Published in Proc Natl Acad Sci U S A on October 01, 1992
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci U S A (1995) 4.22
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol (1992) 3.68
Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol Med (1995) 2.44
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J (1996) 2.12
The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest. J Virol (1994) 1.97
Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia. J Cell Biol (1993) 1.91
Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines. Proc Natl Acad Sci U S A (2000) 1.72
Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein. Proc Natl Acad Sci U S A (1994) 1.69
Human SWI-SNF component BRG1 represses transcription of the c-fos gene. Mol Cell Biol (1999) 1.68
High resolution melting for mutation scanning of TP53 exons 5-8. BMC Cancer (2007) 1.65
Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium. Am J Pathol (1996) 1.65
The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A (1996) 1.62
Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression. Mol Cell Biol (1993) 1.56
Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma. J Clin Invest (1995) 1.43
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression. Mol Cell Biol (1993) 1.42
Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. EMBO J (1995) 1.34
Homologous and nonhomologous recombination resulting in deletion: effects of p53 status, microhomology, and repetitive DNA length and orientation. Mol Cell Biol (2000) 1.29
p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements. Cell Cycle (2012) 1.25
Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53. Proc Natl Acad Sci U S A (1994) 1.24
Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53. Mol Cell Biol (1997) 1.17
Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Mol Cell Biol (1997) 1.13
Cytoplasmic p53 polypeptide is associated with ribosomes. Mol Cell Biol (1997) 1.12
Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts. Proc Natl Acad Sci U S A (1995) 1.10
Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest. Proc Natl Acad Sci U S A (1994) 1.08
Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53. Mol Cell Biol (1994) 1.08
Perturbation of the p53 response by human papillomavirus type 16 E7. J Virol (1997) 1.06
The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol (2002) 1.05
Overexpression of p53 and long-term survival in colon carcinoma. Br J Cancer (1994) 1.01
Post-thymic T cell lymphomas frequently overexpress p53 protein but infrequently exhibit p53 gene mutations. Am J Pathol (1994) 1.00
Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation. Nucleic Acids Res (1996) 0.99
Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter. Mol Cell Biol (1995) 0.97
A p53-independent damage-sensing mechanism that functions as a checkpoint at the G1/S transition in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1997) 0.97
hnRNP Q regulates translation of p53 in normal and stress conditions. Cell Death Differ (2012) 0.92
Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest. Mol Cell Biol (1995) 0.91
p53 expression during normal tissue regeneration in response to acute cutaneous injury in swine. J Clin Invest (1994) 0.88
Inducible growth arrest: new mechanistic insights. Proc Natl Acad Sci U S A (1994) 0.88
Molecular characterization of primary mediastinal B cell lymphoma. Am J Pathol (1996) 0.84
Absence of p21 expression is associated with abnormal p53 in human breast carcinomas. Br J Cancer (1997) 0.84
Molecular diagnosis of p53 mutations in gastric carcinoma by touch preparation. Am J Pathol (1996) 0.83
Cyclin E restores p53 activity in contact-inhibited cells. Mol Cell Biol (1995) 0.83
Effects of tachyplesin on the regulation of cell cycle in human hepatocarcinoma SMMC-7721 cells. World J Gastroenterol (2003) 0.80
Colostrinin-driven neurite outgrowth requires p53 activation in PC12 cells. Cell Mol Neurobiol (2005) 0.80
Anti-tumor activity of Eurycoma longifolia root extracts against K-562 cell line: in vitro and in vivo study. PLoS One (2014) 0.79
Census and evaluation of p53 target genes. Oncogene (2017) 0.77
Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest. J Virol (1999) 0.76
p53 and the PWWP domain containing effector proteins in chromatin damage repair. Cell Dev Biol (2013) 0.76
p53 mutation and expression in lymphoma. Br J Cancer (1995) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01
The p53 proto-oncogene can act as a suppressor of transformation. Cell (1989) 11.67
Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (1990) 11.18
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science (1987) 10.25
G1 events and regulation of cell proliferation. Science (1989) 9.73
A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A (1988) 7.47
Tumor suppressor genes. Science (1991) 5.72
Wild-type p53 can inhibit oncogene-mediated focus formation. Proc Natl Acad Sci U S A (1989) 5.40
p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol (1990) 5.20
Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83
Wild-type p53 can down-modulate the activity of various promoters. Proc Natl Acad Sci U S A (1991) 3.45
Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Cell (1989) 3.21
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc Natl Acad Sci U S A (1990) 3.20
A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro. Science (1988) 2.88
Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Proc Natl Acad Sci U S A (1991) 2.86
Isolation of human cDNA clones of myb-related genes, A-myb and B-myb. Nucleic Acids Res (1988) 2.26
Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression. Proc Natl Acad Sci U S A (1991) 1.99
An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines. Proc Natl Acad Sci U S A (1989) 1.98
G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb. Science (1989) 1.96
Temperature sensitive mutants of BHK cells affected in cell cycle progression. J Cell Physiol (1977) 1.76
Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors. J Biol Chem (1988) 1.70
Expression of thymidine kinase and dihydrofolate reductase genes in mammalian ts mutants of the cell cycle. J Biol Chem (1985) 1.55
Binding of the c-myb proto-oncogene product to the simian virus 40 enhancer stimulates transcription. J Biol Chem (1990) 1.53
Wild type human p53 is antiproliferative in SV40-transformed hamster cells. Oncogene (1990) 1.47
DNA binding activity and transcriptional activator function of the human B-myb protein compared with c-MYB. J Biol Chem (1990) 1.43
Gene expression during the mammalian cell cycle. Biochim Biophys Acta (1986) 1.37
Correlation between cell cycle duration and RNA content. J Cell Physiol (1979) 1.33
Expression of the p53 protein during the cell cycle of human peripheral blood lymphocytes. Exp Cell Res (1985) 1.27
Inhibition of T-cell proliferation by a MYB antisense oligomer is accompanied by selective down-regulation of DNA polymerase alpha expression. Proc Natl Acad Sci U S A (1990) 1.18
Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells. Oncogene (1992) 1.17
Protooncogene expression during the cell cycle. Lab Invest (1986) 1.16
A comparison of cell cycle-related changes in postmitotic and quiescent AF8 cells as measured by cytofluorometry after acridine orange staining. Cancer Res (1978) 1.05
Growth-dependent expression of human Mr 53,000 tumor antigen messenger RNA in normal and neoplastic cells. Cancer Res (1986) 0.98
Molecules involved in proliferation of normal and cancer cells: presidential address. Cancer Res (1987) 0.95
Effect of the myb gene product on expression of the PCNA gene in fibroblasts. Oncogene (1991) 0.89
Cell cycle analysis of human peripheral blood T lymphocytes in long-term culture. Exp Cell Res (1987) 0.81
TPA-induction of c-fos mRNA during the cell cycle of WI-38 human fibroblasts. Biochem Biophys Res Commun (1987) 0.79
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science (1992) 8.68
DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78
Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med (1988) 7.12
Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc Natl Acad Sci U S A (1994) 6.93
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci U S A (1979) 6.93
Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci U S A (1987) 6.90
The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science (1989) 6.89
Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs. Proc Natl Acad Sci U S A (1981) 6.67
Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science (1992) 5.99
DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev (1997) 5.76
Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J Exp Med (1994) 5.67
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90
Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett (1989) 4.75
Rapid analysis of amino acid phenylthiohydantoins by high-performance liquid chromatography. Anal Biochem (1977) 4.64
Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression. J Immunol (1995) 4.31
Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol (1998) 3.95
Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J Exp Med (1989) 3.89
NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science (1993) 3.74
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol (1992) 3.68
Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells. Proc Natl Acad Sci U S A (1982) 3.58
Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res (1994) 3.54
An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A (1990) 3.53
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J (1999) 3.46
Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science (1992) 3.39
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J (2001) 3.37
Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J (1990) 3.27
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature (2001) 3.25
Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41. J Cell Biol (1998) 3.23
H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J (1992) 3.21
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc Natl Acad Sci U S A (1990) 3.20
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A (1997) 3.19
Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus. Mol Cell Biol (1992) 3.10
A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J Exp Med (1996) 2.99
High-resolution structure of the oligomerization domain of p53 by multidimensional NMR. Science (1994) 2.98
DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy. Nucleic Acids Res (1987) 2.93
Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies. Mol Cell Biol (1984) 2.88
Refined solution structure of the oligomerization domain of the tumour suppressor p53. Nat Struct Biol (1995) 2.75
Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science (1988) 2.74
The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J Biol Chem (1987) 2.73
Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis. Proc Natl Acad Sci U S A (1989) 2.73
Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation. J Exp Med (1982) 2.58
Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer. J Immunol (1983) 2.45
Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein. Proc Natl Acad Sci U S A (1993) 2.41
Three-dimensional structure of interleukin 8 in solution. Biochemistry (1990) 2.40
Properties of monocyte chemotactic and activating factor (MCAF) purified from a human fibrosarcoma cell line. J Exp Med (1990) 2.40
Autocrine saturation of pro-urokinase receptors on human A431 cells. Cell (1986) 2.38
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J (2000) 2.38
Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J Exp Med (1996) 2.31
Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 2.22
Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes. J Immunol (1989) 2.12
Amino acid sequences of two mouse immunoglobulin lambda chains. Proc Natl Acad Sci U S A (1971) 2.12
Definition of specific peptide motifs for four major HLA-A alleles. J Immunol (1994) 2.11
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res (1991) 2.09
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J Biol Chem (2000) 2.08
A mouse tumor-specific transplantation antigen is a heat shock-related protein. Proc Natl Acad Sci U S A (1986) 2.06
A model for melanosome biogenesis based on the purification and analysis of early melanosomes. Proc Natl Acad Sci U S A (2001) 2.06
H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element. Proc Natl Acad Sci U S A (1989) 2.05
Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression. Proc Natl Acad Sci U S A (1991) 1.99
Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Proc Natl Acad Sci U S A (1994) 1.98
Gene transfer: DNA microinjection compared with DNA transfection with a very high efficiency. Mol Cell Biol (1982) 1.94
Crystal structure of interleukin 8: symbiosis of NMR and crystallography. Proc Natl Acad Sci U S A (1991) 1.92
Mechanisms influencing the immunodominance of T cell determinants. J Exp Med (1988) 1.91
Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells. Proc Natl Acad Sci U S A (1986) 1.90
Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles. Immunity (1997) 1.84
A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress. J Biol Chem (1995) 1.82
HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles. J Immunol (2000) 1.82
Purification and composition studies of phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase, the first enzyme of histidine biosynthesis. J Biol Chem (1967) 1.82
Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions. Proc Natl Acad Sci U S A (1989) 1.81
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A (2000) 1.80
Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet (1995) 1.80
Interferons increase transcription of a major histocompatibility class I gene via a 5' interferon consensus sequence. Mol Cell Biol (1987) 1.78
A common transformation-related protein in murine sarcomas and leukemias. Cold Spring Harb Symp Quant Biol (1980) 1.74
Interferon-induced transcription of a major histocompatibility class I gene accompanies binding of inducible nuclear factors to the interferon consensus sequence. Proc Natl Acad Sci U S A (1988) 1.73
Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS. J Biol Chem (2000) 1.72
Modulation of metastatic potential by cell surface urokinase of murine melanoma cells. Cancer Res (1988) 1.70
Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. FEBS Lett (1999) 1.68
Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53. Biochemistry (1997) 1.66
High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry (1990) 1.64
p53 regulates the expression of the tumor suppressor gene maspin. J Biol Chem (2000) 1.64
Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science (1992) 1.63
Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression. Oncogene (1993) 1.63
The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum. J Biol Chem (1987) 1.62
Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes. J Virol (2001) 1.62
Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. J Biol Chem (1992) 1.59
Binding of multiple nuclear factors to the 5' upstream regulatory element of the murine major histocompatibility class I gene. Mol Cell Biol (1987) 1.59
An approach to proteomic analysis of human tumors. Mol Carcinog (2000) 1.57