Published in PLoS One on June 11, 2009
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28
Drosophila as a model for age-related impairment in locomotor and other behaviors. Exp Gerontol (2010) 1.13
The influence of skeletal muscle on systemic aging and lifespan. Aging Cell (2013) 1.13
Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn (2013) 1.09
A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo. J Biol Chem (2014) 1.05
Drosophila as a model to study cardiac aging. Exp Gerontol (2010) 1.03
The Drosophila PGC-1α homolog spargel modulates the physiological effects of endurance exercise. PLoS One (2012) 0.88
Two rare human mitofusin 2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology in Drosophila. PLoS One (2012) 0.88
Effects of exercise on circadian rhythms and mobility in aging Drosophila melanogaster. Exp Gerontol (2013) 0.88
3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus. Genes Dev (2013) 0.86
Drosophila models of cardiac disease. Prog Mol Biol Transl Sci (2011) 0.85
Endurance training protocol and longitudinal performance assays for Drosophila melanogaster. J Vis Exp (2012) 0.82
dFatp regulates nutrient distribution and long-term physiology in Drosophila. Aging Cell (2012) 0.80
Dietary composition regulates Drosophila mobility and cardiac physiology. J Exp Biol (2012) 0.79
Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms. Aging (Albany NY) (2015) 0.78
An ongoing role for structural sarcomeric components in maintaining Drosophila melanogaster muscle function and structure. PLoS One (2014) 0.78
Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors. PLoS One (2015) 0.77
Flight restriction prevents associative learning deficits but not changes in brain protein-adduct formation during honeybee ageing. J Exp Biol (2011) 0.77
Genetic manipulation of cardiac ageing. J Physiol (2015) 0.77
The TreadWheel: A Novel Apparatus to Measure Genetic Variation in Response to Gently Induced Exercise for Drosophila. PLoS One (2016) 0.76
Single swim sessions in C. elegans induce key features of mammalian exercise. BMC Biol (2017) 0.75
Effects of Increased Flight on the Energetics and Life History of the Butterfly Speyeria mormonia. PLoS One (2015) 0.75
Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles. PLoS One (2016) 0.75
Dim scotopic illumination accelerates the reentrainment following simulated jetlags in a diurnal experimental model, Drosophila. Commun Integr Biol (2013) 0.75
Comparative approaches to the study of physiology: Drosophila as a physiological tool. Am J Physiol Regul Integr Comp Physiol (2012) 0.75
In case of obesity, longevity-related mechanisms lead to anti-inflammation. Age (Dordr) (2013) 0.75
Fatiguing exercise initiated later in life reduces incidence of fibrillation and improves sleep quality in Drosophila. Age (Dordr) (2015) 0.75
New methods for monitoring mitochondrial biogenesis and mitophagy in vitro and in vivo. Exp Biol Med (Maywood) (2017) 0.75
Comparative Approaches to Understanding the Relation Between Aging and Physical Function. J Gerontol A Biol Sci Med Sci (2015) 0.75
Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants. PLoS One (2015) 0.75
TOR-mediated regulation of metabolism in aging. Aging Cell (2017) 0.75
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev (2006) 8.48
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45
Overview of caloric restriction and ageing. Mech Ageing Dev (2005) 6.68
Updating the evidence that physical activity is good for health: an epidemiological review 2000-2003. J Sci Med Sport (2004) 5.92
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Demography of dietary restriction and death in Drosophila. Science (2003) 4.82
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev (2005) 4.77
Lifespan and reproduction in Drosophila: New insights from nutritional geometry. Proc Natl Acad Sci U S A (2008) 4.43
Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol (2005) 4.30
Mitochondria--a nexus for aging, calorie restriction, and sirtuins? Cell (2008) 3.38
KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proc Natl Acad Sci U S A (2007) 3.30
Insulin regulation of heart function in aging fruit flies. Nat Genet (2004) 3.02
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest (2007) 3.02
Falls among older persons: a public health perspective. Annu Rev Public Health (1992) 2.98
Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell (2008) 2.97
Economic dimensions of slip and fall injuries. J Forensic Sci (1996) 2.84
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell (2007) 2.70
Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J (2005) 2.48
Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila. Exp Gerontol (2005) 2.29
Age-related changes in the structure and function of skeletal muscles. Clin Exp Pharmacol Physiol (2007) 2.22
Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol (1985) (2008) 2.20
Functional senescence in Drosophila melanogaster. Ageing Res Rev (2005) 2.10
Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Cell Metab (2006) 1.99
Effects of exercise and diet on chronic disease. J Appl Physiol (1985) (2005) 1.99
Age and aerobic exercise training effects on whole body and muscle protein metabolism. Am J Physiol Endocrinol Metab (2003) 1.96
Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J Biol Chem (2004) 1.95
Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell (2007) 1.87
Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster. Mech Ageing Dev (1976) 1.86
Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity. J Appl Physiol (1985) (2007) 1.86
Mitochondrial biogenesis and healthy aging. Exp Gerontol (2008) 1.85
Ageing and physical activity: evidence to develop exercise recommendations for older adults. Can J Public Health (2007) 1.79
AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle. Am J Physiol Endocrinol Metab (2001) 1.70
Effect of voluntary exercise on longevity of rats. J Appl Physiol (1985) (1985) 1.53
Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. Aging Cell (2008) 1.52
Oxidative stress and mitochondrial function with aging--the effects of calorie restriction. Aging Cell (2004) 1.50
Physical activity and motor decline in older persons. Muscle Nerve (2007) 1.45
Screening assays for heart function mutants in Drosophila. Biotechniques (2004) 1.43
Physical activity in the prevention of the most frequent chronic diseases: an analysis of the recent evidence. Asian Pac J Cancer Prev (2007) 1.40
Exercise training increases lipid metabolism gene expression in human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.39
Significance of skeletal muscle oxidative enzyme enhancement with endurance training. Clin Physiol (1982) 1.36
Mortality rate and longevity of food-restricted exercising male rats: a reevaluation. J Appl Physiol (1985) (1997) 1.34
Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis. Curr Opin Clin Nutr Metab Care (2008) 1.34
Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction. J Gerontol A Biol Sci Med Sci (2006) 1.25
Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed. Exp Gerontol (2008) 1.25
Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE-P) trial. J Gerontol A Biol Sci Med Sci (2007) 1.25
Dietary restriction alters demographic but not behavioral aging in Drosophila. Aging Cell (2007) 1.24
Training for endurance and strength: lessons from cell signaling. Med Sci Sports Exerc (2006) 1.16
Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am J Physiol Endocrinol Metab (2002) 1.15
Cellular and molecular events controlling skeletal muscle mass in response to altered use. Pflugers Arch (2008) 1.13
Free radical generation and oxidative stress with ageing and exercise: differential effects in the myocardium and liver. Acta Physiol Scand (2000) 1.11
Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging. FASEB J (2006) 1.10
Superoxide dismutase gene expression in skeletal muscle: fiber-specific adaptation to endurance training. Am J Physiol (1999) 1.08
Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins. Free Radic Biol Med (2000) 1.06
Exercise-induced cardioprotection--biochemical, morphological and functional evidence in whole tissue and isolated mitochondria. Int J Cardiol (2006) 1.05
Longevity of exercising male rats: effect of an antioxidant supplemented diet. Mech Ageing Dev (1998) 1.05
Flight activity, mortality rates, and lipoxidative damage in Drosophila. J Gerontol A Biol Sci Med Sci (2006) 1.03
Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention. Appl Physiol Nutr Metab (2007) 1.01
Training effects in mice after long-term voluntary exercise. Med Sci Sports Exerc (2006) 0.99
PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4. Physiol Genomics (2008) 0.96
Predicting which patient will fall again ... and again. J Adv Nurs (1993) 0.94
Genomic plasticity, energy allocations, and the extended longevity phenotypes of Drosophila. Ageing Res Rev (2002) 0.94
Psychological correlates of fasting and vigorous exercise as compensatory strategies in undergraduate women. Eat Behav (2008) 0.93
Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure. Front Biosci (2008) 0.92
Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver. Exp Gerontol (2007) 0.92
Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Front Biosci (2008) 0.90
Exercise- and nutrient-controlled mechanisms involved in maintenance of the musculoskeletal mass. Biochem Soc Trans (2007) 0.89
Exercise-induced cardioprotection: endogenous mechanisms. Med Sci Sports Exerc (2007) 0.88
Dietary restriction in Drosophila is dependent on mitochondrial efficiency and constrained by pre-existing extended longevity. Mech Ageing Dev (2007) 0.84
Cardiac aging. Semin Cell Dev Biol (2006) 0.82
Cardiac and metabolic consequences of aerobic exercise training in experimental diabetes. Curr Diabetes Rev (2007) 0.81
The protective effects of exercise and phosphoinositide 3-kinase (p110alpha) in the failing heart. Clin Sci (Lond) (2009) 0.81
Relationship between perceived needs and assessed needs for services in community-dwelling older persons. Gerontologist (2008) 0.79
The aging heart and exercise training. Arch Gerontol Geriatr Suppl (2002) 0.76
Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol (2009) 1.77
Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages. J Immunol (2010) 1.37
Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem (2008) 1.23
Individual fecundity and senescence in Drosophila and medfly. J Gerontol A Biol Sci Med Sci (2005) 0.95
Curcumin is an early-acting stage-specific inducer of extended functional longevity in Drosophila. Exp Gerontol (2012) 0.89
Chemical regulation of mid- and late-life longevities in Drosophila. Exp Gerontol (2012) 0.85
Dietary restriction in Drosophila is dependent on mitochondrial efficiency and constrained by pre-existing extended longevity. Mech Ageing Dev (2007) 0.84
Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants. Biogerontology (2009) 0.84
dFatp regulates nutrient distribution and long-term physiology in Drosophila. Aging Cell (2012) 0.80
Age-related change in γH2AX of Drosophila muscle: its significance as a marker for muscle damage and longevity. Biogerontology (2015) 0.76