Published in J Struct Funct Genomics on August 22, 2009
Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 1.49
Control of translation efficiency in yeast by codon-anticodon interactions. RNA (2010) 1.46
High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 1.37
The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA. Genes Dev (2011) 1.28
ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments. Nat Methods (2015) 1.17
A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris. PLoS One (2011) 1.08
Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. RNA (2012) 1.05
Purification of transmembrane proteins from Saccharomyces cerevisiae for X-ray crystallography. Protein Expr Purif (2010) 1.05
Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase. Nucleic Acids Res (2011) 0.96
Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1. RNA (2013) 0.95
Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1. Hum Mutat (2015) 0.91
RNA-ID, a highly sensitive and robust method to identify cis-regulatory sequences using superfolder GFP and a fluorescence-based assay. RNA (2012) 0.90
The structure of yeast glutaminyl-tRNA synthetase and modeling of its interaction with tRNA. J Mol Biol (2013) 0.90
Absence of a universal element for tRNAHis identity in Acanthamoeba castellanii. Nucleic Acids Res (2012) 0.87
Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes. RNA (2014) 0.87
Functional analysis of OsPUT1, a rice polyamine uptake transporter. Planta (2011) 0.85
Structure of thymidylate kinase from Ehrlichia chaffeensis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.80
Life without post-transcriptional addition of G-1: two alternatives for tRNAHis identity in Eukarya. RNA (2014) 0.78
S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates. RNA (2016) 0.78
Synonymous Codons: Choose Wisely for Expression. Trends Genet (2017) 0.78
Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae. Microb Cell Fact (2012) 0.76
Structure of triosephosphate isomerase from Cryptosporidium parvum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Structure of a cyclin-dependent kinase from Giardia lamblia. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev (2005) 6.14
A deliberate approach to screening for initial crystallization conditions of biological macromolecules. J Struct Biol (2003) 4.20
Rapid tRNA decay can result from lack of nonessential modifications. Mol Cell (2006) 3.86
tRNA transfers to the limelight. Genes Dev (2003) 3.22
Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov (2008) 2.58
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes. Mol Biochem Parasitol (2006) 2.45
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat Struct Mol Biol (2010) 2.34
Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1. Genes Dev (2008) 2.28
Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. RNA (2003) 2.23
A facile method for high-throughput co-expression of protein pairs. Mol Cell Proteomics (2004) 2.03
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem (2009) 1.87
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem (2005) 1.81
Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data. Nat Biotechnol (2009) 1.78
tRNAHis maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNAHis. Genes Dev (2003) 1.78
Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. RNA (2002) 1.77
Rational modification of a candidate cancer drug for use against Chagas disease. J Med Chem (2009) 1.73
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. Mol Biochem Parasitol (2003) 1.61
The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease. J Med Chem (2005) 1.60
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials. J Med Chem (2007) 1.60
Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C. Mol Cell Biol (2005) 1.55
Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism. EMBO J (2005) 1.47
Control of translation efficiency in yeast by codon-anticodon interactions. RNA (2010) 1.46
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrob Agents Chemother (2007) 1.43
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. J Biol Chem (2004) 1.43
Ultrasound-enhanced thrombolysis: from bedside to bench. Stroke (2008) 1.41
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrob Agents Chemother (2011) 1.37
Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation. J Lipid Res (2005) 1.36
Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem (2012) 1.35
A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae. Nucleic Acids Res (2005) 1.33
tRNAHis guanylyltransferase catalyzes a 3'-5' polymerization reaction that is distinct from G-1 addition. Proc Natl Acad Sci U S A (2006) 1.33
tRNAs marked with CCACCA are targeted for degradation. Science (2011) 1.30
Regulation of tRNA bidirectional nuclear-cytoplasmic trafficking in Saccharomyces cerevisiae. Mol Biol Cell (2009) 1.28
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. J Med Chem (2011) 1.28
The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA. Genes Dev (2011) 1.28
Biochemical genomics approach to map activities to genes. Methods Enzymol (2002) 1.26
Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen (2009) 1.25
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Mol Microbiol (2008) 1.22
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Antimicrob Agents Chemother (2008) 1.21
Structural genomics of pathogenic protozoa: an overview. Methods Mol Biol (2008) 1.20
Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure (2012) 1.18
Identification of critical residues for G-1 addition and substrate recognition by tRNA(His) guanylyltransferase. Biochemistry (2008) 1.15
Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile. Cell Rep (2013) 1.15
Establishing a training set through the visual analysis of crystallization trials. Part II: crystal examples. Acta Crystallogr D Biol Crystallogr (2008) 1.12
Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing. Proc Natl Acad Sci U S A (2007) 1.11
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. J Med Chem (2010) 1.11
Characteristics affecting expression and solubilization of yeast membrane proteins. J Mol Biol (2006) 1.10
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. J Med Chem (2009) 1.10
Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway. Microbes Infect (2002) 1.07
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. EMBO J (2005) 1.06
Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. RNA (2012) 1.05
Purification of transmembrane proteins from Saccharomyces cerevisiae for X-ray crystallography. Protein Expr Purif (2010) 1.05
A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RNA (2002) 1.05
Determination of the oxidation states of manganese in brain, liver, and heart mitochondria. J Neurochem (2004) 1.04
Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis. Chem Rev (2014) 1.00
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem (2006) 1.00
Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.99
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J Mol Biol (2008) 0.98
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J Mol Biol (2010) 0.97
Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase. Nucleic Acids Res (2011) 0.96
Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis. J Med Chem (2014) 0.96
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorg Med Chem (2004) 0.95
Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1. RNA (2013) 0.95
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. J Med Chem (2006) 0.95
Chapter 11. Identification and analysis of tRNAs that are degraded in Saccharomyces cerevisiae due to lack of modifications. Methods Enzymol (2008) 0.95
High-throughput screening of amastigotes of Leishmania donovani clinical isolates against drugs using a colorimetric beta-lactamase assay. Indian J Exp Biol (2009) 0.94
Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie (2010) 0.93
Dietary Ethanol Mediates Selection on Aldehyde Dehydrogenase Activity in Drosophila melanogaster. Integr Comp Biol (2004) 0.93
The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. RNA (2007) 0.92
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. Angew Chem Int Ed Engl (2005) 0.92
RNA-ID, a highly sensitive and robust method to identify cis-regulatory sequences using superfolder GFP and a fluorescence-based assay. RNA (2012) 0.90
Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Curr Top Med Chem (2009) 0.90
The structure of yeast glutaminyl-tRNA synthetase and modeling of its interaction with tRNA. J Mol Biol (2013) 0.90
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol (2010) 0.88
No consensus on definition criteria for stroke registry common data elements. Cerebrovasc Dis Extra (2011) 0.88
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. J Med Chem (2004) 0.87
Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors. Mol Biochem Parasitol (2005) 0.86
Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents. Bioorg Med Chem Lett (2009) 0.85