The genetics of Tourette disorder.

Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biol Psychiatry (2011) 2.28

Tourette syndrome and other tic disorders in childhood, adolescence and adulthood. Dtsch Arztebl Int (2012) 1.72

Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron (2014) 1.45

The genetics of Tourette syndrome. Nat Rev Neurol (2012) 1.13

Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism. Transl Psychiatry (2012) 0.98

CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1. PLoS One (2013) 0.94

Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear. Neurosci Lett (2015) 0.88

Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome. Eur Neuropsychopharmacol (2014) 0.85

Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder. Mov Disord (2013) 0.83

Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition. Exp Neurol (2015) 0.80

The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods. Eur Child Adolesc Psychiatry (2014) 0.80

Genetic Approaches to Understanding Psychiatric Disease. Neurotherapeutics (2017) 0.80

Association of the KCNJ5 gene with Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder. Genes Brain Behav (2014) 0.77

The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery. Front Neurosci (2016) 0.77

Genetic susceptibility and neurotransmitters in Tourette syndrome. Int Rev Neurobiol (2013) 0.76

Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies. Front Neurosci (2016) 0.75

Slitrk Missense Mutations Associated with Neuropsychiatric Disorders Distinctively Impair Slitrk Trafficking and Synapse Formation. Front Mol Neurosci (2016) 0.75

Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population. PLoS One (2015) 0.75

Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature (2008) 20.31

Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet (2003) 15.31

Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47

Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science (2005) 8.20

Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am J Hum Genet (2008) 7.13

Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am J Hum Genet (2008) 5.44

Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2. N Engl J Med (2006) 5.28

A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism. Am J Hum Genet (2008) 5.28

X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. Am J Hum Genet (2004) 5.15

Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet (2008) 5.04

Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nat Genet (2008) 4.87

Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet (2008) 4.78

An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol (2000) 3.99

Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. Mol Psychiatry (2009) 3.56

Histamine in the nervous system. Physiol Rev (2008) 3.47

CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy. Mol Psychiatry (2007) 3.44

Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet (2009) 3.42

Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies. PLoS Genet (2010) 3.39

L-histidine decarboxylase and Tourette's syndrome. N Engl J Med (2010) 2.92

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med (2010) 2.75

CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila. Am J Hum Genet (2009) 2.41

The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission. N Engl J Med (1986) 2.30

CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. Genomics (2003) 2.29

Neurexin 1 (NRXN1) deletions in schizophrenia. Schizophr Bull (2009) 2.25

Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Am J Med Genet B Neuropsychiatr Genet (2010) 2.12

Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biol Psychiatry (2010) 2.07

Tourette syndrome is associated with recurrent exonic copy number variants. Neurology (2010) 1.99

Familial deletion within NLGN4 associated with autism and Tourette syndrome. Eur J Hum Genet (2008) 1.97

The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies. J Psychosom Res (2008) 1.88

Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses. Hum Mol Genet (2006) 1.84

Gilles de la Tourette's syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship. Arch Gen Psychiatry (1986) 1.83

Neurexin 1alpha structural variants associated with autism. Neurosci Lett (2008) 1.80

Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Sci Transl Med (2010) 1.72

A twin study of Tourette syndrome. Arch Gen Psychiatry (1985) 1.65

Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families. Am J Hum Genet (2007) 1.60

A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Schizophr Res (2010) 1.60

Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. Mol Cell Neurosci (2003) 1.57

The genetics of child psychiatric disorders: focus on autism and Tourette syndrome. Neuron (2010) 1.57

Copy number variation in schizophrenia in the Japanese population. Biol Psychiatry (2009) 1.49

High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Mol Psychiatry (2009) 1.45

Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities. Mol Psychiatry (2008) 1.41

Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31 associated with Tourette syndrome. Am J Hum Genet (2001) 1.37

A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome. The Tourette Syndrome Association International Consortium for Genetics. Am J Hum Genet (1999) 1.35

The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: a cross-cultural perspective. J Psychosom Res (2009) 1.32

Familial pattern of Gilles de la Tourette syndrome. Arch Gen Psychiatry (1980) 1.30

Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome. Acta Neurol Scand (2006) 1.26

Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance. Am J Hum Genet (1996) 1.24

Familial pattern and transmission of Gilles de la Tourette syndrome and multiple tics. Arch Gen Psychiatry (1981) 1.21

TCF4, schizophrenia, and Pitt-Hopkins Syndrome. Schizophr Bull (2010) 1.15

Genetic analysis of Tourette syndrome suggesting major gene effect. Am J Hum Genet (1981) 1.14

Lack of association between SLITRK1var321 and Tourette syndrome in a large family-based sample. Neurology (2008) 1.14

Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders. Mol Interv (2006) 1.13

Increased methamphetamine-induced locomotor activity and behavioral sensitization in histamine-deficient mice. J Neurochem (2002) 1.12

The epidemiology of Tourette's syndrome: a pilot study. Schizophr Bull (1982) 1.10

Intermediate inheritance of Tourette syndrome, assuming assortative mating. Am J Hum Genet (1995) 1.07

The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes. J Psychosom Res (2008) 1.07

Pathophysiology of Tourette's syndrome: striatal pathways revisited. Brain Dev (2003) 1.06

SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner. Biol Psychiatry (2009) 1.05

Autosomal dominant gene transmission in a large kindred with Gilles de la Tourette syndrome. Br J Psychiatry (1992) 1.05

Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, Tourette's syndrome, and healthy controls. Neuropsychopharmacology (1995) 1.05

Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. J Comp Neurol (2009) 1.04

Significant linkage for Tourette syndrome in a large French Canadian family. Am J Hum Genet (2000) 1.04

Association of the Slit and Trk-like 1 gene in Taiwanese patients with Tourette syndrome. Pediatr Neurol (2007) 1.03

Bilineal transmission in Tourette's syndrome families. Neurology (1994) 1.03

Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proc Natl Acad Sci U S A (2003) 1.01

Family-based genetic association study of DLGAP3 in Tourette Syndrome. Am J Med Genet B Neuropsychiatr Genet (2010) 0.97

Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder. Psychiatr Genet (2008) 0.97

Additional support for the association of SLITRK1 var321 and Tourette syndrome. Mol Psychiatry (2010) 0.96

Molecular and genomic studies of IMMP2L and mutation screening in autism and Tourette syndrome. Mol Genet Genomics (2006) 0.95

Association of SLITRK1 to Gilles de la Tourette Syndrome. Am J Med Genet B Neuropsychiatr Genet (2009) 0.95

Genetic and clinical analysis of a large Dutch Gilles de la Tourette family. Mol Psychiatry (2006) 0.94

Candidate region for Gilles de la Tourette syndrome at 7q31. Am J Med Genet (2001) 0.91

Bilineal transmission and phenotypic variation of Tourette's disorder in a large pedigree. J Am Acad Child Adolesc Psychiatry (1996) 0.91

Tourette syndrome and klippel-feil anomaly in a child with chromosome 22q11 duplication. Case Rep Med (2009) 0.90

Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate. Psychiatr Genet (2010) 0.89

Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13. Psychiatr Genet (2004) 0.88

A patient with both Gilles de la Tourette's syndrome and chromosome 22q11 deletion syndrome: clue to the genetics of Gilles de la Tourette's syndrome? J Psychosom Res (2006) 0.87

Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. Am J Med Genet A (2004) 0.84

Bilineal transmission in Tourette syndrome. Neurology (1999) 0.83

Polymorphisms of interleukin 1 gene IL1RN are associated with Tourette syndrome. Pediatr Neurol (2010) 0.83

Tourette disorder spectrum maps to chromosome 14q31.1 in an Italian kindred. Neurogenetics (2010) 0.82

Linkage analysis of Tourette syndrome in a large Utah pedigree. Am J Med Genet B Neuropsychiatr Genet (2010) 0.82

Translocation breakpoint in two unrelated Tourette syndrome cases, within a region previously linked to the disorder. Hum Genet (2003) 0.81

Rare NRXN1 promoter variants in patients with schizophrenia. Neurosci Lett (2010) 0.81

Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. Am J Med Genet B Neuropsychiatr Genet (2009) 0.81

An individual with Gilles de la Tourette syndrome and Smith-Magenis microdeletion syndrome: is chromosome 17p11.2 a candidate region for Tourette syndrome putative susceptibility genes? J Intellect Disabil Res (2007) 0.80

Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. Am J Med Genet B Neuropsychiatr Genet (2008) 0.79

Genome-wide TDT analysis in French-Canadian families with Tourette syndrome. Can J Neurol Sci (2010) 0.76

Tourette's syndrome is not associated with interleukin-10 receptor 1 variants on chromosome 11q23.3. Psychiatry Res (2007) 0.75