Distribution and patterns of staining of Neu oncogene product in benign and malignant breast diseases.

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🔗 View Article (PMID 1977159)

Published in Mod Pathol on July 01, 1990

Authors

W Hanna1, H J Kahn, I Andrulis, T Pawson

Author Affiliations

1: Women's College Hospital, Mount Sinai Research Institute, Toronto, Canada.

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SH2 domains recognize specific phosphopeptide sequences. Cell (1993) 17.28

Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. Biochemistry (1994) 13.94

The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res (2005) 12.94

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science (1991) 12.93

BIND--The Biomolecular Interaction Network Database. Nucleic Acids Res (2001) 11.74

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature (2001) 7.31

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature (1993) 7.11

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell (1992) 6.86

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature (1990) 5.57

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (1992) 5.47

A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol (2000) 5.06

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J (1996) 4.65

Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science (1990) 4.21

Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc Natl Acad Sci U S A (1990) 4.13

Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12

The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell (1997) 4.11

ICOS is essential for effective T-helper-cell responses. Nature (2001) 4.01

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Mol Cell Biol (1986) 4.00

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell (1993) 3.94

Binding of GAP to activated PDGF receptors. Science (1990) 3.89

Syk tyrosine kinase required for mouse viability and B-cell development. Nature (1995) 3.87

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science (1994) 3.53

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science (1993) 3.30

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J (1997) 3.27

Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell (1996) 3.19

EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol (1998) 3.10

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J (1990) 3.05

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell (2000) 2.88

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature (1996) 2.81

Cell-free translation of virion RNA from nondefective and transformation-defective Rous sarcoma viruses. J Virol (1976) 2.68

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell (1998) 2.64

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J (1997) 2.62

A strain of Fujinami sarcoma virus which is temperature-sensitive in protein phosphorylation and cellular transformation. Cell (1980) 2.61

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol (1989) 2.45

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron (1994) 2.44

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Nat Cell Biol (2001) 2.41

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature (1995) 2.41

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol Cell Biol (1991) 2.40

A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J (1991) 2.38

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat Immunol (2001) 2.31

Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Oncogene (1988) 2.31

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell (2001) 2.31

Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J (1992) 2.29

SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J Biol Chem (1996) 2.28

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene (1994) 2.27

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J (1996) 2.26

Mutational activation of c-raf-1 and definition of the minimal transforming sequence. Mol Cell Biol (1990) 2.24

Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity. Cell (1984) 2.18

Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. Curr Biol (2001) 2.16

Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat Struct Biol (1998) 2.15

Selective methyl group protonation of perdeuterated proteins. J Mol Biol (1996) 2.15

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Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis. Cell (1984) 2.12

The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils. Mol Cell Biol (1998) 2.10

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J (1997) 2.09

The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Mol Cell Biol (1999) 2.09

The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron (2001) 2.02

UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell (1998) 2.02

Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol (2001) 2.01

Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Cell (1996) 2.00

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase. Mol Cell Biol (1993) 1.96

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins. J Biol Chem (1993) 1.96

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med (1993) 1.95

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor. Mol Cell Biol (1990) 1.95

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J (1994) 1.94

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. Proc Natl Acad Sci U S A (1992) 1.93

The size of Rous sarcoma virus mRNAs active in cell-free translation. Nature (1977) 1.92

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J (1993) 1.91

The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. Nat Struct Biol (1999) 1.85

The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function. Mol Cell Biol (1989) 1.81

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol Cell Biol (2000) 1.81

Role of antibody to S100 protein in diagnostic pathology. Am J Clin Pathol (1983) 1.80

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. Oncogene (1993) 1.79

Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol Cell Biol (1999) 1.79

The PTB domain: a new protein module implicated in signal transduction. Trends Biochem Sci (1995) 1.78

A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity. EMBO J (1986) 1.77

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc Natl Acad Sci U S A (1993) 1.76

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol (1991) 1.76

The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev (2000) 1.74

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol (2001) 1.71

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach. Mol Cell Biol (1993) 1.70

The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem (1999) 1.66

Discoidin domain receptor 1 is activated independently of beta(1) integrin. J Biol Chem (2000) 1.64

Mutational analysis of a phosphotransfer motif essential for v-fps tyrosine kinase activity. Oncogene (1988) 1.63

Role of p120 Ras-GAP in directed cell movement. J Cell Biol (2000) 1.59

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J (1991) 1.58

raf family serine/threonine protein kinases in mitogen signal transduction. Cold Spring Harb Symp Quant Biol (1988) 1.57

Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein. Mol Cell Biol (1985) 1.57

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A (1998) 1.57

A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell. Proc Natl Acad Sci U S A (1987) 1.51

Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. Trends Genet (1994) 1.50

A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J (1992) 1.49

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell (1994) 1.48

Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction. Mol Cell Biol (2001) 1.48

Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors. Mol Cell Biol (2000) 1.47

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis (2000) 1.46

Shc products are substrates of erbB-2 kinase. Oncogene (1993) 1.46

Mapping of multiple phosphorylation sites within the structural and catalytic domains of the Fujinami avian sarcoma virus transforming protein. J Virol (1983) 1.45