Published in J Biol Chem on October 06, 2009
Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist. J Am Chem Soc (2013) 1.24
FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer. PLoS One (2013) 0.97
Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation. Biochemistry (2010) 0.95
Synthetic Peptides as Protein Mimics. Front Bioeng Biotechnol (2016) 0.75
Sequence-Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications. Angew Chem Int Ed Engl (2016) 0.75
Engineered antibody fragments and the rise of single domains. Nat Biotechnol (2005) 6.96
Monoclonal antibody therapy of cancer. Nat Biotechnol (2005) 5.79
Potent antibody therapeutics by design. Nat Rev Immunol (2006) 4.87
Monoclonal antibody successes in the clinic. Nat Biotechnol (2005) 4.43
Antibody framework residues affecting the conformation of the hypervariable loops. J Mol Biol (1992) 2.44
VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure (1998) 2.02
Characterization of a new primary human pancreatic tumor line. Cancer Invest (1986) 1.67
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature (2003) 1.66
Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting. Nat Biotechnol (2007) 1.57
Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces. Chembiochem (2005) 1.42
Nanobodies as novel agents for cancer therapy. Expert Opin Biol Ther (2005) 1.26
Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo. Nat Biotechnol (2000) 1.26
Growth-promoting action of gastrin on human colonic and gastric tumour cells cultured in vitro. Br J Surg (1988) 1.24
Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS technology. J Mol Recognit (2007) 1.21
Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. Cancer Res (1996) 1.19
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene (2005) 1.18
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice. Nat Biotechnol (2000) 1.18
Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice. Cancer Res (1986) 1.15
Ranibizumab for the treatment of neovascular age-related macular degeneration: a review. Clin Ther (2007) 1.12
Anatomy of an antibody molecule: structure, kinetics, thermodynamics and mutational studies of the antilysozyme antibody D1.3. Immunol Rev (1998) 1.10
Identification of gastrin as a growth peptide in human pancreatic cancer. Am J Physiol (1995) 1.09
Affinity maturation of antibodies assisted by in silico modeling. Proc Natl Acad Sci U S A (2008) 1.09
Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNF alpha binding to its receptor. Nat Biotechnol (1997) 1.07
Intramers as promising new tools in functional proteomics. Chem Biol (2001) 1.07
Gastrin regulates growth of human pancreatic cancer in a tonic and autocrine fashion. Am J Physiol (1996) 1.06
Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor. Cancer Res (2004) 1.05
Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer. J Clin Oncol (2002) 1.00
Inhibition of self-binding antibodies (autobodies) by a VH-derived peptide. Science (1988) 0.97
Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice. Am J Pathol (2009) 0.97
Mapping of a discontinuous and highly conformational binding site on follicle stimulating hormone subunit-beta (FSH-beta) using domain Scan and Matrix Scan technology. Mol Divers (2004) 0.96
G17DT: an antigastrin immunogen for the treatment of gastrointestinal malignancy. Expert Opin Biol Ther (2007) 0.96
Systematic exploration of the antigen binding activity of synthetic peptides isolated from the variable regions of immunoglobulins. J Biol Chem (1997) 0.95
A fast mutagenesis procedure to recover soluble and functional scFvs containing amber stop codons from synthetic and semisynthetic antibody libraries. J Immunol Methods (2006) 0.91
Expression of gastrin and its receptor in human gastric cancer tissues. J Cancer Res Clin Oncol (2005) 0.91
A peptide mimetic of an anti-CD4 monoclonal antibody by rational design. Biochem Biophys Res Commun (2003) 0.89
Plastic antibodies: developments and applications. Trends Biotechnol (1998) 0.89
Rapid tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130Cas by gastrin in human colon cancer cells. Biochem Pharmacol (2004) 0.87
A phase II study of G17DT in gastric carcinoma. Eur J Surg Oncol (2004) 0.86
Battle over eye medicine gives drugmaker a dose of reality. Nat Med (2008) 0.86
Therapeutic peptides and peptidomimetics. Curr Opin Biotechnol (1997) 0.86
A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing. Protein Eng (1996) 0.85
Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells. J Biol Chem (1999) 0.84
Analysis of a 17-amino acid residue, virus-neutralizing microantibody. J Gen Virol (2005) 0.84
Designing antibodies for the inhibition of gastrin activity in tumoral cell lines. Int J Cancer (2008) 0.82
Synthetic CD4 exocyclic peptides antagonize CD4 holoreceptor binding and T cell activation. Nat Biotechnol (1996) 0.79
Dissection of an antibody paratope into peptides discloses the idiotope recognized by the cognate anti-idiotypic antibody. J Immunol Methods (2000) 0.76
Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane. Proc Natl Acad Sci U S A (2008) 2.25
Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Res (2006) 1.83
Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. FEBS Lett (2004) 1.59
Comparison study of two commercially available methods for the determination of infliximab, adalimumab, etanercept and anti-drug antibody levels. Clin Chem Lab Med (2013) 1.52
Photoinhibition - a historical perspective. Photosynth Res (2003) 1.47
Vaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of Plasmodium. PLoS One (2012) 1.43
Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces. Chembiochem (2005) 1.42
Islet amyloid polypeptide inserts into phospholipid monolayers as monomer. J Mol Biol (2005) 1.35
High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis. Cancer Res (2012) 1.32
Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation. Clin Cancer Res (2005) 1.31
Pathogenic and non-pathogenic polyglutamine tracts have similar structural properties: towards a length-dependent toxicity gradient. J Mol Biol (2007) 1.31
Proteomic expression analysis of colorectal cancer by two-dimensional differential gel electrophoresis. Proteomics (2005) 1.30
Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays. Mol Cell Proteomics (2009) 1.24
Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS technology. J Mol Recognit (2007) 1.21
Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin Cancer Res (2013) 1.17
Recent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitus. Exp Diabetes Res (2008) 1.15
A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure. Vaccine (2006) 1.15
Proteome analysis of membrane fractions in colorectal carcinomas by using 2D-DIGE saturation labeling. J Proteome Res (2008) 1.12
In-depth characterization of the secretome of colorectal cancer metastatic cells identifies key proteins in cell adhesion, migration, and invasion. Mol Cell Proteomics (2013) 1.11
Kinetic analysis of the interactions of human papillomavirus E6 oncoproteins with the ubiquitin ligase E6AP using surface plasmon resonance. J Mol Biol (2005) 1.10
Affinity maturation of antibodies assisted by in silico modeling. Proc Natl Acad Sci U S A (2008) 1.09
The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation. Mol Cell Biol (2009) 1.08
The spectrum of carcinoid tumours and carcinoid syndromes. Ann Clin Biochem (2003) 1.07
Protein-protein recognition and interaction hot spots in an antigen-antibody complex: free energy decomposition identifies "efficient amino acids". Proteins (2007) 1.03
Differential protein expression on the cell surface of colorectal cancer cells associated to tumor metastasis. Proteomics (2010) 1.03
Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses. J Immunol (2006) 1.00
Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant analysis. J Virol (2005) 1.00
Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies. J Mol Biol (2002) 1.00
Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B. Blood (2010) 0.99
Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis. Mol Cell Proteomics (2006) 0.99
Rational humanization of the powerful antithrombotic anti-GPIbalpha antibody: 6B4. Thromb Haemost (2006) 0.98
A proteomics analysis of cell signaling alterations in colorectal cancer. Mol Cell Proteomics (2007) 0.98
A peptide-based fluorescent ratiometric sensor for quantitative detection of proteins. Anal Biochem (2010) 0.98
A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma. Cancer Res (2008) 0.98
FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer. PLoS One (2013) 0.97
Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. Mol Cancer Ther (2008) 0.97
Mapping of a discontinuous and highly conformational binding site on follicle stimulating hormone subunit-beta (FSH-beta) using domain Scan and Matrix Scan technology. Mol Divers (2004) 0.96
Proteomic analysis of p38alpha mitogen-activated protein kinase-regulated changes in membrane fractions of RAS-transformed fibroblasts. Proteomics (2006) 0.96
Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions. Hum Mol Genet (2011) 0.94
A fast mutagenesis procedure to recover soluble and functional scFvs containing amber stop codons from synthetic and semisynthetic antibody libraries. J Immunol Methods (2006) 0.91
Clinical review 155: Pheochromocytoma in Von Hippel-Lindau disease. J Clin Endocrinol Metab (2003) 0.90
Synergistic effect of oncogenic RET and loss of p18 on medullary thyroid carcinoma development. Cancer Res (2008) 0.90
Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. J Biol Chem (2004) 0.90
Novel snail1 target proteins in human colon cancer identified by proteomic analysis. PLoS One (2010) 0.88
Inhibition of amyloid fibril formation of human amylin by N-alkylated amino acid and alpha-hydroxy acid residue containing peptides. Chemistry (2002) 0.88
Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg(593) to Cys substitution. Thromb Haemost (2006) 0.87
Variations in antigen-antibody association kinetics as a function of pH and salt concentration: a QSAR and molecular modeling study. Biochemistry (2005) 0.87
The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition. Biochim Biophys Acta (2010) 0.87
Light affects the accessibility of the thylakoid light harvesting complex II (LHCII) phosphorylation site to the membrane protein kinase(s). Biochemistry (2003) 0.86
Identification of MST1/STK4 and SULF1 proteins as autoantibody targets for the diagnosis of colorectal cancer by using phage microarrays. Mol Cell Proteomics (2011) 0.86
P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development. Int J Cancer (2009) 0.86
QSAR studies applied to the prediction of antigen-antibody interaction kinetics as measured by BIACORE. Protein Eng (2002) 0.85
Proteomic analysis of the resistance to aplidin in human cancer cells. J Proteome Res (2007) 0.85
Sporadic colon cancer murine models demonstrate the value of autoantibody detection for preclinical cancer diagnosis. Sci Rep (2013) 0.85
Functional aspects of co-variant surface charges in an antibody fragment. Protein Sci (2002) 0.84
Three-dimensional structure of the cross-reactive pollen allergen Che a 3: visualizing cross-reactivity on the molecular surfaces of weed, grass, and tree pollen allergens. J Immunol (2008) 0.84
Serum and tissue profiling in bladder cancer combining protein and tissue arrays. J Proteome Res (2010) 0.84
Identification of cancer autoantigens in serum: toward diagnostic/prognostic testing? Mol Diagn Ther (2010) 0.83
Avian and mammalian reoviruses use different molecular mechanisms to synthesize their {micro}NS isoforms. J Gen Virol (2011) 0.83
A combination of neutral loss and targeted product ion scanning with two enzymatic digestions facilitates the comprehensive mapping of phosphorylation sites. Proteomics (2007) 0.83
Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides. Peptides (2003) 0.83
An optimized predictor panel for colorectal cancer diagnosis based on the combination of tumor-associated antigens obtained from protein and phage microarrays. J Proteomics (2012) 0.83
Designing antibodies for the inhibition of gastrin activity in tumoral cell lines. Int J Cancer (2008) 0.82
Monocyte cyclooxygenase-2 overactivity: a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors? Eur Heart J (2004) 0.82
Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis. J Biol Chem (2006) 0.82
Comparative properties of two peptide-antibody interactions as deduced from epitope delineation. J Immunol Methods (2002) 0.81
Blood-cell-specific acetylcholinesterase splice variations under changing stimuli. Int J Dev Neurosci (2004) 0.81
SUMO assay with peptide arrays on solid support: insights into SUMO target sites. J Biochem (2008) 0.81
The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes. Eur Biophys J (2010) 0.80
Structure-dependent efficacy of infectious bursal disease virus (IBDV) recombinant vaccines. Vaccine (2003) 0.80
Proteomic analysis of 1α,25-dihydroxyvitamin D3 action on human colon cancer cells reveals a link to splicing regulation. J Proteomics (2011) 0.80
A peptide-based, ratiometric biosensor construct for direct fluorescence detection of a protein analyte. Bioconjug Chem (2008) 0.80
Impaired processing of human pro-islet amyloid polypeptide is not a causative factor for fibril formation or membrane damage in vitro. Biochemistry (2009) 0.80
Binding of CDR-derived peptides is mechanistically different from that of high-affinity parental antibodies. J Mol Recognit (2010) 0.79
Active immunization against gonadotrophin-releasing hormone in Chinese male pigs: effects of dose on antibody titer, hormone levels and sexual development. Anim Reprod Sci (2002) 0.79
Spanish human proteome project: dissection of chromosome 16. J Proteome Res (2012) 0.79
Tissue selectivity in multiple endocrine neoplasia type 1-associated tumorigenesis. Cancer Res (2009) 0.79
Functional mapping of conserved, surface-exposed charges of antibody variable domains. J Mol Recognit (2002) 0.79
Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation. Chembiochem (2014) 0.78
Dissecting the oligonucleotide binding properties of a disordered chaperone protein using surface plasmon resonance. Nucleic Acids Res (2013) 0.78
Antibodies on demand: a fast method for the production of human scFvs with minimal amounts of antigen. BMC Biotechnol (2011) 0.78
Validation of surface plasmon resonance screening of a diverse chemical library for the discovery of protein tyrosine phosphatase 1b binders. Anal Biochem (2011) 0.78
Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1. Clin Cancer Res (2003) 0.78