Published in J Clin Invest on July 01, 2009
Immune responses to AAV vectors: overcoming barriers to successful gene therapy. Blood (2013) 2.09
Progress and prospects: immune responses to viral vectors. Gene Ther (2009) 2.05
Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells. Blood (2013) 1.98
Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors. Hum Gene Ther (2011) 1.71
The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver. Blood (2011) 1.56
The complex and evolving story of T cell activation to AAV vector-encoded transgene products. Mol Ther (2010) 1.55
AAV's anatomy: roadmap for optimizing vectors for translational success. Curr Gene Ther (2010) 1.27
Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy. Proc Natl Acad Sci U S A (2011) 1.27
Innate Immune Responses to AAV Vectors. Front Microbiol (2011) 1.24
A virological view of innate immune recognition. Annu Rev Microbiol (2012) 1.14
CpG-depleted adeno-associated virus vectors evade immune detection. J Clin Invest (2013) 1.10
Recognition of virus infection and innate host responses to viral gene therapy vectors. Mol Ther (2010) 1.10
AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cells. Mol Ther (2010) 1.08
Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity. Front Microbiol (2011) 1.08
Advances in cell and gene-based therapies for cystic fibrosis lung disease. Mol Ther (2012) 1.08
Adeno-associated virus: a key to the human genome? Future Virol (2010) 1.03
Toll-like receptors in antiviral innate immunity. J Mol Biol (2013) 1.03
Differential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo. Mol Ther (2013) 1.01
Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism. J Virol (2010) 0.98
MyD88 signaling in B cells regulates the production of Th1-dependent antibodies to AAV. Mol Ther (2012) 0.98
Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome. Virology (2011) 0.98
Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine. J Virol (2010) 0.96
Gene therapy for hemophilia. Front Biosci (Landmark Ed) (2015) 0.94
Covert warfare against the immune system: decoy capsids, stealth genomes, and suppressors. Mol Ther (2013) 0.92
Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions. Front Immunol (2014) 0.91
The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing. J Virol (2012) 0.90
Toll-like receptor 9 is required for opioid-induced microglia apoptosis. PLoS One (2011) 0.90
Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B. J Transl Med (2014) 0.89
Adeno-associated virus activates an innate immune response in normal human cells but not in osteosarcoma cells. J Virol (2011) 0.88
Activation of an antiviral response in normal but not transformed mouse cells: a new determinant of minute virus of mice oncotropism. J Virol (2010) 0.88
Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy. Hum Gene Ther (2012) 0.87
Gene Therapy for Duchenne muscular dystrophy. Expert Opin Orphan Drugs (2015) 0.86
Intra-amniotic rAAV-mediated microdystrophin gene transfer improves canine X-linked muscular dystrophy and may induce immune tolerance. Mol Ther (2015) 0.85
AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Mol Ther (2013) 0.85
Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses. Expert Opin Ther Targets (2010) 0.83
Adeno-associated viral vector-mediated transgene expression is independent of DNA methylation in primate liver and skeletal muscle. PLoS One (2011) 0.82
Advances in Overcoming Immune Responses following Hemophilia Gene Therapy. J Genet Syndr Gene Ther (2011) 0.81
Deficiency in MyD88 Signaling Results in Decreased Antibody Responses to an Adeno-Associated Virus Vector in Murine Pompe Disease. Biores Open Access (2012) 0.81
Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. PLoS One (2015) 0.81
Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies. Mol Ther Methods Clin Dev (2016) 0.80
Targeting co-stimulatory pathways in gene therapy. Front Microbiol (2011) 0.80
Enhancers of adeno-associated virus AAV2 transduction via high throughput siRNA screening. Mol Ther (2011) 0.80
IL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression. PLoS One (2013) 0.80
Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer. J Innate Immun (2015) 0.80
TLR-9 contributes to the antiviral innate immune sensing of rodent parvoviruses MVMp and H-1PV by normal human immune cells. PLoS One (2013) 0.80
Recent advances in gene therapy for lysosomal storage disorders. Appl Clin Genet (2015) 0.79
Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver. Mol Cell Biol (2015) 0.79
Autonomous parvoviruses neither stimulate nor are inhibited by the type I interferon response in human normal or cancer cells. J Virol (2014) 0.79
Toll-like receptor 9 in plasmacytoid dendritic cells fails to detect parvoviruses. J Virol (2013) 0.78
Optimizing NTS-polyplex as a tool for gene transfer to cultured dopamine neurons. PLoS One (2012) 0.78
Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson's disease. J Biomed Sci (2015) 0.78
Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS One (2013) 0.78
Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation. J Clin Invest (2015) 0.77
Adeno-Associated Viral Vectors at the Frontier between Tolerance and Immunity. Front Immunol (2015) 0.77
Obstacles and future of gene therapy for hemophilia. Expert Opin Orphan Drugs (2015) 0.77
Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer. Mol Ther Methods Clin Dev (2014) 0.76
Virus infection recognition and early innate responses to non-enveloped viral vectors. Viruses (2010) 0.76
Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution. Virol J (2013) 0.76
Regulatory and Exhausted T Cell Responses to AAV Capsid. Hum Gene Ther (2017) 0.76
Recombinant adeno-associated virus vectors in the treatment of rare diseases. Expert Opin Orphan Drugs (2015) 0.75
RNA Interference Mediated Interleukin-1β Silencing in Inflamed Chondrocytes Decreases Target and Downstream Catabolic Responses. Arthritis (2016) 0.75
Engineering antibody-like inhibitors to prevent and treat HIV-1 infection. Curr Opin HIV AIDS (2017) 0.75
Engineering antibody-like inhibitors to prevent and treat HIV-1 infection. Curr Opin HIV AIDS (2017) 0.75
Serotype-specific Binding Properties and Nanoparticle Characteristics Contribute to the Immunogenicity of rAAV1 Vectors. Mol Ther (2015) 0.75
Plasmacytoid and conventional dendritic cells cooperate in cross-priming AAV capsid-specific CD8(+) T cells. Blood (2017) 0.75
Pathogen recognition and innate immunity. Cell (2006) 44.14
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Functional role of type I and type II interferons in antiviral defense. Science (1994) 18.92
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med (2006) 13.51
The nature of the principal type 1 interferon-producing cells in human blood. Science (1999) 10.90
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61
Innate immune recognition of viral infection. Nat Immunol (2006) 9.59
Plasmacytoid dendritic cells in immunity. Nat Immunol (2004) 9.11
Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94
Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol (1998) 7.76
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature (2005) 6.14
BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol (2000) 6.04
Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat Genet (2000) 5.80
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat Immunol (2003) 5.36
Recombinant adeno-associated virus for muscle directed gene therapy. Nat Med (1997) 4.87
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nat Med (1999) 4.61
Adeno-associated virus serotypes: vector toolkit for human gene therapy. Mol Ther (2006) 4.36
Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science (2005) 4.32
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
Translating innate immunity into immunological memory: implications for vaccine development. Cell (2006) 3.98
Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc Natl Acad Sci U S A (1997) 3.84
Adeno-associated virus vectors can be efficiently produced without helper virus. Gene Ther (1998) 3.77
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70
Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc Natl Acad Sci U S A (1993) 3.59
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors. Nat Med (1999) 3.39
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A (2003) 3.29
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice. Nat Med (2006) 3.13
Toll-like receptors and Type I interferons. J Biol Chem (2007) 3.07
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol (2004) 3.00
Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors. Proc Natl Acad Sci U S A (1998) 2.80
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nat Med (2006) 2.78
Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column. Hum Gene Ther (2001) 2.69
Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells. J Leukoc Biol (2003) 2.61
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J Exp Med (2006) 2.57
Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation. J Virol (2001) 2.56
Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways. J Virol (2007) 2.33
Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice. Blood (2005) 2.29
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature (2006) 2.16
Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. J Virol (2004) 2.12
Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector. Nat Med (1999) 2.07
Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets. Hum Gene Ther (2007) 1.95
Sustained correction of bleeding disorder in hemophilia B mice by gene therapy. Proc Natl Acad Sci U S A (1999) 1.90
Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. J Virol (2007) 1.84
Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy. Hum Gene Ther (2007) 1.70
In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance. Blood (2007) 1.69
IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice. Hepatology (2007) 1.69
Identification of mouse AAV capsid-specific CD8+ T cell epitopes. Mol Ther (2005) 1.63
Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins. J Clin Invest (2002) 1.63
Humoral immunity to adeno-associated virus type 2 vectors following administration to murine and nonhuman primate muscle. J Virol (2000) 1.57
Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo. J Virol (2007) 1.52
TLR7: A new sensor of viral infection. Proc Natl Acad Sci U S A (2004) 1.49
Immune responses to adeno-associated virus vectors. Curr Gene Ther (2005) 1.45
Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology (2008) 1.41
A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Hum Gene Ther (2002) 1.40
Route of administration determines induction of T-cell-independent humoral responses to adeno-associated virus vectors. Mol Ther (2000) 1.32
The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Mol Ther (2008) 1.31
Factors influencing the development of an anti-factor IX (FIX) immune response following administration of adeno-associated virus-FIX. Blood (2001) 1.29
Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA. J Immunol (2007) 1.28
Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D. J Virol (1997) 1.27
AAV as an immunogen. Curr Gene Ther (2007) 1.21
Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus. J Immunol (2007) 1.20
Effect of suppressive DNA on CpG-induced immune activation. J Immunol (2002) 1.16
A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus. Hum Gene Ther (2001) 1.14
STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo. J Immunol (2008) 1.12
Complement is an essential component of the immune response to adeno-associated virus vectors. J Virol (2008) 1.11
Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors. J Virol (2001) 1.11
Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer. J Virol (2000) 1.09
Phase I clinical trial utilizing gene therapy for limb girdle muscular dystrophy: alpha-, beta-, gamma-, or delta-sarcoglycan gene delivered with intramuscular instillations of adeno-associated vectors. Hum Gene Ther (2000) 1.08
Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigen. Eur J Immunol (2004) 0.95
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol (2004) 3.00
Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta. Blood (2006) 2.35
Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways. J Virol (2007) 2.33
Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. Blood (2012) 1.71
A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood (2008) 1.69
CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses. J Immunol (2007) 1.50
Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. J Immunol (2011) 1.26
Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. J Immunol (2008) 1.26
Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA. Proc Natl Acad Sci U S A (2010) 1.24
Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection. PLoS Pathog (2010) 1.22
Innate immune recognition of viruses and viral vectors. Hum Gene Ther (2009) 1.22
Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus. J Immunol (2007) 1.20
A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. Mol Ther (2008) 1.15
STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo. J Immunol (2008) 1.12
NK cell response to vaccinia virus is regulated by myeloid-derived suppressor cells. J Immunol (2012) 1.11
Cancer immunotherapy: harnessing the immune system to battle cancer. J Clin Invest (2015) 1.04
Natural killer cell responses to viral infection. J Innate Immun (2011) 1.03
Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation. Biol Blood Marrow Transplant (2010) 1.03
Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigen. Eur J Immunol (2004) 0.95
Extent of stimulation controls the formation of memory CD8 T cells. J Immunol (2007) 0.91
Myeloid-derived suppressor cells regulate natural killer cell response to adenovirus-mediated gene transfer. J Virol (2012) 0.90
Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors. Cancer Invest (2011) 0.89
Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta. J Immunol (2005) 0.88
The fate of effector CD8 T cells in vivo is controlled by the duration of antigen stimulation. Immunology (2006) 0.86
Development of a 4-nitroquinoline-1-oxide model of lymph node metastasis in oral squamous cell carcinoma. Oral Oncol (2012) 0.86
NKG2D is required for NK cell activation and function in response to E1-deleted adenovirus. J Immunol (2010) 0.84
Interaction of occupational manganese exposure and alcohol drinking aggravates the increase of liver enzyme concentrations from a cross-sectional study in China. Environ Health (2013) 0.84
The role of natural regulatory T cells in infection. Immunol Res (2011) 0.84
The development and function of memory regulatory T cells after acute viral infections. J Immunol (2012) 0.83
Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses. Expert Opin Ther Targets (2010) 0.83
Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus. J Immunol (2013) 0.82
Determination of beta2-agonists by ion chromatography with direct conductivity detection. J Pharm Biomed Anal (2005) 0.81
In silico syndrome prediction for coronary artery disease in traditional chinese medicine. Evid Based Complement Alternat Med (2012) 0.81
Cognitive function and plasma BDNF levels among manganese-exposed smelters. Occup Environ Med (2014) 0.81
Enantiomeric separation of beta-blockers by HPLC using (R)-1-naphthylglycine and 3,5-dinitrobenzoic acid as chiral stationary phase. J Pharm Biomed Anal (2003) 0.80
Targeting co-stimulatory pathways in gene therapy. Front Microbiol (2011) 0.80
Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation. Blood (2009) 0.80
Immunotherapy of surgical malignancies. Curr Probl Surg (2004) 0.79
Pathway Pattern-based prediction of active drug components and gene targets from H1N1 influenza's treatment with maxingshigan-yinqiaosan formula. Mol Biosyst (2013) 0.79
NK cell-extrinsic IL-18 signaling is required for efficient NK-cell activation by vaccinia virus. Eur J Immunol (2014) 0.79
Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation. J Clin Invest (2015) 0.77
The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis. J Clin Invest (2012) 0.77
Enhanced separation of purine and pyrimidine bases using carboxylic multiwalled carbon nanotubes as additive in capillary zone electrophoresis. Electrophoresis (2006) 0.76
On the use of dispersed nanoparticles modified with single layer beta-cyclodextrin as chiral selecor to enhance enantioseparation of clenbuterol with capillary electrophoresis. Talanta (2005) 0.75
Chiral separation of four fluoroquinolone compounds using capillary electrophoresis with hydroxypropyl-beta-cyclodextrin as chiral selector. J Chromatogr A (2006) 0.75
PD-L1 serves as a double agent in separating GVL from GVHD. J Clin Invest (2017) 0.75
[Prediction of network drug target based on improved model of bipartite graph valuation]. Zhongguo Zhong Yao Za Zhi (2012) 0.75
Driving an improved CAR for cancer immunotherapy. J Clin Invest (2016) 0.75
[Network-based local and global consistency of cardiovascular genes]. Zhongguo Zhong Yao Za Zhi (2012) 0.75
[Influence of simvastatin treatment on Toll-like receptor 4 in monocytes of peripheral blood in patients with sepsis and severe sepsis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue (2016) 0.75
[The relationship between expression of mitogen-activated protein kinase kinase 4 and metastasis in oral squamous cell carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi (2011) 0.75
Preliminary Epidemiology of Human Infections with Highly Pathogenic Avian Influenza A(H7N9) Virus, China, 2017. Emerg Infect Dis (2017) 0.75
Capillary electrophoretic determination of apoptosis of rat cerebellar granule cells induced by 1-methyl-4-phenyl pyridium ion. Electrophoresis (2002) 0.75
[Study on chemical constituents from stem of Mallotus apelta]. Zhong Yao Cai (2005) 0.75