Published in J Am Soc Nephrol on April 14, 2011
Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling. J Pathol (2011) 1.27
Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis. J Am Soc Nephrol (2013) 0.95
Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. Am J Physiol Gastrointest Liver Physiol (2013) 0.94
Molecular pathways and therapies in autosomal-dominant polycystic kidney disease. Physiology (Bethesda) (2015) 0.93
Primary cilia and kidney injury: current research status and future perspectives. Am J Physiol Renal Physiol (2013) 0.90
Third-hit signaling in renal cyst formation. J Am Soc Nephrol (2011) 0.87
Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways. Autophagy (2015) 0.86
Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage. Am J Physiol Renal Physiol (2015) 0.85
Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation. J Am Soc Nephrol (2015) 0.81
Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease. Hum Mol Genet (2012) 0.81
The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions. Biomaterials (2012) 0.81
Kidney: polycystic kidney disease. Wiley Interdiscip Rev Dev Biol (2014) 0.81
Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease. J Am Soc Nephrol (2014) 0.80
Activation of the intrarenal renin-angiotensin-system in murine polycystic kidney disease. Physiol Rep (2015) 0.79
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways. Am J Physiol Lung Cell Mol Physiol (2013) 0.79
The fate of the primary cilium during myofibroblast transition. Mol Biol Cell (2014) 0.77
The bigger the better: determining nephron size in kidney. Pediatr Nephrol (2013) 0.77
Ciliogenesis and the DNA damage response: a stressful relationship. Cilia (2016) 0.76
Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context. J Am Soc Nephrol (2016) 0.76
Unilateral nephrectomy elongates primary cilia in the remaining kidney via reactive oxygen species. Sci Rep (2016) 0.76
Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion-Induced Kidney Growth. J Am Soc Nephrol (2015) 0.75
Pathways, perspectives and pursuits in polycystic kidney disease. J Nephropharmacol (2015) 0.75
Mammalian target of rapamycin inhibition in polycystic kidney disease: From bench to bedside. Kidney Res Clin Pract (2012) 0.75
Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development. J Am Soc Nephrol (2016) 0.75
Chronic Hypobaric Hypoxia Modulates Primary Cilia Differently in Adult and Fetal Ovine Kidneys. Front Physiol (2017) 0.75
The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol (2002) 5.58
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 4.56
The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity (2008) 4.44
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med (2007) 4.40
Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol (2007) 3.76
Autosomal dominant polycystic kidney disease: the last 3 years. Kidney Int (2009) 3.66
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet (2008) 3.14
Intraflagellar transport is essential for endochondral bone formation. Development (2006) 2.90
Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease. J Am Soc Nephrol (2004) 2.69
Overexpression of innate immune response genes in a model of recessive polycystic kidney disease. Kidney Int (2007) 2.64
The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol (2009) 2.05
Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet (2007) 2.03
Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol (2009) 1.99
Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol (2009) 1.98
Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet (2009) 1.94
Murine models of polycystic kidney disease: molecular and therapeutic insights. Am J Physiol Renal Physiol (2003) 1.87
Ciliary biology: understanding the cellular and genetic basis of human ciliopathies. Am J Med Genet C Semin Med Genet (2009) 1.81
S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol (2009) 1.74
Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. J Am Soc Nephrol (2010) 1.70
Pkd1 inactivation induced in adulthood produces focal cystic disease. J Am Soc Nephrol (2008) 1.65
Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. Hum Mol Genet (2009) 1.53
Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. J Am Soc Nephrol (2005) 1.39
Cellular and molecular derangements in acute tubular necrosis. Curr Opin Pediatr (2005) 1.15
Cellular events in renal hypertrophy. Annu Rev Physiol (1989) 1.01
Dominantly transmitted glomerulocystic kidney disease: a distinct genetic entity. J Am Soc Nephrol (1997) 0.97
Renal cystic disease: the role of the primary cilium/centrosome complex in pathogenesis. Adv Chronic Kidney Dis (2006) 0.97
Glomerulocystic kidney disease. Pediatr Nephrol (2010) 0.89
Tubular sodium handling and tubuloglomerular feedback in compensatory renal hypertrophy. Pflugers Arch (1992) 0.88
Reactive oxygen species mediate compensatory glomerular hypertrophy in rat uninephrectomized kidney. J Physiol Sci (2009) 0.87
Tubuloglomerular feedback responses to acute contralateral nephrectomy. Am J Physiol (1991) 0.85
Unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice. Matrix Biol (2007) 0.85
mTOR is out of control in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 0.84
Reversible compensatory hypertrophy in rat kidneys: morphometric characterization. Kidney Int (1993) 0.84
Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: shared disease mechanisms? Nat Clin Pract Nephrol (2009) 0.84
Reversible compensatory hypertrophy in transplanted brown Norway rat kidneys. Kidney Int (1991) 0.83
Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP. Invest Radiol (2010) 0.81
Angiotensin converting enzyme activity in compensatory renal hypertrophy. Bosn J Basic Med Sci (2007) 0.80
Kidney function after unilateral nephrectomy. Exp Pathol (1984) 0.79
Renal sympathetic nerve activity and the weight of the remaining kidney in unilateral nephrectomized rats. J Auton Nerv Syst (1997) 0.79
The growing importance of mTORC1-S6K1 signaling in kidney. Am J Physiol Renal Physiol (2009) 0.78
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell (2004) 6.10
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development (2005) 4.64
The primary cilium as a complex signaling center. Curr Biol (2009) 3.73
Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group. J Clin Oncol (2008) 3.34
Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol (2012) 2.78
Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol (2006) 2.71
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest (2010) 2.29
Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations. Hum Genet (2007) 1.94
A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model. Mol Ther (2003) 1.86
Cystin localizes to primary cilia via membrane microdomains and a targeting motif. J Am Soc Nephrol (2009) 1.79
Characterization of alterations in diabetic myocardial tissue using high resolution MRI. Int J Cardiovasc Imaging (2005) 1.78
Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clin Transl Sci (2012) 1.76
Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am J Pathol (2005) 1.76
Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD/PKHD1). J Am Soc Nephrol (2003) 1.70
Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. J Exp Med (2007) 1.67
Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. Am J Respir Crit Care Med (2008) 1.61
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci U S A (2006) 1.59
Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis. Am J Respir Cell Mol Biol (2008) 1.58
XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans. Mol Biol Cell (2003) 1.57
Desmoplastic fibroma of the jaw: a case report and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2006) 1.45
The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception. J Cell Sci (2005) 1.44
Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol (2007) 1.44
Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene. J Am Soc Nephrol (2002) 1.41
Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma. Breast Cancer Res Treat (2007) 1.41
PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD). Hum Mutat (2004) 1.40
Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice. Lab Invest (2005) 1.38
Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells. J Immunol (2012) 1.36
Characterization of Fabry disease in 352 pediatric patients in the Fabry Registry. Pediatr Res (2008) 1.35
The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol (2008) 1.33
Primary cilia regulate Shh activity in the control of molar tooth number. Development (2009) 1.31
The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency. Hum Mol Genet (2007) 1.30
A mouse model of sensorimotor controlled cortical impact: characterization using longitudinal magnetic resonance imaging, behavioral assessments and histology. J Neurosci Methods (2006) 1.30
Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations. Am J Clin Pathol (2002) 1.30
alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation (2006) 1.28
Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses. Mol Ther (2002) 1.28
Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology (2003) 1.28
Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. J Clin Oncol (2012) 1.27
Altered hepatic and muscle substrate utilization provoked by GLUT4 ablation. Diabetes (2005) 1.27
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal (2007) 1.27
Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. J Pediatr (2006) 1.26
Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. J Immunol (2007) 1.26
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans. J Cell Sci (2006) 1.24
Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes. FASEB J (2012) 1.23
Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial. J Clin Oncol (2002) 1.22
A phase I study of a tropism-modified conditionally replicative adenovirus for recurrent malignant gynecologic diseases. Clin Cancer Res (2010) 1.21
The human survivin promoter: a novel transcriptional targeting strategy for treatment of glioma. J Neurosurg (2006) 1.21
LRRK2 secretion in exosomes is regulated by 14-3-3. Hum Mol Genet (2013) 1.15
Promotion of incisional wound repair by human mesenchymal stem cell transplantation. Exp Dermatol (2008) 1.14
Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity. Clin Cancer Res (2003) 1.14
A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer. Gynecol Oncol (2013) 1.10
Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud's syndrome: a case report emphasizing the cytological and cytogenetic findings. Hum Pathol (2003) 1.10
E-cadherin/beta-catenin and CD10: a limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreas. Am J Clin Pathol (2009) 1.10
Sympathetic hyperinnervation and inflammatory cell NGF synthesis following myocardial infarction in rats. Brain Res (2006) 1.09
Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia. Mol Biol Cell (2006) 1.08
Cytogenetics and molecular biology of osteosarcoma. Lab Invest (2002) 1.08
PKHD1 sequence variations in 78 children and adults with autosomal recessive polycystic kidney disease and congenital hepatic fibrosis. Mol Genet Metab (2009) 1.07
Small cell tumors of bone. Adv Anat Pathol (2010) 1.05
Striking pathology gold: a singular experience with daily reverberations: sinonasal hemangiopericytoma (glomangiopericytoma) and oncogenic osteomalacia. Head Neck Pathol (2012) 1.05
Role of oxygen availability in CFTR expression and function. Am J Respir Cell Mol Biol (2008) 1.05
A phase I clinical trial of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in patients with recurrent gynecologic cancer. Clin Cancer Res (2012) 1.04
MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. Cancer (2003) 1.03
Predominant extrahepatic biliary disease in autosomal recessive polycystic kidney disease: a new association. Pediatr Transplant (2006) 1.02
Analysis of PKD1 for genomic deletion by multiplex ligation-dependent probe assay: absence of hot spots. Genomics (2007) 1.02
An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism. Virology (2004) 1.02
Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging. Cardiovasc Diabetol (2006) 1.02
Solid pseudopapillary tumor of the pancreas: a review of salient clinical and pathologic features. Adv Anat Pathol (2008) 1.01
Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose. Am J Physiol Heart Circ Physiol (2006) 1.01
MKS3-related ciliopathy with features of autosomal recessive polycystic kidney disease, nephronophthisis, and Joubert Syndrome. J Pediatr (2009) 1.00
Apical trypsin increases ion transport and resistance by a phospholipase C-dependent rise of Ca2+. Am J Physiol Lung Cell Mol Physiol (2004) 1.00
Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational control. Breast Cancer Res Treat (2007) 0.99
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression. Cancer Res (2003) 0.99
Microdissection of histologic sections: past, present, and future. Adv Anat Pathol (2002) 0.99
Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung. Pediatrics (2008) 0.99
Productive replication of human adenovirus type 5 in canine cells. J Virol (2005) 0.97
Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo. Int J Oncol (2005) 0.97
A Decade in Banking Ewing Sarcoma: A Report from the Children's Oncology Group. Front Oncol (2013) 0.97
Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways. Cancer Res (2013) 0.96
alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression. Lab Invest (2007) 0.95
LL-37 as a therapeutic target for late stage prostate cancer. Prostate (2010) 0.95
Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds. J Mol Med (Berl) (2007) 0.95
Silencing of transforming growth factor-beta1 in situ by RNA interference for breast cancer: implications for proliferation and migration in vitro and metastasis in vivo. Clin Cancer Res (2008) 0.95
Assessing gait impairment following experimental traumatic brain injury in mice. J Neurosci Methods (2008) 0.95
Exercise training improves cardiac performance in diabetes: in vivo demonstration with quantitative cine-MRI analyses. J Appl Physiol (1985) (2006) 0.94
Transport across a polarized monolayer of Caco-2 cells by transferrin receptor-mediated adenovirus transcytosis. Virology (2004) 0.94
GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Dev Dyn (2011) 0.94
Targeting mesothelioma using an infectivity enhanced survivin-conditionally replicative adenoviruses. J Thorac Oncol (2006) 0.93
A fiber-modified mesothelin promoter-based conditionally replicating adenovirus for treatment of ovarian cancer. Clin Cancer Res (2008) 0.93
The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling. BMC Biol (2013) 0.93
Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients. Am J Hum Genet (2002) 0.93
Review of the Tuberous Sclerosis Renal Guidelines from the 2012 Consensus Conference: Current Data and Future Study. Nephron (2016) 0.93
Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord. Neuropharmacology (2008) 0.93
Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system. Breast Cancer Res (2005) 0.92
Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. Am J Pathol (2006) 0.92
Alterations in human breast cancer adhesion-motility in response to changes in cell surface glycoproteins displaying alpha-L-fucose moieties. Int J Oncol (2008) 0.92
Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin. PLoS One (2012) 0.92
Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors. Am J Physiol Renal Physiol (2011) 0.92
Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury. J Magn Reson Imaging (2011) 0.92
Evaluating regional blood spinal cord barrier dysfunction following spinal cord injury using longitudinal dynamic contrast-enhanced MRI. BMC Med Imaging (2009) 0.91