PubRank

Alessandro Moretta

Author PubWeight™ 204.10‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Innate or adaptive immunity? The example of natural killer cells. Science 2011 8.68
2 Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc Natl Acad Sci U S A 2007 3.60
3 Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 2003 3.52
4 The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med 2009 3.17
5 Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J 2003 3.06
6 Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med 2011 3.03
7 Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res 2002 3.00
8 CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation. J Immunol 2007 2.97
9 Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc Natl Acad Sci U S A 2005 2.80
10 Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood 2009 2.75
11 Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc Natl Acad Sci U S A 2003 2.71
12 The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J Immunol 2004 2.64
13 Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci U S A 2005 2.55
14 Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci U S A 2003 2.51
15 Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J Clin Invest 2011 2.44
16 NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor. Blood 2005 2.31
17 The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). Eur J Immunol 2003 2.29
18 CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci U S A 2004 2.23
19 Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia. Blood 2002 2.21
20 Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 2004 2.17
21 The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood 2007 1.99
22 Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity. Blood 2008 1.96
23 DNAM-1 and PVR regulate monocyte migration through endothelial junctions. J Exp Med 2004 1.96
24 Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc Natl Acad Sci U S A 2004 1.95
25 Surface NK receptors and their ligands on tumor cells. Semin Immunol 2006 1.92
26 Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction. Cancer Res 2004 1.87
27 Cellular ligands of activating NK receptors. Trends Immunol 2005 1.84
28 Killer immunoglobulin-like receptors. Curr Opin Immunol 2004 1.83
29 The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity. Structure 2003 1.82
30 Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus? Blood 2011 1.78
31 NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection. J Immunol 2007 1.78
32 Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets. Blood 2010 1.75
33 Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection. J Exp Med 2006 1.72
34 Effector and regulatory events during natural killer-dendritic cell interactions. Immunol Rev 2006 1.71
35 A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2. Blood 2010 1.67
36 The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells. Eur J Immunol 2003 1.60
37 Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction. Blood 2005 1.57
38 Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation. Blood 2010 1.56
39 The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors. Eur J Immunol 2003 1.55
40 Significant NK cell activation associated with decreased cytolytic function in peripheral blood of HIV-1-infected patients. Eur J Immunol 2004 1.53
41 NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med 2012 1.52
42 The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells. Eur J Immunol 2004 1.50
43 Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. Eur J Immunol 2004 1.48
44 NK cells recognize and kill human glioblastoma cells with stem cell-like properties. J Immunol 2009 1.46
45 Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals. PLoS Pathog 2008 1.44
46 Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells. Eur J Immunol 2005 1.42
47 The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function. Blood 2006 1.41
48 Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc Natl Acad Sci U S A 2002 1.40
49 NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies. Blood 2010 1.38
50 Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes. Blood 2003 1.37
51 Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. Int Immunol 2008 1.36
52 IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors. Eur J Immunol 2003 1.35
53 Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity. Proc Natl Acad Sci U S A 2009 1.34
54 The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes. Proc Natl Acad Sci U S A 2010 1.28
55 Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection. AIDS 2010 1.27
56 HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes. Proc Natl Acad Sci U S A 2003 1.27
57 Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP. PLoS Biol 2011 1.27
58 The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. Blood 2005 1.26
59 IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism. J Clin Invest 2002 1.24
60 Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells. Blood 2008 1.22
61 Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill T-cell blasts and dendritic cells: implications in haploidentical HSCT. Blood 2011 1.22
62 Human NK cells directly recognize Mycobacterium bovis via TLR2 and acquire the ability to kill monocyte-derived DC. Int Immunol 2008 1.20
63 Innate immunity defects in Hermansky-Pudlak type 2 syndrome. Blood 2006 1.19
64 Origin, phenotype and function of human natural killer cells in pregnancy. Trends Immunol 2011 1.18
65 The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. Blood 2009 1.15
66 The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J Immunol 2005 1.15
67 Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function. Eur J Immunol 2008 1.15
68 Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function. Blood 2006 1.14
69 Human natural killer cells: their origin, receptors and function. Eur J Immunol 2002 1.13
70 Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis. Immunol Lett 2005 1.12
71 Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C-/- umbilical cord blood. J Immunol 2014 1.12
72 Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses. Blood 2006 1.11
73 IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors. J Immunol 2005 1.11
74 PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. Mol Immunol 2005 1.11
75 Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys. Blood 2005 1.11
76 Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules. J Immunol 2013 1.11
77 Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells. Front Immunol 2013 1.10
78 Human breast tumor cells induce self-tolerance mechanisms to avoid NKG2D-mediated and DNAM-mediated NK cell recognition. Cancer Res 2011 1.09
79 NK-CTLs, a novel HLA-E-restricted T-cell subset. Trends Immunol 2003 1.09
80 Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells. Blood 2002 1.08
81 Selective cross-talk among natural cytotoxicity receptors in human natural killer cells. Eur J Immunol 2003 1.08
82 Human NK cell infusions prolong survival of metastatic human neuroblastoma-bearing NOD/scid mice. Cancer Immunol Immunother 2007 1.07
83 Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells. Eur J Immunol 2004 1.05
84 Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction. Blood 2009 1.05
85 Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference. Clin Immunol 2009 1.04
86 Pathogen-induced private conversations between natural killer and dendritic cells. Trends Microbiol 2005 1.03
87 Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor. Eur J Immunol 2012 1.03
88 Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. N Engl J Med 2015 1.02
89 NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors. J Immunol 2005 1.01
90 Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining. J Immunol 2010 1.00
91 Neuroblastoma-derived TGF-β1 modulates the chemokine receptor repertoire of human resting NK cells. J Immunol 2013 1.00
92 Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response. PLoS One 2012 0.99
93 Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells. Proc Natl Acad Sci U S A 2002 0.98
94 Human NK cell receptors/markers: a tool to analyze NK cell development, subsets and function. Cytometry A 2013 0.98
95 Perturbations of natural killer cell regulatory functions in respiratory allergic diseases. J Allergy Clin Immunol 2007 0.98
96 M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages. Eur J Immunol 2012 0.97
97 Different checkpoints in human NK-cell activation. Trends Immunol 2004 0.97
98 Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells. Mol Immunol 2004 0.97
99 Human NK Cells induce neutrophil apoptosis via an NKp46- and Fas-dependent mechanism. J Immunol 2012 0.97
100 CD158k/KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome. J Invest Dermatol 2004 0.95
101 NK cells and their receptors during viral infections. Immunotherapy 2011 0.94
102 Molecular and functional characterization of NKG2D, NKp80, and NKG2C triggering NK cell receptors in rhesus and cynomolgus macaques: monitoring of NK cell function during simian HIV infection. J Immunol 2005 0.93
103 Bridging innate NK cell functions with adaptive immunity. Adv Exp Med Biol 2011 0.93
104 Human NK cells and their receptors. Microbes Infect 2002 0.92
105 At the Bench: Preclinical rationale for exploiting NK cells and γδ T lymphocytes for the treatment of high-risk leukemias. J Leukoc Biol 2013 0.92
106 Expression and function of the natural cytotoxicity receptor NKp46 on circulating malignant CD4+ T lymphocytes of Sézary syndrome patients. J Invest Dermatol 2010 0.91
107 CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity. Eur J Immunol 2003 0.91
108 Comparison of different CpG oligodeoxynucleotide classes for their capability to stimulate human NK cells. Eur J Immunol 2006 0.91
109 Human natural killer receptors and their ligands. Curr Protoc Immunol 2002 0.90
110 The immune inhibitory receptor LAIR-1 is highly expressed by plasmacytoid dendritic cells and acts complementary with NKp44 to control IFNα production. PLoS One 2010 0.90
111 Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway. Int Immunol 2008 0.89
112 Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells. PLoS One 2009 0.89
113 NK-DC interaction: on the usefulness of auto-aggression. Autoimmun Rev 2005 0.89
114 Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients. Blood 2005 0.89
115 Functional characterization of natural killer cells in type I leukocyte adhesion deficiency. Blood 2007 0.89
116 NK/DC crosstalk in anti-viral response. Adv Exp Med Biol 2012 0.88
117 Heterogeneity of TLR3 mRNA transcripts and responsiveness to poly (I:C) in human NK cells derived from different donors. Int Immunol 2007 0.87
118 KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting with allogeneic HLA-C2+ DCs or T-cell blasts. Blood 2013 0.86
119 Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity. Eur J Immunol 2007 0.85
120 Role of alloreactive KIR2DS1(+) NK cells in haploidentical hematopoietic stem cell transplantation. J Leukoc Biol 2011 0.85
121 Extending killer Ig-like receptor function: from HLA class I recognition to sensors of microbial products. Trends Immunol 2010 0.84
122 GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues. Int Immunol 2009 0.84
123 Human NK receptors: from the molecules to the therapy of high risk leukemias. FEBS Lett 2011 0.84
124 Structure of the human NK cell triggering receptor NKp46 ectodomain. Biochem Biophys Res Commun 2003 0.83
125 Distinctive lack of CD48 expression in subsets of human dendritic cells tunes NK cell activation. J Immunol 2005 0.83
126 Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ lymphocytopenia associated with novel immunophenotypic and molecular features. Pediatr Infect Dis J 2009 0.83
127 Phenotypic studies of natural killer cell subsets in human transporter associated with antigen processing deficiency. PLoS One 2007 0.83
128 Analysis of the natural killer mediated immune response in metastatic renal cell carcinoma patients. Int J Cancer 2004 0.82
129 Update on natural killer cells: cross-talk with dendritic cells and role in the cure of acute myeloid leukemias. Cancer J 2003 0.82
130 Shaping of adaptive immunity by innate interactions. C R Biol 2004 0.81
131 Natural killer cell-triggering receptors in patients with acute leukaemia. Leuk Lymphoma 2003 0.81
132 TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells. Eur J Immunol 2014 0.81
133 Killer cell immunoglobulin-like receptor expression delineates in situ Sézary syndrome lymphocytes. J Pathol 2003 0.81
134 Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30. Exp Hematol 2009 0.80
135 Human natural killer cell function and their interactions with dendritic cells. Vaccine 2003 0.80
136 Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2. Int Immunol 2004 0.80
137 Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. Acta Crystallogr D Biol Crystallogr 2004 0.79
138 XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells. Eur J Immunol 2014 0.79
139 CMV induces rapid NK cell maturation in HSCT recipients. Immunol Lett 2013 0.79
140 Cognate HLA absence in trans diminishes human NK cell education. J Clin Invest 2016 0.78
141 IFN-alpha-mediated increase in cytolytic activity of maturing NK cell upon exposure to HSV-infected myelomonocytes. Eur J Immunol 2009 0.78
142 Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor. Chembiochem 2004 0.78
143 Persistence of natural killer cells with expansion of a hypofunctional CD56-CD16+KIR+NKG2C+ subset in a patient with atypical Janus kinase 3-deficient severe combined immunodeficiency. J Allergy Clin Immunol 2012 0.78
144 Strategies to optimize the outcome of children given T-cell depleted HLA-haploidentical hematopoietic stem cell transplantation. Best Pract Res Clin Haematol 2011 0.78
145 Cellular and molecular basis of natural killer and natural killer-like activity. Immunol Lett 2003 0.77
146 It's only innate immunity but I like it. Adv Exp Med Biol 2007 0.77
147 Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma. Oncogene 2003 0.77
148 The NK/DC complot. Adv Exp Med Biol 2009 0.77
149 In the thick of the fray: NK cells in inflamed tissues. Adv Exp Med Biol 2007 0.76
150 Aegean reflections on innate immunity. Nat Immunol 2013 0.75
151 Since their identification 40 years ago, natural killer (NK) cells write a never-ending story. Introduction. Curr Top Microbiol Immunol 2016 0.75
152 Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44. Acta Crystallogr D Biol Crystallogr 2002 0.75
153 Expression and crystallographic characterization of the extracellular domain of human natural killer cell triggering receptor NKp46. Acta Crystallogr D Biol Crystallogr 2003 0.75
154 Cell surface expression of activating receptors and co-receptors on peripheral blood NK cells in mixed cryoglobulinemia. Joint Bone Spine 2012 0.75