Published in Annu Rev Physiol on January 01, 2009
The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81
Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet (2013) 2.71
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet (2009) 1.94
Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol (2010) 1.81
Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis. J Am Soc Nephrol (2011) 1.75
The cell biology of polycystic kidney disease. J Cell Biol (2010) 1.58
Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int (2010) 1.54
Canonical TRP channels and mechanotransduction: from physiology to disease states. Pflugers Arch (2010) 1.38
TRP channels of intracellular membranes. J Neurochem (2010) 1.30
Cilia and cell cycle re-entry: more than a coincidence. Cell Cycle (2011) 1.16
Polycystin-1 regulates STAT activity by a dual mechanism. Proc Natl Acad Sci U S A (2011) 1.15
Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations. J Am Soc Nephrol (2013) 1.14
Polycystins and renovascular mechanosensory transduction. Nat Rev Nephrol (2010) 1.13
Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems. Trends Cell Biol (2011) 1.12
Composition and sensory function of the trypanosome flagellar membrane. Curr Opin Microbiol (2010) 1.08
Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells. Biochim Biophys Acta (2010) 1.00
Diagnosis and management of childhood polycystic kidney disease. Pediatr Nephrol (2010) 0.99
Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun (2012) 0.98
Cystic diseases of the kidney: ciliary dysfunction and cystogenic mechanisms. Pediatr Nephrol (2010) 0.98
A method for measuring electrical signals in a primary cilium. Cilia (2012) 0.98
Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. J Am Soc Nephrol (2013) 0.97
Adipose-derived stem cells in functional bone tissue engineering: lessons from bone mechanobiology. Tissue Eng Part B Rev (2011) 0.96
Keeping the balance between proliferation and differentiation: the primary cilium. Curr Genomics (2011) 0.96
A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8. BMC Genomics (2012) 0.96
Non-motile primary cilia as fluid shear stress mechanosensors. Methods Enzymol (2013) 0.95
Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proc Natl Acad Sci U S A (2011) 0.94
Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep (2014) 0.94
The Future of Polycystic Kidney Disease Research--As Seen By the 12 Kaplan Awardees. J Am Soc Nephrol (2015) 0.93
Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors. Am J Physiol Renal Physiol (2011) 0.92
Regulation of STATs by polycystin-1 and their role in polycystic kidney disease. JAKSTAT (2013) 0.91
CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD. Cell Cycle (2012) 0.91
Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton. Ann N Y Acad Sci (2014) 0.90
Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model. J Am Soc Nephrol (2014) 0.90
Autosomal recessive polycystic kidney disease epithelial cell model reveals multiple basolateral epidermal growth factor receptor sorting pathways. Mol Biol Cell (2010) 0.89
Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. Hum Mol Genet (2014) 0.88
Cyst formation following disruption of intracellular calcium signaling. Proc Natl Acad Sci U S A (2014) 0.88
Third-hit signaling in renal cyst formation. J Am Soc Nephrol (2011) 0.87
Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex. Hum Mol Genet (2014) 0.86
Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium. J Neurosci (2015) 0.86
Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. Cell Rep (2012) 0.86
Cilium, centrosome and cell cycle regulation in polycystic kidney disease. Biochim Biophys Acta (2011) 0.85
Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesis. PLoS One (2013) 0.84
Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway. J Biol Chem (2010) 0.84
Experimental verification of a predicted intronic microRNA in human NGFR gene with a potential pro-apoptotic function. PLoS One (2012) 0.83
An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli. Cell Calcium (2015) 0.83
MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein. J Biol Chem (2010) 0.83
Mechanical stimulation of polycystin-1 induces human osteoblastic gene expression via potentiation of the calcineurin/NFAT signaling axis. Cell Mol Life Sci (2012) 0.82
Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis. Cell Signal (2010) 0.82
Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective. Int J Nephrol Urol (2010) 0.82
Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability. Circulation (2015) 0.82
Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma. Proc Natl Acad Sci U S A (2014) 0.82
Macromolecular assembly of polycystin-2 intracytosolic C-terminal domain. Proc Natl Acad Sci U S A (2011) 0.81
Kidney: polycystic kidney disease. Wiley Interdiscip Rev Dev Biol (2014) 0.81
E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease. Dev Cell (2015) 0.81
The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions. Biomaterials (2012) 0.81
Enhancement of renal epithelial cell functions through microfluidic-based coculture with adipose-derived stem cells. Tissue Eng Part A (2013) 0.81
Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant. Proc Natl Acad Sci U S A (2016) 0.80
Calcium transport and local pool regulate polycystin-2 (TRPP2) function in human syncytiotrophoblast. Biophys J (2013) 0.80
PKD2L1/PKD1L3 channel complex with an alkali-activated mechanism and calcium-dependent inactivation. Eur Biophys J (2015) 0.79
Polycystins and cellular Ca2+ signaling. Cell Mol Life Sci (2012) 0.78
Gene expression profiling in cells with enhanced gamma-secretase activity. PLoS One (2009) 0.78
Developmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis? Birth Defects Res C Embryo Today (2014) 0.78
The cytoplasmic tail of FPC antagonizes the full-length protein in the regulation of mTOR pathway. PLoS One (2014) 0.78
Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site. J Cell Sci (2015) 0.78
Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease. Kidney Res Clin Pract (2014) 0.77
Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium. Trends Neurosci (2016) 0.77
The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function. J Biol Chem (2015) 0.77
STAT3 Signaling in Polycystic Kidney Disease. Drug Discov Today Dis Mech (2013) 0.77
Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca signaling. Commun Integr Biol (2010) 0.77
Regulation of integrin expression by Gα12: An additional potential mechanism modulating cell attachment. Cell Adh Migr (2010) 0.77
The spectrum of autosomal dominant polycystic kidney disease in children and adolescents. Pediatr Nephrol (2016) 0.76
Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity. Sci Rep (2015) 0.76
Of mice and men: therapeutic mTOR inhibition in polycystic kidney disease. J Am Soc Nephrol (2010) 0.76
Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease. Kidney Int (2016) 0.75
Gα12 is required for renal cystogenesis induced by Pkd1 inactivation. J Cell Sci (2016) 0.75
Bending the path to TOR. Nat Cell Biol (2010) 0.75
Primary cilia are sensors of electrical field stimulation to induce osteogenesis of human adipose-derived stem cells. FASEB J (2016) 0.75
Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion-Induced Kidney Growth. J Am Soc Nephrol (2015) 0.75
Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. Front Cell Dev Biol (2017) 0.75
Flow-induced focal adhesion remodeling mediated by local cytoskeletal stresses and reorganization. Cell Adh Migr (2015) 0.75
Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes. J Biol Chem (2017) 0.75
Routes and machinery of primary cilium biogenesis. Cell Mol Life Sci (2017) 0.75