Published in N Engl J Med on July 23, 2009
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med (2008) 14.47
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells. Am J Physiol Cell Physiol (2005) 2.92
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78
Case records of the Massachusetts General Hospital. Case 9-2014. A 34-year-old woman with increasing dyspnea. N Engl J Med (2014) 2.61
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci (2006) 2.59
Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J Clin Invest (2008) 2.24
Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life. Hum Brain Mapp (2010) 2.22
Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry (2005) 2.18
Cortical surface shape analysis based on spherical wavelets. IEEE Trans Med Imaging (2007) 2.11
MR connectomics: Principles and challenges. J Neurosci Methods (2010) 2.02
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem (2003) 2.01
Assessment of infant brain development with frequency-domain near-infrared spectroscopy. Pediatr Res (2007) 1.98
Case records of the Massachusetts General Hospital. Case 3-2013. A 72-year-old woman with abdominal pain and distention after peritoneal dialysis. N Engl J Med (2013) 1.96
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Nat Genet (2003) 1.96
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. J Clin Invest (2010) 1.93
Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J Gen Physiol (2009) 1.91
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science (2014) 1.85
Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification. J Am Soc Nephrol (2002) 1.84
FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital Cancer Center experience. Oncologist (2013) 1.76
Radiofrequency ablation for stage I non-small cell lung cancer: management of locoregional recurrence. Ann Thorac Surg (2012) 1.74
The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell (2010) 1.67
Dendritic cell involvement in pulmonary granuloma formation elicited by bacillus calmette-guérin in rats. Am J Respir Crit Care Med (2002) 1.62
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 25-2003. A newborn boy with petechiae and thrombocytopenia. N Engl J Med (2003) 1.59
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol (2011) 1.58
Imaging primary lung cancers in mice to study radiation biology. Int J Radiat Oncol Biol Phys (2010) 1.48
Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients--a hypothesis-generating exploratory study. Radiology (2013) 1.46
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. J Hepatol (2012) 1.45
Case records of the Massachusetts General Hospital. Case 36-2005. A 61-year-old woman with seizure, disturbed gait, and altered mental status. N Engl J Med (2005) 1.41
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Res (2010) 1.41
The use of Google Glass for airway assessment and management. Paediatr Anaesth (2014) 1.40
Case records of the Massachusetts General Hospital. Case 35-2006. A newborn boy with hypotonia. N Engl J Med (2006) 1.38
Predicting the location of entorhinal cortex from MRI. Neuroimage (2009) 1.35
Enteropathogenic Escherichia coli infection leads to appearance of aberrant tight junctions strands in the lateral membrane of intestinal epithelial cells. Cell Microbiol (2004) 1.34
Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16. Ann Neurol (2003) 1.33
Radiofrequency ablation for treatment of medically inoperable stage I non-small cell lung cancer. J Thorac Cardiovasc Surg (2008) 1.32
Diffusion-weighted imaging abnormalities in the splenium after seizures. Epilepsia (2003) 1.28
Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and follow-up in tuberous sclerosis complex. J Comput Assist Tomogr (2012) 1.27
Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation. Int J Radiat Oncol Biol Phys (2007) 1.23
Detailed semiautomated MRI based morphometry of the neonatal brain: preliminary results. Neuroimage (2006) 1.22
Size-optimized 32-channel brain arrays for 3 T pediatric imaging. Magn Reson Med (2011) 1.22
Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. Biomed Opt Express (2011) 1.20
An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21. Am J Hum Genet (2002) 1.20
Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells. Am J Physiol Gastrointest Liver Physiol (2006) 1.19
Acute fibrinous and organizing pneumonia in systemic lupus erythematosus: a case report and review of the literature. Pathol Int (2010) 1.19
Matrix metalloproteinase-9-deficient dendritic cells have impaired migration through tracheal epithelial tight junctions. Am J Respir Cell Mol Biol (2003) 1.15
Development of cerebral fiber pathways in cats revealed by diffusion spectrum imaging. Neuroimage (2009) 1.15
Utility of a new bolus-injectable nanoparticle for clinical cancer staging. Neoplasia (2007) 1.14
FDG PET/CT in assessment of pulmonary lymphangitic carcinomatosis. AJR Am J Roentgenol (2010) 1.12
New directions in clinical imaging of cortical dysplasias. Epilepsia (2009) 1.09
Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines. Ann N Y Acad Sci (2012) 1.06
PET and MR imaging: the odd couple or a match made in heaven? J Nucl Med (2013) 1.05
Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2. J Membr Biol (2007) 1.05
Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2. AJNR Am J Neuroradiol (2004) 1.05
Pediatric functional magnetic resonance imaging: progress and challenges. Top Magn Reson Imaging (2002) 1.04
Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy. Int J Radiat Oncol Biol Phys (2009) 1.03
Regional and hemispheric asymmetries of cerebral hemodynamic and oxygen metabolism in newborns. Cereb Cortex (2012) 1.03
Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates. Neuroimage (2013) 1.03
Probabilistic atlas can improve reconstruction from optical imaging of the neonatal brain. Opt Express (2009) 1.03
Vitamin D 1alpha-hydroxylase gene mutations in patients with 1alpha-hydroxylase deficiency. J Clin Endocrinol Metab (2007) 1.00
Can noise reduction filters improve low-radiation-dose chest CT images? Pilot study. Radiology (2003) 1.00
In vivo proton beam range verification using spine MRI changes. Int J Radiat Oncol Biol Phys (2010) 1.00
HPAF-II, a cell culture model to study pancreatic epithelial cell structure and function. Pancreas (2004) 0.99
Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy. Clin Imaging (2009) 0.98
Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation. Radiographics (2012) 0.98
Quantitative comparison and analysis of sulcal patterns using sulcal graph matching: a twin study. Neuroimage (2011) 0.96
Outcome of influenza infection managed with oseltamivir in lung transplant recipients. J Heart Lung Transplant (2008) 0.95
Regional infant brain development: an MRI-based morphometric analysis in 3 to 13 month olds. Cereb Cortex (2012) 0.94
Changes in white matter microstructure in patients with TLE and hippocampal sclerosis. Epileptic Disord (2009) 0.94
Case records of the Massachusetts General Hospital. Case 7-2009. A pregnant woman with a large mass in the fetal oral cavity. N Engl J Med (2009) 0.93
Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights. Cereb Cortex (2012) 0.92
Dendritic cells and the regulation of a granulomatous immune response in the lung. Am J Respir Cell Mol Biol (2002) 0.92
Patient recruitment into a multicenter randomized clinical trial for kidney disease: report of the focal segmental glomerulosclerosis clinical trial (FSGS CT). Clin Transl Sci (2012) 0.92
Non-invasive optical measurement of cerebral metabolism and hemodynamics in infants. J Vis Exp (2013) 0.92
Computed tomography (CT) of the chest at less than 1 mSv: an ongoing prospective clinical trial of chest CT at submillisievert radiation doses with iterative model image reconstruction and iDose4 technique. J Comput Assist Tomogr (2014) 0.91
Implantable diagnostic device for cancer monitoring. Biosens Bioelectron (2009) 0.91
Cholesterol depletion alters detergent-specific solubility profiles of selected tight junction proteins and the phosphorylation of occludin. Exp Cell Res (2007) 0.91
Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature. Pediatrics (2005) 0.91
Intrafamilial phenotypic variability in tuberous sclerosis complex. J Child Neurol (2007) 0.91
Changes in cerebral cortex of children treated for medulloblastoma. Int J Radiat Oncol Biol Phys (2007) 0.91
Diffusion-weighted imaging in neonates. Neuroimaging Clin N Am (2011) 0.90
Shape analysis with overcomplete spherical wavelets. Med Image Comput Comput Assist Interv (2008) 0.90
Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. PLoS One (2013) 0.89
Cloning and characterization of two neuropeptide genes from cereal cyst nematode, Heterodera avanae from India. Bioinformation (2012) 0.89
Associations between the size of the amygdala in infancy and language abilities during the preschool years in normally developing children. Neuroimage (2009) 0.89
Parenchymal abnormalities associated with cerebral venous sinus thrombosis: assessment with diffusion-weighted MR imaging. AJNR Am J Neuroradiol (2004) 0.88
Case records of the Massachusetts General Hospital. Case 26-2007 - a 61-year-old man with recurrent fevers. N Engl J Med (2007) 0.88
Proton magnetic resonance spectroscopy and diffusion-weighted imaging in isolated sulfite oxidase deficiency. J Child Neurol (2006) 0.87
Effect of MRI acoustic noise on cerebral fludeoxyglucose uptake in simultaneous MR-PET imaging. Invest Radiol (2013) 0.87
Diffusion MR imaging of acute ischemic stroke. Neuroimaging Clin N Am (2002) 0.87
Demographic determinants of risk, colon distribution and density scores of diverticular disease. World J Gastroenterol (2011) 0.86
A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting cerebral ischemic insults. Neuroimage (2012) 0.86
Radial and tangential neuronal migration pathways in the human fetal brain: anatomically distinct patterns of diffusion MRI coherence. Neuroimage (2013) 0.86
The relationship between the presence of sulcal pits and intelligence in human brains. Neuroimage (2011) 0.86
Effects of sutures and fontanels on MEG and EEG source analysis in a realistic infant head model. Neuroimage (2013) 0.86
Whole genome sequencing identifies SCN2A mutation in monozygotic twins with Ohtahara syndrome and unique neuropathologic findings. Epilepsia (2013) 0.86
Detection of postmortem human cerebellar cortex and white matter pathways using high angular resolution diffusion tractography: a feasibility study. Neuroimage (2012) 0.86
Treatment of deep intramuscular and musculoskeletal abscess: experience with 99 CT-guided percutaneous catheter drainage procedures. AJR Am J Roentgenol (2011) 0.85
Dynamic statistical parametric mapping for analyzing the magnetoencephalographic epileptiform activity in patients with epilepsy. J Child Neurol (2005) 0.84
ChRIS- A web-based neuroimaging and informatics system for collecting, organizing, processing, visualizing and sharing of medical data. Conf Proc IEEE Eng Med Biol Soc (2015) 0.84