PubRank

Neil L Harrison

Author PubWeight™ 60.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A 2004 7.51
2 Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol 2003 3.43
3 Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci 2005 2.91
4 Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature 2003 2.89
5 Extrasynaptic GABAA receptors: form, pharmacology, and function. J Neurosci 2009 2.39
6 An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. J Neurophysiol 2005 2.22
7 Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. J Neurosci 2008 1.45
8 Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice. Alcohol Clin Exp Res 2007 1.39
9 Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus. J Pharmacol Exp Ther 2008 1.22
10 Alcohol regulates gene expression in neurons via activation of heat shock factor 1. J Neurosci 2007 1.19
11 Charged residues in the beta2 subunit involved in GABAA receptor activation. J Biol Chem 2003 1.18
12 Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. J Pharmacol Exp Ther 2006 1.14
13 A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor. J Biol Chem 2003 1.14
14 Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit. J Neurophysiol 2002 1.14
15 Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus. J Pharmacol Exp Ther 2007 1.13
16 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor. J Med Chem 2002 1.11
17 A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. J Biol Chem 2004 1.09
18 The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: effects of TM2 mutations in the alpha and beta subunits. Anesthesiology 2003 1.08
19 Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology 2002 1.08
20 Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology 2007 1.07
21 Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. Eur J Neurosci 2006 1.06
22 Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharmacol Exp Ther 2005 1.03
23 Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels. J Neurosci 2012 1.02
24 Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor. J Biol Chem 2004 0.99
25 GABAA receptors in the thalamus: alpha4 subunit expression and alcohol sensitivity. Alcohol 2007 0.98
26 The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor. J Physiol 2006 0.98
27 The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem. J Pharmacol Exp Ther 2008 0.97
28 Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. Biochemistry 2004 0.93
29 Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors. Neurosci Lett 2004 0.93
30 Molecular volume determines the activity of the halogenated alkane bromoform at wild-type and mutant GABA(A) receptors. Brain Res 2003 0.92
31 Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors. J Gen Physiol 2008 0.92
32 Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit. J Chem Inf Model 2008 0.91
33 The regulation of neuronal gene expression by alcohol. Pharmacol Ther 2009 0.90
34 Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res 2005 0.90
35 The activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors. J Gen Physiol 2010 0.89
36 Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology 2008 0.86
37 The effects of isoflurane on desensitized wild-type and alpha 1(S270H) gamma-aminobutyric acid type A receptors. Anesth Analg 2004 0.86
38 Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a γ-aminobutyric acid type A receptor mechanism. Anesthesiology 2013 0.84
39 Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists. Anesthesiology 2003 0.83
40 Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway. Brain Behav 2013 0.82
41 GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice. Brain Res 2006 0.80
42 Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors. Alcohol Clin Exp Res 2008 0.79
43 Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy. Blood 2003 0.77
44 Knockin' on the door of general anesthetic mechanisms: but will U.S. researchers be shut out? Anesth Analg 2003 0.76
45 Acetaldehyde, not ethanol, impairs myelin formation and viability in primary mouse oligodendrocytes. Alcohol Clin Exp Res 2015 0.75
46 General anesthesia research: aroused from a deep sleep? Nat Neurosci 2002 0.75
47 Subunit-dependent block by isoflurane of wild-type and mutant alpha(1)S270H GABA(A) receptor currents in Xenopus oocytes. Neurosci Lett 2005 0.75