Published in Science on January 25, 1991
Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci U S A (1991) 2.29
The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J Exp Med (1993) 1.80
Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis. Proc Natl Acad Sci U S A (1991) 1.47
Homeostatic control of immunity by TCR peptide-specific Tregs. J Clin Invest (2004) 1.34
A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution. Proc Natl Acad Sci U S A (1993) 1.34
Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis. J Exp Med (1999) 1.33
T cell vaccination induces T cell receptor Vbeta-specific Qa-1-restricted regulatory CD8(+) T cells. Proc Natl Acad Sci U S A (1998) 1.32
Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. Restricted V alpha/beta rearrangements may indicate antigen-driven selection. J Clin Invest (1993) 1.23
Immunization with T cell receptor V beta chain peptides deletes pathogenic T cells and prevents the induction of collagen-induced arthritis in mice. J Clin Invest (1996) 0.86
Successful prevention and treatment of autoimmune encephalomyelitis by short-term administration of anti-T-cell receptor alpha beta antibody. Immunology (1994) 0.85
Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions. Ann Clin Transl Neurol (2015) 0.84
T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease. Proc Natl Acad Sci U S A (1995) 0.84
Staphylococcal enterotoxin B-induced T-cell anergy is mediated by regulatory T cells. Immunology (1998) 0.84
Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J Exp Med (1991) 0.83
Tumour necrosis factor receptor gene therapy affects cellular immune responses in collagen induced arthritis in mice. Ann Rheum Dis (2005) 0.83
T-cell-receptor dose and the time of treatment during murine retrovirus infection for maintenance of immune function. Immunology (1996) 0.82
Heterogeneity of T-cell receptor alpha-chain complementarity-determining region 3 in myelin basic protein-specific T cells increases with severity of multiple sclerosis. Proc Natl Acad Sci U S A (1994) 0.79
Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells. Immunology (2003) 0.78
Lack of restriction of T cell receptor beta variable gene usage in cerebrospinal fluid lymphocytes in acute optic neuritis. J Neurol Neurosurg Psychiatry (1999) 0.78
Injection of T-cell receptor peptide reduces immunosenescence in aged C57BL/6 mice. Immunology (1998) 0.77
Cell death and the immune response: a lesson from the privileged. J Clin Immunol (1997) 0.76
A self-reactive class I-restricted T-cell response of H-2b mice to determinants of the V beta 8.2 domain of the T-cell receptor for antigen. Immunology (1994) 0.75
Antigenized antibodies expressing Vbeta8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis. J Immune Based Ther Vaccines (2004) 0.75
Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression. Neuroscience (2008) 2.01
Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains. J Immunol (2001) 1.79
Interaction of lactoferrin, monocytes, and T lymphocyte subsets in the regulation of steady-state granulopoiesis in vitro. J Clin Invest (1981) 1.79
Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial. Nat Med (1996) 1.78
Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells. J Immunol (1999) 1.50
Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis. Proc Natl Acad Sci U S A (1991) 1.47
Design, engineering and production of functional single-chain T cell receptor ligands. Protein Eng (1999) 1.46
Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells. J Immunol (2001) 1.35
Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity. Ann Neurol (1992) 1.25
Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat Med (1996) 1.25
Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J Neuroimmunol (1990) 1.20
Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J Neuroimmunol (1992) 1.20
Two separate 18-amino acid domains of tau promote the polymerization of tubulin. J Biol Chem (1989) 1.19
Myelin basic protein: structure, function and antigenic determinants. Immunol Rev (1978) 1.17
Response of human T lymphocyte lines to myelin basic protein: association of dominant epitopes with HLA class II restriction molecules. J Neurosci Res (1989) 1.16
17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis. J Neurosci Res (2001) 1.14
Specificity of T lymphocyte lines for peptides of myelin basic protein. J Immunol (1985) 1.13
Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol (1998) 1.12
Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis. J Immunol (1991) 1.11
Male SJL mice do not relapse after induction of EAE with PLP 139-151. J Neurosci Res (1996) 1.11
Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis. J Clin Invest (2000) 1.10
Association of melanoma tumor antigen activity with beta2-microglobulin. Cancer Res (1979) 1.06
Experimental autoimmune encephalomyelitis mediated by T lymphocyte lines: genotype of antigen-presenting cells influences immunodominant epitope of basic protein. J Immunol (1986) 1.04
Regulation of encephalitogenic T cells with recombinant TCR ligands. J Immunol (2000) 1.01
Allergic encephalomyelitis: the structure of encephalitogenic determinant. Proc Natl Acad Sci U S A (1968) 1.01
Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein. J Neurosci Res (1991) 1.01
A myelin basic protein-specific T lymphocyte line that mediates experimental autoimmune encephalomyelitis. J Immunol (1985) 0.99
Allergic encephalomyelitis: enzymatic degradation of the encephalitogenic basic protein from bovine spinal cord. Arch Biochem Biophys (1969) 0.99
Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells. J Immunol (1993) 0.98
Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice. J Immunol (1991) 0.98
Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis. J Immunol (1992) 0.96
Human transfer factor: effects on lymphocyte transformation. J Immunol (1976) 0.96
Human transfer factor activity in the guinea pig: absence of antigen specificity. Clin Immunol Immunopathol (1977) 0.95
Inactivation of S-adenosylhomocysteine hydrolase by 5'-deoxy-5'-methylthioadenosine. Biochem Biophys Res Commun (1981) 0.95
Allergic encephalomyelitis: cleavage of the C-tryptophyl bond in the encephalitogenic basic protein from bovne myelin. Arch Biochem Biophys (1969) 0.93
The structure of the terminal regions of the encephalitogenic basic protein from bovine myelin. Arch Biochem Biophys (1969) 0.93
Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis. J Neuroimmunol (2010) 0.93
Gangliosides induce selective modulation of CD4 from helper T lymphocytes. J Immunol (1987) 0.93
Suppression and reversal of allergic encephalomyelitis in guinea pigs with a non-encephalitogenic analogue of the tryptophan region of the myelin basic protein. J Immunol (1976) 0.93
Where, when, and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis. J Immunol (1993) 0.92
Selection of encephalitogenic rat T-lymphocyte clones recognizing an immunodominant epitope on myelin basic protein. J Neurosci Res (1989) 0.92
Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis. J Immunol (1990) 0.92
Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides. J Immunol (1994) 0.92
T cell lines specific for an immunodominant epitope of human basic protein define an encephalitogenic determinant for experimental autoimmune encephalomyelitis-resistant LOU/M rats. J Immunol (1991) 0.91
A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis. Mult Scler (2005) 0.90
Myelin basic protein specific T cell lines and clones derived from the CNS of rats with EAE only recognize encephalitogenic epitopes. J Neurosci Res (1991) 0.89
Human T-cell response to myelin basic protein in multiple sclerosis patients and healthy subjects. J Neurosci Res (1988) 0.89
Human transfer factor: fractionation and biologic activity. J Immunol (1976) 0.88
Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation. Biochem Pharmacol (1982) 0.88
Biological activity of region 65-102 of the myelin basic protein. J Neurosci Res (1986) 0.88
The role of 5'-methylthioadenosine phosphorylase in 5'-methylthioadenosine-mediated inhibition of lymphocyte transformation. Biochim Biophys Acta (1979) 0.87
Human transfer factors: structural properties suggested by HPRP chromatography and enzymatic sensitivities. J Immunol (1979) 0.87
Protection against experimental encephalomyelitis. Idiotypic autoregulation induced by a nonencephalitogenic T cell clone expressing a cross-reactive T cell receptor V gene. J Immunol (1991) 0.87
Experimental allergic encephalomyelitis in Lewis rats: immunoregulation of disease by a single amino acid substitution in the disease-inducing determinant. J Immunol (1981) 0.86
OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis. J Neurosci Res (1996) 0.86
Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia. Lancet (1992) 0.85
Delineation and synthesis of the membrane receptor-binding domain of sex hormone-binding globulin. J Biol Chem (1990) 0.85
The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells. Int Immunol (1998) 0.85
T cell receptor peptides in treatment of autoimmune disease: rationale and potential. J Neurosci Res (1996) 0.85
Immunoregulation of encephalitogenic MBP-NAc1-11-reactive T cells by CD4+ TCR-specific T cells involves IL-4, IL-10 and IFN-gamma. Autoimmunity (1999) 0.85
Definition of encephalitogenic and immunodominant epitopes of guinea pig myelin basic protein (Gp-BP) in Lewis rats tolerized neonatally with Gp-BP or Gp-BP peptides. J Immunol (1994) 0.85
IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R alpha and gamma chains. J Neuroimmunol (1999) 0.85
Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in Buffalo rats. J Neuroimmunol (1990) 0.84
Proteolipid protein interactions in transfectants: implications for myelin assembly. J Neurosci Res (1994) 0.84
Myelin basic protein-stimulated rosette-forming T cells in multiple sclerosis. Neurochem Res (1978) 0.84
Allergic encephalomyelitis: isolation and characterization of encephalitogenic peptides from the basic protein of bovine spinal cord. Arch Biochem Biophys (1969) 0.84
Experimental allergic encephalomyelitis in Lewis rats: chemical synthesis of disease-inducing determinant. Science (1977) 0.84
Substrate specificity of rat brain calcium-activated and phospholipid-dependent protein kinase. Biochem Biophys Res Commun (1986) 0.84
Gender differences in protection from EAE induced by oral tolerance with a peptide analogue of MBP-Ac1-11. J Neurosci Res (1999) 0.84
Determinants of human myelin basic protein that induce encephalitogenic T cells in Lewis rats. J Immunol (1989) 0.83
Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J Exp Med (1991) 0.83
The effects of plasma from guinea pigs with tumor on PHA stimulated lymphocyte cultures. Cell Immunol (1976) 0.83
T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice. J Neuroimmunol (1989) 0.83
Ganglioside (GM1)-treated T cells shed CD4. Immunopharmacology (1992) 0.83
Gender differences in experimental autoimmune encephalomyelitis develop during the induction of the immune response to encephalitogenic peptides. J Neurosci Res (1998) 0.83
T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats. J Exp Med (1989) 0.82
Transmembrane signalling associated with ganglioside-induced CD4 modulation. Immunopharmacology (1991) 0.82
Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. J Immunol (1998) 0.82
Response of rat encephalitogenic T lymphocyte lines to synthetic peptides of myelin basic protein. J Neurosci Res (1987) 0.82
Transfer factor therapy in patients with cancer. Cancer (1976) 0.82
Human CD8+ T cell clone regulates autologous CD4+ myelin basic protein specific T cells. Autoimmunity (1992) 0.81
Detection of breast tumor antigen-sensitive circulating T-lymphocytes by antigen-stimulated active rosette formation. Cancer Res (1979) 0.81
Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides. J Neurosci Res (1993) 0.81
Adoptive transfer of experimental allergic encephalomyelitis and localization of the encephalitogenic epitope in the SWR mouse. J Neuroimmunol (1991) 0.81
Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis. Cytokine (2000) 0.81