Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development.

PubWeight™: 2.01‹?› | Rank: Top 2%

🔗 View Article (PMC 86919)

Published in Mol Cell Biol on April 01, 2001

Authors

W F Vogel1, A Aszódi, F Alves, T Pawson

Author Affiliations

1: Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5. W.Vogel@em.uni-frankfurt.de

Articles citing this

Stromal effects on mammary gland development and breast cancer. Science (2002) 5.22

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13

The extracellular matrix in development and morphogenesis: a dynamic view. Dev Biol (2009) 2.82

Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol (2010) 2.79

Hormonal and local control of mammary branching morphogenesis. Differentiation (2006) 2.60

Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discov (2011) 2.49

Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res (2005) 2.46

Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. Int J Biochem Cell Biol (2007) 2.12

Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev (2012) 1.96

Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling. Structure (2012) 1.68

Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell (2005) 1.53

Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol Cancer (2010) 1.51

Integrated morphodynamic signalling of the mammary gland. Nat Rev Mol Cell Biol (2011) 1.50

Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Mol Biol Cell (2003) 1.44

p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J (2003) 1.44

Comparative mechanisms of branching morphogenesis in diverse systems. J Mammary Gland Biol Neoplasia (2006) 1.39

Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Am J Pathol (2004) 1.39

Discoidin domain receptor functions in physiological and pathological conditions. Int Rev Cell Mol Biol (2014) 1.29

Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. J Biol Chem (2013) 1.27

The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest (2001) 1.25

Crystallographic insight into collagen recognition by discoidin domain receptor 2. Structure (2009) 1.25

Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy. BMC Genomics (2007) 1.24

Long-range mechanical force enables self-assembly of epithelial tubular patterns. Proc Natl Acad Sci U S A (2012) 1.24

Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. Matrix Biol (2010) 1.17

Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Res (2014) 1.13

Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity. Oncotarget (2014) 1.07

Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation. PLoS One (2012) 1.04

Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy. Am J Pathol (2011) 1.02

Discoidin domain receptors in disease. Matrix Biol (2013) 1.01

DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin. Mol Biol Cell (2011) 1.00

Identification of disulfide-linked dimers of the receptor tyrosine kinase DDR1. J Biol Chem (2007) 1.00

Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment. Breast Cancer Res (2011) 0.97

Wnt5a as an effector of TGFβ in mammary development and cancer. J Mammary Gland Biol Neoplasia (2011) 0.96

Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. Genomics (2009) 0.96

Collagen recognition and transmembrane signalling by discoidin domain receptors. Biochim Biophys Acta (2012) 0.96

Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2. J Mol Biol (2009) 0.94

Retracted Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis. Am J Pathol (2006) 0.94

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. Nat Med (2016) 0.94

Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. J Mol Biol (2014) 0.90

The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells. Fertil Steril (2009) 0.90

Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase. J Cell Biochem (2006) 0.89

Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture. Exp Cell Res (2011) 0.89

Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts. Bone (2013) 0.89

Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia (2013) 0.87

Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 loss. Mol Cancer Ther (2013) 0.87

Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells. Clin Exp Metastasis (2011) 0.85

Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. Breast Cancer Res Treat (2015) 0.85

KIBRA: In the brain and beyond. Cell Signal (2014) 0.85

Collagen XV inhibits epithelial to mesenchymal transition in pancreatic adenocarcinoma cells. PLoS One (2013) 0.85

Identification of receptor tyrosine kinase, discoidin domain receptor 1 (DDR1), as a potential biomarker for serous ovarian cancer. Int J Mol Sci (2011) 0.84

Self/nonself perception, reproduction and the extended MHC. Self Nonself (2010) 0.84

Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition. Int J Cancer (2014) 0.83

Lessons from the alpha2 integrin knockout mouse. Am J Pathol (2002) 0.83

High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma. J Exp Clin Cancer Res (2015) 0.82

Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery. Drug Discov Today (2014) 0.81

Semi-automatic classification of skeletal morphology in genetically altered mice using flat-panel volume computed tomography. PLoS Genet (2007) 0.81

Discoidin domain receptor 1: isoform expression and potential functions in cirrhotic human liver. Am J Pathol (2011) 0.81

Mesenchymal Stem Cells Sense Three Dimensional Type I Collagen through Discoidin Domain Receptor 1. Open Stem Cell J (2009) 0.80

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1). Mol Biol Cell (2014) 0.80

Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications. J Biol Chem (2014) 0.80

Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. Oncotarget (2015) 0.79

Collagen type IV at the fetal-maternal interface. Placenta (2014) 0.77

Discoidin domain receptor-1 and periostin: new players in chronic kidney disease. Nephrol Dial Transplant (2015) 0.76

Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1. BMC Cancer (2014) 0.76

Collagen Fibril Ultrastructure in Mice Lacking Discoidin Domain Receptor 1. Microsc Microanal (2016) 0.76

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis. Matrix Biol (2016) 0.75

KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy. ESMO Open (2016) 0.75

Articles cited by this

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell (1991) 14.23

Signaling--2000 and beyond. Cell (2000) 11.78

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell (1998) 5.92

Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev (1997) 5.57

The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell (1997) 4.11

An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell (1997) 2.89

Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Cell (1996) 2.55

Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development (1995) 2.50

Discoidin domain receptors: structural relations and functional implications. FASEB J (1999) 2.23

Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell (1994) 2.07

Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene (1995) 1.81

The discoidin domain family revisited: new members from prokaryotes and a homology-based fold prediction. Protein Sci (1998) 1.74

Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J Cell Biol (1998) 1.69

Discoidin domain receptor 1 is activated independently of beta(1) integrin. J Biol Chem (2000) 1.64

Colony stimulating factor 1 is required for mammary gland development during pregnancy. Proc Natl Acad Sci U S A (1994) 1.53

Molecular genetics of implantation in the mouse. Dev Genet (1997) 1.46

A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. Proc Natl Acad Sci U S A (1993) 1.36

Signaling networks--do all roads lead to the same genes? Cell (1999) 1.34

Overexpression of protein tyrosine kinases in human esophageal cancer. Pathobiology (1997) 1.32

Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biol Reprod (1997) 1.24

Expression patterns of the novel receptor-like tyrosine kinase, DDR, in human breast tumours. Oncogene (1995) 1.21

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period. Dev Genet (1997) 1.18

Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Genes Dev (2000) 1.12

NEP: a novel receptor-like tyrosine kinase expressed in proliferating neuroepithelia. Oncogene (1993) 1.10

Structure and expression of the Tyro 10 receptor tyrosine kinase. Oncogene (1994) 1.10

Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain. Proc Natl Acad Sci U S A (1994) 1.01

Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues. J Biol Chem (1993) 1.01

Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line. Cell Growth Differ (1994) 1.00

Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines. Oncogene (1996) 0.92

Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain. Oncogene (1994) 0.90

Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. FEBS Lett (1996) 0.90

Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors. FASEB J (2000) 0.90

Pediatric brain tumors express multiple receptor tyrosine kinases including novel cell adhesion kinases. Pediatr Neurosurg (1996) 0.87

The genomic structure of discoidin receptor tyrosine kinase. Genome Res (1996) 0.85

Expression of collagen alpha 1(VI), alpha 2(VI), and alpha 3(VI) chains in the pregnant mouse uterus. Biol Reprod (1995) 0.84

Type V collagen is an epithelial cell cycle inhibitor that is induced by and mimics the effects of transforming growth factor beta1. Cell Growth Differ (1998) 0.82

Articles by these authors

SH2 domains recognize specific phosphopeptide sequences. Cell (1993) 17.28

Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. Biochemistry (1994) 13.94

The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res (2005) 12.94

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science (1991) 12.93

BIND--The Biomolecular Interaction Network Database. Nucleic Acids Res (2001) 11.74

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature (2001) 7.31

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature (1993) 7.11

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell (1992) 6.86

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature (1990) 5.57

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (1992) 5.47

A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol (2000) 5.06

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J (1996) 4.65

Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science (1990) 4.21

Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc Natl Acad Sci U S A (1990) 4.13

Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12

The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell (1997) 4.11

ICOS is essential for effective T-helper-cell responses. Nature (2001) 4.01

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Mol Cell Biol (1986) 4.00

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell (1993) 3.94

Binding of GAP to activated PDGF receptors. Science (1990) 3.89

Syk tyrosine kinase required for mouse viability and B-cell development. Nature (1995) 3.87

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science (1994) 3.53

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science (1993) 3.30

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J (1997) 3.27

Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell (1996) 3.19

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J (1990) 3.05

Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science (1996) 3.01

Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J (1998) 2.96

Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol (1999) 2.94

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell (2000) 2.88

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature (1996) 2.81

Oncogenic potential of EAG K(+) channels. EMBO J (1999) 2.74

Cell-free translation of virion RNA from nondefective and transformation-defective Rous sarcoma viruses. J Virol (1976) 2.68

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell (1998) 2.64

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J (1997) 2.62

A strain of Fujinami sarcoma virus which is temperature-sensitive in protein phosphorylation and cellular transformation. Cell (1980) 2.61

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol (1989) 2.45

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron (1994) 2.44

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Nat Cell Biol (2001) 2.41

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature (1995) 2.41

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol Cell Biol (1991) 2.40

Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J Biol Chem (1999) 2.38

A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J (1991) 2.38

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat Immunol (2001) 2.31

Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Oncogene (1988) 2.31

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell (2001) 2.31

Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J (1992) 2.29

SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J Biol Chem (1996) 2.28

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene (1994) 2.27

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J (1996) 2.26

Mutational activation of c-raf-1 and definition of the minimal transforming sequence. Mol Cell Biol (1990) 2.24

Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity. Cell (1984) 2.18

Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. Curr Biol (2001) 2.16

Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat Struct Biol (1998) 2.15

Selective methyl group protonation of perdeuterated proteins. J Mol Biol (1996) 2.15

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions. Curr Biol (1996) 2.13

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem (1993) 2.13

Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis. Cell (1984) 2.12

The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils. Mol Cell Biol (1998) 2.10

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J (1997) 2.09

The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Mol Cell Biol (1999) 2.09

The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron (2001) 2.02

UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell (1998) 2.02

Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Cell (1996) 2.00

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase. Mol Cell Biol (1993) 1.96

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins. J Biol Chem (1993) 1.96

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor. Mol Cell Biol (1990) 1.95

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med (1993) 1.95

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J (1994) 1.94

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. Proc Natl Acad Sci U S A (1992) 1.93

The size of Rous sarcoma virus mRNAs active in cell-free translation. Nature (1977) 1.92

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J (1993) 1.91

Symptomless Plasmodium vivax infections in native Amazonians. Lancet (1999) 1.90

The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. Nat Struct Biol (1999) 1.85

The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function. Mol Cell Biol (1989) 1.81

Functional consequences of integrin gene mutations in mice. Circ Res (2001) 1.81

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol Cell Biol (2000) 1.81

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. Oncogene (1993) 1.79

Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol Cell Biol (1999) 1.79

The PTB domain: a new protein module implicated in signal transduction. Trends Biochem Sci (1995) 1.78

A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity. EMBO J (1986) 1.77

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol (1991) 1.76

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc Natl Acad Sci U S A (1993) 1.76

Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. Oncogene (1995) 1.75

The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev (2000) 1.74

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol (2001) 1.71

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach. Mol Cell Biol (1993) 1.70

The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem (1999) 1.66

Discoidin domain receptor 1 is activated independently of beta(1) integrin. J Biol Chem (2000) 1.64

Mutational analysis of a phosphotransfer motif essential for v-fps tyrosine kinase activity. Oncogene (1988) 1.63

Role of voltage-gated potassium channels in cancer. J Membr Biol (2005) 1.60

Role of p120 Ras-GAP in directed cell movement. J Cell Biol (2000) 1.59

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J (1991) 1.58

raf family serine/threonine protein kinases in mitogen signal transduction. Cold Spring Harb Symp Quant Biol (1988) 1.57

Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein. Mol Cell Biol (1985) 1.57

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A (1998) 1.57

Stage-and tissue-specific expression of a Col2a1-Cre fusion gene in transgenic mice. Matrix Biol (2001) 1.55