Published in Neurobiol Dis on October 06, 2009
ATP7A-related copper transport diseases-emerging concepts and future trends. Nat Rev Neurol (2011) 2.01
Copper signaling in the mammalian nervous system: synaptic effects. J Neurosci Res (2012) 1.03
Peptidylgycine α-amidating monooxygenase and copper: a gene-nutrient interaction critical to nervous system function. J Neurosci Res (2010) 0.88
Evaluation of candidate genes from orphan FEB and GEFS+ loci by analysis of human brain gene expression atlases. PLoS One (2011) 0.86
Probing the production of amidated peptides following genetic and dietary copper manipulations. PLoS One (2011) 0.85
Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. J Neurochem (2013) 0.85
Pam heterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function. Ann N Y Acad Sci (2014) 0.83
In vivo and in vitro analyses of amygdalar function reveal a role for copper. J Neurophysiol (2014) 0.83
Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci (2010) 0.83
Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning. Horm Behav (2014) 0.80
Maternal iron supplementation attenuates the impact of perinatal copper deficiency but does not eliminate hypotriiodothyroninemia nor impaired sensorimotor development. J Nutr Biochem (2011) 0.79
60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C. J Mol Endocrinol (2015) 0.77
Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum. BMC Endocr Disord (2014) 0.75
Canine Models for Copper Homeostasis Disorders. Int J Mol Sci (2016) 0.75
Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity. J Cell Sci (2016) 0.75
Prediction of protein amidation sites by feature selection and analysis. Mol Genet Genomics (2013) 0.75
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (1996) 3.99
Molecular mechanisms of copper uptake and distribution. Curr Opin Chem Biol (2002) 2.74
Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J (2007) 2.55
Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. J Biol Chem (1994) 2.22
Atp7a determines a hierarchy of copper metabolism essential for notochord development. Cell Metab (2006) 2.14
New insights into copper monooxygenases and peptide amidation: structure, mechanism and function. Cell Mol Life Sci (2000) 2.02
Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus. J Comp Neurol (2002) 1.88
Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nat Med (1997) 1.80
Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. J Neurosci (2007) 1.70
Intracellular copper transport in mammals. J Nutr (2004) 1.67
Copper deficiency myelopathy (human swayback). Mayo Clin Proc (2006) 1.64
Copper and iron disorders of the brain. Annu Rev Neurosci (2007) 1.62
NMDA receptor activation mediates copper homeostasis in hippocampal neurons. J Neurosci (2005) 1.61
Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing. J Appl Physiol (1985) (2008) 1.60
Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status. J Nutr (2006) 1.53
NPY Y1 receptor antagonist prevents NPY-induced torpor-like hypothermia in cold-acclimated Siberian hamsters. Am J Physiol Regul Integr Comp Physiol (2007) 1.52
Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. J Neurosci (1999) 1.52
Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J Neurosci (1997) 1.47
Vmat2 heterozygous mutant mice display a depressive-like phenotype. J Neurosci (2007) 1.45
Cholecystokinin-immunopositive basket and Schaffer collateral-associated interneurones target different domains of pyramidal cells in the CA1 area of the rat hippocampus. Neuroscience (2002) 1.38
Old iron, young copper: from Mars to Venus. Biometals (2001) 1.37
Copper metabolism in mottled mouse mutants: copper therapy of brindled (Mobr) mice. Biochem J (1979) 1.36
Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen. PLoS One (2008) 1.36
Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors. Eur J Neurosci (2003) 1.36
C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb Technol (1994) 1.32
Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice. J Exp Med (2007) 1.32
Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Proc Natl Acad Sci U S A (2006) 1.30
Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev Biol (2005) 1.29
Occurrence of copper proteins through the three domains of life: a bioinformatic approach. J Proteome Res (2007) 1.24
Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus. Biol Psychiatry (2006) 1.23
Metallochaperone for Cu,Zn-superoxide dismutase (CCS) protein but not mRNA is higher in organs from copper-deficient mice and rats. Arch Biochem Biophys (2003) 1.19
Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans. Am J Physiol Heart Circ Physiol (2004) 1.18
Developmental changes in the expression of ATP7A during a critical period in postnatal neurodevelopment. Neuroscience (2006) 1.18
Studies on the rate of release and turnover of ceruloplasmin and apoceruloplasmin in rat plasma. J Biol Chem (1970) 1.14
Copper deficiency in the developing rat brain: a possible model for Menkes' steely-hair disease. J Neurochem (1974) 1.11
Copper homeostasis in the CNS: a novel link between the NMDA receptor and copper homeostasis in the hippocampus. Mol Neurobiol (2006) 1.11
Trafficking of a secretory granule membrane protein is sensitive to copper. J Biol Chem (2007) 1.09
Abnormal motor function persists following recovery from perinatal copper deficiency in rats. J Nutr (2004) 1.08
Copper-replacement treatment for symptomatic Menkes disease: ethical considerations. Clin Genet (2005) 1.07
Role of copper in the proteosome-mediated degradation of the multicopper oxidase hephaestin. J Biol Chem (2004) 1.06
Induction of integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1. J Cell Biol (1999) 1.04
Menkes disease: recent advances and new aspects. J Med Genet (1997) 1.04
Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. Endocrinology (2003) 1.04
Variable response of selected cuproproteins in rat choroid plexus and cerebellum following perinatal copper deficiency. Genes Nutr (2006) 1.02
Standardization of serum ceruloplasmin concentrations in international enzyme units with o-dianisidine dihydrochloride as substrate. Clin Chem (1974) 1.00
Mechanistic investigation of peptidylglycine alpha-hydroxylating monooxygenase via intrinsic tryptophan fluorescence and mutagenesis. Biochemistry (2003) 0.98
Biomarkers of copper status: a brief update. Br J Nutr (2008) 0.98
Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice. Comp Biochem Physiol B Biochem Mol Biol (2006) 0.96
Identification of an apoceruloplasmin-like substance in the plasma of copper-deficient rats. J Biol Chem (1970) 0.95
Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. J Biol Chem (2002) 0.95
Altered ATP7A expression and other compensatory responses in a murine model of Menkes disease. Neurobiol Dis (2007) 0.95
Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. BMC Med Genet (2008) 0.95
Subchronic toxicity of cupric sulfate administered in drinking water and feed to rats and mice. Fundam Appl Toxicol (1993) 0.94
ATOX1: a novel copper-responsive transcription factor in mammals? Int J Biochem Cell Biol (2008) 0.94
Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res (1996) 0.94
Activation of the NPY Y5 receptor regulates both feeding and energy expenditure. Am J Physiol (1999) 0.94
Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper. Endocrinology (2008) 0.91
Further characterization of peptidylglycine alpha-amidating monooxygenase from bovine neurointermediate pituitary. Mol Endocrinol (1987) 0.89
Plasticity in hippocampal peptidergic systems induced by repeated electroconvulsive shock. Neuropsychopharmacology (2002) 0.88
Analysis of the anxiolytic-like effect of TRH and the response of amygdalar TRHergic neurons in anxiety. Psychoneuroendocrinology (2008) 0.86
Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors. Neurobiol Dis (2005) 0.86
Intragenic deletions at Atp7a in mouse models for Menkes disease. Genomics (2001) 0.85
Regional specificity in alterations of rat brain copper and catecholamines following perinatal copper deficiency. J Neurochem (1994) 0.85
Different housing conditions alter the behavioural phenotype of CCK(2) receptor-deficient mice. Behav Brain Res (2008) 0.83
ICV NPY Y1 receptor agonist but not Y5 agonist induces torpor-like hypothermia in cold-acclimated Siberian hamsters. Am J Physiol Regul Integr Comp Physiol (2007) 0.83
Peptidylglycine-alpha-amidating monooxygenase activity and protein are lower in copper-deficient rats and suckling copper-deficient mice. Arch Biochem Biophys (2005) 0.82
Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system. FEBS J (2005) 0.82
Constant-pressure perfusion of rat hindlimb shows alpha- and beta-adrenergic stimulation of oxygen consumption. Am J Physiol (1995) 0.80
Effects of pentylenetetrazole-induced kindling on thyrotropin-releasing hormone biosynthesis and receptors in rat brain. Neuroscience (1999) 0.78
Rapid increases in peptide processing enzyme expression in hippocampal neurons. J Neurochem (1993) 0.78
Cholecystokinin-8 and nerve growth factor: two endogenous molecules working for the upkeep and repair of the nervous system. Curr Drug Targets CNS Neurol Disord (2002) 0.78
Uptake of dehydroascorbic acid and ascorbic acid to isolated nerve terminals and secretory granules from ox neurohypophyses. Acta Physiol Scand (1986) 0.78
Menke's kinky hair syndrome--a rare medical condition. J Pak Med Assoc (2005) 0.77
[Clinical manifestations for early diagnosis of the patient with classical Menkes disease]. No To Hattatsu (2002) 0.77
Inhibition of brown fat activity during hypothalamic stimulation in the rat. Am J Physiol (1996) 0.77
[Neonatal onset of Menkes disease: diagnosis interest of cupremia and microscopic examination of the hairs]. Arch Pediatr (2007) 0.77
CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (PTZ)-treated adult rats. Neuropharmacology (2005) 0.77
Precious metal economy. Cell Metab (2006) 0.76
Kainic acid seizures in the rat: differential expression of chromogranin A, carboxypeptidase H and peptidylglycine alpha-amidating monooxigenase in subfields of the hippocampal formation. Acta Neuropathol (1993) 0.76
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature (2007) 4.59
Automated design of ligands to polypharmacological profiles. Nature (2012) 3.54
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab (2007) 3.43
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron (2003) 3.40
A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell (2008) 2.76
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron (2011) 2.71
Dioxygen binds end-on to mononuclear copper in a precatalytic enzyme complex. Science (2004) 2.57
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology (2003) 2.56
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet (2011) 2.38
Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proc Natl Acad Sci U S A (2008) 2.23
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nat Neurosci (2010) 2.19
Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition. Neuron (2006) 1.98
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98
Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. J Neurosci (2006) 1.88
N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology (2007) 1.83
Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity. Endocrinology (2003) 1.73
Different presynaptic roles of synapsins at excitatory and inhibitory synapses. J Neurosci (2004) 1.72
Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology (2006) 1.71
ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Mol Cell Biol (2004) 1.70
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab (2010) 1.64
Kalirin, a multifunctional Rho guanine nucleotide exchange factor, is necessary for maintenance of hippocampal pyramidal neuron dendrites and dendritic spines. J Neurosci (2003) 1.60
Kalirin-7 is required for synaptic structure and function. J Neurosci (2008) 1.54
Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. Arterioscler Thromb Vasc Biol (2013) 1.54
Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status. J Nutr (2006) 1.53
Aberrant responses in social interaction of dopamine transporter knockout mice. Behav Brain Res (2004) 1.52
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther (2010) 1.48
Vmat2 heterozygous mutant mice display a depressive-like phenotype. J Neurosci (2007) 1.45
Metabolic crossroads of iron and copper. Nutr Rev (2010) 1.43
Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene. Neuropsychopharmacology (2005) 1.39
Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase. Spectroscopic definition of the resting sites and the putative CuIIM-OOH intermediate. Biochemistry (2004) 1.36
Hypothalamic Sirt1 regulates food intake in a rodent model system. PLoS One (2009) 1.34
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology (2004) 1.33
Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons. J Neurosci (2008) 1.33
Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. PLoS Biol (2005) 1.31
Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron (2009) 1.31
Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev Biol (2005) 1.29
Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms. J Neurosci (2002) 1.29
WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. J Neurosci (2011) 1.29
microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs. RNA (2011) 1.26
Neuroanatomical phenotypes in the reeler mouse. Neuroimage (2006) 1.26
Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. J Neurosci (2005) 1.24
New roles of carboxypeptidase E in endocrine and neural function and cancer. Endocr Rev (2012) 1.23
Behavioral and morphological responses to cocaine require kalirin7. Biol Psychiatry (2010) 1.21
Kalirin: a dual Rho guanine nucleotide exchange factor that is so much more than the sum of its many parts. Neuroscientist (2005) 1.21
Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. J Biol Chem (2010) 1.19
Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal (2011) 1.19
Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. J Neurosci (2013) 1.19
Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. BMC Cell Biol (2007) 1.19
Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. J Med Chem (2012) 1.19
Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy. Neuron (2013) 1.16
Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. J Pharmacol Exp Ther (2006) 1.15
Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum (2009) 1.15
ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis. Mol Cell Neurosci (2007) 1.14
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J Clin Invest (2004) 1.13
Not all secretory granules are created equal: Partitioning of soluble content proteins. Mol Biol Cell (2006) 1.12
Cu,Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copper-deficient rats and mice. Exp Biol Med (Maywood) (2004) 1.11
PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. Biochem Biophys Res Commun (2005) 1.11
Multiple novel isoforms of Trio are expressed in the developing rat brain. Gene (2005) 1.11
Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. Neuropsychopharmacology (2006) 1.10
Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. Biochemistry (2009) 1.10
Supplying copper to the cuproenzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem (2003) 1.09
Trafficking of a secretory granule membrane protein is sensitive to copper. J Biol Chem (2007) 1.09
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. PLoS One (2012) 1.08
Abnormal motor function persists following recovery from perinatal copper deficiency in rats. J Nutr (2004) 1.08
Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. J Cell Sci (2009) 1.07
Synapsins differentially control dopamine and serotonin release. J Neurosci (2010) 1.07
Synaptic plasticity, a symphony in GEF. ACS Chem Neurosci (2010) 1.06
Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. Neuron (2013) 1.06
Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions. J Biol Chem (2006) 1.06
Genomic organization and differential expression of Kalirin isoforms. Gene (2002) 1.05
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. Hippocampus (2008) 1.05
Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract. Am J Physiol Endocrinol Metab (2007) 1.04
Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. Endocrinology (2003) 1.04
Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice. Eur J Neurosci (2002) 1.03
Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation. Mol Biol Cell (2007) 1.03
Variable response of selected cuproproteins in rat choroid plexus and cerebellum following perinatal copper deficiency. Genes Nutr (2006) 1.02
AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. Endocrinology (2012) 1.02