Modern approaches to pediatric brain injury therapy.

PubWeight™: 0.84‹?›

🔗 View Article (PMC 2874892)

Published in J Trauma on August 01, 2009

Authors

Peter A Walker1, Matthew T Harting, James E Baumgartner, Stephen Fletcher, Nathan Strobel, Charles S Cox

Author Affiliations

1: Department of Pediatric Surgery, University of Texas Medical School at Houston, Texas 77030, USA.

Articles cited by this

Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med (2002) 21.40

Marrow stromal cells as stem cells for nonhematopoietic tissues. Science (1997) 17.06

Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood (2004) 13.79

Mesenchymal stem cells as trophic mediators. J Cell Biochem (2006) 9.38

The stem-cell niche as an entity of action. Nature (2006) 7.73

Classification of traumatic brain injury for targeted therapies. J Neurotrauma (2008) 3.58

Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial. JAMA (2004) 3.54

Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science (2002) 3.18

Pathophysiology of traumatic brain injury. Br J Anaesth (2007) 3.06

Cerebral metabolic suppression during hypothermic circulatory arrest in humans. Ann Thorac Surg (1999) 2.90

Edema and brain trauma. Neuroscience (2004) 2.78

Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg (1997) 2.68

The incidence of traumatic brain injury among children in the United States: differences by race. J Head Trauma Rehabil (2005) 2.66

Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci U S A (2003) 2.59

Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells (2005) 2.52

New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. J Clin Oncol (2003) 2.19

Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke (2008) 2.18

A prospective, randomized, and controlled study of fluid management in children with severe head injury: lactated Ringer's solution versus hypertonic saline. Crit Care Med (1998) 2.17

Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci (1995) 2.13

Posttraumatic vasospasm: the epidemiology, severity, and time course of an underestimated phenomenon: a prospective study performed in 299 patients. J Neurosurg (2005) 2.11

Animal models of head trauma. NeuroRx (2005) 2.09

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke (1989) 2.00

Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. J Neurosurg (2005) 1.99

Use of hypertonic saline in the treatment of severe refractory posttraumatic intracranial hypertension in pediatric traumatic brain injury. Crit Care Med (2000) 1.98

Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography. J Neurosurg (1992) 1.88

Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurgery (2001) 1.87

Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuroprotective therapy. J Cereb Blood Flow Metab (2006) 1.86

Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res (2002) 1.85

Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury. Crit Care Med (2000) 1.82

Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem Int (2006) 1.81

Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp Neurol (2006) 1.69

Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery (2005) 1.64

Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells (2007) 1.59

Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy. Surgery (2008) 1.59

Influence of early variables in traumatic brain injury on functional independence measure scores and rehabilitation length of stay and charges. Arch Phys Med Rehabil (1995) 1.59

Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant (2002) 1.57

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation (2008) 1.57

Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysis. J Neurotrauma (2008) 1.55

Central pontine myelinolysis. Eur Neurol (2002) 1.50

Traumatic brain injury: assessment, resuscitation and early management. Br J Anaesth (2007) 1.49

Early microvascular and neuronal consequences of traumatic brain injury: a light and electron microscopic study in rats. J Neurotrauma (1994) 1.36

Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma (1997) 1.36

Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model. Brain Res (2007) 1.35

Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia. J Neurotrauma (2007) 1.34

Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers. J Neurosci Res (2007) 1.33

Long-term recovery after bone marrow stromal cell treatment of traumatic brain injury in rats. J Neurosurg (2006) 1.27

Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts. Neuropathology (2007) 1.26

Serum biomarker concentrations and outcome after pediatric traumatic brain injury. J Neurotrauma (2007) 1.24

The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury. J Neuropathol Exp Neurol (1999) 1.23

Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury. Exp Neurol (2006) 1.18

Evidence for prolonged release of excitatory amino acids in severe human head trauma. Relationship to clinical events. Ann N Y Acad Sci (1995) 1.16

Hypertonic saline: a clinical review. Neurosurg Rev (2007) 1.13

Quantitative relationship between brain temperature and energy utilization rate measured in vivo using 31P and 1H magnetic resonance spectroscopy. Pediatr Res (1995) 1.12

Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem (1995) 1.11

Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients. J Neurosurg (2000) 1.11

Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine. Mediators Inflamm (2008) 1.08

Time of hypotension and discharge outcome in children with severe traumatic brain injury. J Neurotrauma (2008) 1.08

Outcomes following childhood head injury: a population study. J Neurol Neurosurg Psychiatry (2004) 1.08

Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury. J Neurotrauma (2002) 1.06

MR imaging in the detection of diffuse axonal injury with mild traumatic brain injury. Neurol Res (2008) 1.00

Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. J Neurotrauma (1999) 0.95

Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats. J Neurotrauma (2008) 0.95

Plasma expanders. An update. Am J Surg (1988) 0.95

Hypertonic sodium resuscitation is associated with renal failure and death. Ann Surg (1995) 0.93

Volume replacement with lactated Ringer's or 3% hypertonic saline solution during combined experimental hemorrhagic shock and traumatic brain injury. J Trauma (2006) 0.90

Metabotropic glutamate receptor antagonists and agonists: potential neuroprotectors in diffuse brain injury. J Clin Neurosci (2006) 0.90

A comparison of hypertonic to isotonic fluid in the resuscitation of brain injury and hemorrhagic shock. J Surg Res (1991) 0.90

Hypothermia for neuroprotection after cardiac arrest: mechanisms, clinical trials and patient care. J Neurol Sci (2007) 0.89

The effect of hypothermia on H2O2 production during ischemia and reperfusion: a microdialysis study in the gerbil hippocampus. Neurosci Lett (1997) 0.89

Comparison between hypertonic saline and mannitol in the reduction of elevated intracranial pressure in a rodent model of acute cerebral injury. J Neurosurg Anesthesiol (2000) 0.87

Factors influencing admission among children with a traumatic brain injury. Acad Emerg Med (2002) 0.87

Long-term survival of transplanted stem cells in immunocompetent mice with muscular dystrophy. Am J Pathol (2008) 0.86

Neonatal ischemic neuroprotection by modest hypothermia is associated with attenuated brain acidosis. Stroke (1995) 0.85

Definitions and criteria for stem cells. Methods Mol Biol (2008) 0.84

Combined hemorrhagic shock and head injury: effects of hypertonic saline (7.5%) resuscitation. J Trauma (1991) 0.83

Malignant cerebral edema in patients with hypertensive intracerebral hemorrhage associated with hypertonic saline infusion: a rebound phenomenon? J Neurosurg Anesthesiol (1998) 0.83

Intra-ischemic hypothermia attenuates intercellular adhesion molecule-1 (ICAM-1) and migration of neutrophil. Neurol Res (2001) 0.82

Challenging the gold standard: should mannitol remain our first-line defense against intracranial hypertension? J Neurosci Nurs (2008) 0.82

Preliminary outcome analysis of a long-term rehabilitation program for severe acquired brain injury. Arch Phys Med Rehabil (2000) 0.81

Changes in brain organic osmolytes in experimental cerebral ischemia. J Neurol Sci (1998) 0.80

Relative effects of mannitol and hypertonic saline on calpain activity, apoptosis and polymorphonuclear infiltration in traumatic focal brain injury. Brain Res (2006) 0.79

A case report of syndrome of inappropriate secretion of antidiuretic hormone with marked edema due to administration of hypertonic saline. Ther Apher Dial (2007) 0.78

Hypothermia inhibits translocation of CaM kinase II and PKC-alpha, beta, gamma isoforms and fodrin proteolysis in rat brain synaptosome during ischemia-reperfusion. J Neurosci Res (2002) 0.78

Traumatic brain injury in children--clinical implications. Exp Toxicol Pathol (2004) 0.77

Variations of p38 MAPK and sICAM-1 with therapeutic effect of different resuscitation fluids on severe traumatic patients. Chin J Traumatol (2007) 0.76

Articles by these authors

Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev (2009) 3.43

Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A (2005) 2.56

Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States. Genet Med (2007) 2.20

Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats. J Cereb Blood Flow Metab (2009) 1.80

Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann Neurol (2011) 1.64

Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy. Surgery (2008) 1.59

Life-threatening hyperkalaemia following therapeutic barbiturate coma. Intensive Care Med (2002) 1.54

Intravenous mesenchymal stem cell therapy for traumatic brain injury. J Neurosurg (2009) 1.51

Long-term survival after aggressive resection of pulmonary metastases among children and adolescents with osteosarcoma. J Pediatr Surg (2006) 1.50

Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling. Stem Cells Dev (2010) 1.44

Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: preserving the blood brain barrier via an interaction with splenocytes. Exp Neurol (2010) 1.42

Arrested development and disrupted callosal microstructure following pediatric traumatic brain injury: relation to neurobehavioral outcomes. Neuroimage (2008) 1.33

Late intellectual and academic outcomes following traumatic brain injury sustained during early childhood. J Neurosurg (2006) 1.32

Stability of common biochemical analytes in serum gel tubes subjected to various storage temperatures and times pre-centrifugation. Ann Clin Biochem (2008) 1.16

Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. Am J Physiol Heart Circ Physiol (2008) 1.16

Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population. J Neuroinflammation (2012) 1.15

Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children. Neurosurgery (2011) 1.14

Subacute neural stem cell therapy for traumatic brain injury. J Surg Res (2008) 1.14

Selective knockout of gold active sites. Angew Chem Int Ed Engl (2010) 1.13

Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB-mediated increase in interleukin-6 production. Stem Cells Dev (2010) 1.10

Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock. PLoS One (2011) 1.10

Age as a prognostic factor for patients with osteosarcoma: an analysis of 438 patients. J Cancer Res Clin Oncol (2009) 1.10

Mesenchymal stem cells regulate blood-brain barrier integrity through TIMP3 release after traumatic brain injury. Sci Transl Med (2012) 1.09

Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol (2013) 1.07

Progenitor cell therapies for traumatic brain injury: barriers and opportunities in translation. Dis Model Mech (2009) 1.03

Resuscitation-induced intestinal edema decreases the stiffness and residual stress of the intestine. Shock (2005) 1.03

Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Crit Care Med (2007) 1.03

Intestinal edema decreases intestinal contractile activity via decreased myosin light chain phosphorylation. Crit Care Med (2006) 1.03

Resuscitation-induced gut edema and intestinal dysfunction. J Trauma (2005) 1.01

Congenital diaphragmatic hernia in the preterm infant. Surgery (2010) 1.00

Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury. Shock (2005) 0.99

Edema-induced intestinal dysfunction is mediated by STAT3 activation. Shock (2007) 0.97

Neuroimaging features of epidermal nevus syndrome. AJNR Am J Neuroradiol (2003) 0.96

Admission rapid thrombelastography delivers real-time "actionable" data in pediatric trauma. J Pediatr Surg (2013) 0.96

Human mesenchymal stem cells inhibit endothelial proliferation and angiogenesis via cell-cell contact through modulation of the VE-Cadherin/β-catenin signaling pathway. Stem Cells Dev (2012) 0.96

Effects of primary and secondary intra-abdominal hypertension on mesenteric lymph flow: implications for the abdominal compartment syndrome. Shock (2005) 0.96

Hypertonic saline resuscitation prevents hydrostatically induced intestinal edema and ileus. Crit Care Med (2006) 0.96

Effect of needle diameter and flow rate on rat and human mesenchymal stromal cell characterization and viability. Tissue Eng Part C Methods (2010) 0.95

Intravenous multipotent adult progenitor cell therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury. Stem Cells Transl Med (2013) 0.95

Immunomagnetic enrichment and flow cytometric characterization of mouse microglia. J Neurosci Methods (2013) 0.94

Bone marrow-derived stromal cell therapy for traumatic brain injury is neuroprotective via stimulation of non-neurologic organ systems. Surgery (2012) 0.94

Component separation for complex congenital abdominal wall defects: not just for adults anymore. J Pediatr Surg (2013) 0.94

Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(β-TRCP) in neuroblastoma cells. Cancer (2011) 0.93

The effect of LVAD aortic outflow-graft placement on hemodynamics and flow: Implantation technique and computer flow modeling. Tex Heart Inst J (2005) 0.90

Measurement of intestinal edema using an impedance analyzer circuit. J Surg Res (2006) 0.90

Cell therapies for traumatic brain injury. Neurosurg Focus (2008) 0.89

Patients with impending abdominal compartment syndrome do not respond to early volume loading. Am J Surg (2003) 0.89

Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat. J Trauma (2011) 0.89

Autologous bone marrow mononuclear cells therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury. J Trauma Acute Care Surg (2013) 0.87

Nuclear factor-kappaB activation by edema inhibits intestinal contractile activity. Crit Care Med (2010) 0.87

Sequelae of recurrent laryngeal nerve injury after patent ductus arteriosus ligation. Int J Pediatr Otorhinolaryngol (2006) 0.87

Induction of cardioplegic arrest immediately activates the myocardial apoptosis signal pathway. Am J Physiol Heart Circ Physiol (2006) 0.87

Effects of nonocclusive mesenteric hypertension on intestinal function: implications for gastroschisis-related intestinal dysfunction. Pediatr Res (2012) 0.86

Integrating sensory and motor mapping in a comprehensive MEG protocol: clinical validity and replicability. Neuroimage (2004) 0.86

Mild hypothermia impairs left ventricular diastolic but not systolic function. J Invest Surg (2005) 0.86

Resuscitation-induced intestinal edema and related dysfunction: state of the science. J Surg Res (2009) 0.86

Working memory and corpus callosum microstructural integrity after pediatric traumatic brain injury: a diffusion tensor tractography study. J Neurotrauma (2013) 0.86

A novel physiologic model for the study of abdominal compartment syndrome (ACS). J Trauma (2010) 0.86

Massive nodular melanoma: a case report. Dermatol Online J (2007) 0.86

Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. J Pediatr Surg (2011) 0.86

Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem (2014) 0.85

Acute hemodynamic decompensation following patent ductus arteriosus ligation in premature infants. J Invest Surg (2008) 0.85

ECMO for meconium aspiration syndrome: support for relaxed entry criteria. ASAIO J (2007) 0.85

Dietary fiber enhances TGF-β signaling and growth inhibition in the gut. Am J Physiol Gastrointest Liver Physiol (2011) 0.85

Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children. Pediatr Crit Care Med (2015) 0.85

Regional hypothermia reduces mucosal NF-kappaB and PMN priming via gut lymph during canine mesenteric ischemia/reperfusion. J Surg Res (2003) 0.85

Application and machine accuracy of a new frameless computed tomography-guided stereotactic brain biopsy system in dogs. Vet Radiol Ultrasound (2013) 0.84

Is it time to replace the Wada test and put awake craniotomy to sleep? Epilepsia (2014) 0.84

Molding helmet therapy in the treatment of brachycephaly and plagiocephaly. J Craniofac Surg (2004) 0.84

A novel mechanism for neutrophil priming in trauma: potential role of peritoneal fluid. Surgery (2010) 0.84

The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest. J Thorac Cardiovasc Surg (2003) 0.84

Isolation of mesenchymal stem cells (MSCs) from green fluorescent protein positive (GFP+) transgenic rodents: the grass is not always green(er). Stem Cells Dev (2010) 0.84

Strategies for modulating the inflammatory response after decompression from abdominal compartment syndrome. Scand J Trauma Resusc Emerg Med (2012) 0.84

Hypertonic saline alters hydraulic conductivity and up-regulates mucosal/submucosal aquaporin 4 in resuscitation-induced intestinal edema. Crit Care Med (2009) 0.84

Long-term treatment effectiveness of molding helmet therapy in the correction of posterior deformational plagiocephaly: a five-year follow-up. Cleft Palate Craniofac J (2007) 0.84

Localization of ictal and interictal bursting epileptogenic activity in focal cortical dysplasia: agreement of magnetoencephalography and electrocorticography. Neurol Res (2002) 0.83

Optimization of TaDREB3 gene expression in transgenic barley using cold-inducible promoters. Plant Biotechnol J (2013) 0.83

Effects of poloxamer 188 on human PMN cells. Surgery (2008) 0.83

Microscopic minimally invasive approach to nonsyndromic craniosynostosis. J Craniofac Surg (2009) 0.83

Seventy-one important questions for the conservation of marine biodiversity. Conserv Biol (2014) 0.82

Mean diffusivity in the amygdala correlates with anxiety in pediatric TBI. Brain Imaging Behav (2012) 0.82

Pretreatment with bone morphogenetic protein-7 (BMP-7) mimics ischemia preconditioning following intestinal ischemia/reperfusion injury in the intestine and liver. Shock (2008) 0.81

Surgical management of metastatic melanoma to the ventricle. Tex Heart Inst J (2003) 0.81

The pulmonary first-pass effect, xenotransplantation and translation to clinical trials--a commentary. Brain (2008) 0.81

Progenitor cell therapy for the treatment of central nervous system injury: a review of the state of current clinical trials. Stem Cells Int (2010) 0.81

Delayed institution of extracorporeal membrane oxygenation is associated with increased mortality rate and prolonged hospital stay. J Pediatr Surg (2002) 0.81