Published in Biol Psychiatry on July 29, 2009
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol (2012) 3.31
Astrocyte scar formation aids central nervous system axon regeneration. Nature (2016) 2.51
The genetics of child psychiatric disorders: focus on autism and Tourette syndrome. Neuron (2010) 1.57
Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2013) 1.22
The genetics of Tourette syndrome. Nat Rev Neurol (2012) 1.13
Slitrks as emerging candidate genes involved in neuropsychiatric disorders. Trends Neurosci (2011) 1.04
IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem (2014) 1.02
The genetics of Tourette disorder. Curr Opin Genet Dev (2011) 0.99
The Inheritance of Tourette Disorder: A review. J Obsessive Compuls Relat Disord (2014) 0.91
Control of neural circuit formation by leucine-rich repeat proteins. Trends Neurosci (2014) 0.89
Animal models of tic disorders: a translational perspective. J Neurosci Methods (2014) 0.87
The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks. Mol Cells (2012) 0.84
The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods. Eur Child Adolesc Psychiatry (2014) 0.80
Characterization of SLITRK1 variation in obsessive-compulsive disorder. PLoS One (2013) 0.79
Tourette syndrome: gene expression as a tool to discover drug targets. Neurotherapeutics (2010) 0.77
Porcine SLITRK1: Molecular cloning and characterization. FEBS Open Bio (2014) 0.75
Slitrk1 is localized to excitatory synapses and promotes their development. Sci Rep (2016) 0.75
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. Hum Mol Genet (2015) 0.75
Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies. Front Neurosci (2016) 0.75
14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease. Neuroscience (2015) 0.75
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron (2011) 10.61
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet (2009) 3.42
A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet (2011) 3.13
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proc Natl Acad Sci U S A (2005) 2.76
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet (2013) 2.76
Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism (2012) 2.67
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. JAMA (2013) 2.58
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders. Neuron (2013) 2.45
Sequence kernel association tests for the combined effect of rare and common variants. Am J Hum Genet (2013) 2.41
Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nat Neurosci (2004) 2.28
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J Neurosci (2010) 2.20
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Strong synaptic transmission impact by copy number variations in schizophrenia. Proc Natl Acad Sci U S A (2010) 1.85
Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks. Biol Psychiatry (2009) 1.85
Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa. Am J Hum Genet (2011) 1.85
A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism. Proc Natl Acad Sci U S A (2012) 1.85
The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders. Trends Neurosci (2009) 1.84
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. PLoS Genet (2010) 1.80
Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice. J Neurosci (2012) 1.71
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet (2011) 1.63
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Arch Neurol (2009) 1.61
Family-based association tests for sequence data, and comparisons with population-based association tests. Eur J Hum Genet (2013) 1.55
Analysis of rare, exonic variation amongst subjects with autism spectrum disorders and population controls. PLoS Genet (2013) 1.53
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci (2012) 1.52
Whole exome sequencing reveals minimal differences between cell line and whole blood derived DNA. Genomics (2013) 1.51
The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo. J Neurosci (2003) 1.50
Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes. PLoS Genet (2013) 1.48
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet (2011) 1.43
Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Am J Psychiatry (2004) 1.40
Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder. Am J Hum Genet (2013) 1.39
A genome-wide study reveals copy number variants exclusive to childhood obesity cases. Am J Hum Genet (2010) 1.36
Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia. Prog Neurobiol (2010) 1.36
Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions. Autism Res (2010) 1.35
Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiol Aging (2006) 1.32
Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency. Mol Autism (2013) 1.32
An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene. Am J Med Genet B Neuropsychiatr Genet (2008) 1.31
Altered Abeta formation and long-term potentiation in a calsenilin knock-out. J Neurosci (2003) 1.27
A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatr Genet (2003) 1.25
Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proc Natl Acad Sci U S A (2006) 1.25
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions. Nat Genet (2002) 1.24
Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasets. Am J Hum Genet (2012) 1.23
Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia. Neurochem Res (2002) 1.23
Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD. Front Psychiatry (2013) 1.22
Symptom domains in autism and related conditions: evidence for familiality. Am J Med Genet (2002) 1.21
Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay. Mol Autism (2013) 1.20
DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics. Mol Autism (2014) 1.20
Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model. PLoS One (2009) 1.19
The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol Cell Neurosci (2002) 1.18
The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures. Hum Mutat (2013) 1.17
The increasing prevalence of reported diagnoses of childhood psychiatric disorders: a descriptive multinational comparison. Eur Child Adolesc Psychiatry (2014) 1.16
A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Biochim Biophys Acta (2004) 1.15
Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: efficient identification of known microduplications and identification of a novel microduplication in ASMT. BMC Med Genomics (2008) 1.15
SHANK3 haploinsufficiency: a "common" but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders. Mol Autism (2013) 1.14
Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism. Proc Natl Acad Sci U S A (2013) 1.13
Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brain. J Neurosci Methods (2007) 1.12
Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait. Biol Psychiatry (2013) 1.11
Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks. Dis Markers (2011) 1.11
Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism. Am J Med Genet B Neuropsychiatr Genet (2008) 1.08
Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development. Mol Cell Biol (2006) 1.06
Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Arch Gen Psychiatry (2006) 1.04
In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism. Brain Res (2010) 1.03
A large-scale survey of the novel 15q24 microdeletion syndrome in autism spectrum disorders identifies an atypical deletion that narrows the critical region. Mol Autism (2010) 1.03
Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS One (2012) 1.01
Network topologies and convergent aetiologies arising from deletions and duplications observed in individuals with autism. PLoS Genet (2013) 1.00
Linking white and grey matter in schizophrenia: oligodendrocyte and neuron pathology in the prefrontal cortex. Front Neuroanat (2009) 0.99
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. Eur J Hum Genet (2011) 0.99
Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Hum Mol Genet (2004) 0.99
AnnTools: a comprehensive and versatile annotation toolkit for genomic variants. Bioinformatics (2012) 0.99
Familial symptom domains in monozygotic siblings with autism. Am J Med Genet B Neuropsychiatr Genet (2004) 0.98
Lack of evidence for association of the serotonin transporter gene SLC6A4 with autism. Biol Psychiatry (2006) 0.95
A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching. Mol Cell Neurosci (2007) 0.95
Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide. J Neurosci (2012) 0.95
Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine. BMC Genomics (2007) 0.95
Brief report: the Autism Mental Status Examination: development of a brief autism-focused exam. J Autism Dev Disord (2012) 0.94
Analysis of a purported SHANK3 mutation in a boy with autism: clinical impact of rare variant research in neurodevelopmental disabilities. Brain Res (2010) 0.93
Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders. Biol Psychiatry (2009) 0.92
Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. Gene (2006) 0.92
The genetics of autism spectrum disorders. Neuromolecular Med (2006) 0.92
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PLoS One (2009) 0.91
BACE1 and BACE2 in pathologic and normal human muscle. Exp Neurol (2003) 0.91
Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor. J Neurochem (2007) 0.90
Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2. Autism Res (2014) 0.90
Multiplexed variation scanning for 1,000 amplicons in hundreds of patients using mismatch repair detection (MRD) on tag arrays. Proc Natl Acad Sci U S A (2005) 0.90
Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold. Mol Neurodegener (2011) 0.89
Network- and attribute-based classifiers can prioritize genes and pathways for autism spectrum disorders and intellectual disability. Am J Med Genet C Semin Med Genet (2012) 0.88
Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling. FASEB J (2011) 0.88