Published in Trends Neurosci on September 14, 2009
The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res (2010) 2.68
Neurobiology of the incubation of drug craving. Trends Neurosci (2011) 2.65
Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci U S A (2011) 2.62
Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol (2011) 2.51
How addictive drugs disrupt presynaptic dopamine neurotransmission. Neuron (2011) 2.50
Reward, addiction, withdrawal to nicotine. Annu Rev Neurosci (2011) 1.83
Enkephalin surges in dorsal neostriatum as a signal to eat. Curr Biol (2012) 1.74
Addiction science: Uncovering neurobiological complexity. Neuropharmacology (2013) 1.50
Identifying neurobiological phenotypes associated with alcohol use disorder severity. Neuropsychopharmacology (2011) 1.41
Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proc Natl Acad Sci U S A (2012) 1.33
Role of BDNF and GDNF in drug reward and relapse: a review. Neurosci Biobehav Rev (2009) 1.31
Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion. J Neurosci (2014) 1.30
Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder. PLoS One (2010) 1.29
Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons. Nat Neurosci (2012) 1.25
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. J Neurosci (2011) 1.25
Model-based and model-free Pavlovian reward learning: revaluation, revision, and revelation. Cogn Affect Behav Neurosci (2014) 1.22
Operant self-stimulation of dopamine neurons in the substantia nigra. PLoS One (2013) 1.16
Striatocortical pathway dysfunction in addiction and obesity: differences and similarities. Crit Rev Biochem Mol Biol (2012) 1.14
A thalamo-hippocampal-ventral tegmental area loop may produce the positive feedback that underlies the psychotic break in schizophrenia. Biol Psychiatry (2010) 1.13
The evolution of dopamine systems in chordates. Front Neuroanat (2011) 1.11
CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat. Neurobiol Dis (2013) 1.10
Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: a [11C] FLB-457 and PET study. Neurobiol Dis (2012) 1.05
Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. Neuroscience (2011) 1.05
Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. J Pharmacol Exp Ther (2012) 1.05
The missing p in psychiatric training: why it is important to teach pain to psychiatrists. Arch Gen Psychiatry (2011) 1.04
Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms. Biol Psychiatry (2013) 1.04
Dual roles of dopamine in food and drug seeking: the drive-reward paradox. Biol Psychiatry (2012) 1.03
Stress, depression and Parkinson's disease. Exp Neurol (2011) 1.01
Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. Front Integr Neurosci (2012) 1.00
Endogenous GDNF in ventral tegmental area and nucleus accumbens does not play a role in the incubation of heroin craving. Addict Biol (2010) 1.00
Chronic exposure to nicotine is associated with reduced reward-related activity in the striatum but not the midbrain. Biol Psychiatry (2011) 0.99
Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration. CNS Neurol Disord Drug Targets (2010) 0.98
Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field. Neuropsychopharmacology (2013) 0.98
Mechanistic insights into nicotine withdrawal. Biochem Pharmacol (2011) 0.98
Diet-induced obesity: dopamine transporter function, impulsivity and motivation. Int J Obes (Lond) (2012) 0.96
Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. Transl Psychiatry (2012) 0.96
Recurrent, robust and scalable patterns underlie human approach and avoidance. PLoS One (2010) 0.96
Impact of expected value on neural activity in rat substantia nigra pars reticulata. Eur J Neurosci (2011) 0.96
Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats. Front Behav Neurosci (2010) 0.95
Synchrony of corticostriatal-midbrain activation enables normal inhibitory control and conflict processing in recovering alcoholic men. Biol Psychiatry (2011) 0.94
Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: association to striatal D2/D3 receptors. Hum Brain Mapp (2014) 0.93
Firing properties and functional connectivity of substantia nigra pars compacta neurones recorded with a multi-electrode array in vitro. J Physiol (2010) 0.92
Neural responses to subliminally presented cannabis and other emotionally evocative cues in cannabis-dependent individuals. Psychopharmacology (Berl) (2013) 0.92
Historical and current perspective on tobacco use and nicotine addiction. Trends Neurosci (2011) 0.91
Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. J Pharmacol Exp Ther (2012) 0.91
Basal ganglia circuit loops, dopamine and motivation: A review and enquiry. Behav Brain Res (2015) 0.90
Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson's disease. Mol Psychiatry (2013) 0.90
Hub and switches: endocannabinoid signalling in midbrain dopamine neurons. Philos Trans R Soc Lond B Biol Sci (2012) 0.89
Dopaminergic and cholinergic learning mechanisms in nicotine addiction. Ann N Y Acad Sci (2015) 0.89
GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum. Behav Brain Res (2012) 0.88
Increased brain response to appetitive tastes in the insula and amygdala in obese compared with healthy weight children when sated. Int J Obes (Lond) (2014) 0.88
The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. J Neurochem (2012) 0.88
Ultrasonic Vocalizations as a Measure of Affect in Preclinical Models of Drug Abuse: A Review of Current Findings. Curr Neuropharmacol (2015) 0.88
Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase. Brain Struct Funct (2013) 0.87
Biphasic dopamine regulation in mesoaccumbens pathway in response to non-contingent binge and escalating methamphetamine regimens in the Wistar rat. Psychopharmacology (Berl) (2011) 0.87
How acute and chronic alcohol consumption affects brain networks: insights from multimodal neuroimaging. Alcohol Clin Exp Res (2012) 0.87
Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. Proc Natl Acad Sci U S A (2015) 0.87
Long-range projection neurons of the mouse ventral tegmental area: a single-cell axon tracing analysis. Front Neuroanat (2015) 0.86
Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel. Psychopharmacology (Berl) (2015) 0.85
Dissociated effects of anticipating smoking versus monetary reward in the caudate as a function of smoking abstinence. Biol Psychiatry (2013) 0.85
Altered fronto-striatal and fronto-cerebellar circuits in heroin-dependent individuals: a resting-state FMRI study. PLoS One (2013) 0.84
Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions. Ann N Y Acad Sci (2015) 0.84
Heads for learning, tails for memory: reward, reinforcement and a role of dopamine in determining behavioral relevance across multiple timescales. Front Neurosci (2013) 0.84
Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens. J Neurochem (2013) 0.84
Flavor-independent maintenance, extinction, and reinstatement of fat self-administration in mice. Biol Psychiatry (2013) 0.84
Molecular mechanisms underlying alcohol-drinking behaviours. Nat Rev Neurosci (2016) 0.83
Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression. PLoS One (2014) 0.83
Involvement of cholinergic mechanisms in the behavioral effects of dietary fat consumption. Brain Res (2012) 0.83
Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. Cold Spring Harb Perspect Med (2013) 0.82
Potential programming of dopaminergic circuits by early life stress. Psychopharmacology (Berl) (2010) 0.82
Dopamine and α-synuclein dysfunction in Smad3 null mice. Mol Neurodegener (2011) 0.81
Dorsolateral neostriatum contribution to incentive salience: opioid or dopamine stimulation makes one reward cue more motivationally attractive than another. Eur J Neurosci (2016) 0.80
Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The Role of Reward System. Curr Neuropharmacol (2015) 0.80
The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice. Physiol Behav (2015) 0.80
Temporal difference error prediction signal dysregulation in cocaine dependence. Neuropsychopharmacology (2014) 0.80
Humor as a reward mechanism: event-related potentials in the healthy and diseased brain. PLoS One (2014) 0.79
Stimulation of nicotine reward and central cholinergic activity in Sprague-Dawley rats exposed perinatally to a fat-rich diet. Psychopharmacology (Berl) (2013) 0.79
A mutation in CLOCK leads to altered dopamine receptor function. J Neurochem (2012) 0.79
Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease. Front Genet (2013) 0.79
Effects of cortical and striatal dopamine D1 receptor blockade on cued versus noncued behavioral responses. Behav Neurosci (2011) 0.79
Memory re-consolidation and drug conditioning: an apomorphine conditioned locomotor stimulant response can be enhanced or reversed by a single high versus low apomorphine post-trial treatment. Psychopharmacology (Berl) (2011) 0.78
Histamine is required for H₃ receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation. Br J Pharmacol (2013) 0.78
Thorndike's Law 2.0: Dopamine and the Regulation of Thrift. Front Neurosci (2012) 0.78
Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5. Neuropsychopharmacology (2015) 0.78
Biological substrates of addiction. Wiley Interdiscip Rev Cogn Sci (2014) 0.78
Dopamine β-hydroxylase inhibitors enhance the discriminative stimulus effects of cocaine in rats. J Pharmacol Exp Ther (2013) 0.78
Further human evidence for striatal dopamine release induced by administration of ∆9-tetrahydrocannabinol (THC): selectivity to limbic striatum. Psychopharmacology (Berl) (2015) 0.78
A Direct Cortico-Nigral Pathway as Revealed by Constrained Spherical Deconvolution Tractography in Humans. Front Hum Neurosci (2016) 0.77
Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease. J Neurochem (2016) 0.77
Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans. Sci Rep (2016) 0.77
What can rodent models tell us about apathy and associated neuropsychiatric symptoms in Parkinson's disease? Transl Psychiatry (2016) 0.77
Varenicline enhances dopamine release facilitation more than nicotine after long-term nicotine treatment and withdrawal. Pharmacol Res Perspect (2014) 0.77
The dopamine system and alcohol dependence. Shanghai Arch Psychiatry (2014) 0.77
Enhanced upregulation of CRH mRNA expression in the nucleus accumbens of male rats after a second injection of methamphetamine given thirty days later. PLoS One (2014) 0.77
Angiotensin AT1 and AT2 receptor antagonists modulate nicotine-evoked [³H]dopamine and [³H]norepinephrine release. Biochem Pharmacol (2013) 0.76
Neurochemical and behavioral features in genetic absence epilepsy and in acutely induced absence seizures. ISRN Neurol (2013) 0.76
Coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons. Sci Rep (2015) 0.76
Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system. J Neurosci Res (2014) 0.76
Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter. Neuropharmacology (2014) 0.76
Brain regions affected by impaired control modulate responses to alcohol and smoking cues. J Stud Alcohol Drugs (2014) 0.76
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci (2005) 16.18
Predictive reward signal of dopamine neurons. J Neurophysiol (1998) 15.02
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol (1973) 14.99
Dopamine, learning and motivation. Nat Rev Neurosci (2004) 11.97
Parsing reward. Trends Neurosci (2003) 7.88
Subsecond dopamine release promotes cocaine seeking. Nature (2003) 6.53
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci (2000) 6.02
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron (2008) 5.65
Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl (1971) 4.49
Brain dopamine and reward. Annu Rev Psychol (1989) 4.41
A cellular mechanism of reward-related learning. Nature (2001) 4.09
The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? J Physiol (2006) 3.97
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience (2000) 3.95
Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J Neurosci (1989) 3.66
What is the amygdala? Trends Neurosci (1998) 3.62
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annu Rev Neurosci (2000) 3.59
EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS. Acta Physiol Scand Suppl (1964) 3.57
Involvement of the dorsal striatum in cue-controlled cocaine seeking. J Neurosci (2005) 3.44
A triple dissociation of memory systems: hippocampus, amygdala, and dorsal striatum. Behav Neurosci (1993) 3.15
Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward "wanting" without enhanced "liking" or response reinforcement. J Neurosci (2000) 3.06
Long-term synaptic depression in the striatum: physiological and pharmacological characterization. J Neurosci (1992) 2.54
Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine-seeking behavior by rats. J Neurosci (2004) 2.39
Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty. Nat Neurosci (2003) 2.38
Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes. Proc Natl Acad Sci U S A (1994) 2.27
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition. Nat Neurosci (2003) 2.24
The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems. J Neurosci (1987) 2.15
Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards. Behav Neurosci (2005) 2.02
Dopaminergic control of synaptic plasticity in the dorsal striatum. Eur J Neurosci (2001) 1.98
Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. J Neurosci (2000) 1.98
Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens. Proc Natl Acad Sci U S A (2005) 1.94
Different molecular cascades in different sites of the brain control memory consolidation. Trends Neurosci (2006) 1.90
Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area. J Neurosci (1999) 1.89
The neostriatal mosaic: compartmental distribution of calcium-binding protein and parvalbumin in the basal ganglia of the rat and monkey. Proc Natl Acad Sci U S A (1985) 1.83
Long-term Potentiation in the Striatum is Unmasked by Removing the Voltage-dependent Magnesium Block of NMDA Receptor Channels. Eur J Neurosci (1992) 1.80
Dopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slices. Brain Res (1990) 1.78
A role for conditioned ventral tegmental glutamate release in cocaine seeking. J Neurosci (2007) 1.65
Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists. Behav Neurosci (1991) 1.64
Responses to reward in monkey dorsal and ventral striatum. Exp Brain Res (1991) 1.61
Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Res (1995) 1.59
The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro. Neurosci Lett (1991) 1.56
Self-administration of cocaine on a progressive ratio schedule in rats: dose-response relationship and effect of haloperidol pretreatment. Psychopharmacology (Berl) (1989) 1.55
Effect of noxious tail pinch on the discharge rate of mesocortical and mesolimbic dopamine neurons: selective activation of the mesocortical system. Brain Res (1989) 1.45
Chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area. J Neurosci (2000) 1.41
Self-administration of d-amphetamine by rats. Psychopharmacologia (1968) 1.38
Simultaneous LTP of non-NMDA- and LTD of NMDA-receptor-mediated responses in the nucleus accumbens. Nature (1994) 1.37
Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors. J Neurosci (1997) 1.35
Modulation of long-term depression by dopamine in the mesolimbic system. J Neurosci (2000) 1.35
Dopaminergic modulation of long-term synaptic plasticity in rat prefrontal neurons. Cereb Cortex (2003) 1.34
Neuronal activity in monkey striatum related to the expectation of predictable environmental events. J Neurophysiol (1992) 1.32
Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. J Neurosci (2009) 1.32
D1 receptors modulate glutamate transmission in the ventral tegmental area. J Neurosci (1995) 1.30
Intracranial self-stimulation in relation to the ascending dopaminergic systems of the midbrain: a moveable electrode mapping study. Brain Res (1980) 1.28
Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration. Neurodegeneration (1996) 1.27
Injections of N-methyl-D-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens. Synapse (1999) 1.26
Novelty-evoked elevations of nucleus accumbens dopamine: dependence on impulse flow from the ventral subiculum and glutamatergic neurotransmission in the ventral tegmental area. Eur J Neurosci (2001) 1.25
Cholinergic axons in the rat ventral tegmental area synapse preferentially onto mesoaccumbens dopamine neurons. J Comp Neurol (2006) 1.22
Synaptic plasticity in an in vitro slice preparation of the rat nucleus accumbens. Eur J Neurosci (1993) 1.17
Dual character, asynaptic and synaptic, of the dopamine innervation in adult rat neostriatum: a quantitative autoradiographic and immunocytochemical analysis. J Comp Neurol (1996) 1.15
Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivation. J Neurosci (2008) 1.15
D1/D5 dopamine receptors inhibit depotentiation at CA1 synapses via cAMP-dependent mechanism. J Neurosci (1998) 1.12
Reinforcement as consolidation. Psychol Rev (1969) 1.09
Corticotropin-releasing factor binding protein within the ventral tegmental area is expressed in a subset of dopaminergic neurons. J Comp Neurol (2008) 1.08
Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. J Neurosci (2001) 1.04
A map of the rat mesencephalon for electrical self-stimulation. Brain Res (1972) 1.03
Unilateral dopamine denervation blocks corticostriatal LTP. J Neurophysiol (1999) 1.03
Synaptic plasticity in the basal ganglia. Behav Brain Res (2008) 1.01
Long-term potentiation at excitatory amino acid synapses on midbrain dopamine neurons. Neuroreport (1999) 1.00
Facilitating effects of pre- and posttrial amphetamine administration on discrimination learning in mice. Agents Actions (1969) 1.00
Topographic organization of ascending dopaminergic projections. Ann N Y Acad Sci (1988) 1.00
Reward or reinforcement: what's the difference? Neurosci Biobehav Rev (1989) 1.00
Contingent and non-contingent actions of sucrose and saccharin reinforcers: effects on taste preference and memory. Physiol Behav (1984) 0.98
Pimozide and amphetamine have opposing effects on the reward summation function. Pharmacol Biochem Behav (1984) 0.95
D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacol Biochem Behav (1993) 0.94
Late prenatal ontogeny of central monoamine neurons in the rat: Fluorescence histochemical observations. Z Anat Entwicklungsgesch (1973) 0.93
Roles of dopamine receptors in long-term depression: enhancement via D1 receptors and inhibition via D2 receptors. Receptors Channels (1996) 0.92
Intracranial self-stimulation: mapping against the lateral boundaries of the dopaminergic cells of the substantia nigra. Brain Res (1981) 0.91
Brain stimulation reward and dopamine terminal fields. I. Caudate-putamen, nucleus accumbens and amygdala. Brain Res (1984) 0.87
Parametric analysis of brain stimulation reward in the rat: I. The transient process and the memory-containing process. J Comp Physiol Psychol (1974) 0.87
Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats. Psychopharmacology (Berl) (2004) 0.86
Brain stimulation reward and dopamine terminal fields. II. Septal and cortical projections. Brain Res (1984) 0.85
THE REPRODUCTIVE BEHAVIOR OF RING DOVES. Sci Am (1964) 0.83
Brainstem pathways of reward. J Comp Physiol Psychol (1969) 0.83
Drive, incentive, and reinforcement: the antecedents and consequences of motivation. Nebr Symp Motiv (2004) 0.82
Changes in morphine self-administration and morphine dependence after lesions of the caudate nucleus in rats. Psychopharmacologia (1975) 0.80
Post-trial reinforcing hypothalamic stimulation can facilitate avoidance learning. Neurosci Lett (1976) 0.78
Memory facilitation by self-stimulation reinforcement mediated by the nigro-neostriatal bundle. Physiol Behav (1978) 0.78