Published in Biochemistry on May 18, 2004
Eukaryotic Y-family polymerases bypass a 3-methyl-2'-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo. Nucleic Acids Res (2008) 1.21
A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenine. Mol Cell Biol (2007) 1.15
Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent. DNA Repair (Amst) (2008) 0.91
Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes. Mol Cancer Res (2011) 0.89
Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair. Mutat Res (2010) 0.84
An active site aromatic triad in Escherichia coli DNA Pol IV coordinates cell survival and mutagenesis in different DNA damaging agents. PLoS One (2011) 0.84
High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells. Mutat Res (2009) 0.82
Synthesis and characterization of DNA minor groove binding alkylating agents. Chem Res Toxicol (2012) 0.82
Effect of n3-methyladenine and an isosteric stable analogue on DNA polymerization. J Nucleic Acids (2010) 0.80
Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts. Nucleic Acids Res (2005) 0.77
3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro. DNA Repair (Amst) (2011) 0.76
Ecology. Ecology for a crowded planet. Science (2004) 2.72
MDM2 SNP309 genotype is associated with ferritin and LDH serum levels in children with stage 4 neuroblastoma. Pediatr Blood Cancer (2010) 1.40
Tumour p53 mutations exhibit promoter selective dominance over wild type p53. Oncogene (2002) 1.30
Tumor and metastasis suppression by the human RNASET2 gene. Int J Oncol (2005) 1.25
An unprecedented nucleic acid capture mechanism for excision of DNA damage. Nature (2010) 1.17
Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice. Proc Natl Acad Sci U S A (2009) 1.09
A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts. Hum Mol Genet (2008) 1.09
Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase. Mol Cell (2010) 1.07
A study of 7-deaza-2'-deoxyguanosine 2'-deoxycytidine base pairing in DNA. Nucleic Acids Res (2007) 1.06
The biological effects of N3-methyladenine. J Cell Biochem (2004) 1.04
Identification of new p53 target microRNAs by bioinformatics and functional analysis. BMC Cancer (2013) 1.02
Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes. DNA Repair (Amst) (2002) 1.02
Characterization of DNA with an 8-oxoguanine modification. Nucleic Acids Res (2011) 1.02
Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin. Clin Cancer Res (2007) 1.01
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst) (2004) 0.99
Transcriptional functionality of germ line p53 mutants influences cancer phenotype. Clin Cancer Res (2007) 0.99
The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis. Nucleic Acids Res (2012) 0.98
Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics. Cell Cycle (2013) 0.98
Characterization of the p53 mutants ability to inhibit p73 beta transactivation using a yeast-based functional assay. Oncogene (2003) 0.97
Vitamin E Prevents Alzheimer's Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production. J Alzheimers Dis (2000) 0.97
Structure of p73 DNA-binding domain tetramer modulates p73 transactivation. Proc Natl Acad Sci U S A (2012) 0.96
A functional genetic study identifies HAND1 mutations in septation defects of the human heart. Hum Mol Genet (2009) 0.94
A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards. Biochemistry (2008) 0.94
A facile synthetic approach to 7-deazaguanine nucleosides via a Boc protection strategy. Org Lett (2009) 0.93
Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent. J Biol Chem (2002) 0.93
Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent. DNA Repair (Amst) (2008) 0.91
Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. PLoS Genet (2013) 0.91
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase. Proc Natl Acad Sci U S A (2010) 0.90
Structure of B-DNA with cations tethered in the major groove. Biochemistry (2005) 0.90
Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending. J Am Chem Soc (2002) 0.90
Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress. J Neurosci Res (2002) 0.90
Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes. Mol Cancer Res (2011) 0.89
Design of triple helix forming C-glycoside molecules. J Am Chem Soc (2003) 0.89
Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors. Biochemistry (2012) 0.88
p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system. PLoS One (2011) 0.88
Thermodynamic and hydration effects for the incorporation of a cationic 3-aminopropyl chain into DNA. Nucleic Acids Res (2002) 0.87
Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach. Biochem Pharmacol (2013) 0.87
DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters. Biochemistry (2003) 0.85
Incorporation of cationic chains in the Dickerson-Drew dodecamer: correlation of energetics, structure, and ion and water binding. Biochemistry (2005) 0.85
A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing. Biochim Biophys Acta (2013) 0.85
MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma. Pediatr Blood Cancer (2009) 0.84
O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integr Biol (Camb) (2012) 0.84
Thermodynamic characterization of DNA with 3-deazaadenine and 3-methyl-3-deazaadenine substitutions: the effect of placing a hydrophobic group in the minor groove of DNA. J Phys Chem B (2010) 0.84
The effect of 3-methyladenine DNA glycosylase-mediated DNA repair on the induction of toxicity and diabetes by the beta-cell toxicant streptozotocin. Toxicol Sci (2006) 0.84
Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Res (2013) 0.84
Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair. Mutat Res (2010) 0.84
PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53. Biochim Biophys Acta (2013) 0.83
Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity. Biochim Biophys Acta (2002) 0.83
Introduction of cationic charge into DNA near the major groove edge of a guanine x cytosine base pair: characterization of oligodeoxynucleotides substituted with 7-aminomethyl-7-deaza-2'-deoxyguanosine. J Am Chem Soc (2009) 0.83
Molecular recognition via triplex formation of mixed purine/pyrimidine DNA sequences using oligoTRIPs. J Am Chem Soc (2005) 0.83
Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs. Future Med Chem (2012) 0.83
Triple helix forming TRIPside molecules that target mixed purine/pyrimidine DNA sequences. Biochemistry (2004) 0.83
P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. PLoS One (2013) 0.83
TP53 mutants in the tower of babel of cancer progression. Hum Mutat (2014) 0.82
Synthesis and characterization of DNA minor groove binding alkylating agents. Chem Res Toxicol (2012) 0.82
Evidence in Escherichia coli that N3-methyladenine lesions and cytotoxicity induced by a minor groove binding methyl sulfonate ester can be modulated in vivo by netropsin. Biochemistry (2003) 0.82
Synthesis, Structure, and Nucleophile-Induced Rearrangements of Spiroketones. J Org Chem (1999) 0.82
Altering the electrostatic potential in the major groove: thermodynamic and structural characterization of 7-deaza-2'-deoxyadenosine:dT base pairing in DNA. J Phys Chem B (2011) 0.82
High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells. Mutat Res (2009) 0.82
Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide. Eur J Cancer (2005) 0.81
∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites. Oncotarget (2014) 0.81
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain. FEBS J (2013) 0.81