Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers.

PubWeight™: 0.93‹?›

🔗 View Article (PMID 19726758)

Published in FASEB J on September 02, 2009

Authors

Debora Dell'Era Dosch1, Kurt Ballmer-Hofer

Author Affiliations

1: Paul Scherrer Institut, 5232-Villigen, AG, Switzerland.

Articles citing this

Structural determinants of growth factor binding and specificity by VEGF receptor 2. Proc Natl Acad Sci U S A (2010) 1.60

Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem (2012) 1.10

Single-spanning transmembrane domains in cell growth and cell-cell interactions: More than meets the eye? Cell Adh Migr (2010) 1.01

Function of members of the neuropilin family as essential pleiotropic cell surface receptors. Biochemistry (2012) 0.99

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases. Nat Rev Cancer (2012) 0.99

The role of the VEGF-C/VEGFRs axis in tumor progression and therapy. Int J Mol Sci (2012) 0.97

Understanding cytokine and growth factor receptor activation mechanisms. Crit Rev Biochem Mol Biol (2012) 0.88

Targeting extracellular domains D4 and D7 of vascular endothelial growth factor receptor 2 reveals allosteric receptor regulatory sites. Mol Cell Biol (2012) 0.85

Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers. Proc Natl Acad Sci U S A (2014) 0.83

Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain. J Biol Chem (2015) 0.77

The SCHOOL of nature: II. Protein order, disorder and oligomericity in transmembrane signaling. Self Nonself (2010) 0.77

The SCHOOL of nature: III. From mechanistic understanding to novel therapies. Self Nonself (2010) 0.77

Effects of receptor tyrosine kinase inhibitors on VEGF165 a- and VEGF165 b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2. Br J Pharmacol (2015) 0.76

Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes. Biochem Pharmacol (2017) 0.75

Articles by these authors

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med (2003) 3.17

Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. J Biol Chem (2003) 2.23

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood (2010) 1.85

Structural determinants of growth factor binding and specificity by VEGF receptor 2. Proc Natl Acad Sci U S A (2010) 1.60

Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nat Struct Mol Biol (2007) 1.48

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood (2008) 1.38

Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function. J Biol Chem (2005) 1.31

Recombinant human VEGF165b protein is an effective anti-cancer agent in mice. Eur J Cancer (2008) 1.30

Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling. Biochim Biophys Acta (2009) 1.24

A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis. Blood (2009) 1.22

Structure and function of VEGF receptors. IUBMB Life (2009) 1.15

Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR. FASEB J (2008) 1.11

Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer. Clin Cancer Res (2011) 1.05

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood (2010) 0.97

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. Blood (2011) 0.96

Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering. FASEB J (2011) 0.95

The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor. Int J Biochem Cell Biol (2009) 0.95

A plasmid-based multigene expression system for mammalian cells. Nat Commun (2010) 0.92

Isolation and characterization of a scFv antibody specific for tumor endothelial marker 1 (TEM1), a new reagent for targeted tumor therapy. Cancer Lett (2005) 0.91

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proc Natl Acad Sci U S A (2013) 0.90

The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling. J Cell Mol Med (2011) 0.89

Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity. J Biol Chem (2006) 0.87

Targeting extracellular domains D4 and D7 of vascular endothelial growth factor receptor 2 reveals allosteric receptor regulatory sites. Mol Cell Biol (2012) 0.85

Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3. PLoS One (2010) 0.84

A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through alpha5beta1 integrin. Blood (2008) 0.83

Structure determination of VEGF-E by sulfur SAD. Acta Crystallogr D Biol Crystallogr (2006) 0.82

High-level secretion of recombinant full-length streptavidin in Pichia pastoris and its application to enantioselective catalysis. Protein Expr Purif (2013) 0.78

Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis. Oncol Rep (2007) 0.78

Preliminary study of plasma vascular endothelial growth factor (VEGF) during low- and high-dose radiation therapy of dogs with spontaneous tumors. Vet Radiol Ultrasound (2004) 0.78

Targeting human cancer cells with VEGF receptor-2-directed liposomes. Oncol Rep (2005) 0.77