Involvement of hippocampal jun-N terminal kinase pathway in the enhancement of learning and memory by nicotine.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 2794924)

Published in Neuropsychopharmacology on January 01, 2010

Authors

Justin W Kenney1, Cédrick Florian, George S Portugal, Ted Abel, Thomas J Gould

Author Affiliations

1: Department of Psychology, Temple University, Philadelphia, PA 19122, USA.

Articles citing this

Substance abuse, memory, and post-traumatic stress disorder. Neurobiol Learn Mem (2013) 0.97

Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory. Learn Mem (2012) 0.96

Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning. Hippocampus (2012) 0.93

Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning. Neurobiol Learn Mem (2013) 0.93

Nicotine and extinction of fear conditioning. Neuroscience (2009) 0.84

Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory. Neurobiol Learn Mem (2014) 0.83

Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus. PLoS One (2012) 0.81

Withdrawal from chronic nicotine and subsequent sensitivity to nicotine challenge on contextual learning. Behav Brain Res (2013) 0.80

Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear. Brain Res (2014) 0.79

Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory. Neuropharmacology (2015) 0.77

Stronger learning recruits additional cell-signaling cascades: c-Jun-N-terminal kinase 1 (JNK1) is necessary for expression of stronger contextual fear conditioning. Neurobiol Learn Mem (2014) 0.77

Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory. Physiol Behav (2015) 0.77

Low dose nicotine attenuates Aβ neurotoxicity through activation early growth response gene 1 pathway. PLoS One (2015) 0.76

Withdrawal From Chronic Nicotine Reduces Thyroid Hormone Levels and Levothyroxine Treatment Ameliorates Nicotine Withdrawal-Induced Deficits in Hippocampus-Dependent Learning in C57BL/6J Mice. Nicotine Tob Res (2014) 0.75

c-Jun-N-terminal kinase 1 is necessary for nicotine-induced enhancement of contextual fear conditioning. Neurosci Lett (2016) 0.75

Articles cited by this

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A (2001) 11.06

Modality-specific retrograde amnesia of fear. Science (1992) 9.36

Cigarette smoking among adults--United States, 2000. MMWR Morb Mortal Wkly Rep (2002) 7.32

Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J (1996) 6.07

Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02

Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci (2007) 4.98

Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell (1997) 4.83

Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol (2004) 4.59

The neuroscience of mammalian associative learning. Annu Rev Psychol (2005) 4.21

Transcription factors in long-term memory and synaptic plasticity. Physiol Rev (2009) 3.73

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nat Neurosci (1998) 3.33

Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev (2006) 3.30

Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat. J Comp Neurol (1989) 3.08

Review. Context-induced relapse to drug seeking: a review. Philos Trans R Soc Lond B Biol Sci (2008) 2.98

MAP kinases and the control of nuclear events. Oncogene (2007) 2.74

Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study. Neuropsychopharmacology (2007) 2.73

Relapse to smoking. Clin Psychol Rev (2005) 2.73

The role of mRNA and protein stability in gene expression. FASEB J (1989) 2.64

Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement. Psychopharmacology (Berl) (2005) 2.49

JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell (2003) 2.45

Understanding contextual fear conditioning: insights from a two-process model. Neurosci Biobehav Rev (2004) 2.44

Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. Science (1986) 2.43

Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain. Eur J Neurosci (2004) 2.42

Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity. Neuron (2001) 2.23

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. Genes Dev (1989) 2.17

Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors. J Neurosci (1999) 2.12

Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. Prog Neurobiol (2003) 2.06

Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memory. Neuropharmacology (2006) 1.94

The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus. J Neurosci (1999) 1.94

Ca2+ permeability of the (alpha4)3(beta2)2 stoichiometry greatly exceeds that of (alpha4)2(beta2)3 human acetylcholine receptors. Mol Pharmacol (2006) 1.91

Importance of nonpharmacological factors in nicotine self-administration. Physiol Behav (2002) 1.83

Dissociating nicotine and nonnicotine components of cigarette smoking. Pharmacol Biochem Behav (2000) 1.81

Modulation of hippocampus-dependent learning and synaptic plasticity by nicotine. Mol Neurobiol (2008) 1.71

AKAP signaling complexes at the cytoskeleton. J Cell Sci (2001) 1.60

c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. J Neurosci (2002) 1.59

Nicotine enhancement of contextual fear conditioning. Behav Brain Res (1999) 1.57

Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J Neurosci (2005) 1.54

Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training. Neurobiol Learn Mem (2003) 1.49

Hippocampal alpha4beta2 nicotinic acetylcholine receptor involvement in the enhancing effect of acute nicotine on contextual fear conditioning. J Neurosci (2007) 1.48

The role of protein synthesis in memory consolidation: progress amid decades of debate. Neurobiol Learn Mem (2007) 1.39

Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience (2004) 1.33

Hippocampal CRE-mediated gene expression is required for contextual memory formation. Nat Neurosci (2002) 1.33

Nicotine enhances trace cued fear conditioning but not delay cued fear conditioning in C57BL/6 mice. Behav Brain Res (2004) 1.29

Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation. J Biol Chem (1998) 1.27

Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1. Mol Cell Neurosci (2002) 1.25

A comparative study of the disposition of nicotine and its metabolites in three inbred strains of mice. Drug Metab Dispos (1985) 1.24

Acute and chronic nicotine exposure differentially facilitate the induction of LTP. Brain Res (1999) 1.23

Memory retrieval after contextual fear conditioning induces c-Fos and JunB expression in CA1 hippocampus. Genes Brain Behav (2003) 1.18

Nicotine enhances both foreground and background contextual fear conditioning. Neurosci Lett (2005) 1.13

Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex. J Neurosci (2002) 1.12

Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. Learn Mem (2008) 1.11

beta2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice. Psychopharmacology (Berl) (2006) 1.11

LTP, memory and structural plasticity. Curr Mol Med (2002) 1.10

Nicotine enhances context learning but not context-shock associative learning. Behav Neurosci (2008) 1.09

JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1. Eur J Neurosci (2007) 1.05

Contextual renewal of nicotine seeking in rats and its suppression by the cannabinoid-1 receptor antagonist Rimonabant (SR141716A). Neuropharmacology (2008) 1.04

Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain. Neuropharmacology (2000) 1.02

Contextual stimuli modulate extinction and reinstatement in rodents self-administering intravenous nicotine. Psychopharmacology (Berl) (2008) 1.01

Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. Behav Neurosci (2007) 0.93

Hippocampal microtubule-associated protein-2 alterations with contextual memory. Brain Res (1999) 0.91

Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task. Eur J Neurosci (2003) 0.91

Time-dependent changes in transcriptional profiles within five rat brain regions in response to nicotine treatment. Brain Res Mol Brain Res (2004) 0.89

Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioning. Learn Mem (2005) 0.88

NMDA and AMPA receptors contribute to the nicotinic cholinergic excitation of CA1 interneurons in the rat hippocampus. J Neurophysiol (2003) 0.88

Chronic nicotine enhances basal and nicotine-induced Fos immunoreactivity preferentially in the medial prefrontal cortex of the rat. Neuropsychopharmacology (1997) 0.87

Differential effects of acute and chronic nicotine on Elk-1 in rat hippocampus. Neuroreport (2007) 0.81

Articles by these authors

Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron (2009) 5.22

Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02

Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. Learn Mem (2005) 3.37

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J Biol Chem (2005) 2.47

Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning. Learn Mem (2003) 2.34

A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem (2006) 2.11

Sleep deprivation impairs cAMP signalling in the hippocampus. Nature (2009) 1.83

Modulation of hippocampus-dependent learning and synaptic plasticity by nicotine. Mol Neurobiol (2008) 1.71

Withdrawal from chronic nicotine administration impairs contextual fear conditioning in C57BL/6 mice. J Neurosci (2005) 1.68

Post-training reversible inactivation of the hippocampus enhances novel object recognition memory. Learn Mem (2010) 1.65

Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus. Physiol Genomics (2012) 1.64

Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. Proc Natl Acad Sci U S A (2004) 1.64

The mouse: genetics meets behaviour. Nat Rev Genet (2002) 1.62

Long-term effects of culture of preimplantation mouse embryos on behavior. Proc Natl Acad Sci U S A (2004) 1.57

The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology (2012) 1.53

Hippocampal alpha4beta2 nicotinic acetylcholine receptor involvement in the enhancing effect of acute nicotine on contextual fear conditioning. J Neurosci (2007) 1.48

Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem (2007) 1.48

The effects of DHBE and MLA on nicotine-induced enhancement of contextual fear conditioning in C57BL/6 mice. Psychopharmacology (Berl) (2005) 1.39

The role of protein synthesis in memory consolidation: progress amid decades of debate. Neurobiol Learn Mem (2007) 1.39

Genetic evidence for a role of CREB in sustained cortical arousal. J Neurophysiol (2003) 1.37

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol (2010) 1.34

Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced training. J Neurophysiol (2002) 1.30

Astrocyte-derived adenosine and A1 receptor activity contribute to sleep loss-induced deficits in hippocampal synaptic plasticity and memory in mice. J Neurosci (2011) 1.29

Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. J Neurosci (2006) 1.25

Involvement of the hippocampal CA3-region in acquisition and in memory consolidation of spatial but not in object information in mice. Neurobiol Learn Mem (2003) 1.25

Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions. Brain Res (2009) 1.24

Adrenergic signaling plays a critical role in the maintenance of waking and in the regulation of REM sleep. J Neurophysiol (2004) 1.23

Combinatorial chromatin modifications and memory storage: a code for memory? Learn Mem (2006) 1.23

The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components. Neurochem Res (2004) 1.23

A loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis. Proc Natl Acad Sci U S A (2008) 1.21

Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes. Mol Cell Biol (2003) 1.19

Temporal spacing of synaptic stimulation critically modulates the dependence of LTP on cyclic AMP-dependent protein kinase. Hippocampus (2003) 1.18

Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning. Neurobiol Learn Mem (2007) 1.16

Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learn Mem (2011) 1.16

Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP. Neuropsychopharmacology (2006) 1.15

Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus. Learn Mem (2006) 1.14

Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. Learn Mem (2011) 1.14

Behavioral epigenetics. Ann N Y Acad Sci (2011) 1.14

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. Behav Brain Res (2008) 1.14

Nicotine enhances both foreground and background contextual fear conditioning. Neurosci Lett (2005) 1.13

Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinction. J Neurosci (2006) 1.12

beta2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice. Psychopharmacology (Berl) (2006) 1.11

Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proc Natl Acad Sci U S A (2009) 1.09

Nicotine enhances context learning but not context-shock associative learning. Behav Neurosci (2008) 1.09

Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice. Behav Neurosci (2008) 1.07

Quantification of brain maturation and growth patterns in C57BL/6J mice via computational neuroanatomy of diffusion tensor images. Cereb Cortex (2008) 1.06

Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. Brain Res (2008) 1.05

NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors. J Clin Invest (2012) 1.04

Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory. J Neurosci (2007) 1.04

Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrains. Brain Res (2003) 1.03

Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze. Behav Neurosci (2003) 1.03

Strain-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning. Behav Genet (2011) 1.03

The role of NR4A transcription factors in memory formation. Brain Res Bull (2011) 1.03

Neuronal nicotinic acetylcholine receptors: involvement in Alzheimer's disease and schizophrenia. Behav Cogn Neurosci Rev (2002) 1.02

Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors. Biol Psychiatry (2012) 1.02

Differential role for CBP and p300 CREB-binding domain in motor skill learning. Behav Neurosci (2006) 1.02

Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. Am J Pathol (2005) 1.02

Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning. Neurobiol Learn Mem (2012) 1.01

Genetic approaches to the study of synaptic plasticity and memory storage. CNS Spectr (2003) 1.01

Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential. Neuropsychopharmacology (2004) 1.00

Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. PLoS Comput Biol (2010) 0.99

Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors. J Neurosci (2009) 0.99

Compartmentalized PKA signaling events are required for synaptic tagging and capture during hippocampal late-phase long-term potentiation. Eur J Cell Biol (2006) 0.99

Bupropion dose-dependently reverses nicotine withdrawal deficits in contextual fear conditioning. Pharmacol Biochem Behav (2007) 0.99

Interactive effects of ethanol and nicotine on learning in C57BL/6J mice depend on both dose and duration of treatment. Psychopharmacology (Berl) (2007) 0.99

Aging impairs hippocampus-dependent long-term memory for object location in mice. Neurobiol Aging (2011) 0.99

Impulsive responding on the peak-interval procedure. Behav Processes (2006) 0.98

Acute ethanol has biphasic effects on short- and long-term memory in both foreground and background contextual fear conditioning in C57BL/6 mice. Alcohol Clin Exp Res (2007) 0.98

Metaplasticity of the late-phase of long-term potentiation: a critical role for protein kinase A in synaptic tagging. Eur J Neurosci (2006) 0.98

Age-related impairment in the 250-millisecond delay eyeblink classical conditioning procedure in C57BL/6 mice. Learn Mem (2002) 0.97

The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J mice. Psychopharmacology (Berl) (2011) 0.97

Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits. Eur Neuropsychopharmacol (2009) 0.96

The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity. Cell Signal (2012) 0.96

Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine. J Neurosci (2011) 0.96

Atomoxetine reverses nicotine withdrawal-associated deficits in contextual fear conditioning. Neuropsychopharmacology (2007) 0.96

Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory. Learn Mem (2012) 0.96

Associative learning, the hippocampus, and nicotine addiction. Curr Drug Abuse Rev (2008) 0.95

Nicotine withdrawal disrupts new contextual learning. Pharmacol Biochem Behav (2008) 0.95

Genetic and pharmacological demonstration of a role for cyclic AMP-dependent protein kinase-mediated suppression of protein phosphatases in gating the expression of late LTP. Eur J Neurosci (2002) 0.95

The hippocampus and cingulate cortex differentially mediate the effects of nicotine on learning versus on ethanol-induced learning deficits through different effects at nicotinic receptors. Neuropsychopharmacology (2009) 0.94

Differential involvement of NMDA and AMPA receptors within the nucleus accumbens in consolidation of information necessary for place navigation and guidance strategy of mice. Learn Mem (2003) 0.94

Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory. J Neurosci (2012) 0.94

Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gs alpha. Neuropsychopharmacology (2004) 0.93

Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. Behav Neurosci (2007) 0.93

Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning. Hippocampus (2012) 0.93

Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex. Mol Pain (2008) 0.92

Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation. Hippocampus (2006) 0.92

Nicotine withdrawal disrupts both foreground and background contextual fear conditioning but not pre-pulse inhibition of the acoustic startle response in C57BL/6 mice. Behav Brain Res (2008) 0.92

Reversible inactivation of the entorhinal cortex disrupts the establishment and expression of latent inhibition of cued fear conditioning in C57BL/6 mice. Hippocampus (2007) 0.92

Fear conditioning increases NREM sleep. Behav Neurosci (2007) 0.92

Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus. Neuropharmacology (2010) 0.91

A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci (2008) 0.91

Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus. Learn Mem (2008) 0.91

Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A. Learn Mem (2009) 0.91

The interactive effects of nicotinic and muscarinic cholinergic receptor inhibition on fear conditioning in young and aged C57BL/6 mice. Pharmacol Biochem Behav (2004) 0.91