Published in Aging Cell on May 23, 2007
Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med (2008) 3.38
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell (2009) 3.37
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A (2010) 2.09
Mechanisms and molecular probes of sirtuins. Chem Biol (2008) 1.90
Redox control of the cell cycle in health and disease. Antioxid Redox Signal (2009) 1.72
SIRT6 in DNA repair, metabolism and ageing. J Intern Med (2008) 1.61
Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. Genes Dev (2012) 1.59
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
mTOR's role in ageing: protein synthesis or autophagy? Aging (Albany NY) (2009) 1.59
SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell (2008) 1.48
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. Diabetes (2010) 1.48
SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol (2010) 1.48
Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47
The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes. J Biol Chem (2009) 1.40
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
Acetic acid effects on aging in budding yeast: are they relevant to aging in higher eukaryotes? Cell Cycle (2009) 1.31
SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med (2013) 1.30
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev (2013) 1.29
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle (2008) 1.28
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS One (2012) 1.27
Exercise-training in young Drosophila melanogaster reduces age-related decline in mobility and cardiac performance. PLoS One (2009) 1.23
Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem (2008) 1.23
The regulation of aging: does autophagy underlie longevity? Trends Cell Biol (2009) 1.22
p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell (2009) 1.20
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. Hum Mol Genet (2011) 1.17
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
Survival strategies of a sterol auxotroph. Development (2010) 1.16
How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy. Trends Cell Biol (2015) 1.16
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
"Sly as a FOXO": new paths with Forkhead signaling in the brain. Curr Neurovasc Res (2007) 1.12
The sirtuin family's role in aging and age-associated pathologies. J Clin Invest (2013) 1.12
The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) (2013) 1.08
Forkhead box class O transcription factors in liver function and disease. J Gastroenterol Hepatol (2013) 1.07
Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci (2012) 1.07
Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice. J Gerontol A Biol Sci Med Sci (2011) 1.06
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J (2014) 1.06
Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J (2014) 1.05
SIRT2 as a Therapeutic Target for Age-Related Disorders. Front Pharmacol (2012) 1.04
The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica (2011) 1.03
Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy. J Cell Mol Med (2009) 1.03
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem Cells Dev (2011) 1.02
Epigenetic control of aging. Antioxid Redox Signal (2010) 1.02
Redox regulation of FoxO transcription factors. Redox Biol (2015) 1.01
The emerging role of acetylation in the regulation of autophagy. Autophagy (2013) 1.01
Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00
The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology. Circ Res (2009) 1.00
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. EMBO J (2013) 0.99
The role of sirtuins in modulating redox stressors. Free Radic Biol Med (2011) 0.99
The tangled circuitry of metabolism and apoptosis. Mol Cell (2013) 0.99
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells. FEBS Lett (2008) 0.98
KEGG orthology-based annotation of the predicted proteome of Acropora digitifera: ZoophyteBase - an open access and searchable database of a coral genome. BMC Genomics (2013) 0.98
C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. PLoS Genet (2012) 0.96
Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure. Hepatology (2013) 0.96
Calorie restriction and stroke. Exp Transl Stroke Med (2011) 0.95
Redox signaling pathways involved in neuronal ischemic preconditioning. Curr Neuropharmacol (2012) 0.95
Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. BMB Rep (2013) 0.93
Transcription Regulation by Class III Histone Deacetylases (HDACs)-Sirtuins. Transl Oncogenomics (2008) 0.93
Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. Int J Physiol Pathophysiol Pharmacol (2011) 0.93
Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY) (2012) 0.93
Nutrition and healthy ageing: calorie restriction or polyphenol-rich "MediterrAsian" diet? Oxid Med Cell Longev (2013) 0.93
The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. PLoS Genet (2012) 0.92
The diversity of histone versus nonhistone sirtuin substrates. Genes Cancer (2013) 0.92
Regulation of sirtuin function by posttranslational modifications. Front Pharmacol (2012) 0.91
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell (2015) 0.90
Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. FASEB J (2013) 0.90
Retracted Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein. J Biol Chem (2012) 0.89
A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. J Biol Chem (2013) 0.89
Sirtuins in epigenetic regulation. Chem Rev (2015) 0.88
Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice. Am J Physiol Endocrinol Metab (2011) 0.88
Regulation of Foxo-dependent transcription by post-translational modifications. Curr Drug Targets (2011) 0.88
Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor. Aging (Albany NY) (2011) 0.87
Sirtuins, bioageing, and cancer. J Aging Res (2011) 0.86
The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression. Oxid Med Cell Longev (2015) 0.86
Global Gene Expression Profiling Reveals Functional Importance of Sirt2 in Endothelial Cells under Oxidative Stress. Int J Mol Sci (2013) 0.86
Role and Therapeutic Potential of the Pro-Longevity Factor FOXO and Its Regulators in Neurodegenerative Disease. Front Pharmacol (2012) 0.85
The molecular genetics of sirtuins: association with human longevity and age-related diseases. Int J Mol Epidemiol Genet (2010) 0.85
IKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function. PLoS One (2013) 0.85
New nucleophilic mechanisms of ros-dependent epigenetic modifications: comparison of aging and cancer. Aging Dis (2013) 0.85
SIRT1, 2, 3 protect mouse oocytes from postovulatory aging. Aging (Albany NY) (2016) 0.85
NAD and the aging process: Role in life, death and everything in between. Mol Cell Endocrinol (2016) 0.85
Sirt1's complex roles in neuroprotection. Cell Mol Neurobiol (2009) 0.84
Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. PLoS One (2015) 0.84
Sirtuin biology and relevance to diabetes treatment. Diabetes Manag (Lond) (2012) 0.83
Intake of red wine in different meals modulates oxidized LDL level, oxidative and inflammatory gene expression in healthy people: a randomized crossover trial. Oxid Med Cell Longev (2014) 0.83
SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort. PLoS One (2014) 0.83
Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin. J Biol Chem (2014) 0.83
SIRTain regulators of premature senescence and accelerated aging. Protein Cell (2015) 0.82
High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor. PLoS One (2014) 0.81
Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions. Aging (Albany NY) (2009) 0.81
Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis. PLoS One (2011) 0.81
SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway. Front Aging Neurosci (2014) 0.81
The sirtuins in the pathogenesis of cancer. Clin Epigenetics (2010) 0.81
FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis. Oncogene (2013) 0.81
New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder. Adv Exp Med Biol (2009) 0.81
TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med (2005) 5.77
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 3.09
Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity (2008) 2.78
Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Biochemistry (2010) 2.48
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany NY) (2009) 2.32
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates. Proc Natl Acad Sci U S A (2007) 2.30
Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Mol Ther (2006) 1.99
OX40 ligand shuts down IL-10-producing regulatory T cells. Proc Natl Acad Sci U S A (2006) 1.92
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One (2010) 1.67
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat Med (2009) 1.66
SATB1 is an independent prognostic marker for gastric cancer in a Chinese population. Oncol Rep (2010) 1.56
SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell (2008) 1.48
NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem (2009) 1.43
Expression of SATB1 and heparanase in gastric cancer and its relationship to clinicopathologic features. APMIS (2010) 1.37
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev (2013) 1.29
Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood (2006) 1.27
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell (2011) 1.21
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats. PLoS One (2011) 1.08
Distinct biological roles for the notch ligands Jagged-1 and Jagged-2. J Biol Chem (2009) 1.06
Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats. Neuropeptides (2008) 1.06
cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood (2011) 1.00
Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index. Sci Transl Med (2013) 0.98
Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation. Am J Physiol Cell Physiol (2008) 0.95
Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem (2010) 0.93
Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus. J Immunol (2010) 0.93
Special AT-rich sequence binding protein 1 regulates the multidrug resistance and invasion of human gastric cancer cells. Oncol Lett (2012) 0.92
Conversion of intratumoral regulatory T cells by human gastric cancer cells is dependent on transforming growth factor-β1. J Surg Oncol (2011) 0.86
Developmental biology: cell fate in the mammary gland. Nature (2007) 0.85
Up-regulation of P-glycoprotein is involved in the increased paclitaxel resistance in human esophageal cancer radioresistant cells. Scand J Gastroenterol (2012) 0.84
MG-132 inhibits telomerase activity, induces apoptosis and G(1) arrest associated with upregulated p27kip1 expression and downregulated survivin expression in gastric carcinoma cells. Cancer Invest (2008) 0.84
Murine Sirt3 protein isoforms have variable half-lives. Gene (2011) 0.84
Identification of GATA2 and AP-1 Activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene. Mol Cells (2009) 0.83
Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. Exp Cell Res (2013) 0.82
The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep (2005) 0.82
Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production. Am J Physiol Endocrinol Metab (2012) 0.82
Inhibitory effect of ubiquitin-proteasome pathway on proliferation of esophageal carcinoma cells. World J Gastroenterol (2004) 0.81
Potent 4-amino-5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett (2006) 0.81
Targeted Facebook Advertising is a Novel and Effective Method of Recruiting Participants into a Human Papillomavirus Vaccine Effectiveness Study. JMIR Res Protoc (2016) 0.79
Novel 5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett (2006) 0.79
Synergistic enhancement of cancer therapy using a combination of fusion protein MG7-scFv/SEB and tumor necrosis factor alpha. Protein Pept Lett (2013) 0.78
Retracted Knockdown of cancerous inhibitor of protein phosphatase 2A may sensitize metastatic castration-resistant prostate cancer cells to cabazitaxel chemotherapy. Tumour Biol (2014) 0.78
The usefulness of endoscopic ultrasound in the differential diagnosis between benign and malignant gastric ulcer. Scand J Gastroenterol (2010) 0.78
Upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells. Cancer Invest (2009) 0.78
Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells. Cancer Invest (2008) 0.77
Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells. J Immunol (2010) 0.77
Inhibition of adenovirus-mediated p27kip1 gene on growth of esophageal carcinoma cell strain. World J Gastroenterol (2003) 0.77
Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells. Fertil Steril (2008) 0.76
A cyclooxygase-2 inhibitor NS-398-enhanced apoptosis of esophageal carcinoma cell EC9706 by adjusting expression of survivin and caspase-3. Cancer Invest (2011) 0.76
Correction: Adverse Events of Anti-Tumor Necrosis Factor α Therapy in Ankylosing Spondylitis. PLoS One (2015) 0.75
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol (2017) 0.75
Adenovirus expressing p27kip1 suppresses growth of established esophageal carcinoma xenografts. World J Gastroenterol (2005) 0.75
Construction of Novel Thermosensitive Magnetic Cationic Liposomes as a Drug and Gene Co-Delivery System. J Nanosci Nanotechnol (2015) 0.75
Effects of adenovirus-mediated human cyclooxygenase-2 antisense RNA on the growth of hepatocellular carcinoma. World J Gastroenterol (2005) 0.75
[Expression of DOG-1 in gastrointestinal stromal tumors and its significance]. Zhonghua Wei Chang Wai Ke Za Zhi (2013) 0.75
Nogo-B Facilitates LPS-Mediated Immune Responses by Up-Regulation of TLR4-Signaling in Macrophage RAW264.7. Cell Physiol Biochem (2017) 0.75
Corrigendum: Inference of immune cell composition on the expression profiles of mouse tissue. Sci Rep (2017) 0.75
Emergency Department Point-of-Care Hip Ultrasound and Its Role in the Diagnosis of Septic Hip Arthritis: A Case Report. Pediatr Emerg Care (2016) 0.75
Pediatric Cranial Vault Fractures: Analysis of Demographics, Injury Patterns, and Factors Predictive of Mortality. J Craniofac Surg (2015) 0.75
Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors. Bioorg Med Chem Lett (2006) 0.75
Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors. Bioorg Med Chem Lett (2006) 0.75
Schisandrin B inhibits the proliferation and invasion of glioma cells by regulating the HOTAIR-micoRNA-125a-mTOR pathway. Neuroreport (2016) 0.75
T lymphocyte subsets determination and DNA ploidy analysis in the differential diagnosis between benign and malignant ascites. Cancer Invest (2009) 0.75