Activation of Cu,Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS.

SOD1 integrates signals from oxygen and glucose to repress respiration. Cell (2013) 1.28

The right to choose: multiple pathways for activating copper,zinc superoxide dismutase. J Biol Chem (2009) 1.21

Import, maturation, and function of SOD1 and its copper chaperone CCS in the mitochondrial intermembrane space. Antioxid Redox Signal (2010) 1.12

Superoxide dismutases and superoxide reductases. Chem Rev (2014) 1.12

Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. Mol Cell Biol (2010) 1.03

Copper chaperone-dependent and -independent activation of three copper-zinc superoxide dismutase homologs localized in different cellular compartments in Arabidopsis. Plant Physiol (2011) 1.02

Cellular distribution of copper to superoxide dismutase involves scaffolding by membranes. Proc Natl Acad Sci U S A (2013) 0.96

Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS). Proc Natl Acad Sci U S A (2012) 0.94

Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense. Proc Natl Acad Sci U S A (2014) 0.93

Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae. Biochemistry (2010) 0.92

Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis. Front Cell Neurosci (2014) 0.89

Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1. Biochem J (2012) 0.85

Functional partnership of the copper export machinery and glutathione balance in human cells. J Biol Chem (2012) 0.84

Species-specific activation of Cu/Zn SOD by its CCS copper chaperone in the pathogenic yeast Candida albicans. J Biol Inorg Chem (2013) 0.84

Post-translational modification of Cu/Zn superoxide dismutase under anaerobic conditions. Biochemistry (2012) 0.83

An expanding range of functions for the copper chaperone/antioxidant protein Atox1. Antioxid Redox Signal (2013) 0.83

ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. Am J Physiol Heart Circ Physiol (2015) 0.83

The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation. J Biol Chem (2015) 0.82

Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis. Front Cell Neurosci (2013) 0.78

YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes. Antioxid Redox Signal (2014) 0.78

Yeast copper-zinc superoxide dismutase can be activated in the absence of its copper chaperone. J Biol Inorg Chem (2013) 0.77

A primary role for disulfide formation in the productive folding of prokaryotic Cu,Zn-superoxide dismutase. J Biol Chem (2014) 0.77

The megavirus chilensis Cu,Zn-superoxide dismutase: the first viral structure of a typical cellular copper chaperone-independent hyperstable dimeric enzyme. J Virol (2014) 0.76

Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper-ion entry site. J Biol Chem (2017) 0.75

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30

Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem (1969) 43.83

Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier. Yeast (1991) 14.51

The biology of oxygen radicals. Science (1978) 13.21

Superoxide dismutase assays. Methods Enzymol (1984) 3.99

Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell (1994) 3.88

The copper chaperone for superoxide dismutase. J Biol Chem (1997) 3.47

Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions. Annu Rev Biochem (1993) 3.33

A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage. J Biol Chem (2001) 3.01

Heterodimeric structure of superoxide dismutase in complex with its metallochaperone. Nat Struct Biol (2001) 2.67

Thiol/disulfide exchange equilibria and disulfide bond stability. Methods Enzymol (1995) 2.61

The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J Biol Chem (1994) 2.57

Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS. EMBO J (2004) 2.55

Monitoring disulfide bond formation in the eukaryotic cytosol. J Cell Biol (2004) 2.08

Mimicking the active site of protein disulfide-isomerase by substitution of proline 34 in Escherichia coli thioredoxin. J Biol Chem (1991) 1.92

Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria. J Biol Chem (2003) 1.83

A widespread transposable element masks expression of a yeast copper transport gene. Genes Dev (1996) 1.79

Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability. J Biol Chem (2004) 1.77

The yeast copper/zinc superoxide dismutase and the pentose phosphate pathway play overlapping roles in oxidative stress protection. J Biol Chem (1996) 1.73

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci U S A (2000) 1.70

Copper stress causes an in vivo requirement for the Escherichia coli disulfide isomerase DsbC. J Biol Chem (2005) 1.64

Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone. Proc Natl Acad Sci U S A (2004) 1.62

Yeast lacking superoxide dismutase. Isolation of genetic suppressors. J Biol Chem (1992) 1.62

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc Natl Acad Sci U S A (2008) 1.58

The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity. Proc Natl Acad Sci U S A (1995) 1.58

Signaling components of redox active endosomes: the redoxosomes. Antioxid Redox Signal (2009) 1.50

Determination of the reduction-oxidation potential of the thioredoxin-like domains of protein disulfide-isomerase from the equilibrium with glutathione and thioredoxin. Biochemistry (1993) 1.49

Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A (2004) 1.45

Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. J Biol Chem (2004) 1.45

A Pro to His mutation in active site of thioredoxin increases its disulfide-isomerase activity 10-fold. New refolding systems for reduced or randomly oxidized ribonuclease. J Biol Chem (1992) 1.44

Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS. J Biol Chem (2005) 1.39

The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions. Mol Microbiol (1996) 1.37

Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. J Biol Chem (2004) 1.33

Superoxide dismutase: the first twenty years (1968-1988). Free Radic Biol Med (1988) 1.33

Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS. Hum Mol Genet (2008) 1.30

Corticotropin-releasing factor increases GABA synaptic activity and induces inward current in 5-hydroxytryptamine dorsal raphe neurons. J Neurosci (2008) 1.29

The coupling between disulphide status, metallation and dimer interface strength in Cu/Zn superoxide dismutase. J Mol Biol (2006) 1.28

Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS. J Mol Biol (2007) 1.26

Copper activation of superoxide dismutase 1 (SOD1) in vivo. Role for protein-protein interactions with the copper chaperone for SOD1. J Biol Chem (2000) 1.24

Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. Proc Natl Acad Sci U S A (1998) 1.21

Metal transporters that contribute copper to metallochaperones in Saccharomyces cerevisiae. Mol Genet Genomics (2001) 1.18

Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron. J Mol Biol (2002) 1.17

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein. Proc Natl Acad Sci U S A (1996) 1.14

Nitric oxide and superoxide: interference with hypoxic signaling. Cardiovasc Res (2007) 1.12

Human SOD1 before harboring the catalytic metal: solution structure of copper-depleted, disulfide-reduced form. J Biol Chem (2005) 1.12

Suppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles. Mol Cell Biol (1996) 0.97

A bacterial thioredoxin-like protein that is exposed to the periplasm has redox properties comparable with those of cytoplasmic thioredoxins. J Biol Chem (1995) 0.94

Thermodynamic basis for redox regulation of the Yap1 signal transduction pathway. Biochemistry (2006) 0.87

A pH-dependent superoxide dismutase activity for zinc-free bovine erythrocuprein. Reexamination of the role of zinc in the holoprotein. J Inorg Biochem (1982) 0.85

[Free radicals in medicine and biology]. Sem Hop (1982) 0.81

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45

Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. Science (2003) 3.08

Misfolded CuZnSOD and amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2003) 2.65

Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab (2009) 2.45

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. Nat Struct Biol (2003) 2.26

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. J Biol Chem (2008) 2.01

Structure of the Hsp110:Hsc70 nucleotide exchange machine. Mol Cell (2008) 1.96

Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease. Hum Mol Genet (2009) 1.79

Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability. J Biol Chem (2004) 1.77

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants. Proc Natl Acad Sci U S A (2004) 1.76

The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation. Biochemistry (2009) 1.75

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis. J Mol Biol (2003) 1.68

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS. Proc Natl Acad Sci U S A (2009) 1.67

The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix. J Biol Chem (2008) 1.63

The copper-iron connection in biology: structure of the metallo-oxidase Fet3p. Proc Natl Acad Sci U S A (2005) 1.55

An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate. J Biol Chem (2003) 1.52

A novel NADH kinase is the mitochondrial source of NADPH in Saccharomyces cerevisiae. EMBO J (2003) 1.47

The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2. EMBO J (2006) 1.34

Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast. J Biol Chem (2010) 1.33

Battles with iron: manganese in oxidative stress protection. J Biol Chem (2012) 1.32

Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS. Hum Mol Genet (2008) 1.30

Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine. J Bacteriol (2003) 1.29

SOD1 integrates signals from oxygen and glucose to repress respiration. Cell (2013) 1.28

Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy. Proc Natl Acad Sci U S A (2010) 1.25

Alternative start sites in the Saccharomyces cerevisiae GLR1 gene are responsible for mitochondrial and cytosolic isoforms of glutathione reductase. J Biol Chem (2003) 1.23

The right to choose: multiple pathways for activating copper,zinc superoxide dismutase. J Biol Chem (2009) 1.21

Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis. J Biol Chem (2008) 1.20

Polycomb group targeting through different binding partners of RING1B C-terminal domain. Structure (2010) 1.19

Characterization of Pgp3, a Chlamydia trachomatis plasmid-encoded immunodominant antigen. J Bacteriol (2010) 1.18

Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface. Biochemistry (2003) 1.18

Molecular recognition of insulin by a synthetic receptor. J Am Chem Soc (2011) 1.16

Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis. Biochemistry (2012) 1.16

Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae. J Biol Chem (2005) 1.16

Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module. Proc Natl Acad Sci U S A (2012) 1.15

The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase. J Biol Chem (2006) 1.15

Shall we dance? How a multicopper oxidase chooses its electron transfer partner. Acc Chem Res (2007) 1.14

The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection. Free Radic Biol Med (2008) 1.14

Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs. Structure (2013) 1.11

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg. Protein Sci (2005) 1.11

Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2. Biochemistry (2012) 1.10

Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A. Arch Biochem Biophys (2009) 1.09

Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites. Science (2013) 1.07

Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis. Exp Biol Med (Maywood) (2009) 1.06

The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. Nucleic Acids Res (2008) 1.06

The interaction of mitochondrial iron with manganese superoxide dismutase. J Biol Chem (2009) 1.06

Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability. J Biol Chem (2006) 1.05

Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A (2014) 1.04

Monothiol glutaredoxins and A-type proteins: partners in Fe-S cluster trafficking. Dalton Trans (2013) 1.04

Characterization of human soluble high and low activity catechol-O-methyltransferase catalyzed catechol estrogen methylation. Pharmacogenetics (2002) 1.04

Crystal structure of the yeast nicotinamidase Pnc1p. Arch Biochem Biophys (2007) 1.03

The many highways for intracellular trafficking of metals. J Biol Inorg Chem (2003) 1.02

Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis. J Biol Chem (2009) 1.02

The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem J (2002) 1.01

Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family. Biochem J (2005) 1.01

A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi. J Biol Chem (2013) 1.01

N-terminal residues of the Vibrio cholerae virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids. J Biol Chem (2011) 1.00

Sequence-specific recognition and cooperative dimerization of N-terminal aromatic peptides in aqueous solution by a synthetic host. J Am Chem Soc (2006) 1.00

Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone. J Biol Chem (2008) 1.00

Regiospecific solid-phase synthesis of branched oligoribonucleotides that mimic intronic lariat RNA intermediates. J Org Chem (2014) 0.99

Manganese homeostasis in Saccharomyces cerevisiae. Chem Rev (2009) 0.98

The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways. J Biol Chem (2004) 0.98

A new zinc-protein coordination site in intracellular metal trafficking: solution structure of the Apo and Zn(II) forms of ZntA(46-118). J Mol Biol (2002) 0.98

Allosteric motions in structures of yeast NAD+-specific isocitrate dehydrogenase. J Biol Chem (2008) 0.97

Down-regulation of a manganese transporter in the face of metal toxicity. Mol Biol Cell (2009) 0.96

Amino acid changes in elongation factor Tu of Mycoplasma pneumoniae and Mycoplasma genitalium influence fibronectin binding. Infect Immun (2009) 0.96

Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis. Free Radic Biol Med (2007) 0.95

Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae. Biochem J (2005) 0.95

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein. J Mol Biol (2002) 0.94

Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes. Free Radic Biol Med (2012) 0.94

Identifying catalytic residues in CPAF, a Chlamydia-secreted protease. Arch Biochem Biophys (2009) 0.94

Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense. Proc Natl Acad Sci U S A (2014) 0.93

Structural and biophysical properties of the pathogenic SOD1 variant H46R/H48Q. Biochemistry (2009) 0.92

Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells. Biochem Biophys Res Commun (2002) 0.92

Functions and cellular compartmentation of the thioredoxin and glutathione pathways in yeast. Antioxid Redox Signal (2013) 0.92

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc Natl Acad Sci U S A (2013) 0.92

Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis. J Biol Chem (2005) 0.92

Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R. Biochemistry (2010) 0.91

Characterization of a covalent polysulfane bridge in copper-zinc superoxide dismutase . Biochemistry (2010) 0.91

The effect of phosphate accumulation on metal ion homeostasis in Saccharomyces cerevisiae. J Biol Inorg Chem (2010) 0.91

Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system. Mol Biol Cell (2011) 0.90

Structure of the thioredoxin-like domain of yeast glutaredoxin 3. Acta Crystallogr D Biol Crystallogr (2008) 0.89

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases. Acta Neuropathol Commun (2014) 0.89

Histidine ligand variants of a flavo-diiron protein: effects on structure and activities. J Biol Inorg Chem (2012) 0.87

Regulation of manganese antioxidants by nutrient sensing pathways in Saccharomyces cerevisiae. Genetics (2011) 0.86

Analysis of hypoxia and hypoxia-like states through metabolite profiling. PLoS One (2011) 0.86

Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1. Biochem J (2012) 0.85