Mechanism of action of BAY v 3522, a new cephalosporin with unusually good activity against enterococci.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 245288)

Published in Antimicrob Agents Chemother on September 01, 1991

Authors

G Amalfitano1, A Grossato, R Fontana

Author Affiliations

1: Institute of Microbiology, University of Verona, Italy.

Articles cited by this

The life and times of the Enterococcus. Clin Microbiol Rev (1990) 16.58

Recognition of group D streptococcal species of human origin by biochemical and physiological tests. Appl Microbiol (1972) 13.09

Susceptibility of group D streptococcus (enterococcus) to 21 antibiotics in vitro, with special reference to species differences. Am J Med Sci (1969) 10.08

Identification of a streptococcal penicillin-binding protein that reacts very slowly with penicillin. J Bacteriol (1983) 4.42

Binding of beta-lactam antibiotics to penicillin-binding proteins of Staphylococcus aureus and Streptococcus faecalis: relation to antibacterial activity. Antimicrob Agents Chemother (1980) 3.87

Defective killing of enterococci: a common property of antimicrobial agents acting on the cell wall. Antimicrob Agents Chemother (1980) 3.54

One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin. J Gen Microbiol (1985) 2.73

Enterococci. Biologic and epidemiologic characteristics and in vitro susceptibility. Arch Intern Med (1982) 2.49

Transition from resistance to hypersusceptibility to beta-lactam antibiotics associated with loss of a low-affinity penicillin-binding protein in a Streptococcus faecium mutant highly resistant to penicillin. Antimicrob Agents Chemother (1985) 2.19

The penicillin-binding proteins in Streptococcus faecalis ATCC 9790. Eur J Biochem (1980) 2.07

Identification of the lethal target of benzylpenicillin in Streptococcus faecalis by in vivo penicillin binding studies. Nature (1980) 1.96

Penicillin-binding proteins and the intrinsic resistance to beta-lactams in gram-positive cocci. J Antimicrob Chemother (1985) 1.73

In Streptococcus faecium penicillin-binding protein 5 alone is sufficient for growth at sub-maximal but not at maximal rate. J Gen Microbiol (1986) 1.51

Streptococcus faecium mutants that are temperature sensitive for cell growth and show alterations in penicillin-binding proteins. J Bacteriol (1987) 1.38

Bacteriostatic and bactericidal activities of beta-lactams against Streptococcus (Enterococcus) faecium are associated with saturation of different penicillin-binding proteins. Antimicrob Agents Chemother (1987) 1.26

Paradoxical response of Enterococcus faecalis to the bactericidal activity of penicillin is associated with reduced activity of one autolysin. Antimicrob Agents Chemother (1990) 1.26

Correlation of penicillin-induced lysis of Enterococcus faecium with saturation of essential penicillin-binding proteins and release of lipoteichoic acid. Antimicrob Agents Chemother (1990) 1.17

In vitro activity of Bay v 3522, a new cephalosporin, compared with activities of other agents. Antimicrob Agents Chemother (1990) 1.03

In vitro response to bactericidal activity of cell wall-active antibiotics does not support the general opinion that enterococci are naturally tolerant to these antibiotics. Antimicrob Agents Chemother (1990) 1.03

Mechanisms of resistance of enterococci to beta-lactam antibiotics. Eur J Clin Microbiol Infect Dis (1990) 0.96

Comparative in-vitro activity of Sch 34343, imipenem, cefpirome and cefotaxime. J Antimicrob Chemother (1985) 0.87

In vitro activity of BAY v 3522, a new oral cephalosporin. Antimicrob Agents Chemother (1990) 0.78

In vitro activity of BAY v 3522, a new cephalosporin for oral administration. Antimicrob Agents Chemother (1990) 0.77

Articles by these authors

Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob Agents Chemother (1999) 9.01

Lung cancer mortality in the Mayo Lung Project: impact of extended follow-up. J Natl Cancer Inst (2000) 6.77

Appearance of IMP-1 metallo-beta-lactamase in Europe. Lancet (1999) 5.41

Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny. Antimicrob Agents Chemother (2000) 5.26

Identification of a streptococcal penicillin-binding protein that reacts very slowly with penicillin. J Bacteriol (1983) 4.42

Regulation of penicillin-binding protein activity: description of a methicillin-inducible penicillin-binding protein in Staphylococcus aureus. Antimicrob Agents Chemother (1985) 3.98

Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-beta-lactamase. Clin Infect Dis (2000) 2.61

Genotypic identification of methicillin-resistant coagulase-negative staphylococci by polymerase chain reaction. Antimicrob Agents Chemother (1991) 2.61

In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette. Antimicrob Agents Chemother (2001) 2.29

Transition from resistance to hypersusceptibility to beta-lactam antibiotics associated with loss of a low-affinity penicillin-binding protein in a Streptococcus faecium mutant highly resistant to penicillin. Antimicrob Agents Chemother (1985) 2.19

Solubilization and isolation of the membrane-bound DD-carboxypeptidase of Streptococcus faecalis ATCC9790. Properties of the purified enzyme. Eur J Biochem (1978) 2.10

Comparison of the MB/BacT and BACTEC 460 TB systems for recovery of mycobacteria from various clinical specimens. J Clin Microbiol (1999) 2.09

The penicillin-binding proteins in Streptococcus faecalis ATCC 9790. Eur J Biochem (1980) 2.07

Identification of the lethal target of benzylpenicillin in Streptococcus faecalis by in vivo penicillin binding studies. Nature (1980) 1.96

Identification of 54 mycobacterial species by PCR-restriction fragment length polymorphism analysis of the hsp65 gene. J Clin Microbiol (2001) 1.95

Bacteriolytic activity in staphylococci. Infect Immun (1977) 1.90

Molecular heterogeneity of bla(VIM-2)-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase. FEMS Microbiol Lett (2001) 1.80

Penicillin-binding proteins and the intrinsic resistance to beta-lactams in gram-positive cocci. J Antimicrob Chemother (1985) 1.73

Carbapenem-resistant Pseudomonas aeruginosa with acquired bla(vim) metallo-beta-lactamase determinants, Italy. Emerg Infect Dis (2000) 1.65

Reliability of the MB/BacT system for testing susceptibility of Mycobacterium tuberculosis complex isolates to antituberculous drugs. J Clin Microbiol (2000) 1.62

Streptococcus faecium ATCC 9790 penicillin-binding proteins and penicillin sensitivity are heavily influenced by growth conditions: proposal for an indirect mechanism of growth inhibition by beta-lactams. J Bacteriol (1983) 1.60

Gastroesophageal reflux and bronchial asthma: prevalence and effect of cisapride therapy. J Pediatr Gastroenterol Nutr (1993) 1.55

Diffusion of meropenem and imipenem through the outer membrane of Escherichia coli K-12 and correlation with their antibacterial activities. Antimicrob Agents Chemother (1992) 1.54

In Streptococcus faecium penicillin-binding protein 5 alone is sufficient for growth at sub-maximal but not at maximal rate. J Gen Microbiol (1986) 1.51

Rapid increase of resistance to erythromycin and clindamycin in Streptococcus pyogenes in Italy, 1993-1995. The Italian Surveillance Group for Antimicrobial Resistance. Emerg Infect Dis (1997) 1.49

Peptidoglycan synthesis in cocci and rods of a pH-dependent, morphologically conditional mutant of Klebsiella pneumoniae. J Bacteriol (1979) 1.40

Nonradioactive DNA probe for detection of gene for methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother (1991) 1.39

Identification of a gene (arpU) controlling muramidase-2 export in Enterococcus hirae. J Bacteriol (1995) 1.38

Streptococcus faecium mutants that are temperature sensitive for cell growth and show alterations in penicillin-binding proteins. J Bacteriol (1987) 1.38

Identification of a genetic element (psr) which negatively controls expression of Enterococcus hirae penicillin-binding protein 5. J Bacteriol (1993) 1.36

Relative importances of outer membrane permeability and group 1 beta-lactamase as determinants of meropenem and imipenem activities against Enterobacter cloacae. Antimicrob Agents Chemother (1995) 1.29

Bacteriostatic and bactericidal activities of beta-lactams against Streptococcus (Enterococcus) faecium are associated with saturation of different penicillin-binding proteins. Antimicrob Agents Chemother (1987) 1.26

Paradoxical response of Enterococcus faecalis to the bactericidal activity of penicillin is associated with reduced activity of one autolysin. Antimicrob Agents Chemother (1990) 1.26

Detection of bacterial phosphatase activity by means of an original and simple test. J Clin Pathol (1979) 1.26

Resistance of Streptococcus pyogenes to erythromycin and related antibiotics in Italy. The Italian Surveillance Group for Antimicrobial Resistance. Clin Infect Dis (1998) 1.23

Comparative evaluation of ligation-mediated PCR and spoligotyping as screening methods for genotyping of Mycobacterium tuberculosis strains. J Clin Microbiol (1999) 1.23

Control of cell septation by lateral wall extension in a pH-conditional morphology mutant of Klebsiella pneumoniae. J Bacteriol (1980) 1.22

Modification of penicillin-binding protein 5 associated with high-level ampicillin resistance in Enterococcus faecium. Antimicrob Agents Chemother (1996) 1.21

Characterization of a conditional mutant with altered envelope showing pH-dependent morphology and temperature-dependent division. J Gen Microbiol (1974) 1.19

Different staphylococcal species contain various numbers of penicillin-binding proteins ranging from four (Staphylococcus aureus) to only one (Staphylococcus hyicus). J Bacteriol (1985) 1.19

Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides. J Biol Chem (1985) 1.18

Brief report: no evidence for parvovirus B19 or hepatitis E virus as a cause of acute liver failure. Dig Dis Sci (2006) 1.16

Accelerated bone mass senescence after hematopoietic stem cell transplantation. Transl Med UniSa (2013) 1.13

Division blocks in temperature-sensitive mutants of Streptococcus faecium (S. faecalis ATCC 9790). J Bacteriol (1983) 1.10

Alterations in peptidoglycan chemical composition associated with rod-to-sphere transition in a conditional mutant of Klebsiella pneumoniae. J Bacteriol (1979) 1.09

Vancomycin-resistant Bacillus circulans carrying the vanA gene responsible for vancomycin resistance in enterococci. Eur J Clin Microbiol Infect Dis (1997) 1.08

The two-competing site (TCS) model for cell shape regulation in bacteria: the envelope as an integration point for the regulatory circuits of essential physiological events. Adv Microb Physiol (1994) 1.06

Target for bacteriostatic and bactericidal activities of beta-lactam antibiotics against Escherichia coli resides in different penicillin-binding proteins. Antimicrob Agents Chemother (1995) 1.05

Penicillins activate autolysins extracted from both Escherichia coli and Klebsiella pneumoniae envelopes. Antimicrob Agents Chemother (1977) 1.05

In vitro response to bactericidal activity of cell wall-active antibiotics does not support the general opinion that enterococci are naturally tolerant to these antibiotics. Antimicrob Agents Chemother (1990) 1.03

Relevance of inapparent coinfection by hepatitis B virus in alpha interferon-treated patients with hepatitis C virus chronic hepatitis. J Med Virol (1997) 1.02

Emergence of linezolid resistance in Enterococcus faecium not dependent on linezolid treatment. Eur J Clin Microbiol Infect Dis (2006) 1.02

Early initiation of deoxyribonucleic acid replication and shortening of generation time associated with inhibition of lateral wall formation by mecillinam. J Bacteriol (1981) 1.00

OPSI threat in hematological patients. Transl Med UniSa (2013) 0.99

Close association between shape alteration and loss of immunity to superinfection in a wild-type Klebsiella pneumoniae stable lysogen which can be both immune and nonimmune to superinfection. J Virol (1978) 0.99

Detection of penicillin-binding proteins immunologically related to penicillin-binding protein 5 of Enterococcus hirae ATCC 9790 in Enterococcus faecium and Enterococcus faecalis. FEMS Microbiol Lett (1991) 0.97

Molecular typing of erythromycin-resistant streptococcus pyogenes strains with the M phenotype isolated in Italy. Eur J Clin Microbiol Infect Dis (1999) 0.97

Activities of oral antibiotics on Providencia strains isolated from institutionalized elderly patients with urinary tract infections. Antimicrob Agents Chemother (1995) 0.97

Outbreak of linezolid-resistant Staphylococcus haemolyticus in an Italian intensive care unit. Eur J Clin Microbiol Infect Dis (2011) 0.95

vanA gene cluster in a vancomycin-resistant clinical isolate of Bacillus circulans. Antimicrob Agents Chemother (1998) 0.95

Nosocomial cluster of Candida guillermondii fungemia in surgical patients. Eur J Clin Microbiol Infect Dis (2003) 0.93

Cell division, macromolecular synthesis and morphology dependent on the state of the envelope in a mutant of Klebsiella pneumoniae. J Gen Microbiol (1974) 0.93

Carbapenem-hydrolyzing metallo-beta-lactamases in Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis (1999) 0.91

Impaired response to alpha interferon in patients with an inapparent hepatitis B and hepatitis C virus coinfection. Arch Virol (1997) 0.90

Lamivudine therapy in chronic delta hepatitis: a multicentre randomized-controlled pilot study. Aliment Pharmacol Ther (2005) 0.90

Anoplin, a novel antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis. Biochim Biophys Acta (2001) 0.89

Stimulation of spreading of trypsinized human fibroblasts by lysozymes from Staphylococcus aureus, hen egg white, and human urine. In Vitro (1980) 0.89

High incidence of erythromycin-resistant Streptococcus pyogenes in Monza (North Italy) in untreated children with symptoms of acute pharyngo-tonsillitis: an epidemiological and molecular study. Microb Drug Resist (1997) 0.89

Clustering and risk factors of methicillin-resistant Staphylococcus aureus carriage in two Italian long-term care facilities. Infection (2008) 0.88

Division of temperature-sensitive Streptococcus faecium mutants after return to the permissive temperature. J Bacteriol (1984) 0.87

Quantification of cytomegalovirus DNA by a fully automated real-time PCR for early diagnosis and monitoring of active viral infection in solid organ transplant recipients. J Clin Virol (2012) 0.86

Molecular analysis of vanA enterococci isolated from humans and animals in northeastern Italy. Microb Drug Resist (2001) 0.86

Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity. Nutr Res (2012) 0.85

Variations of serum levels of adiponectin and resistin in chronic viral hepatitis. J Endocrinol Invest (2013) 0.84

Inhibition of bacterial cell surface extension by various means causes blocking of macromolecular synthesis. Res Microbiol (1997) 0.83

Long-term outcome of hepatitis B virus-related Chronic Hepatitis under protracted nucleos(t)ide analogues. J Viral Hepat (2013) 0.83

Leptomeningeal dissemination of juvenile pilocytic astrocytoma: case report. Surg Neurol (1994) 0.83

Antimicrobial susceptibility profiles of Pseudomonas aeruginosa and Staphylococcus aureus isolated in Italy from patients with hospital-acquired infections. Int J Antimicrob Agents (2004) 0.83

Unawareness of HBV infection among inpatients in a Southern Italian hospital. J Viral Hepat (2011) 0.83

A napkin-associated outbreak of Burkholderia cenocepacia bacteraemia in haemodialysis patients. J Hosp Infect (2006) 0.82

Outbreak of vancomycin-resistant Enterococcus spp. in an Italian general intensive care unit. Clin Microbiol Infect (2006) 0.82

Detection and quantification of hepatitis B virus DNA by SYBR green real-time polymerase chain reaction. Eur J Clin Microbiol Infect Dis (2007) 0.82

Danazol: in vitro effects on human hemopoiesis and in vivo activity in hypoplastic and myelodysplastic disorders. Eur J Haematol (1991) 0.82

First case of bloodstream infection due to Candida magnoliae in a Chinese oncological patient. J Clin Microbiol (2007) 0.82

Hb-M "Hyde Park": a de novo mutation, identified by mass spectrometry and DNA analysis. Haematologica (1992) 0.82

Epidemiological analysis of vancomycin-resistant enterococci in a large tertiary-care hospital in Northern Italy. Eur J Clin Microbiol Infect Dis (2001) 0.82

The role of divalent cations in the rigid layer of morphological and conditional mutant of Klebsiella pneumoniae Mir M7. Ann Microbiol (Paris) (1974) 0.81

Bacteriostatic and bactericidal activity of levofloxacin against clinical isolates from cystic fibrosis patients. Eur J Clin Microbiol Infect Dis (2004) 0.81

"High risk" anterior basal skull fractures. Surgical treatment of 64 consecutive cases. J Neurosurg Sci (1995) 0.81

Conformation and lytic activity of eumenine mastoparan: a new antimicrobial peptide from wasp venom. J Pept Res (2004) 0.80

PBP binding and periplasmic concentration as determinants of the antibacterial activities of three new oral cephalosporins in Escherichia coli. New Microbiol (1994) 0.80

Envelope protein alterations in a conditional mutant of Klebsiella pneumoniae with pH dependent morphology and temperature dependent division. Ann Microbiol (Paris) (1974) 0.80

Molecular epidemiology and antibiotic susceptibility of Burkholderia cepacia-complex isolates from an Italian cystic fibrosis centre. Eur J Clin Microbiol Infect Dis (2006) 0.80

Utility of molecular identification in opportunistic mycotic infections: a case of cutaneous Alternaria infectoria infection in a cardiac transplant recipient. J Clin Microbiol (2004) 0.80

Diagnostic aspects of cutaneous lesions due to Histoplasma capsulatum in African AIDS patients in nonendemic areas. Eur J Clin Microbiol Infect Dis (2003) 0.80

The Sentinel Project: an update on the prevalence of antimicrobial resistance in community-acquired respiratory Streptococcus pneumoniae and Haemophilus spp. in Italy. Int J Antimicrob Agents (2005) 0.80

Interaction with CEP-1 beta-lactamase of RU 51746-2, the active form of the new oral cephalosporin RU 51807. J Chemother (1991) 0.80