Published in Genome Med on September 07, 2009
Genetics of osteoporosis: accelerating pace in gene identification and validation. Hum Genet (2009) 1.14
The role of midkine in skeletal remodelling. Br J Pharmacol (2014) 0.84
Characterization of complex, co-adapted skeletal biomechanics phenotypes: a needed paradigm shift in the genetics of bone structure and function. Curr Osteoporos Rep (2014) 0.77
A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women. Bone Rep (2016) 0.75
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91
VarScan: variant detection in massively parallel sequencing of individual and pooled samples. Bioinformatics (2009) 16.04
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell (1997) 13.53
Osteoporosis prevention, diagnosis, and therapy. JAMA (2001) 12.60
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med (2002) 11.28
The diagnosis of osteoporosis. J Bone Miner Res (1994) 10.90
Endocrine regulation of energy metabolism by the skeleton. Cell (2007) 10.41
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell (1997) 7.47
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet (2001) 6.56
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20
The promise and perils of Wnt signaling through beta-catenin. Science (2002) 6.11
Leptin regulates bone formation via the sympathetic nervous system. Cell (2002) 5.95
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum Mol Genet (2001) 5.72
Wnt signaling in disease and in development. Cell Res (2005) 5.53
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet (2001) 4.97
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem (2002) 4.52
Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res (2009) 4.40
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell (2001) 4.36
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J (2003) 4.32
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem (2005) 4.13
Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast. Dev Dyn (2002) 4.01
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. J Med Genet (2002) 4.00
Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med (2004) 3.88
Osteocytes, mechanosensing and Wnt signaling. Bone (2008) 3.57
High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res (2003) 3.48
Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology (2007) 3.46
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res (2006) 3.44
New sequence variants associated with bone mineral density. Nat Genet (2008) 3.43
Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nat Genet (2000) 3.12
DMP1-targeted Cre expression in odontoblasts and osteocytes. J Dent Res (2007) 3.07
Massively parallel sequencing: the next big thing in genetic medicine. Am J Hum Genet (2009) 3.01
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood (2006) 2.91
Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet (2003) 2.86
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A (2005) 2.67
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J Bone Miner Res (2006) 2.61
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA (2008) 2.52
Genome-wide association with bone mass and geometry in the Framingham Heart Study. BMC Med Genet (2007) 2.32
Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin. Proc Natl Acad Sci U S A (1992) 2.20
Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science (2004) 2.15
Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. Int J Dev Biol (2004) 2.15
Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet (1996) 1.89
Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. J Bone Miner Res (2007) 1.82
Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13) Am J Hum Genet (1997) 1.75
Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol (2003) 1.64
Wnt signaling as a therapeutic target for bone diseases. Expert Opin Ther Targets (2009) 1.61
Leptin and the sympathetic connection of fat to bone. Osteoporos Int (2007) 1.61
Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass. J Bone Miner Res (2008) 1.54
Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass. J Bone Miner Res (2008) 1.52
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev (2003) 1.51
Molecular studies of identification of genes for osteoporosis: the 2002 update. J Endocrinol (2003) 1.48
LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density. J Hum Genet (2004) 1.47
LRP5 and Wnt signaling: a union made for bone. J Bone Miner Res (2004) 1.45
Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo. J Bone Miner Res (2006) 1.44
Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice. J Bone Miner Res (2006) 1.43
Tumor formation by genetic mutations in the components of the Wnt signaling pathway. Cancer Sci (2003) 1.42
Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study. Hum Mol Genet (2005) 1.42
Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metab (2002) 1.33
Molecular bases of the sympathetic regulation of bone mass. Bone (2008) 1.21
Identification of mouse Duffy antigen receptor for chemokines (Darc) as a BMD QTL gene. Genome Res (2007) 1.21
The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res (1995) 1.18
Wnt signaling: a win for bone. Arch Biochem Biophys (2008) 1.17
Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population. Bone (1996) 1.14
Wnt signalling pathway: a new target for the treatment of osteoporosis. Expert Opin Ther Targets (2005) 1.13
Mammalian genome targeting using site-specific recombinases. Front Biosci (2006) 1.12
LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women. Bone (2005) 1.11
Quantitative trait loci for biomechanical performance and femoral geometry in an intercross of recombinant congenic mice: restriction of the Bmd7 candidate interval. FASEB J (2009) 1.11
Human genetics of osteoporosis. Best Pract Res Clin Endocrinol Metab (2008) 1.10
Transgenic mice that express Cre recombinase in osteoclasts. Genesis (2004) 1.09
Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. J Clin Endocrinol Metab (1995) 1.03
Human ALOX12, but not ALOX15, is associated with BMD in white men and women. J Bone Miner Res (2006) 1.00
Identification of LTBP2 on chromosome 14q as a novel candidate gene for bone mineral density variation and fracture risk association. J Clin Endocrinol Metab (2008) 0.98
Bone strength and related traits in HcB/Dem recombinant congenic mice. J Bone Miner Res (2001) 0.97
Long-term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats. J Cell Biochem (2006) 0.97
Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. Genomics (2009) 0.96
LRP5 gene polymorphisms and idiopathic osteoporosis in men. Bone (2005) 0.94
LRP5 coding polymorphisms influence the variation of peak bone mass in a normal population of French-Canadian women. Bone (2007) 0.93
A genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.). Genetics (2008) 0.92
Recombinant DNA technologies for construction of precisely designed transgene constructs. Curr Pharm Biotechnol (2009) 0.92
A QTL for osteoporosis detected in an F2 population derived from White Leghorn chicken lines divergently selected for bone index. Anim Genet (2007) 0.92
Vitamin D receptor gene polymorphism, bone mass, body size, and vitamin D receptor density. Calcif Tissue Int (1995) 0.92
A quantitative trait locus for normal variation in forearm bone mineral density in pedigreed baboons maps to the ortholog of human chromosome 11q. J Clin Endocrinol Metab (2005) 0.91
Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci. Bone (2009) 0.90
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem (2009) 0.90
Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians. J Bone Miner Res (2010) 0.90
Variation in the BMP2 gene: bone mineral density and ultrasound in young adult and elderly women. Calcif Tissue Int (2007) 0.90
Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. Calcif Tissue Int (2007) 0.89
QTL with pleiotropic effects on serum levels of bone-specific alkaline phosphatase and osteocalcin maps to the baboon ortholog of human chromosome 6p23-21.3. J Bone Miner Res (2006) 0.89
Cortical tibial bone volume in two strains of mice: effects of sciatic neurectomy and genetic regulation of bone response to mechanical loading. Bone (1999) 0.88
Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes. Methods Mol Biol (2009) 0.87
Genetic determination of osteoporosis: lessons learned from a large genome-wide linkage study. Hum Biol (2007) 0.86
Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss, and bone mass in postmenopausal women: the OFELY Study. J Bone Miner Res (1996) 0.85
The search for human osteoporosis genes. J Musculoskelet Neuronal Interact (2006) 0.84
A close examination of genes within quantitative trait loci of bone mineral density in whole mouse genome. Crit Rev Eukaryot Gene Expr (2008) 0.83
The Wnt signaling pathway and bone metabolism. Curr Opin Rheumatol (2007) 1.23
Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading. J Bone Miner Res (2014) 1.02
Acromegaly Quality of Life Questionnaire (AcroQoL). Health Qual Life Outcomes (2004) 1.00
Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts. Health Qual Life Outcomes (2005) 0.97
PEDF and the serpins: phylogeny, sequence conservation, and functional domains. J Struct Biol (2005) 0.95
Hyperthermia: from diagnostic and treatments to new discoveries. Recent Pat Biotechnol (2012) 0.79
Validation of a new tool to assess health-related quality of life in psoriasis: the PSO-LIFE questionnaire. Health Qual Life Outcomes (2012) 0.78
[Initial treatment trends in patient with osteoporosis: use of antiresorptive agents and pharmacologic supplements (calcium and vitamin D) in clinical practice]. Reumatol Clin (2011) 0.75
Estimating the burden of genital warts in Taiwan. Sex Health (2017) 0.75
Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profiling. Adv Exp Med Biol (2003) 0.75