Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors.

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Published in Ann Oncol on July 24, 2009

Authors

H A Wakelee1, A Patnaik, B I Sikic, M Mita, N L Fox, R Miceli, S J Ullrich, G A Fisher, A W Tolcher

Author Affiliations

1: Department of Medicine-Oncology, Stanford University, Stanford, CA 94305-5826, USA. hwakelee@stanford.edu

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Modulation of multidrug resistance: at the threshold. J Clin Oncol (1993) 1.28

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Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance. J Clin Oncol (1994) 1.25

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STRL22 is a receptor for the CC chemokine MIP-3alpha. Biochem Biophys Res Commun (1997) 1.13

Metabolism of round spermatids from rats: lactate as the preferred substrate. Biol Reprod (1982) 1.09

Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833. Oncol Res (1995) 1.09

Inhibition by brefeldin A of presentation of exogenous protein antigens to MHC class II-restricted T cells. Nature (1990) 1.08

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Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with node-positive breast cancer treated with either adjuvant chemotherapy or hormone therapy. Cancer J Sci Am (1999) 1.08

Correlation of CT findings with clinical evaluations in 261 patients with symptomatic bronchiectasis. AJR Am J Roentgenol (1999) 1.07

Continuous infusion or bolus injection in cancer chemotherapy. Ann Intern Med (1983) 1.06

Clinical studies with modulators of multidrug resistance. Hematol Oncol Clin North Am (1995) 1.06

Occupational allergy to laboratory animals: an epidemiologic study. J Occup Med (1986) 1.05

Clinical trials of modulation of multidrug resistance. Pharmacokinetic and pharmacodynamic considerations. Cancer (1993) 1.05

Tumour markers CEA, NSE, SCC, TPA and CYFRA 21.1 in resectable non-small cell lung cancer. Anticancer Res (2000) 1.04

Reoperation for locally recurrent breast cancer in patients previously treated with conservative surgery. Br J Surg (1999) 1.04

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Improved therapeutic index of bleomycin when administered by continuous infusion in mice. Cancer Treat Rep (1978) 1.02

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Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance. J Clin Oncol (1992) 1.01

Cloning, sequencing, and expression of Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase in Escherichia coli. Arch Biochem Biophys (1997) 1.01

Pulmonary toxicity of antitumor agents. Cancer Treat Rev (1983) 1.00

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Cloning and nucleotide sequence of the murine hsp84 cDNA and chromosome assignment of related sequences. Gene (1987) 0.97

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Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer. Clin Cancer Res (1999) 0.96

Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats. Am J Physiol Gastrointest Liver Physiol (2000) 0.96

Is steroid receptor profile in contralateral breast cancer a marker of independence of the corresponding primary tumour? Eur J Cancer (1998) 0.95

Dissociation of antitumor potency from anthracycline cardiotoxicity in a doxorubicin analog. Science (1985) 0.95

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