Published in Mutat Res on January 05, 2010
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Ecology. Ecology for a crowded planet. Science (2004) 2.72
Noncanonical DNA motifs as transactivation targets by wild type and mutant p53. PLoS Genet (2008) 1.67
Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity. Proc Natl Acad Sci U S A (2003) 1.63
Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation. Proc Natl Acad Sci U S A (2005) 1.49
MDM2 SNP309 genotype is associated with ferritin and LDH serum levels in children with stage 4 neuroblastoma. Pediatr Blood Cancer (2010) 1.40
Functional evolution of the p53 regulatory network through its target response elements. Proc Natl Acad Sci U S A (2008) 1.34
Tumour p53 mutations exhibit promoter selective dominance over wild type p53. Oncogene (2002) 1.30
A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network. Proc Natl Acad Sci U S A (2006) 1.29
The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes. Mol Cell Biol (2006) 1.24
An unprecedented nucleic acid capture mechanism for excision of DNA damage. Nature (2010) 1.17
A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1. Mol Cell Biol (2007) 1.13
Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences. Proc Natl Acad Sci U S A (2010) 1.11
A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts. Hum Mol Genet (2008) 1.09
Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation. Mol Cancer Res (2010) 1.07
A study of 7-deaza-2'-deoxyguanosine 2'-deoxycytidine base pairing in DNA. Nucleic Acids Res (2007) 1.06
The biological effects of N3-methyladenine. J Cell Biochem (2004) 1.04
Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes. DNA Repair (Amst) (2002) 1.02
Characterization of DNA with an 8-oxoguanine modification. Nucleic Acids Res (2011) 1.02
Identification of new p53 target microRNAs by bioinformatics and functional analysis. BMC Cancer (2013) 1.02
Functional analysis of CDKN2A/p16INK4a 5'-UTR variants predisposing to melanoma. Hum Mol Genet (2010) 1.01
Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin. Clin Cancer Res (2007) 1.01
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst) (2004) 0.99
Transcriptional functionality of germ line p53 mutants influences cancer phenotype. Clin Cancer Res (2007) 0.99
Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics. Cell Cycle (2013) 0.98
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Characterization of the p53 mutants ability to inhibit p73 beta transactivation using a yeast-based functional assay. Oncogene (2003) 0.97
Structure of p73 DNA-binding domain tetramer modulates p73 transactivation. Proc Natl Acad Sci U S A (2012) 0.96
Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair. Biochemistry (2004) 0.95
A functional genetic study identifies HAND1 mutations in septation defects of the human heart. Hum Mol Genet (2009) 0.94
A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards. Biochemistry (2008) 0.94
A facile synthetic approach to 7-deazaguanine nucleosides via a Boc protection strategy. Org Lett (2009) 0.93
Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent. J Biol Chem (2002) 0.93
Potentiating the p53 network. Discov Med (2010) 0.92
Functional diversity in the gene network controlled by the master regulator p53 in humans. Cell Cycle (2005) 0.92
Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent. DNA Repair (Amst) (2008) 0.91
Structure of B-DNA with cations tethered in the major groove. Biochemistry (2005) 0.90
Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending. J Am Chem Soc (2002) 0.90
Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes. Mol Cancer Res (2011) 0.89
Design of triple helix forming C-glycoside molecules. J Am Chem Soc (2003) 0.89
Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors. Biochemistry (2012) 0.88
p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system. PLoS One (2011) 0.88
Thermodynamic and hydration effects for the incorporation of a cationic 3-aminopropyl chain into DNA. Nucleic Acids Res (2002) 0.87
Exposure of human lymphocytes and lymphoblastoid cells to simulated microgravity strongly affects energy metabolism and DNA repair. J Cell Biochem (2005) 0.87
Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach. Biochem Pharmacol (2013) 0.87
DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters. Biochemistry (2003) 0.85
Incorporation of cationic chains in the Dickerson-Drew dodecamer: correlation of energetics, structure, and ion and water binding. Biochemistry (2005) 0.85
A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing. Biochim Biophys Acta (2013) 0.85
Thermodynamic characterization of DNA with 3-deazaadenine and 3-methyl-3-deazaadenine substitutions: the effect of placing a hydrophobic group in the minor groove of DNA. J Phys Chem B (2010) 0.84
MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma. Pediatr Blood Cancer (2009) 0.84
The effect of 3-methyladenine DNA glycosylase-mediated DNA repair on the induction of toxicity and diabetes by the beta-cell toxicant streptozotocin. Toxicol Sci (2006) 0.84
Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Res (2013) 0.84
The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound. PLoS One (2010) 0.83
A cross-platform comparison of affymetrix and Agilent microarrays reveals discordant miRNA expression in lung tumors of c-Raf transgenic mice. PLoS One (2013) 0.83
Molecular recognition via triplex formation of mixed purine/pyrimidine DNA sequences using oligoTRIPs. J Am Chem Soc (2005) 0.83
PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53. Biochim Biophys Acta (2013) 0.83
Introduction of cationic charge into DNA near the major groove edge of a guanine x cytosine base pair: characterization of oligodeoxynucleotides substituted with 7-aminomethyl-7-deaza-2'-deoxyguanosine. J Am Chem Soc (2009) 0.83
Triple helix forming TRIPside molecules that target mixed purine/pyrimidine DNA sequences. Biochemistry (2004) 0.83
Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs. Future Med Chem (2012) 0.83
P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. PLoS One (2013) 0.83
Synthesis and characterization of DNA minor groove binding alkylating agents. Chem Res Toxicol (2012) 0.82
TP53 mutants in the tower of babel of cancer progression. Hum Mutat (2014) 0.82
High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells. Mutat Res (2009) 0.82
Altering the electrostatic potential in the major groove: thermodynamic and structural characterization of 7-deaza-2'-deoxyadenosine:dT base pairing in DNA. J Phys Chem B (2011) 0.82