Published in Liver Int on July 07, 2009
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology (2010) 5.35
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol (2010) 2.50
Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. Trends Endocrinol Metab (2011) 1.53
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. PPAR Res (2010) 1.11
Hepatic Steatosis as a Marker of Metabolic Dysfunction. Nutrients (2015) 0.92
Mitochondrial fatty acid oxidation in obesity. Antioxid Redox Signal (2012) 0.88
Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart study. Eur J Gastroenterol Hepatol (2012) 0.87
Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol (2011) 0.87
Nutrition and nonalcoholic Fatty liver disease: the significance of cholesterol. Int J Hepatol (2012) 0.86
Metabolic inflexibility and insulin resistance in obese adolescents with non-alcoholic fatty liver disease. Pediatr Diabetes (2014) 0.84
Endoplasmic reticulum proteostasis in hepatic steatosis. Nat Rev Endocrinol (2016) 0.82
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. J Med Chem (2014) 0.82
From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations. Am J Physiol Endocrinol Metab (2014) 0.81
The eSS rat, a nonobese model of disordered glucose and lipid metabolism and fatty liver. Diabetol Metab Syndr (2010) 0.79
Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy. Cell Metab (2016) 0.77
Liver fat accumulation in response to overfeeding with a high-fat diet: a comparison between South Asian and Caucasian men. Nutr Metab (Lond) (2015) 0.75
Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease. Nutrients (2017) 0.75
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab (2002) 6.79
Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res (2008) 4.88
Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol (2007) 3.83
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology (2009) 3.67
Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes. Diabetes Care (2005) 3.60
Dynamics of human adipose lipid turnover in health and metabolic disease. Nature (2011) 2.90
One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial. Diabetes Care (2009) 2.75
Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes (2011) 2.43
Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study. PLoS One (2007) 2.38
FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurol (2011) 2.36
Gene expression in human NAFLD. Am J Physiol Gastrointest Liver Physiol (2008) 2.33
From the metabolic syndrome to NAFLD or vice versa? Dig Liver Dis (2010) 2.24
Liver fat in the metabolic syndrome. J Clin Endocrinol Metab (2007) 2.17
Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr (2005) 2.11
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes (2007) 2.08
Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes (2007) 2.06
Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr (2007) 2.04
Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. PLoS Med (2008) 1.94
Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes (2004) 1.92
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol (2011) 1.89
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr (2012) 1.80
Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterology (2008) 1.78
Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes (2010) 1.76
Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes (2003) 1.71
Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease. J Gastroenterol Hepatol (2012) 1.67
Physical inactivity and obesity: a vicious circle. Obesity (Silver Spring) (2008) 1.65
Effect of liver fat on insulin clearance. Am J Physiol Endocrinol Metab (2007) 1.64
Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans. Circulation (2003) 1.64
Dietary fat content modifies liver fat in overweight nondiabetic subjects. J Clin Endocrinol Metab (2005) 1.62
Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period. Diabetes (2007) 1.59
Lowering of LDL cholesterol rather than moderate weight loss improves endothelium-dependent vasodilatation in obese women with previous gestational diabetes. Diabetes Care (2003) 1.56
Regulation of human metabolism by hypoxia-inducible factor. Proc Natl Acad Sci U S A (2010) 1.56
Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. Am J Clin Nutr (2008) 1.54
Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes. Diabetes Care (2011) 1.53
Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes (2002) 1.46
Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum. Obesity (Silver Spring) (2009) 1.39
Leukocyte activation by triglyceride-rich lipoproteins. Arterioscler Thromb Vasc Biol (2008) 1.36
Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy. AIDS (2002) 1.34
Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis. Arterioscler Thromb Vasc Biol (2002) 1.33
The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes (2005) 1.32
Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. Obes Res (2002) 1.31
Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity. Diabetes (2008) 1.30
Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metab (2009) 1.28
Fatty acid metabolism in adipose tissue, muscle and liver in health and disease. Essays Biochem (2006) 1.27
Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus. J Am Coll Cardiol (2008) 1.26
Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes (2008) 1.24
Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. PLoS Genet (2010) 1.24
Brain metabolic alterations in patients with type 1 diabetes-hyperglycemia-induced injury. J Cereb Blood Flow Metab (2004) 1.23
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients. Brain (2009) 1.23
Stearoyl-CoA desaturase: rogue or innocent bystander? Prog Lipid Res (2012) 1.23
Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J Clin Endocrinol Metab (2004) 1.21
Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition. Diabetes Care (2010) 1.21
De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. J Biol Chem (2009) 1.20
The nicotinic acid receptor--a new mechanism for an old drug. Lancet (2004) 1.19
Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes (2002) 1.17
Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care (2007) 1.16
Growth patterns in young adult monozygotic twin pairs discordant and concordant for obesity. Twin Res (2004) 1.15
Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport. Am J Physiol Endocrinol Metab (2011) 1.14
Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring) (2008) 1.14
Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. Am J Physiol Endocrinol Metab (2008) 1.13
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. J Clin Endocrinol Metab (2003) 1.13
Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Diabetes (2013) 1.12
Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest (2014) 1.12
Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J Clin Endocrinol Metab (2006) 1.11
GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus. Mol Genet Metab (2011) 1.11
Increased brain fatty acid uptake in metabolic syndrome. Diabetes (2010) 1.10