
Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am J Hum Genet (2009) 1.78
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells. Nat Chem Biol (2011) 1.75
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nat Struct Mol Biol (2008) 1.66
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. J Mol Biol (2006) 1.59
Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis. Structure (2011) 1.53
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nat Struct Mol Biol (2006) 1.52
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. J Am Chem Soc (2007) 1.46
The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure (2011) 1.45
In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem (2008) 1.39
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. Biochim Biophys Acta (2009) 1.32
Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells. J Biol Chem (2013) 1.31
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. J Biol Chem (2008) 1.28
Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. J Biol Chem (2002) 1.26
Rapid purification of RNAs using fast performance liquid chromatography (FPLC). RNA (2006) 1.25
Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. Proc Natl Acad Sci U S A (2011) 1.24
HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science (2013) 1.21
Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology. Nat Chem Biol (2012) 1.21
Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat Chem Biol (2012) 1.20
Recent advances in GFP folding reporter and split-GFP solubility reporter technologies. Application to improving the folding and solubility of recalcitrant proteins from Mycobacterium tuberculosis. J Struct Funct Genomics (2005) 1.18
Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants. Biochemistry (2006) 1.15
Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. J Biol Chem (2009) 1.12
Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2009) 1.12
Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB. Proc Natl Acad Sci U S A (2008) 1.12
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proc Natl Acad Sci U S A (2013) 1.12
Vimentin coil 1A-A molecular switch involved in the initiation of filament elongation. J Mol Biol (2009) 1.10
Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway. Future Microbiol (2011) 1.10
Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. J Biol Chem (2007) 1.10
Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates. J Biol Chem (2012) 1.09
O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis. J Am Chem Soc (2005) 1.08
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. J Biol Chem (2002) 1.07
Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Mol Cell (2006) 1.07
NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2010) 1.06
The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation. Gastroenterology (2009) 1.05
O-GlcNAc modification and the tauopathies: insights from chemical biology. Curr Alzheimer Res (2009) 1.04
Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion. Chem Biol (2012) 1.03
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chem Biol (2010) 1.03
Translational insensitivity to potent activation of PKR by HCV IRES RNA. Antiviral Res (2009) 1.02
A potential for overestimating the absolute magnitudes of second virial coefficients by small-angle X-ray scattering. Anal Biochem (2013) 0.99
Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase. J Mol Biol (2010) 0.99
Characterization of a beta-N-acetylhexosaminidase and a beta-N-acetylglucosaminidase/beta-glucosidase from Cellulomonas fimi. FEBS J (2006) 0.99
Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase. J Mol Biol (2004) 0.99
Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase. Biochem J (2006) 0.99
Mammalian Notch is modified by D-Xyl-alpha1-3-D-Xyl-alpha1-3-D-Glc-beta1-O-Ser: implementation of a method to study O-glucosylation. Glycobiology (2009) 0.98
A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase. Org Biomol Chem (2006) 0.98
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond. Chem Soc Rev (2014) 0.96
Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody. Amino Acids (2010) 0.95
Visualizing the reaction coordinate of an O-GlcNAc hydrolase. J Am Chem Soc (2010) 0.95
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chem Biol (2010) 0.94
Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes. Curr Signal Transduct Ther (2010) 0.94
Experimental mapping of soluble protein domains using a hierarchical approach. Nucleic Acids Res (2011) 0.92
Binding of G-quadruplexes to the N-terminal recognition domain of the RNA helicase associated with AU-rich element (RHAU). J Biol Chem (2013) 0.92
Analysis of a new family of widely distributed metal-independent alpha-mannosidases provides unique insight into the processing of N-linked glycans. J Biol Chem (2011) 0.92
Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. PLoS One (2012) 0.91
Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor. Chem Commun (Camb) (2006) 0.90
AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains. Antimicrob Agents Chemother (2011) 0.90
Luminescent Zn and Pd tetranaphthaloporphyrins. Inorg Chem (2003) 0.90
Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ. J Am Chem Soc (2007) 0.90
Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Sci (2009) 0.89
Analysis of keystone enzyme in Agar hydrolysis provides insight into the degradation (of a polysaccharide from) red seaweeds. J Biol Chem (2012) 0.89
Differential recognition and hydrolysis of host carbohydrate antigens by Streptococcus pneumoniae family 98 glycoside hydrolases. J Biol Chem (2009) 0.89
Regulation of the interferon-inducible 2'-5'-oligoadenylate synthetases by adenovirus VA(I) RNA. J Mol Biol (2012) 0.89
A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. Angew Chem Int Ed Engl (2009) 0.88
Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase. Carbohydr Res (2009) 0.87
Recognition of viral RNA stem-loops by the tandem double-stranded RNA binding domains of PKR. RNA (2013) 0.87
Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships. J Am Chem Soc (2009) 0.87
Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity. BMC Biol (2014) 0.86
Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase. J Biol Chem (2011) 0.86
Delineating high-density areas in spatial Poisson fields from strip-transect sampling using indicator geostatistics: application to unexploded ordnance removal. J Environ Manage (2006) 0.85
Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion. J Biol Chem (2012) 0.85
Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2. Angew Chem Int Ed Engl (2014) 0.84
The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1. Nucleic Acids Res (2013) 0.84
Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides. J Am Chem Soc (2011) 0.83
Streptococcus pneumoniae endohexosaminidase D; feasibility of using N-glycan oxazoline donors for synthetic glycosylation of a GlcNAc-asparagine acceptor. Org Biomol Chem (2010) 0.83
Studying salt effects on protein stability using ribonuclease t1 as a model system. Biophys Chem (2011) 0.83
Resonance energy transfer between green fluorescent protein variants: complexities revealed with myosin fusion proteins. Biochemistry (2006) 0.82
Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease. Nat Commun (2012) 0.82
Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity. J Am Chem Soc (2015) 0.80
Phenylalanine induces Burkholderia cenocepacia phenylacetic acid catabolism through degradation to phenylacetyl-CoA in synthetic cystic fibrosis sputum medium. Microb Pathog (2011) 0.80
Native RNA purification by gel filtration chromatography. Methods Mol Biol (2012) 0.80
In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside. PLoS One (2013) 0.80
Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds. Plant Biotechnol J (2013) 0.80