PubRank

Kevin A Reynolds

Author PubWeight™ 49.26‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A 2009 1.91
2 Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP. Chem Biol 2005 1.50
3 Antibacterial targets in fatty acid biosynthesis. Curr Opin Microbiol 2007 1.37
4 Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH. Chem Biol 2008 1.37
5 Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. J Biol Chem 2002 1.31
6 Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity. J Am Chem Soc 2009 1.29
7 Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chem Biol 2008 1.27
8 Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. ACS Chem Biol 2009 1.17
9 Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH). J Bacteriol 2005 1.16
10 Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Antimicrob Agents Chemother 2002 1.14
11 Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster. J Biol Chem 2003 1.10
12 Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chem Biol 2002 1.10
13 Multiple pathways for acetate assimilation in Streptomyces cinnamonensis. J Ind Microbiol Biotechnol 2005 1.07
14 Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes. Chem Biol 2007 1.06
15 Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis. J Am Chem Soc 2007 1.04
16 The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase. Chem Biol 2002 1.03
17 The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. Biochemistry 2003 1.03
18 Iterative chain elongation by a pikromycin monomodular polyketide synthase. J Am Chem Soc 2003 0.99
19 Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase. J Am Chem Soc 2003 0.99
20 Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster. Chem Biol 2006 0.97
21 Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity. Biochemistry 2002 0.93
22 1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH). Antimicrob Agents Chemother 2004 0.91
23 High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain. Metab Eng 2009 0.90
24 Antimalarial activity of natural and synthetic prodiginines. J Med Chem 2011 0.89
25 A pH-stability study of phoslactomycin B and analysis of the acid and base degradation products. J Antibiot (Tokyo) 2005 0.89
26 Biosynthetic origin of hygromycin A. Antimicrob Agents Chemother 2003 0.88
27 An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. Protein Eng Des Sel 2004 0.87
28 Biosynthetic origins of the natural product, thiolactomycin: a unique and selective inhibitor of type II dissociated fatty acid synthases. J Am Chem Soc 2003 0.87
29 An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. Biochemistry 2002 0.86
30 Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia. Biochemistry 2011 0.85
31 cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme. J Am Chem Soc 2008 0.84
32 Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor. J Biol Chem 2011 0.83
33 An O-phosphotransferase catalyzes phosphorylation of hygromycin A in the antibiotic-producing organism Streptomyces hygroscopicus. Antimicrob Agents Chemother 2008 0.82
34 Elucidation of final steps of the marineosins biosynthetic pathway through identification and characterization of the corresponding gene cluster. J Am Chem Soc 2014 0.81
35 The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux. Antimicrob Agents Chemother 2009 0.81
36 Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH). Bioorg Med Chem Lett 2006 0.81
37 The plmS2-encoded cytochrome P450 monooxygenase mediates hydroxylation of phoslactomycin B in Streptomyces sp. strain HK803. J Bacteriol 2005 0.81
38 Generation of novel pikromycin antibiotic products through mutasynthesis. Chembiochem 2008 0.80
39 Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates. Bioorg Chem 2007 0.80
40 Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation. Microbiology 2004 0.80
41 Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388. Chem Biol 2009 0.79
42 Recent developments in the production of novel polyketides by combinatorial biosynthesis. Biotechnol Genet Eng Rev 2002 0.79
43 Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains. Chembiochem 2009 0.78
44 Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett 2008 0.78
45 Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization. J Org Chem 2014 0.78
46 Identification and disruptional analysis of the Streptomyces cinnamonensis msdA gene, encoding methylmalonic acid semialdehyde dehydrogenase. J Ind Microbiol Biotechnol 2005 0.77
47 Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase. Chembiochem 2015 0.76
48 Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins. Appl Environ Microbiol 2009 0.76
49 Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer. Biochemistry 2012 0.76
50 Streptomyces coelicolor RedP and FabH enzymes, initiating undecylprodiginine and fatty acid biosynthesis, exhibit distinct acyl-CoA and malonyl-acyl carrier protein substrate specificities. FEMS Microbiol Lett 2012 0.75
51 Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase III (mtFabH) assay: principles and method. Methods Mol Med 2008 0.75