Published in Proc Natl Acad Sci U S A on January 15, 1991
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med (2005) 3.85
On the molecular mechanism of chloroquine's antimalarial action. Proc Natl Acad Sci U S A (1996) 3.29
Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment. J Exp Med (1992) 1.78
Severe malarial anemia: innate immunity and pathogenesis. Int J Biol Sci (2011) 1.65
Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials. Biochem J (1999) 1.62
Fluxes in "free" and total zinc are essential for progression of intraerythrocytic stages of Plasmodium falciparum. Chem Biol (2012) 1.59
Phagocytosis of the malarial pigment, hemozoin, impairs expression of major histocompatibility complex class II antigen, CD54, and CD11c in human monocytes. Infect Immun (1998) 1.46
Macrophage migration inhibitory factor release by macrophages after ingestion of Plasmodium chabaudi-infected erythrocytes: possible role in the pathogenesis of malarial anemia. Infect Immun (2000) 1.37
Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in Plasmodium falciparum. J Cell Biol (1998) 1.31
Optimization of xanthones for antimalarial activity: the 3,6-bis-omega-diethylaminoalkoxyxanthone series. Antimicrob Agents Chemother (2002) 1.27
Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia. Infect Immun (2006) 1.26
Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum. Antimicrob Agents Chemother (2004) 1.21
Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors. Parasitol Res (2006) 1.17
Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans. Proc Natl Acad Sci U S A (1994) 1.16
Heme on innate immunity and inflammation. Front Pharmacol (2014) 1.15
Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine. Infect Immun (2002) 1.13
A magneto-optic route toward the in vivo diagnosis of malaria: preliminary results and preclinical trial data. Biophys J (2008) 1.11
Synthetic Plasmodium-like hemozoin activates the immune response: a morphology - function study. PLoS One (2009) 1.10
Zinc finger-like motifs in rat ribosomal proteins S27 and S29. Nucleic Acids Res (1993) 1.07
Heme and blood-feeding parasites: friends or foes? Parasit Vectors (2010) 1.07
Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores. Antimicrob Agents Chemother (2000) 1.07
Evaluation of a novel magneto-optical method for the detection of malaria parasites. PLoS One (2014) 1.06
Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. PLoS Negl Trop Dis (2009) 1.06
Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis. Sci Rep (2013) 1.06
Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. Schizophr Res (2009) 1.05
The neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy. Biochemistry (2010) 1.05
Zinc protoporphyrin IX binds heme crystals to inhibit the process of crystallization in Plasmodium falciparum. Mol Med (2003) 1.00
Hemozoin: oil versus water. Parasitol Int (2007) 1.00
Lipophilic mediated assays for beta-hematin inhibitors. Comb Chem High Throughput Screen (2010) 0.99
Potential biomarkers and their applications for rapid and reliable detection of malaria. Biomed Res Int (2014) 0.96
Malarial hemozoin: from target to tool. Biochim Biophys Acta (2014) 0.96
Improved methods for magnetic purification of malaria parasites and haemozoin. Malar J (2010) 0.95
Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum. J Biol Chem (2012) 0.93
The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy. Biochem J (1996) 0.93
Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition. Malar J (2012) 0.93
The basis of the immunomodulatory activity of malaria pigment (hemozoin). J Biol Inorg Chem (2006) 0.92
Involvement of heme in the antimalarial action of chloroquine. Trans Am Clin Climatol Assoc (1998) 0.89
Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of Retnla expression and secretion. Infect Immun (2012) 0.88
Taste for blood: hemoglobin as a nutrient source for pathogens. PLoS Pathog (2012) 0.88
On the mechanisms involved in biological heme crystallization. J Bioenerg Biomembr (2011) 0.87
On the mechanism of chloroquine resistance in Plasmodium falciparum. PLoS One (2010) 0.87
Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT). PLoS One (2012) 0.87
Antimalarial 9-anilinoacridine compounds directed at hematin. Antimicrob Agents Chemother (2003) 0.87
Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease. Proc Natl Acad Sci U S A (1999) 0.87
Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria. Malar J (2010) 0.87
Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: role of IL-1beta and 15-HETE. Malar J (2008) 0.86
The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor. J Am Chem Soc (2013) 0.83
Regulation of heme polymerizing activity and the antimalarial action of chloroquine. Antimicrob Agents Chemother (1997) 0.83
Comparative analysis of gene expression changes mediated by individual constituents of hemozoin. Chem Res Toxicol (2009) 0.83
Increase on the initial soluble heme levels in acidic conditions is an important mechanism for spontaneous heme crystallization in vitro. PLoS One (2010) 0.82
Matrix Metalloproteinase-9 and Haemozoin: Wedding Rings for Human Host and Plasmodium falciparum Parasite in Complicated Malaria. J Trop Med (2011) 0.82
Ligands of the peripheral benzodiazepine receptor are potent inhibitors of Plasmodium falciparum and Toxoplasma gondii in vitro. Antimicrob Agents Chemother (2002) 0.81
Plasmodium falciparum-infected erythrocytes and beta-hematin induce partial maturation of human dendritic cells and increase their migratory ability in response to lymphoid chemokines. Infect Immun (2011) 0.81
In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum. Parasitol Res (2003) 0.80
A novel way to grow hemozoin-like crystals in vitro and its use to screen for hemozoin inhibiting antimalarial compounds. PLoS One (2012) 0.79
On the preparation of beta-haematin. Biochem J (2000) 0.78
A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs. Curr Pharm Des (2012) 0.78
Hemozoin "knobs" in Opisthorchis felineus infected liver. Parasit Vectors (2015) 0.77
Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia. Am J Hematol (2012) 0.77
Unsaturated glycerophospholipids mediate heme crystallization: biological implications for hemozoin formation in the kissing bug Rhodnius prolixus. PLoS One (2014) 0.77
Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study. Sci Rep (2016) 0.76
Growth of Large Hematin Crystals in Biomimetic Solutions. Cryst Growth Des (2014) 0.76
Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds. Malar J (2015) 0.75
Dendrimeric template of Plasmodium falciparum histidine rich protein II repeat motifs bearing Asp→Asn mutation exhibits heme binding and β-hematin formation. PLoS One (2014) 0.75
A surprising journey in translational medicine. Mol Med (2014) 0.75
Detergent-Mediated Formation of β-Hematin: Heme Crystallization Promoted by Detergents Implicates Nanostructure Formation for Use as a Biological Mimic. Cryst Growth Des (2016) 0.75
Superparamagnetic Properties of Hemozoin. Sci Rep (2016) 0.75
Efficient monitoring of the blood-stage infection in a malaria rodent model by the rotating-crystal magneto-optical method. Sci Rep (2016) 0.75
In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains. Am J Trop Med Hyg (2014) 0.75
Significance of higher drug concentration in erythrocytes of mice infected with Schistosoma japonicum and treated orally with mefloquine at single doses. Parasitol Res (2015) 0.75
Quinolines block every step of malaria heme crystal growth. Proc Natl Acad Sci U S A (2017) 0.75
In vitro antiplasmodial activity and prophylactic potentials of extract and fractions of Trema orientalis (Linn.) stem bark. BMC Complement Altern Med (2017) 0.75
Human malaria parasites in continuous culture. Science (1976) 59.70
Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle. Proc Natl Acad Sci U S A (1990) 3.01
THE STRUCTURE OF ALPHA-CHLOROHEMIN. Acta Crystallogr (1965) 2.47
Pinocytotic uptake and the digestion of hemoglobin in malaria parasites. J Protozool (1965) 1.76
Solution structures of ferrihaem in some dipolar aprotic solvents and their binary aqueous mixtures. Biochem J (1969) 1.58
The state of ferriprotoporphyrin IX in malaria pigment. J Biol Chem (1987) 1.52
ELECTRON SPIN RESONANCE IN HAEMIN, HAEMATIN AND HAEMOGLOBIN AT 4.2 DEGREES K. Nature (1964) 1.38
Plasmodium lophurae: composition and properties of hemozoin, the malarial pigment. Exp Parasitol (1979) 1.23
The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. Arch Biochem Biophys (1953) 1.22
Host heme catabolism in drug-sensitive and drug-resistant malaria. J Lab Clin Med (1977) 1.08
A rapid, sensitive mass spectrometric method for investigating microscale chemical reactions of surface adsorbed peptides and proteins. Biochem Biophys Res Commun (1986) 1.05
The composition of haemozoin from Plasmodium falciparum. Trans R Soc Trop Med Hyg (1990) 1.00
X-ray absorption spectroscopy. Application to biological molecules. Biochim Biophys Acta (1982) 0.99
Characterization of the malaria pigment (hemozoin) from the avian malaria parasite Plasmodium lophurae. J Protozool (1968) 0.93
Studies on the nature of malarial pigment (haemozion). I. The pigment of the simian species, Plasmodium knowlesi and P. Cynomolgi. Ann Trop Med Parasitol (1956) 0.91
Substituted deuteroporphyrins. VI. Ligand-exchange and dimerization reactions of deuterohemins. Biochemistry (1969) 0.87
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A (1986) 15.20
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature (1988) 13.42
Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature (1986) 11.09
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med (1986) 10.91
The biology of cachectin/TNF--a primary mediator of the host response. Annu Rev Immunol (1989) 9.63
Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science (1986) 9.19
Cachectin: more than a tumor necrosis factor. N Engl J Med (1987) 8.74
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding. J Virol (2000) 8.62
Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. J Exp Med (1985) 8.18
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med (1985) 8.16
Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med (1988) 7.96
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature (1985) 7.22
Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med (1988) 7.22
Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med (1994) 7.19
Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus. N Engl J Med (1976) 7.02
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet (1990) 6.32
Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu Rev Biochem (1988) 5.75
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature (1993) 5.60
Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. J Immunol (1985) 5.38
MIF as a glucocorticoid-induced modulator of cytokine production. Nature (1995) 5.21
Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci U S A (2000) 5.20
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med (1988) 5.16
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature (1995) 5.13
A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science (1985) 4.98
Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci U S A (1984) 4.04
Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med (1988) 4.02
Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu Rev Med (1994) 3.95
Identification and characterization of macrophage inflammatory protein 2. Proc Natl Acad Sci U S A (1989) 3.88
Advanced glycosylation end products in patients with diabetic nephropathy. N Engl J Med (1991) 3.81
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci U S A (2001) 3.80
Studies of endotoxin-induced decrease in lipoprotein lipase activity. J Exp Med (1981) 3.70
Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells. Proc Natl Acad Sci U S A (1982) 3.69
Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol (1993) 3.68
Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines. FASEB J (1989) 3.67
Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites. Nature (1992) 3.67
Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu Rev Microbiol (1997) 3.66
Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). Biochemistry (1994) 3.58
Metabolism and functions of trypanothione in the Kinetoplastida. Annu Rev Microbiol (1992) 3.57
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology (1994) 3.46
The role of cachectin/TNF in endotoxic shock and cachexia. Immunol Today (1988) 3.40
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science (1986) 3.36
Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet (1988) 3.30
On the molecular mechanism of chloroquine's antimalarial action. Proc Natl Acad Sci U S A (1996) 3.29
Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro. Proc Natl Acad Sci U S A (1971) 3.27
Nonenzymatic browning in vivo: possible process for aging of long-lived proteins. Science (1981) 3.25
Evidence for extensive subcellular organization of asparagine-linked oligosaccharide processing and lysosomal enzyme phosphorylation. J Biol Chem (1983) 3.22
Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med (1984) 3.14
Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med (1993) 3.09
Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties. J Exp Med (1988) 3.06
Immunochemical detection of advanced glycosylation end products in vivo. J Biol Chem (1992) 3.06
Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: role of defective triglyceride removal. Mol Biochem Parasitol (1980) 3.05
Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle. Proc Natl Acad Sci U S A (1990) 3.01
Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest (1991) 3.00
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. Science (1985) 2.94
The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis. J Exp Med (1990) 2.89
Plasmodium hemozoin formation mediated by histidine-rich proteins. Science (1996) 2.78
Cachectin/tumour necrosis factor. Lancet (1989) 2.77
Perceived health status and morbidity and mortality: evidence from the Kuopio ischaemic heart disease risk factor study. Int J Epidemiol (1996) 2.73
An agent cleaving glucose-derived protein crosslinks in vitro and in vivo. Nature (1996) 2.71
Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting. Proc Natl Acad Sci U S A (1983) 2.67
Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses. J Cell Biol (1988) 2.66
Macrophage inflammatory protein 1 modulates macrophage function. J Immunol (1992) 2.66
Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response. J Intern Med (2008) 2.55
Protein glycation, diabetes, and aging. Recent Prog Horm Res (2001) 2.51
Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. J Exp Med (1990) 2.44
Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. Clin Exp Immunol (1989) 2.41
Beer binging and mortality: results from the Kuopio ischaemic heart disease risk factor study, a prospective population based study. BMJ (1997) 2.40
Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts. J Exp Med (1991) 2.32
Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype. J Exp Med (1986) 2.28
Aging of proteins: isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose. Proc Natl Acad Sci U S A (1984) 2.26
Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: the role of cachectin (tumor necrosis factor). Immunol Lett (1985) 2.23
Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis. J Exp Med (1989) 2.21
Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells. J Immunol (1985) 2.21
Structure of carbohydrate of hemoglobin AIc. J Biol Chem (1977) 2.21
Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages. Proc Natl Acad Sci U S A (1992) 2.20
Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells. J Immunol (1985) 2.15
Diabetic cataract formation: potential role of glycosylation of lens crystallins. Proc Natl Acad Sci U S A (1978) 2.14
High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules. Proc Natl Acad Sci U S A (1985) 2.11
Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A (1997) 2.10
Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications. Proc Natl Acad Sci U S A (1992) 2.09
Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.09
The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest (1990) 2.08
Hopelessness and risk of mortality and incidence of myocardial infarction and cancer. Psychosom Med (1997) 2.06
A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A (1999) 2.04
Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Adv Pharmacol (1992) 2.04
Lipoprotein lipase suppression in 3T3-L1 cells by a haematoprotozoan-induced mediator from peritoneal exudate cells. Parasite Immunol (1984) 2.03
Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci U S A (1996) 2.02
Role for the Salmonella flavohemoglobin in protection from nitric oxide. J Biol Chem (1998) 2.02
Lipid advanced glycosylation: pathway for lipid oxidation in vivo. Proc Natl Acad Sci U S A (1993) 2.00
Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase. EMBO J (1994) 2.00
Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. II. Expression in situ in lymphoid and nonlymphoid tissues. Cell Immunol (1995) 1.99
Malaria parasite exit from the host erythrocyte: a two-step process requiring extraerythrocytic proteolysis. Proc Natl Acad Sci U S A (2001) 1.99
Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines. J Immunol (1993) 1.99
Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. Am J Physiol (1989) 1.99
Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings. Surgery (1988) 1.98
In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol (1987) 1.97
The plasmodium digestive vacuole: metabolic headquarters and choice drug target. Parasitol Today (1995) 1.96
Depressive symptoms and increased risk of stroke mortality over a 29-year period. Arch Intern Med (1998) 1.96