Published in Blood on December 10, 2009
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer. Front Immunol (2015) 1.06
Comparison of mesenchymal stem cell markers in multiple human adult stem cells. Int J Stem Cells (2014) 1.02
Exon array analysis using re-defined probe sets results in reliable identification of alternatively spliced genes in non-small cell lung cancer. BMC Genomics (2010) 1.01
CD44 Acts as a Signaling Platform Controlling Tumor Progression and Metastasis. Front Immunol (2015) 1.00
Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target. Stem Cells Transl Med (2015) 0.99
Differential Expression of Key Signaling Proteins in MCF10 Cell Lines, a Human Breast Cancer Progression Model. Mol Cell Pharmacol (2012) 0.98
Inhibition of lymphangiogenesis and angiogenesis in breast tumor xenografts and lymph nodes by a peptide derived from transmembrane protein 45A. Neoplasia (2013) 0.96
Prognostic significance of CD44s expression in resected non-small cell lung cancer. BMC Cancer (2011) 0.94
c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice. Mol Biol Cell (2011) 0.91
Effect of CD44 binding peptide conjugated to an engineered inert matrix on maintenance of breast cancer stem cells and tumorsphere formation. PLoS One (2013) 0.90
The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives. Curr Opin Hematol (2011) 0.90
Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44. Cell Death Dis (2013) 0.87
Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins. PLoS One (2013) 0.87
Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan. BMC Cancer (2012) 0.86
Survivin is a novel target of CD44-promoted breast tumor invasion. Am J Pathol (2011) 0.86
CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells. Front Immunol (2015) 0.84
CD44 enhances tumor aggressiveness by promoting tumor cell plasticity. Oncotarget (2015) 0.82
Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment. J Biol Chem (2014) 0.82
Neutrophil-Epithelial Interactions: A Double-Edged Sword. Am J Pathol (2016) 0.82
Knock-down of CD44 regulates endothelial cell differentiation via NFκB-mediated chemokine production. PLoS One (2014) 0.82
CD82 restrains pathological angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells. Circulation (2014) 0.81
Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6. Biosci Rep (2015) 0.79
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Modulation of CD44 Activity by A6-Peptide. Front Immunol (2015) 0.78
CD44: target for antiangiogenesis therapy. Blood (2009) 0.77
Cluster of Differentiation 44 (CD44) Gene Variants: A Putative Cancer Stem Cell Marker in Risk Prediction of Bladder Cancer in North Indian Population. Indian J Clin Biochem (2016) 0.76
Pancreatic cancer stem cell markers and exosomes - the incentive push. World J Gastroenterol (2016) 0.76
Expression of CD44v6 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Oncol Lett (2011) 0.76
Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets. Theranostics (2017) 0.75
A CD44v(+) subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis (2017) 0.75
CD44v6-Peptide Functionalized Nanoparticles Selectively Bind to Metastatic Cancer Cells. Adv Sci (Weinh) (2016) 0.75
Multifaceted Interpretation of Colon Cancer Stem Cells. Int J Mol Sci (2017) 0.75
TGF beta-1 induced CD44v6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis. J Biol Chem (2017) 0.75
Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers. Oncotarget (2017) 0.75
Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer (2004) 6.73
EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev (2009) 5.61
Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med (2006) 5.49
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature (2008) 5.15
The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood (2004) 3.50
Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell (2006) 3.28
Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol (2006) 3.21
Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science (2014) 3.19
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med (2003) 3.17
CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev (2002) 3.07
Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell (2007) 2.51
Mechanisms of motility in metastasizing cells. Mol Cancer Res (2010) 2.42
Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clin Exp Metastasis (2007) 2.41
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail. EMBO J (2006) 2.38
The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci (2005) 2.35
Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell (2010) 2.26
Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. J Biol Chem (2003) 2.23
EMT as the ultimate survival mechanism of cancer cells. Semin Cancer Biol (2012) 2.22
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol (2009) 2.17
[Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting. J Nucl Med (2006) 2.15
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature (2008) 2.09
The role of the Angiopoietins in vascular morphogenesis. Angiogenesis (2009) 1.98
Sprouty proteins, masterminds of receptor tyrosine kinase signaling. Angiogenesis (2008) 1.95
Spheroid-based engineering of a human vasculature in mice. Nat Methods (2008) 1.90
Molecular networks that regulate cancer metastasis. Semin Cancer Biol (2012) 1.88
Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood (2010) 1.85
Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell (2013) 1.85
Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest (2012) 1.85
Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res (2007) 1.71
Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. Am J Physiol Heart Circ Physiol (2009) 1.71
Angiopoietins in angiogenesis. Cancer Lett (2012) 1.69
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest (2009) 1.68
Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT. J Nucl Med (2010) 1.67
Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells. Arterioscler Thromb Vasc Biol (2013) 1.65
NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin. EMBO J (2008) 1.62
Mouse models of breast cancer metastasis. Breast Cancer Res (2006) 1.62
Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A (2010) 1.61
Structural determinants of growth factor binding and specificity by VEGF receptor 2. Proc Natl Acad Sci U S A (2010) 1.60
The angiogenic switch in carcinogenesis. Semin Cancer Biol (2009) 1.59
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development (2008) 1.59
Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy. Cancer Res (2013) 1.59
Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth. Cancer Res (2009) 1.58
Eph receptor and ephrin ligand-mediated interactions during angiogenesis and tumor progression. Exp Cell Res (2005) 1.57
MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res (2012) 1.56
Spheroid-based human endothelial cell microvessel formation in vivo. Nat Protoc (2009) 1.55
Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. Am J Pathol (2008) 1.53
Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin Cancer Res (2009) 1.52
Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res (2013) 1.50
Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering. Nat Immunol (2008) 1.50
Distinct mechanisms of tumor invasion and metastasis. Trends Mol Med (2007) 1.48
Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nat Struct Mol Biol (2007) 1.48
Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin. Mol Biol Cell (2006) 1.43
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest (2013) 1.41
Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem (2002) 1.38
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood (2008) 1.38
Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1. J Biol Chem (2008) 1.38
Cadherins and the tumour progression: is it all in a switch? Cancer Lett (2002) 1.37
[Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma. Clin Cancer Res (2007) 1.35
Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia (2004) 1.33
Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS One (2013) 1.33
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function. EMBO J (2007) 1.32
Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function. J Biol Chem (2005) 1.31
Recombinant human VEGF165b protein is an effective anti-cancer agent in mice. Eur J Cancer (2008) 1.30
Corrupt policemen: inflammatory cells promote tumor angiogenesis. Curr Opin Oncol (2009) 1.29
Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci (2003) 1.28
Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology (2008) 1.27
Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Mol Biol Cell (2005) 1.27
Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy. Clin Cancer Res (2013) 1.26
Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model. J Cell Mol Med (2009) 1.24
Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling. Biochim Biophys Acta (2009) 1.24
Multitasking in tumor progression: signaling functions of cell adhesion molecules. Ann N Y Acad Sci (2004) 1.24
The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking. J Cell Biol (2009) 1.23
Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor. J Cell Sci (2007) 1.23
Myeloid cells contribute to tumor lymphangiogenesis. PLoS One (2009) 1.22
Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. FASEB J (2003) 1.20
Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements. Arterioscler Thromb Vasc Biol (2004) 1.20
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. J Pathol (2012) 1.16
Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis. Am J Pathol (2007) 1.16
Structure and function of VEGF receptors. IUBMB Life (2009) 1.15
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J (2011) 1.12
Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR. FASEB J (2008) 1.11
Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2 BP/90K. FASEB J (2008) 1.11
Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking. J Leukoc Biol (2006) 1.11
Semaphorin SEMA3F affects multiple signaling pathways in lung cancer cells. Cancer Res (2007) 1.11
Concepts of metastasis in flux: the stromal progression model. Semin Cancer Biol (2012) 1.10
Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors. Cancer Res (2006) 1.10
The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors. Am J Pathol (2006) 1.09
Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS One (2010) 1.09
Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies. Exp Cell Res (2004) 1.09
Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. J Biol Chem (2010) 1.08
Rebuilding cancer metastasis in the mouse. Mol Oncol (2013) 1.08
Adhesion proteins meet receptors: a common theme? Adv Cancer Res (2008) 1.08
The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood (2005) 1.07