Published in Acta Crystallogr D Biol Crystallogr on July 17, 2009
The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells. Immunity (2014) 1.57
Guidelines for the successful generation of protein-ligand complex crystals. Acta Crystallogr D Struct Biol (2017) 0.79
Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review. Am J Respir Crit Care Med (2008) 5.06
Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea. J Bacteriol (2003) 3.72
Critically ill patients with severe acute respiratory syndrome. JAMA (2003) 3.10
Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med (2006) 3.06
Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis. BMC Med (2013) 1.94
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J Neurosci (2005) 1.75
A randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial. Crit Care Med (2008) 1.71
The noninvasive staging of non-small cell lung cancer: the guidelines. Chest (2003) 1.57
Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Bioorg Med Chem Lett (2008) 1.16
The histamine H3 receptor as a therapeutic drug target for CNS disorders. Drug Discov Today (2009) 1.06
Unsafe driving in North American automobile commercials. J Public Health (Oxf) (2005) 1.05
Errors Associated with IV Infusions in Critical Care. Can J Hosp Pharm (2012) 1.04
Morbidity and mortality of patients with invasive group A streptococcal infections admitted to the ICU. Chest (2006) 0.97
Survey of information technology in Intensive Care Units in Ontario, Canada. BMC Med Inform Decis Mak (2008) 0.96
Fragment-based activity space: smaller is better. Curr Opin Chem Biol (2008) 0.96
Effect of influenza vaccines against mismatched strains: a systematic review protocol. Syst Rev (2012) 0.96
Evaluation of standard and modified severity of illness scores in the obstetric patient. J Crit Care (2010) 0.95
Lung Organ Failure Score (LOFS): probability of severe pulmonary organ failure after multiple injuries including chest trauma. Injury (2011) 0.94
An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett (2010) 0.93
Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction. Org Biomol Chem (2004) 0.92
The implications of groundwater velocity variations on microbial transport and wellhead protection - review of field evidence. FEMS Microbiol Ecol (2004) 0.91
Deletion of bone marrow-derived receptor for advanced glycation end products inhibits atherosclerotic plaque progression. Eur J Clin Invest (2011) 0.90
Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes. Biochemistry (2010) 0.90
Temporal change, reproducibility, and interobserver variability in pressure-volume curves in adults with acute lung injury and acute respiratory distress syndrome. Crit Care Med (2003) 0.89
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem (2010) 0.88
Safety of pressure-volume curve measurement in acute lung injury and ARDS using a syringe technique. Chest (2002) 0.88
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem (2012) 0.87
Fragment-based discovery of BACE1 inhibitors using functional assays. Biochemistry (2009) 0.86
The multiple roles of computational chemistry in fragment-based drug design. J Comput Aided Mol Des (2009) 0.85
Structure--activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2' and P3' side chains. Bioorg Med Chem Lett (2003) 0.85
Assay development and data analysis of receptor-ligand binding based on scintillation proximity assay. Metab Eng (2005) 0.85
Critical role of macrophages in glucocorticoid driven vascular calcification in a mouse-model of atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 0.85
Peptide deformylase inhibitors with activity against respiratory tract pathogens. Bioorg Med Chem Lett (2004) 0.85
Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex. ChemMedChem (2014) 0.84
Quantification of isoflavones and lignans in serum using isotope dilution liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2003) 0.84
Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group. Bioorg Med Chem Lett (2002) 0.84
Prediction of cyclin-dependent kinase 2 inhibitor potency using the fragment molecular orbital method. J Cheminform (2011) 0.83
Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT(2C) agonists for the treatment of metabolic disorders. Bioorg Med Chem Lett (2010) 0.83
Fragment-based discovery and optimization of BACE1 inhibitors. Bioorg Med Chem Lett (2010) 0.83
Discovery of a novel Hsp90 inhibitor by fragment linking. ChemMedChem (2010) 0.82
Analysis of CARD15 polymorphisms in Korean patients with ankylosing spondylitis reveals absence of common variants seen in western populations. J Rheumatol (2004) 0.82
8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor. Bioorg Med Chem Lett (2006) 0.82
Systemic transplantation of progenitor cells accelerates wound epithelialization and neovascularization in the hairless mouse ear wound model. J Surg Res (2009) 0.82
Fragment-based identification of Hsp90 inhibitors. ChemMedChem (2009) 0.82
Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis. Biochemistry (2012) 0.81
Membrane tetraheme cytochrome c(m552) of the ammonia-oxidizing nitrosomonas europaea: a ubiquinone reductase. Biochemistry (2008) 0.81
Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis. J Med Chem (2012) 0.81
GDF-15 protects from macrophage accumulation in a mousemodel of advanced atherosclerosis. Eur J Med Res (2013) 0.80
Peptidomimetic inhibitors of bacterial peptide deformylase. Bioorg Med Chem Lett (2011) 0.80
Fragment screening by biochemical assay. Expert Opin Drug Discov (2006) 0.80
Quantification of isoflavones and lignans in urine using gas chromatography/mass spectrometry. Anal Biochem (2003) 0.79
A multicenter survey of Ontario intensive care unit nurses regarding the use of sedatives and analgesics for adults receiving mechanical ventilation. J Crit Care (2007) 0.79
Clara cell protein 16: A biomarker for detecting secondary respiratory complications in patients with multiple injuries. J Trauma Acute Care Surg (2012) 0.79
Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. J Med Chem (2005) 0.78
An in silico method for predicting Ames activities of primary aromatic amines by calculating the stabilities of nitrenium ions. J Chem Inf Model (2010) 0.78
Fighting obesity with a sugar-based library: discovery of novel MCH-1R antagonists by a new computational-VAST approach for exploration of GPCR binding sites. J Chem Inf Model (2013) 0.78
[Effectiveness of inpatient psychodynamic psychotherapy: a follow-up study]. Z Psychosom Med Psychother (2009) 0.78
Detection of critical illness-related corticosteroid insufficiency using 1 μg adrenocorticotropic hormone test. Shock (2013) 0.77
TBAF-catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds. Org Biomol Chem (2011) 0.77
Human endothelial-like differentiated precursor cells maintain their endothelial characteristics when cocultured with mesenchymal stem cell and seeded onto human cancellous bone. Mediators Inflamm (2013) 0.77
Nicotinic acid has anti-atherogenic and anti-inflammatory properties on advanced atherosclerotic lesions independent of its lipid-modifying capabilities. J Cardiovasc Pharmacol (2011) 0.77
High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand. Protein Sci (2010) 0.77
Picking up the pieces with FBDD or FADD: invest early for future success. Drug Discov Today (2009) 0.77
Prospective evaluation of an internet-linked handheld computer critical care knowledge access system. Crit Care (2004) 0.77
Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain. Bioorg Med Chem Lett (2003) 0.77
The selection and design of GPCR ligands: from concept to the clinic. Comb Chem High Throughput Screen (2004) 0.76
Cell membrane modification for rapid display of bi-functional peptides: a novel approach to reduce complement activation. Open Cardiovasc Med J (2010) 0.76
Novel MK2 inhibitors by fragment screening. Comb Chem High Throughput Screen (2009) 0.76
Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters. Bioorg Med Chem Lett (2011) 0.76
1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability. Bioorg Med Chem Lett (2011) 0.75
HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives. Bioorg Med Chem Lett (2009) 0.75
What to do if you are referred to the NMC. Nurs Times (2014) 0.75
Steve Carney talks to Mark Ashton and Mark Whittaker about Evotec and their approach to fragment-based drug discovery. Drug Discov Today (2007) 0.75
E. coli O157 persistence in the environment. Microbiology (2002) 0.75
Regional citrate anticoagulation for PrismaFlex continuous renal replacement therapy. Ann Pharmacother (2009) 0.75
Development of self-indicating resin. Comb Chem High Throughput Screen (2007) 0.75
Minimisation of palladium content in Suzuki cross-coupling reactions. Comb Chem High Throughput Screen (2006) 0.75
A soluble-polymer system for the asymmetric transfer hydrogenation of ketones. J Org Chem (2004) 0.75
Convergent radial tracing of viral and solute transport in gneiss saprolite. Ground Water (2009) 0.75
Tetrahydrofuran-based amino acids as library scaffolds. J Comb Chem (2004) 0.75