Published in J Biol Chem on July 17, 2009
Amino acid addition to Vibrio cholerae LPS establishes a link between surface remodeling in gram-positive and gram-negative bacteria. Proc Natl Acad Sci U S A (2012) 1.83
The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A. Antimicrob Agents Chemother (2011) 1.78
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides. Mol Microbiol (2010) 1.37
Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition. Mol Microbiol (2011) 1.10
Polymyxin B resistance in El Tor Vibrio cholerae requires lipid acylation catalyzed by MsbB. J Bacteriol (2010) 1.09
Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface. Mol Microbiol (2010) 0.97
The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation. Infect Immun (2012) 0.90
The lipid A from Vibrio fischeri lipopolysaccharide: a unique structure bearing a phosphoglycerol moiety. J Biol Chem (2011) 0.88
Interchangeable domains in the Kdo transferases of Escherichia coli and Haemophilus influenzae. Biochemistry (2010) 0.87
The outer membrane of Gram-negative bacteria: lipid A isolation and characterization. Methods Mol Biol (2013) 0.83
Isolation and chemical characterization of lipid A from gram-negative bacteria. J Vis Exp (2013) 0.80
Measurement of protein using bicinchoninic acid. Anal Biochem (1985) 74.03
The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res (2000) 49.22
Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem (2007) 8.60
Regulation of fatty acid biosynthesis in Escherichia coli. Microbiol Rev (1993) 5.09
A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J Clin Invest (1996) 2.94
A PhoP/PhoQ-induced Lipase (PagL) that catalyzes 3-O-deacylation of lipid A precursors in membranes of Salmonella typhimurium. J Biol Chem (2000) 2.32
Diversity of endotoxin and its impact on pathogenesis. J Endotoxin Res (2006) 2.24
Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB. J Biol Chem (1997) 2.17
Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity. Infect Immun (2001) 2.16
Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. J Biol Chem (1996) 2.02
A gene coding for 3-deoxy-D-manno-octulosonic-acid transferase in Escherichia coli. Identification, mapping, cloning, and sequencing. J Biol Chem (1991) 1.98
Lipopolysaccharides of Vibrio cholerae. I. Physical and chemical characterization. Biochim Biophys Acta (2003) 1.86
Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein. J Biol Chem (1999) 1.75
Chemical structure of the lipopolysaccharide of Haemophilus influenzae strain I-69 Rd-/b+. Description of a novel deep-rough chemotype. Eur J Biochem (1988) 1.73
A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A. J Biol Chem (2002) 1.60
Escherichia coli msbB gene as a virulence factor and a therapeutic target. Infect Immun (1999) 1.59
Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli. J Biol Chem (1992) 1.59
Structural characterization of the cell surface lipooligosaccharides from a nontypable strain of Haemophilus influenzae. Biochemistry (1992) 1.56
Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. J Biol Chem (2004) 1.52
Biosynthesis of lipopolysaccharide in Escherichia coli. Cytoplasmic enzymes that attach 3-deoxy-D-manno-octulosonic acid to lipid A. J Biol Chem (1989) 1.43
Redefining the requisite lipopolysaccharide structure in Escherichia coli. ACS Chem Biol (2006) 1.38
Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli. J Biol Chem (1995) 1.37
The lipid A 1-phosphatase of Helicobacter pylori is required for resistance to the antimicrobial peptide polymyxin. J Bacteriol (2006) 1.33
Study of the role of the htrB gene in Salmonella typhimurium virulence. Infect Immun (1997) 1.28
Identification of a lipopolysaccharide alpha-2,3-sialyltransferase from Haemophilus influenzae. Mol Microbiol (2001) 1.28
A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope. J Biol Chem (1992) 1.26
Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity. Proc Natl Acad Sci U S A (2000) 1.21
An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C. J Biol Chem (2002) 1.17
Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis. Biochemistry (2008) 1.16
Occurrence of 2-keto-deoxyoctonic acid 5-phosphate in lipopolysaccharides of Vibrio cholerae Ogawa and Inaba. J Bacteriol (1985) 1.14
A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae. J Biol Chem (1997) 1.13
A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence. J Biol Chem (1999) 1.10
Deciphering the unusual acylation pattern of Helicobacter pylori lipid A. J Bacteriol (2008) 1.07
Bordetella pertussis waaA encodes a monofunctional 2-keto-3-deoxy-D-manno-octulosonic acid transferase that can complement an Escherichia coli waaA mutation. J Bacteriol (1999) 1.03
Structural variability and originality of the Bordetella endotoxins. J Endotoxin Res (2001) 1.02
3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli. J Biol Chem (2000) 1.01
Preparation, immunogenicity, and protective efficacy, in a murine model, of a conjugate vaccine composed of the polysaccharide moiety of the lipopolysaccharide of Vibrio cholerae O139 bound to tetanus toxoid. Infect Immun (2001) 0.97
Endotoxin biosynthesis in Pseudomonas aeruginosa: enzymatic incorporation of laurate before 3-deoxy-D-manno-octulosonate. J Bacteriol (1994) 0.97
The chemical structure of the lipid A component of lipopolysaccharides from Vibrio cholerae. Eur J Biochem (1981) 0.84
3-deoxy-D-manno-octulosonate transferase and late acyltransferases of lipopolysaccharide biosynthesis. Methods Enzymol (1992) 0.82
Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem (2007) 8.60
A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium Campylobacter jejuni. Proc Natl Acad Sci U S A (2010) 2.21
Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate. Mol Microbiol (2007) 2.05
Biosynthesis and export of bacterial lipopolysaccharides. Annu Rev Biochem (2014) 1.90
Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis. Nat Rev Microbiol (2013) 1.88
Amino acid addition to Vibrio cholerae LPS establishes a link between surface remodeling in gram-positive and gram-negative bacteria. Proc Natl Acad Sci U S A (2012) 1.83
The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A. Antimicrob Agents Chemother (2011) 1.78
Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. J Biol Chem (2004) 1.52
Modulating the innate immune response by combinatorial engineering of endotoxin. Proc Natl Acad Sci U S A (2013) 1.45
The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway. J Bacteriol (2006) 1.43
Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa. PLoS Pathog (2011) 1.40
An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid A. J Biol Chem (2006) 1.39
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides. Mol Microbiol (2010) 1.37
Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A. J Biol Chem (2005) 1.35
The LptA protein of Escherichia coli is a periplasmic lipid A-binding protein involved in the lipopolysaccharide export pathway. J Biol Chem (2008) 1.34
The lipid A 1-phosphatase of Helicobacter pylori is required for resistance to the antimicrobial peptide polymyxin. J Bacteriol (2006) 1.33
Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition. Mol Microbiol (2011) 1.10
Deciphering the unusual acylation pattern of Helicobacter pylori lipid A. J Bacteriol (2008) 1.07
The polysaccharide capsule of Campylobacter jejuni modulates the host immune response. Infect Immun (2012) 1.05
IR and UV photodissociation as analytical tools for characterizing lipid A structures. Anal Chem (2011) 1.04
Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments. Mol Microbiol (2010) 1.04
Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics. J Bacteriol (2008) 1.02
Defining gene-phenotype relationships in Acinetobacter baumannii through one-step chromosomal gene inactivation. MBio (2014) 1.00
EptC of Campylobacter jejuni mediates phenotypes involved in host interactions and virulence. Infect Immun (2012) 0.98
Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface. Mol Microbiol (2010) 0.97
Characterization of unique modification of flagellar rod protein FlgG by Campylobacter jejuni lipid A phosphoethanolamine transferase, linking bacterial locomotion and antimicrobial peptide resistance. J Biol Chem (2011) 0.95
Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium. Proc Natl Acad Sci U S A (2009) 0.90
The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation. Infect Immun (2012) 0.90
Remodeling of Helicobacter pylori lipopolysaccharide. J Endotoxin Res (2005) 0.89
High-throughput database search and large-scale negative polarity liquid chromatography-tandem mass spectrometry with ultraviolet photodissociation for complex proteomic samples. Mol Cell Proteomics (2013) 0.89
Amino acid residues of Escherichia coli acyl carrier protein involved in heterologous protein interactions. Biochemistry (2003) 0.88
193 nm ultraviolet photodissociation mass spectrometry for the structural elucidation of lipid A compounds in complex mixtures. Anal Chem (2014) 0.85
The outer surface lipoprotein VolA mediates utilization of exogenous lipids by Vibrio cholerae. MBio (2013) 0.85
Identification of a broad family of lipid A late acyltransferases with non-canonical substrate specificity. Mol Microbiol (2014) 0.83
The Vps/VacJ ABC transporter is required for intercellular spread of Shigella flexneri. Infect Immun (2013) 0.83
Virulence and stress-related periplasmic protein (VisP) in bacterial/host associations. Proc Natl Acad Sci U S A (2013) 0.83
Antimicrobial peptide resistance of Vibrio cholerae results from an LPS modification pathway related to nonribosomal peptide synthetases. ACS Chem Biol (2014) 0.82
Characterization of Pseudomonas aeruginosa LpxT reveals dual positional lipid A kinase activity and co-ordinated control of outer membrane modification. Mol Microbiol (2014) 0.82
The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis. J Biol Chem (2013) 0.81
Isolation and chemical characterization of lipid A from gram-negative bacteria. J Vis Exp (2013) 0.80
Development of reagents and assays for the detection of pathogenic Burkholderia species. Faraday Discuss (2011) 0.76
Characterization of the Vibrio cholerae VolA surface-exposed lipoprotein lysophospholipase. J Bacteriol (2014) 0.75