Published in BMC Genet on July 05, 2009
The evolution of human genetic and phenotypic variation in Africa. Curr Biol (2010) 1.65
Evolution of lactase persistence: an example of human niche construction. Philos Trans R Soc Lond B Biol Sci (2011) 1.45
Genetic origins of lactase persistence and the spread of pastoralism in Africa. Am J Hum Genet (2014) 1.27
The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity. Hum Genet (2011) 1.08
Lactose intolerance: diagnosis, genetic, and clinical factors. Clin Exp Gastroenterol (2012) 1.01
Tracing pastoralist migrations to southern Africa with lactase persistence alleles. Curr Biol (2014) 0.97
Lactase persistence genotypes and malaria susceptibility in Fulani of Mali. Malar J (2011) 0.90
Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population. PLoS One (2012) 0.84
Lactase non-persistent genotype influences milk consumption and gastrointestinal symptoms in Northern Russians. BMC Gastroenterol (2011) 0.83
The peopling of the African continent and the diaspora into the new world. Curr Opin Genet Dev (2014) 0.79
The lactase persistence genotype is a protective factor for the metabolic syndrome. Genet Mol Biol (2014) 0.78
Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture. Trans Am Clin Climatol Assoc (2011) 0.78
Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry. J Pediatr Gastroenterol Nutr (2015) 0.76
The lactase -13910C>T polymorphism (rs4988235) is associated with overweight/obesity and obesity-related variables in a population sample of Portuguese young adults. Eur J Clin Nutr (2016) 0.75
High osteoporosis risk among East Africans linked to lactase persistence genotype. Bonekey Rep (2016) 0.75
The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. Nutrients (2015) 0.75
Convergent adaptation of human lactase persistence in Africa and Europe. Nat Genet (2006) 9.44
Identification of a variant associated with adult-type hypolactasia. Nat Genet (2002) 7.49
Demic expansions and human evolution. Science (1993) 5.59
Emergence of modern human behavior: Middle Stone Age engravings from South Africa. Science (2002) 3.96
The dawn of human matrilineal diversity. Am J Hum Genet (2008) 3.60
Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Hum Mol Genet (2003) 2.81
The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans. Am J Hum Genet (2004) 2.39
Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut (2003) 2.33
An upstream polymorphism associated with lactase persistence has increased enhancer activity. Gastroenterology (2003) 2.15
T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. Hum Mol Genet (2005) 2.05
Diagnosis of placental malaria. J Clin Microbiol (2002) 1.97
A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut (2004) 1.95
Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol Suppl (1994) 1.95
A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence? Hum Genet (2006) 1.89
Enhancer identification through comparative genomics. Semin Cell Dev Biol (2007) 1.56
Genetic substructure in South African Bantu-speakers: evidence from autosomal DNA and Y-chromosome studies. Am J Phys Anthropol (2002) 1.11
The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population. J Med Genet (2007) 1.11
Transcriptional downregulation of the lactase (LCT) gene during childhood. Gut (2005) 1.09
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus. Carcinogenesis (2005) 1.03
Correlation of intestinal disaccharidase activities with the C/T-13910 variant and age. World J Gastroenterol (2007) 0.99
Bantu and European Y-lineages in Sub-Saharan Africa. Ann Hum Genet (2002) 0.96
The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int J Cancer (2009) 1.97
Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation. Am J Hum Genet (2008) 1.80
Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa. Antivir Ther (2009) 1.66
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer. Cancer Res (2006) 1.66
Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy. Malar J (2007) 1.66
Rapid increase in the prevalence of sulfadoxine-pyrimethamine resistance among Plasmodium falciparum isolated from pregnant women in Ghana. J Infect Dis (2008) 1.58
Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation. Curr Pharmacogenomics Person Med (2011) 1.49
The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications. Int J Cancer (2013) 1.24
Ready to put metadata on the post-2015 development agenda? Linking data publications to responsible innovation and science diplomacy. OMICS (2014) 1.24
The T-box transcription factor Tbx2: its role in development and possible implication in cancer. IUBMB Life (2010) 1.18
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors. Genes Chromosomes Cancer (2007) 1.13
Oesophageal cancer in Africa. IUBMB Life (2002) 1.08
Garlic-derived anticancer agents: structure and biological activity of ajoene. Biofactors (2010) 1.04
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus. Carcinogenesis (2005) 1.03
Correlation of intestinal disaccharidase activities with the C/T-13910 variant and age. World J Gastroenterol (2007) 0.99
The cumulative effects of polymorphisms in the DNA mismatch repair genes and tobacco smoking in oesophageal cancer risk. PLoS One (2012) 0.99
A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer. Mol Cancer Res (2009) 0.99
Analysis of X chromosome inactivation in autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet (2008) 0.98
Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. Am J Hum Genet (2005) 0.97
Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa. Carcinogenesis (2011) 0.96
Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer. Clin Chem Lab Med (2008) 0.96
The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. BMC Genet (2010) 0.95
UV-mediated regulation of the anti-senescence factor Tbx2. J Biol Chem (2007) 0.95
CYP3A5 genotypes and risk of oesophageal cancer in two South African populations. Cancer Lett (2004) 0.94
Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus. Clin Chem Lab Med (2005) 0.92
Health research in Africa: getting priorities right. Trop Med Int Health (2012) 0.92
Mitochondrial DNA subhaplogroups L0a2 and L2a modify susceptibility to peripheral neuropathy in malawian adults on stavudine containing highly active antiretroviral therapy. J Acquir Immune Defic Syndr (2013) 0.92
MicroRNA polymorphisms and environmental smoke exposure as risk factors for oesophageal squamous cell carcinoma. PLoS One (2013) 0.91
Heterozygous p.Asp50Asn mutation in the GJB2 gene in two Cameroonian patients with keratitis-ichthyosis-deafness (KID) syndrome. BMC Med Genet (2013) 0.90
Lactase persistence genotypes and malaria susceptibility in Fulani of Mali. Malar J (2011) 0.90
ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients. Front Genet (2012) 0.89
Absence seizures associated with efavirenz initiation. Pediatr Infect Dis J (2011) 0.89
The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity. Clin Pharmacol Ther (2002) 0.89
PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients. BMC Med Genet (2012) 0.89
Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans. BMC Res Notes (2009) 0.88
Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study. PLoS One (2011) 0.87
Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population. Carcinogenesis (2012) 0.87
CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women. BMC Cancer (2010) 0.87
The role of inflammation in HPV infection of the Oesophagus. BMC Cancer (2013) 0.84
Aberrant methylation of the MSH3 promoter and distal enhancer in esophageal cancer patients exposed to first-hand tobacco smoke. J Cancer Res Clin Oncol (2014) 0.84
High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients. Pharmacogenet Genomics (2013) 0.84
In search of genetic markers for nonsyndromic deafness in Africa: a study in Cameroonians and Black South Africans with the GJB6 and GJA1 candidate genes. OMICS (2014) 0.83
Translating biotechnology to knowledge-based innovation, peace, and development? Deploy a Science Peace Corps--an open letter to world leaders. OMICS (2014) 0.82
A Fas gene polymorphism influences herpes simplex virus type 2 infection in South African women. J Med Virol (2010) 0.82
Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria. Malar J (2012) 0.81
Feedback regulation of the α2(1) collagen gene via the Mek-Erk signaling pathway. IUBMB Life (2011) 0.81
Targeting neddylation in cancer therapy. Future Oncol (2012) 0.81
Esophageal cancer risk in relation to GGC and CAG trinucleotide repeat lengths in the androgen receptor gene. Int J Cancer (2003) 0.80
Molecularly defined adult-type hypolactasia in school-aged children with a previous history of cow's milk allergy. World J Gastroenterol (2006) 0.80
Photolon, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis. Int J Biochem Cell Biol (2007) 0.80
Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells. Eur J Med Chem (2012) 0.80
A role for Tbx2 in the regulation of the alpha2(1) collagen gene in human fibroblasts. J Cell Biochem (2007) 0.79
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer. J Med Virol (2011) 0.78
Differential effects of novel tumour-derived p53 mutations on the transformation of NIH-3T3 cells. Biol Chem (2008) 0.78
Progression of esophageal dysplasia to cancer. Ann N Y Acad Sci (2014) 0.78
Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines. Anticancer Agents Med Chem (2011) 0.78
Species-specific regulation of the alpha-2(I) procollagen gene by proximal promoter elements. IUBMB Life (2005) 0.78
Tumour cells down-regulate CCN2 gene expression in co-cultured fibroblasts in a Smad7- and ERK-dependent manner. Cell Commun Signal (2013) 0.77
Association of DCC, MLH1, GSTT1, GSTM1, and TP53 gene polymorphisms with colorectal cancer in Kazakhstan. Tumour Biol (2014) 0.77
Wnt/β-Catenin and MEK-ERK Signaling are Required for Fibroblast-Derived Extracellular Matrix-Mediated Endoderm Differentiation of Embryonic Stem Cells. Stem Cell Rev (2015) 0.77
Infrequent somatic deletion of the 5' region of the COL1A2 gene in oesophageal squamous cell cancer patients. Clin Chem Lab Med (2002) 0.77
CCR2, CX3CR1, RANTES and SDF1 genetic polymorphisms influence HIV infection in a Zimbabwean pediatric population. J Infect Dev Ctries (2014) 0.77
A novel role of annexin A2 in human type I collagen gene expression. J Cell Biochem (2015) 0.76
How does mother-to-child transmission of HIV differ among African populations? Lessons from MBL2 genetic variation in Zimbabweans. OMICS (2014) 0.76
Mitochondrial subhaplogroups and differential risk of stavudine-induced lipodystrophy in Malawian HIV/AIDS patients. Pharmacogenomics (2013) 0.76
Addressing diseases in Africa. Clin Chem Lab Med (2002) 0.75
Evaluation of DNA damage in a population of bats (Chiroptera) residing in an abandoned monazite mine. Mutat Res (2004) 0.75
Genotyping of alcohol dehydrogenase type 2 and 3 using a two-buffer polyacrylamide gel electrophoresis system. Clin Chem Lab Med (2003) 0.75
Understanding the Implications of Mitochondrial DNA Variation in the Health of Black Southern African Populations: The 2014 Workshop. Hum Mutat (2015) 0.75
Fibrodysplasia ossificans progressiva in South Africa: difficulties in management in a developing country. J Clin Rheumatol (2011) 0.75
Phosphorylation of the alpha 2(1) procollagen promoter binding proteins is required for promoter activity. IUBMB Life (2006) 0.75