Published in Cell on July 13, 1990
Mechanism and regulation of eukaryotic protein synthesis. Microbiol Rev (1992) 6.27
Turnover mechanisms of the stable yeast PGK1 mRNA. Mol Cell Biol (1995) 5.83
Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev (1996) 4.34
AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A). Mol Cell Biol (1994) 3.64
Role of polyadenylation in nucleocytoplasmic transport of mRNA. Mol Cell Biol (1996) 3.26
Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3' processing signal AAUAAA. EMBO J (1991) 2.94
Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function. Mol Cell Biol (1994) 2.93
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO J (1991) 2.84
Assembly of a processive messenger RNA polyadenylation complex. EMBO J (1993) 2.58
Host factor Hfq of Escherichia coli stimulates elongation of poly(A) tails by poly(A) polymerase I. Proc Natl Acad Sci U S A (2000) 2.57
Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3' untranslated region. EMBO J (1994) 2.47
U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3' untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation. Mol Cell Biol (1992) 2.40
Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 protein. Mol Cell Biol (1991) 2.35
Separation of factors required for cleavage and polyadenylation of yeast pre-mRNA. Mol Cell Biol (1992) 2.34
Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system. Mol Cell Biol (1995) 2.17
EDEN and EDEN-BP, a cis element and an associated factor that mediate sequence-specific mRNA deadenylation in Xenopus embryos. EMBO J (1998) 2.10
Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3' nontranslated region. Mol Cell Biol (1995) 2.04
Involvement of long terminal repeat U3 sequences overlapping the transcription control region in human immunodeficiency virus type 1 mRNA 3' end formation. Mol Cell Biol (1991) 1.99
Using translational enhancers to increase transgene expression in Drosophila. Proc Natl Acad Sci U S A (2012) 1.98
Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? J Virol (1999) 1.98
Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein. Mol Cell Biol (1991) 1.95
A negative regulatory element in the human papillomavirus type 16 genome acts at the level of late mRNA stability. J Virol (1991) 1.95
PCF11 encodes a third protein component of yeast cleavage and polyadenylation factor I. Mol Cell Biol (1997) 1.88
Translational efficiency is regulated by the length of the 3' untranslated region. Mol Cell Biol (1996) 1.87
Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase. Mol Cell Biol (1992) 1.84
Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. Mol Cell Biol (1994) 1.83
Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol (1992) 1.81
A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts. Genes Dev (2001) 1.74
In vivo DNA expression of functional brome mosaic virus RNA replicons in Saccharomyces cerevisiae. J Virol (1997) 1.71
The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells. Nucleic Acids Res (1996) 1.64
Different forms of soluble cytoplasmic mRNA binding proteins and particles in Xenopus laevis oocytes and embryos. J Cell Biol (1991) 1.63
Addition of destabilizing poly (A)-rich sequences to endonuclease cleavage sites during the degradation of chloroplast mRNA. Proc Natl Acad Sci U S A (1996) 1.60
A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. EMBO J (1994) 1.60
The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males. Genetics (1993) 1.60
Different complexes are formed on the 3' end of histone mRNA with nuclear and polyribosomal proteins. Nucleic Acids Res (1991) 1.58
Transient activity assays of the Trypanosoma brucei variant surface glycoprotein gene promoter: control of gene expression at the posttranscriptional level. Mol Cell Biol (1991) 1.55
Downstream DNA sequences are required to activate a gene expressed in the root cortex of embryos and seedlings. Plant Cell (1992) 1.54
Point mutations in the stem-loop at the 3' end of mouse histone mRNA reduce expression by reducing the efficiency of 3' end formation. Mol Cell Biol (1994) 1.53
The histone mRNA 3' end is required for localization of histone mRNA to polyribosomes. Nucleic Acids Res (1992) 1.50
The 3' untranslated region of satellite tobacco necrosis virus RNA stimulates translation in vitro. Mol Cell Biol (1993) 1.50
Autoregulation of poly(A)-binding protein synthesis in vitro. Nucleic Acids Res (1995) 1.47
Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase. Mol Cell Biol (1993) 1.45
PUB1: a major yeast poly(A)+ RNA-binding protein. Mol Cell Biol (1993) 1.45
Both the 5' untranslated region and the sequences surrounding the start site contribute to efficient initiation of translation in vitro. Mol Cell Biol (1991) 1.42
Retracted Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcriptional level. EMBO J (1991) 1.42
Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex. Mol Cell Biol (1999) 1.40
AUUUA sequences direct mRNA deadenylation uncoupled from decay during Xenopus early development. Mol Cell Biol (1998) 1.39
In vitro deadenylation of mammalian mRNA by a HeLa cell 3' exonuclease. EMBO J (1991) 1.39
The duplicated Saccharomyces cerevisiae gene SSM1 encodes a eucaryotic homolog of the eubacterial and archaebacterial L1 ribosomal proteins. Mol Cell Biol (1995) 1.38
Regulation of polyadenylation in hepatitis B viruses: stimulation by the upstream activating signal PS1 is orientation-dependent, distance-independent, and additive. Nucleic Acids Res (1991) 1.36
Binding of a phosphoprotein to the 3' untranslated region of the mouse protamine 2 mRNA temporally represses its translation. Mol Cell Biol (1993) 1.35
Rapid mRNA degradation mediated by the c-fos 3' AU-rich element and that mediated by the granulocyte-macrophage colony-stimulating factor 3' AU-rich element occur through similar polysome-associated mechanisms. Mol Cell Biol (1995) 1.35
Detecting high-resolution polymorphisms in human coding loci by combining PCR and single-strand conformation polymorphism (SSCP) analysis. Am J Hum Genet (1991) 1.35
LCR/MEL: a versatile system for high-level expression of heterologous proteins in erythroid cells. Nucleic Acids Res (1992) 1.34
The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally. EMBO J (1992) 1.33
The deadenylation conferred by the 3' untranslated region of a developmentally controlled mRNA in Xenopus embryos is switched to polyadenylation by deletion of a short sequence element. Mol Cell Biol (1994) 1.31
The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol (1999) 1.29
Functional mRNA can be generated by RNA polymerase III. Mol Cell Biol (1995) 1.29
apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor. Proc Natl Acad Sci U S A (1993) 1.27
Multiple sequence elements and a maternal mRNA product control cdk2 RNA polyadenylation and translation during early Xenopus development. Mol Cell Biol (1994) 1.26
Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene. Nucleic Acids Res (1997) 1.26
Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene. Nucleic Acids Res (1991) 1.26
The 5' and 3' TAR elements of human immunodeficiency virus exert effects at several points in the virus life cycle. J Virol (1998) 1.25
MicroRNA-mediated up-regulation of an alternatively polyadenylated variant of the mouse cytoplasmic {beta}-actin gene. Nucleic Acids Res (2008) 1.25
The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation. Mol Cell Biol (2000) 1.24
Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway. Nucleic Acids Res (1994) 1.24
Regulation of the ovine intestinal Na+/glucose co-transporter (SGLT1) is dissociated from mRNA abundance. Biochem J (1993) 1.23
Cytoplasmic protein binding to highly conserved sequences in the 3' untranslated region of mouse protamine 2 mRNA, a translationally regulated transcript of male germ cells. Proc Natl Acad Sci U S A (1991) 1.23
Degradation products of the mRNA encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean and transgenic petunia. Plant Cell (1992) 1.23
A testis cytoplasmic RNA-binding protein that has the properties of a translational repressor. Mol Cell Biol (1996) 1.23
Cytoplasmic delivery of ribozymes leads to efficient reduction in alpha-lactalbumin mRNA levels in C127I mouse cells. EMBO J (1992) 1.21
Effects of mutations in the Saccharomyces cerevisiae RNA14, RNA15, and PAP1 genes on polyadenylation in vivo. Mol Cell Biol (1995) 1.20
Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor. Nucleic Acids Res (1995) 1.20
Posttranscriptional regulation of gene networks by GU-rich elements and CELF proteins. RNA Biol (2008) 1.18
Molecular characterization of a novel rat protein structurally related to poly(A) binding proteins and the 70K protein of the U1 small nuclear ribonucleoprotein particle (snRNP) Nucleic Acids Res (1992) 1.15
Mitochondrial biogenesis in the liver during development and oncogenesis. J Bioenerg Biomembr (1997) 1.14
Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival. J Exp Med (1994) 1.14
Control of the translational efficiency of beta-F1-ATPase mRNA depends on the regulation of a protein that binds the 3' untranslated region of the mRNA. Mol Cell Biol (1997) 1.13
The nucleus-limited Hsr-omega-n transcript is a polyadenylated RNA with a regulated intranuclear turnover. J Cell Biol (1994) 1.13
Polyadenylation of maternal mRNA during oocyte maturation: poly(A) addition in vitro requires a regulated RNA binding activity and a poly(A) polymerase. EMBO J (1992) 1.12
A regulatory role for the 5' and 3' untranslated regions in differential expression of hsp83 in Leishmania. Nucleic Acids Res (1994) 1.11
Poly(A) polymerase contains multiple functional domains. Mol Cell Biol (1994) 1.10
A conserved element in the leader mediates post-meiotic translation as well as cytoplasmic polyadenylation of a Drosophila spermatocyte mRNA. EMBO J (1990) 1.08
A pollen-, ovule-, and early embryo-specific poly(A) binding protein from Arabidopsis complements essential functions in yeast. Plant Cell (1996) 1.08
Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophila melanogaster. Mol Cell Biol (1994) 1.06
Initiation of translation can occur only in a restricted region of the CYC1 mRNA of Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.05
Tat-dependent occlusion of the HIV poly(A) site. EMBO J (1993) 1.04
Functional analysis of the tobacco mosaic virus tRNA-like structure in cytoplasmic gene regulation. Nucleic Acids Res (1991) 1.03
Comparative analyses of the secondary structures of synthetic and intracellular yeast MFA2 mRNAs. Proc Natl Acad Sci U S A (1998) 1.02
Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro. Mol Cell Biol (1995) 1.02
UTP-dependent and -independent pathways of mRNA turnover in Trypanosoma brucei mitochondria. Mol Cell Biol (2000) 1.01
Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA. Nucleic Acids Res (1995) 1.01
A new G-tailing method for the determination of the poly(A) tail length applied to hepatitis A virus RNA. Nucleic Acids Res (2001) 1.00
Translational regulation of human beta interferon mRNA: association of the 3' AU-rich sequence with the poly(A) tail reduces translation efficiency in vitro. Mol Cell Biol (1993) 0.99
Messenger RNA polyadenylylation: a universal modification. Proc Natl Acad Sci U S A (1995) 0.98
5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants. Nucleic Acids Res (1992) 0.98
Transcription termination and polyadenylation in retroviruses. Microbiol Rev (1993) 0.96
3'-Processed mRNA is preferentially translated in Chlamydomonas reinhardtii chloroplasts. Mol Cell Biol (1998) 0.96
mRNA encoding the beta-subunit of the mitochondrial F1-ATPase complex is a localized mRNA in rat hepatocytes. Biochem J (1997) 0.95
Cytoplasmic regulation of mRNA function: the importance of the 3' untranslated region. Cell (1993) 3.07
Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3' untranslated region. EMBO J (1994) 2.47
A conserved role of a DEAD box helicase in mRNA masking. RNA (2001) 2.20
RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization. Genes Dev (1998) 1.84
A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts. Genes Dev (2001) 1.74
The role of cyclin synthesis, modification and destruction in the control of cell division. J Cell Sci Suppl (1989) 1.69
Autoregulation of poly(A)-binding protein synthesis in vitro. Nucleic Acids Res (1995) 1.47
The poly(A)-binding protein facilitates in vitro translation of poly(A)-rich mRNA. Eur J Biochem (1988) 1.30
Dual roles of p82, the clam CPEB homolog, in cytoplasmic polyadenylation and translational masking. RNA (1999) 1.21
New ways of initiating translation in eukaryotes. Mol Cell Biol (2001) 1.20
The ATP requirement for initiation of eukaryotic translation varies according to the mRNA species. Eur J Biochem (1991) 1.18
A 250-nucleotide UA-rich element in the 3' untranslated region of Xenopus laevis Vg1 mRNA represses translation both in vivo and in vitro. RNA (2001) 1.09
Vg1 RBP intracellular distribution and evolutionarily conserved expression at multiple stages during development. Mech Dev (1999) 1.09
Unmasking mRNA in clam oocytes: role of phosphorylation of a 3' UTR masking element-binding protein at fertilization. Dev Biol (1996) 1.08
The clam 3' UTR masking element-binding protein p82 is a member of the CPEB family. RNA (1999) 1.05
The polyribosomal poly(A)-binding protein is highly conserved in vertebrate species. Comparison in duck, mouse and rabbit. FEBS Lett (1981) 0.92
Potential role of mRNP proteins in cytoplasmic control of gene expression in duck erythroblasts. Mol Biol Rep (1981) 0.88
Gel retardation and UV-crosslinking assays to detect specific RNA-protein interactions in the 5' or 3' UTRs of translationally regulated mRNAs. Methods Mol Biol (1998) 0.88
Ca2+ is required for phosphorylation of clam p82/CPEB in vitro: implications for dual and independent roles of MAP and Cdc2 kinases. Dev Biol (1999) 0.87
Differential accumulation of ribonucleotide reductase subunits in clam oocytes: the large subunit is stored as a polypeptide, the small subunit as untranslated mRNA. J Cell Biol (1986) 0.86
Levels of free PABP are limited by newly polyadenylated mRNA in early Spisula embryogenesis. Nucleic Acids Res (2000) 0.82